The relationship between menarche and the length of reproductive age and lipid profile in perimenopausal and postmenopausal women

Aim. To conduct a comparative analysis of serum orexin A levels in women of different age periods with and without sleep disorder and vasomotor symptoms. To evaluate the dynamics of orexin A levels under menopausal hormone therapy. Materials and methods. The study included 50 postmenopausal women and 30 women of reproductive age with a regular menstrual cycle. Using block randomization, patients are divided into 3 groups: group 1 (main group), n=25, -STRAW+ 10 (+1b and +1c), patients with sleep disorder and vasomotor symptoms; group 2 (comparison group), n=25, STRAW+ 10 (+1b and +1c), patients with vasomotor symptoms without sleep disorder; group 3 (control group), n=30, STRAW+ 10 (-4), women of reproductive age without sleep disorder. Group 1 patients were given menopausal hormone therapy. A comparative analysis was carried out using the questionnaire for assessing menopausal symptoms severity by the Greene Scale (the Greene Climacteric Scale) and Rating Scale for subjective sleep characteristics. After 12 weeks of treatment, a control examination was performed. Results. In group 1 women, the serum orexin A levels were significantly higher compared to the women without the symptoms. The link between the orexin A levels and menopause syndrome severity was established. A significant decrease in the menopausal symptoms severity after 12 weeks of menopausal hormone therapy was shown. It was accompanied by a 1,3-fold decrease in orexin A levels. Conclusions. The obtained data indicate the possible role of orexin A and the orexin neuropeptide system in the pathogenesis of sleep disorder and vasomotor symptoms in postmenopausal women.

Download Full-text

Study the relationship between various bacterial infections and lipid profile in Samarra hospital patients

10.36295/asro.2020.2368 ◽

2020 ◽

Vol 23 (06) ◽

pp. 52-63

Author(s):

Osama Nadhom Nijris ◽

Faesal Ghaz Hassen ◽

Asmaa Easa Mahmood

Keyword(s):

Lipid Profile ◽

Bacterial Infections ◽

Hospital Patients ◽

The Relationship

Download Full-text

The Relationship Between Dietary Lipids and Serum Visfatin and Adiponectin Levels in Postmenopausal Women

Endocrine Metabolic & Immune Disorders - Drug Targets ◽

10.2174/1871530314666140527143009 ◽

2014 ◽

Vol 14 (2) ◽

pp. 84-92 ◽

Cited By ~ 2

Author(s):

Ali Rahbar ◽

Iraj Nabipour

Keyword(s):

Postmenopausal Women ◽

Dietary Lipids ◽

The Relationship

Download Full-text

Environmental exposures to endocrine disrupting chemicals (EDCs) and their role in endometriosis: a systematic literature review

Reviews on Environmental Health ◽

10.1515/reveh-2020-0046 ◽

2020 ◽

Vol 0 (0) ◽

Cited By ~ 1

Author(s):

Diksha Sirohi ◽

Ruqaiya Al Ramadhani ◽

Luke D. Knibbs

Keyword(s):

Bisphenol A ◽

Phthalate Esters ◽

Endocrine Disrupting Chemicals ◽

Environmental Pollutants ◽

Positive Association ◽

Environmental Chemicals ◽

Reproductive Age ◽

Organochlorinated Pesticides ◽

Endocrine Disrupting ◽

The Relationship

AbstractPurposeEndocrine-related diseases and disorders are on the rise globally. Synthetically produced environmental chemicals (endocrine-disrupting chemicals (EDCs)) mimic hormones like oestrogen and alter signalling pathways. Endometriosis is an oestrogen-dependent condition, affecting 10–15% of women of the reproductive age, and has substantial impacts on the quality of life. The aetiology of endometriosis is believed to be multifactorial, ranging from genetic causes to immunologic dysfunction due to environmental exposure to EDCs. Hence, we undertook a systematic review and investigated the epidemiological evidence for an association between EDCs and the development of endometriosis. We also aimed to assess studies on the relationship between body concentration of EDCs and the severity of endometriosis.MethodFollowing PRISMA guidelines, a structured search of PubMed, Embase and Scopus was conducted (to July 2018). The included studies analysed the association between one or more EDCs and the prevalence of endometriosis. The types of EDCs, association and outcome, participant characteristics and confounding variables were extracted and analysed. Quality assessment was performed using standard criteria.ResultsIn total, 29 studies were included. Phthalate esters were positively associated with the prevalence of endometriosis. The majority (71%) of studies revealed a significant association between bisphenol A, organochlorinated environmental pollutants (dioxins, dioxin-like compounds, organochlorinated pesticides, polychlorinated biphenyls) and the prevalence of endometriosis. A positive association between copper, chromium and prevalence of endometriosis was demonstrated in one study only. Cadmium, lead and mercury were not associated with the prevalence of endometriosis. There were conflicting results for the association between nickel and endometriosis. The relationship of EDCs and severity of endometriosis was not established in the studies.ConclusionWe found some evidence to suggest an association between phthalate esters, bisphenol A, organochlorinated environmental pollutants and the prevalence of endometriosis. Disentangling these exposures from various other factors that affect endometriosis is complex, but an important topic for further research.

Download Full-text

Diurnal Salivary Cortisol in Sarcopenic Postmenopausal Women: The OsteoLaus Cohort

Calcified Tissue International ◽

10.1007/s00223-021-00863-y ◽

2021 ◽

Author(s):

Elena Gonzalez Rodriguez ◽

Pedro Marques-Vidal ◽

Bérengère Aubry-Rozier ◽

Georgios Papadakis ◽

Martin Preisig ◽

...

Keyword(s):

Postmenopausal Women ◽

Salivary Cortisol ◽

Population Based ◽

Cross Sectional Study ◽

Body Composition Assessment ◽

Cross Sectional ◽

X Ray ◽

Free Cortisol ◽

Cortisol Levels ◽

The Relationship

AbstractSarcopenia, similar to hypercortisolism, is characterized by loss of muscle mass and strength. Cortisol circadian rhythm changes with aging (blunted late-day nadir values) were suggested to contribute to this decline. We aimed to explore the relationship between diurnal salivary cortisol values and sarcopenia diagnosis and its components in postmenopausal women. This is a cross-sectional study within the OsteoLaus population-based cohort in Lausanne (Switzerland). Participants had a body composition assessment by dual X-ray absorptiometry (DXA), a grip strength (GS) measure, and salivary cortisol measures (at awakening, 30 min thereafter, 11 AM (sc-11AM) and 8 PM (sc-8PM)). Associations between salivary cortisol and sarcopenia diagnosed by six different criteria (based on appendicular lean mass (ALM) assessed by DXA, and muscle strength by GS), and its components, were analyzed. 471 women aged > 50 years (63.0 ± 7.5) were included. Various definitions identified different participants as sarcopenic, who consistently presented higher salivary cortisol at 11 AM and/or 8 PM. There were no associations between salivary cortisol levels and ALM measures, either absolute or after correction to height squared (ALM index) or body mass index. GS was inversely correlated to sc-11AM (r = − 0.153, p < 0.001) and sc-8PM (r = − 0.118, p = 0.002). Each 10 nmol/l increase of sc-11AM, respectively sc-8PM, was associated with a GS decrease of 1.758 (SE 0.472) kg, respectively 2.929 (SE 1.115) kg. In postmenopausal women, sarcopenia is associated with higher salivary cortisol levels at 11 AM and 8 PM. An increase of daily free cortisol levels in the physiological range could participate to sarcopenia development by decreasing muscle function in postmenopausal women.

Download Full-text