Stability of different mesoporous silica particles during an in vitro digestion

In recent decades, the versatility of mesoporous silica particles and their relevance to develop controlled release systems have been demonstrated. Within them, gated materials able to modulate payload delivery represent great advantages. However, the role played by the porous matrix in this kind of systems is scarce. In this work, different mesoporous silica materials (MCM-41, MCM-48, SBA-15 and UVM-7) are functionalized with oleic acid as a molecular gate. All systems are fully characterized and their ability to confine the entrapped cargo and release it in the presence of bile salts is validated with release assays and in vitro digestion experiments. The cargo release profile of each synthesized support is studied, paying attention to the inorganic scaffold. Obtained release profiles fit to Korsmeyer–Peppas model, which explains the differences among the studied supports. Based on the results, UVM-7 material was the most appropriate system for duodenal delivery and was tested in an in vivo model of the Wistar rat. Payload confinement and its complete release after gastric emptying is achieved, establishing the possible use of mesoporous silica particles as protection and direct release agents into the duodenum and, hence, demonstrating that these systems could serve as an alternative to the administration methods employed until now.

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Modulating Release of Metoprolol Tartrate with Nanostructured Silica Particles

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.602-603.55 ◽

2014 ◽

Vol 602-603 ◽

pp. 55-58

Author(s):

Xiao Yun Jia ◽

Ya Zhen Wu ◽

Qing Cai ◽

Xiao Ping Yang ◽

De Ping Liu ◽

...

Keyword(s):

Mesoporous Silica ◽

In Vitro Release ◽

Silica Particles ◽

Ammonium Bromide ◽

Water Medium ◽

Metoprolol Tartrate ◽

Silica Nanospheres ◽

Nanostructured Silica ◽

Mesoporous Silica Nanospheres

To develop a kind of gastrointestinal timed-release preparation for Metoprolol Tartrate, nanostructured silica particles were chose for the purpose. Briefly, MCM-41 type mesoporous silica nanospheres with a size of 100-200 nm were synthesized through the reaction of tetraethyl orthosilicate (TEOS) in the water medium at 353 K, with introducing some cetyltrimethyl ammonium bromide (CTAB) as porogens. Various analytical methods, including FT-IR, XRD, TEM, N2 physisorption and thermal analysis, were applied to characterize the final products. Metoprolol Tartrate was then loaded into the mesoporous silica nanospheres by soaking. Results of the release of the drug in simulated gastric juice indicated that the drug can release up to 24 h and its maximum released amount was 4.5%. In the simulated intestinal juice the maximum cumulative released amount of metorprolol was 10.8%.In vitro release behavior revealed that the mesoporous silica were appropriate used as drug delivery system.

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Hydrocolloid-Based Coatings with Nanoparticles and Transglutaminase Crosslinker as Innovative Strategy to Produce Healthier Fried Kobbah

Foods ◽

10.3390/foods9060698 ◽

2020 ◽

Vol 9 (6) ◽

pp. 698 ◽

Cited By ~ 2

Author(s):

Asmaa Al-Asmar ◽

Concetta Valeria L. Giosafatto ◽

Mohammed Sabbah ◽

Loredana Mariniello

Keyword(s):

Zeta Potential ◽

Mesoporous Silica ◽

Oil Content ◽

In Vitro Digestion ◽

Grass Pea ◽

Color Analysis ◽

Browning Index ◽

Innovative Strategy ◽

Pea Flour

This study addresses the effect of coating solutions on fried kobbah. Coating solutions were made of pectin (PEC) and grass pea flour (GPF), treated or not with transglutaminase (TGase) and nanoparticles (NPs)—namely mesoporous silica NPs (MSN) or chitosan NPs (CH–NPs). Acrylamide content (ACR), water, oil content and color of uncoated (control) and coated kobbah were investigated. Zeta potential, Z-average and in vitro digestion experiments were carried out. Zeta potential of CH–NPs was stable from pH 2.0 to pH 6.0 around + 35 mV but decreasing at pH > 6.0. However, the Z-average of CH–NPs increased by increasing the pH. All coating solutions were prepared at pH 6.0. ACR of the coated kobbah with TGase-treated GPF in the presence nanoparticles (MSN or CH–NPs) was reduced by 41.0% and 47.5%, respectively. However, the PEC containing CH–NPs showed the higher reduction of the ACR by 78.0%. Water content was higher in kobbah coated by PEC + CH–NPs solutions, while the oil content was lower. The color analysis indicated that kobbah with lower browning index containing lower ACR. Finally, in vitro digestion studies of both coating solutions and coated kobbah, demonstrated that the coating solutions and kobbah made by means of TGase or nanoparticles were efficiently digested.

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Development of a gliclazide ionic liquid and its mesoporous silica particles: an effective formulation strategy to improve oral absorption properties

RSC Advances ◽

10.1039/d1ra07499g ◽

2022 ◽

Vol 12 (2) ◽

pp. 1062-1076

Author(s):

Bijian Zhou ◽

Dan Teng ◽

Jinghui Li ◽

Yanhong Zhang ◽

Minghui Qi ◽

...

Keyword(s):

Ionic Liquid ◽

Mesoporous Silica ◽

Oral Absorption ◽

Silica Particles ◽

Dissolution Behavior ◽

Absorption Properties ◽

Enhanced Solubility

An ionic liquid (IL) form of gliclazide with enhanced solubility characteristics was successfully synthesized. This IL could be loaded into mesoporous silica carrier and exhibited improved dissolution behavior in vitro.

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In vitro biocompatibility of calcined mesoporous silica particles and fetal blood cells

International Journal of Nanomedicine ◽

10.2147/ijn.s32711 ◽

2012 ◽

pp. 3111 ◽

Cited By ~ 1

Author(s):

Abdul-Kader Souid ◽

Mohammed Taleb Al Samri ◽

Biradar ◽

Balhaj ◽

Al-Hammadi ◽

...

Keyword(s):

Mesoporous Silica ◽

Blood Cells ◽

Silica Particles ◽

Fetal Blood ◽

In Vitro Biocompatibility

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Real-Time Tracking of Highly Luminescent Mesoporous Silica Particles Modified with Europium β-Diketone Chelates in Living Cells

Nanomaterials ◽

10.3390/nano11020343 ◽

2021 ◽

Vol 11 (2) ◽

pp. 343

Author(s):

Jong-Seok Kim ◽

Sung Lee ◽

Hansol Doh ◽

Myeong Kim ◽

Do Kim

Keyword(s):

Mesoporous Silica ◽

Silica Particles ◽

Mouse Bone Marrow ◽

High Concentration ◽

Europium Complexes ◽

Imaging Probes ◽

In Vitro Diagnostic ◽

Real Time Tracking

Highly luminescent europium complexes modified mesoporous silica particles (MSP) were synthesized as an imaging probes for both in-vitro diagnostic and in-vivo cellular tracking agents. Europium β-diketone chelates (4,4,4-trifluoro-l-(2-thienyl)-l,3-butanedione) trioctylphosphine europium (III) (Eu(TTA)3(P(Oct)3)3) were incorporated inside the nanocavities that existed in hierarchical MSP (Eu@MSP). The MSP and Eu@MSP on mouse bone marrow-derived macrophages (BMDMs) did not show any toxic effect. The MSP and Eu@MSP in the BMDMs were found at cytoplasm without any degradation and immunogenicity. However, both pro- and anti-inflammatory cytokines of macrophages were significantly increased when lipopolysaccharide and a high concentration (100 μg/mL) of MSP and Eu@MSP were treated simultaneously.

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