Evaluation of the effect of dose change of Fe3O4 nanoparticles on electrochemical biosensor compatibility using hydrogels as an experimental living organism model

Heavy metal ions contamination has become more serious which is caused by the releasing of toxic water from industrial area and landfill that are very harmful to all living organism especially human and can even cause death if contaminated in small amount of heavy metal concentration. Currently, peoples are using classic method namely electrochemical treatment, chemical oxidation/reduction, chemical precipitation and reverse osmosis to eliminate the metal ions from toxic water. Unfortunately, these methods are costly and not environmentally friendly as compared to bioadsorption method, where agricultural waste is used as biosorbent to remove heavy metals. Two types of agricultural waste used in this research namely oil palm mesocarp fiber (Elaesis guineensis sp.) (OPMF) and mangrove bark (Rhizophora apiculate sp.) (MB) biomass. Through chemical treatment, the removal efficiency was found to improve. The removal efficiency is examined based on four specification namely dosage, of biosorbent to adsorb four types of metals ion explicitly nickel, lead, copper, and chromium. The research has found that the removal efficiency of MB was lower than OPMF; whereas, the multiple metals ions removal efficiency decreased in the order of Pb2+ > Cu2+ > Ni2+ > Cr2+.

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Risk Management Infrastructure as a Living Organism

CFA Digest ◽

10.2469/dig.v43.n3.38 ◽

2013 ◽

Vol 43 (3) ◽

Author(s):

Chen Sui

Keyword(s):

Risk Management ◽

Living Organism

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Preparation and In-vitro Evaluation of Fe3O4 Encapsulated by Chitosan Loaded Capecitabine Nanoparticles for the Treatment of Breast Cancer

International Journal of Drug Delivery Technology ◽

10.25258/ijddt.v6i3.8888 ◽

2016 ◽

Vol 6 (3) ◽

Author(s):

Shanmuganathan S. ◽

Nigma S. ◽

Anbarasan B. ◽

Harika B.

Keyword(s):

Fe3o4 Nanoparticles ◽

Polymer Concentration ◽

In Vitro Release ◽

Entrapment Efficiency ◽

In Vitro Evaluation ◽

Sem Image ◽

Therapeutic Molecules ◽

Dialysis Method ◽

Vitro Release

Nanoparticulate Carriers which is biodegradable, biocompatible and bio adhesive have significant feasible applications for administration of therapeutic molecules. The present study was aimed to formulate and optimise Capecitabine loaded Chitosan-Fe3O4 Nanoparticles and to study the in-vitro evaluation by sigma dialysis method. Capecitabine loaded chitosan – Fe3O4 nanoparticles batches with different ratios of drug: polymer (1:1, 1:2, 1:3, 1:4, 1:5, 1:6) were prepared by ionic gelation method. Increase in polymer concentration increases the nanoparticle drug content. Entrapment efficiency was 60.12% with drug to polymer ratio F3 (1:3). In-vitro release was found to be 65.20% for 12 hrs. Capecitabine from chitosanFe3O4 nanoparticles SEM image reveals discrete spherical structure and particles with size range of 100-500nm. FTIR studies represent the functional groups present with no characteristics change in formulations. Samples stored at refrigerator conditions showed better stability compared with samples kept at other conditions during 8 weeks of storage.

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The size of extracellular vesicles secreted by different types of stem cells

Nauchno-prakticheskii zhurnal «Patogenez» ◽

10.25557/gm.2018.4.9747 ◽

2018 ◽

pp. 38-42

Author(s):

И.Б. Алчинова ◽

М.В. Полякова ◽

И.Н. Сабурина ◽

М.Ю. Карганов

Keyword(s):

Stem Cells ◽

Extracellular Vesicles ◽

Culture Media ◽

Living Organism ◽

Isolation And Characterization ◽

Transmission Electron ◽

Study Results ◽

Multipotent Mesenchymal Stem Cells ◽

Rat Adipose Tissue ◽

Almost All

Механизм терапевтического действия мультипотентных мезенхимных стволовых клеток (ММСК) на облученный организм в последнее время вызывает повышенный интерес исследователей. В качестве активного участника паракринного механизма реализации этого эффекта предлагают рассматривать внеклеточные везикулы, секретируемые практически всеми клетками живого организма. Цель работы: выделить и охарактеризовать внеклеточные везикулы, продуцируемые стволовыми клетками различной природы. Материалы и методы. Суспензии внеклеточных везикул, выделенных по модифицированному протоколу дифференциального центрифугирования из культуральных жидкостей от культур ММСК костного мозга человека 2-го пассажа и ММСК жировой ткани крысы 4-го пассажа, были проанализированы методом просвечивающей электронной микроскопии и методом анализа траекторий наночастиц. Результаты. Исследование показало наличие в обоих образцах микрочастиц размерами до и около 100 нм, однако процентное содержание частиц разных размеров в суспензии различалось для двух анализируемых типов клеток. Заключение. Полученные результаты могут свидетельствовать о специфике секреции, обусловленной клеточным типом. A mechanism of the therapeutic effect of multipotent mesenchymal stem cells (MMSC) on irradiated body has recently arisen much interest of researchers. Extracellular vesicles (EVs) secreted by almost all cells of a living organism were suggested to actively contribute to the paracrine mechanism of this effect. The aim of the study was isolation and characterization of extracellular vesicles produced by various types of stem cells. Materials and methods. Suspensions of EVs were isolated from culture media of passage 2 human bone marrow-derived MMSC and passage 4 rat adipose tissue-derived MMSC using a modified protocol of differential centrifugation and then studied using transmission electron microscopy and nanoparticle tracking analysis. Results. The study showed the presence of microparticles with a size of >100 nm in the examined samples. However, the percent content of particles with different sizes in the suspension was different in two analyzed types of cell culture. Conclusion. The study results might reflect a specificity of secretion determined by the cell type.

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Features of radiothermoluminescence of polypropylene and ethylene propylenediene elastomer SKEPT-4044 compositions with nanoscale metal-containing fillers

Physics and Chemistry of Materials Treatment ◽

10.30791/0015-3214-2020-3-66-73 ◽

2020 ◽

pp. 66-73

Author(s):

A.M. Magerramov ◽

◽

N.I. Kurbanova ◽

M.N. Bayramov ◽

N.A. Alimirzoyeva ◽

...

Keyword(s):

Transition Temperature ◽

Molecular Mobility ◽

Fe3o4 Nanoparticles ◽

Low Temperatures ◽

Frost Resistance ◽

Relaxation Processes ◽

Ethylene Propylene ◽

Temperature Range ◽

Β Relaxation

Using radiothermoluminescence (RTL), the molecular mobility features in the temperature range of 77-300 K were studied for the polypropylene (PP)/ethylene propylene diene elastomer SKEPT-4044 with NiO, Cu2O and Fe3O4 nanoparticles (NPs) based on ABS-acrylonitrile butadiene or SCS-divinyl styrene matrices. It has been shown that the introduction of nanofillers in PP significantly affects the nature and temperature of γ- and β-relaxation processes, while the region of manifestation of the β-process noticeably shifts to the region of low temperatures. Composites with Cu2O NPs have a higher β-transition temperature Tβ than composites with other NPs. It was found that PP/SKEPT-4044 composites with Cu2O NPs with a dispersion of 11-15 nm and acrylonitrile butadiene thermoplastics have optimal frost resistance compared to other compositions.

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