Metal-mediated oxidative damage to cellular and isolated DNA by gallic acid, a metabolite of antioxidant propyl gallate

2004 ◽  
Vol 558 (1-2) ◽  
pp. 111-120 ◽  
Author(s):  
Hatasu Kobayashi ◽  
Shinji Oikawa ◽  
Kazutaka Hirakawa ◽  
Shosuke Kawanishi
Keyword(s):  
Oxidative Damage ◽  
Gallic Acid ◽  
Propyl Gallate

Gallic Acid and Gallic Acid Nanoparticle Modulate Insulin Secretion Pancreatic β-Islets against Silica Nanoparticle–Induced Oxidative Damage

2022 ◽  
Author(s):  
Akram Ahangarpour ◽  
Hassan Sharifinasab ◽  
Heibatullah Kalantari ◽  
Mohammad Amin Dehghani ◽  
Nader Shakiba Maram ◽  
...  
Keyword(s):  
Insulin Secretion ◽  
Oxidative Damage ◽  
Gallic Acid ◽  
Silica Nanoparticle

scholarly journals On mechanism behind UV-A light enhanced antibacterial activity of gallic acid and propyl gallate against Escherichia coli O157:H7

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Qingyang Wang ◽  
Erick Falcao de Oliveira ◽  
Solmaz Alborzi ◽  
Luis J. Bastarrachea ◽  
Rohan V. Tikekar
Keyword(s):  
Escherichia Coli ◽  
Antibacterial Activity ◽  
Gallic Acid ◽  
Propyl Gallate ◽  
Escherichia Coli O157

Propyl Gallate Synthesis Using Acidophilic Tannase and Simultaneous Production of Tannase and Gallic Acid by Marine Aspergillus awamori BTMFW032

2011 ◽  
Vol 164 (5) ◽  
pp. 612-628 ◽  
Author(s):  
P. S. Beena ◽  
Soorej M. Basheer ◽  
Sarita G. Bhat ◽  
Ali H. Bahkali ◽  
M. Chandrasekaran
Keyword(s):  
Gallic Acid ◽  
Propyl Gallate ◽  
Aspergillus Awamori ◽  
Simultaneous Production

Protective effects of gallic acid against chronic cerebral hypoperfusion-induced cognitive deficit and brain oxidative damage in rats

2014 ◽  
Vol 733 ◽  
pp. 62-67 ◽  
Author(s):  
Mehrdad Shahrani Korani ◽  
Yaghoub Farbood ◽  
Alireza Sarkaki ◽  
Hadi Fathi Moghaddam ◽  
Mohammad Taghi Mansouri
Keyword(s):  
Oxidative Damage ◽  
Gallic Acid ◽  
Cognitive Deficit ◽  
Chronic Cerebral Hypoperfusion ◽  
Cerebral Hypoperfusion ◽  
Protective Effects

scholarly journals Gallic Acid Derivatives Propyl Gallate and Epigallocatechin Gallate Reduce rRNA Transcription via Induction of KDM2A Activation

Biomolecules ◽  
2021 ◽  
Vol 12 (1) ◽  
pp. 30
Author(s):  
Yuji Tanaka ◽  
Makoto Tsuneoka
Keyword(s):  
Cell Proliferation ◽  
Gallic Acid ◽  
Cancer Cell ◽  
Propyl Gallate ◽  
Epigallocatechin Gallate ◽  
Cancer Cell Line ◽  
Rrna Gene ◽  
Ros Production ◽  
Rrna Transcription ◽  
Mcf 7

We previously reported that lysine-demethylase 2A (KDM2A), a Jumonji-C histone demethylase, is activated by gallic acid to reduce H3K36me2 levels in the rRNA gene promoter and consequently inhibit rRNA transcription and cell proliferation in the breast cancer cell line MCF-7. Gallic acid activates AMP-activated protein kinase (AMPK) and increases reactive oxygen species (ROS) production to activate KDM2A. Esters of gallic acid, propyl gallate (PG) and epigallocatechin gallate (EGCG), and other chemicals, reduce cancer cell proliferation. However, whether these compounds activate KDM2A has yet to be tested. In this study, we found that PG and EGCG decreased rRNA transcription and cell proliferation through KDM2A in MCF-7 cells. The activation of both AMPK and ROS production by PG or EGCG was required to activate KDM2A. Of note, while the elevation of ROS production by PG or EGCG was limited in time, it was sufficient to activate KDM2A. Importantly, the inhibition of rRNA transcription and cell proliferation by gallic acid, PG, or EGCG was specifically observed in MCF-7 cells, whereas it was not observed in non-tumorigenic MCF10A cells. Altogether, these results suggest that the derivatization of gallic acid may be used to obtain new compounds with anti-cancer activity.

Sign in / Sign up

Export Citation Format

Share Document