Green synthesis of water soluble PEDOT catalyzed by copper phosphate nanozyme and cell death modes in PEDOT mediated photothermal therapy

2018 ◽  
Vol 14 (5) ◽  
pp. 1774-1775 ◽  
Author(s):  
Zhentao Hua ◽  
Bing Li ◽  
Yajun Sun ◽  
Kezheng Chen ◽  
Wei Wang
Keyword(s):  
Cell Death ◽  
Green Synthesis ◽  
Photothermal Therapy ◽  
Water Soluble ◽  
Copper Phosphate

scholarly journals Facile fabricating of rGO and Au/rGO nanocomposites using Brassica oleracea var. gongylodes biomass for non-invasive approach in cancer therapy

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Fatemeh Yousefimehr ◽  
Saeed Jafarirad ◽  
Roya Salehi ◽  
Mohammad Sadegh Zakerhamidi
Keyword(s):  
Breast Cancer ◽  
Green Synthesis ◽  
Cancer Cells ◽  
Brassica Oleracea ◽  
Photothermal Therapy ◽  
Breast Cancer Cells ◽  
Near Infrared ◽  
Therapeutic Effects ◽  
Invasive Approach ◽  
Au Nps

AbstractIn this study, we report a facile green-synthesis route for the fabrication of reduced graphene oxide (rGO) using biomass of Brassica oleracea var. gongylodes (B. oleracea). In addition, we have attempted to provide a green synthesis approach to prepare Gold nanoparticles (Au NPs) on the surface of rGO by using stem extract of B. oleracea. The synthesized Au/rGO nanocomposite was evaluated using UV–visible and FTIR spectroscopy, XRD, Raman, FE-SEM, EDX, AFM and DLS techniques. The obtained results demonstrated that the synthesized Au NPs on the surface of rGO was spherical with sizes ranging about 12–18 nm. The Au/rGO NC was, also, developed as photo-synthesizer system for the photothermal therapy (PTT) of MCF7 breast cancer cells. The near-infrared (NIR) photothermal properties of Au/rGO NCs was evaluated using a continuous laser at 808 nm with power densities of 1 W.cm−2. Their photothermal efficacy on MCF7 breast cancer cells after optimizing the proper concentration of the NCs were evaluated by MTT assay, Cell cycle and DAPI staining. In addition, the potential of the synthesized Au/rGO NCs on reactive oxygen species generating and antioxidant activity were assessed by DPPH. Au/rGO NCs possess high capacity to light-to-heat conversion for absorption in range NIR light, and it is able to therapeutic effects on MCF7 cells at a low concentration. The maximum amount of cell death is 40.12% which was observed in treatment groups that received a combination of Au/rGO NCs and laser irradiation. The results demonstrate that the nanomaterials synthesized by green approach lead to efficient destruction of cancer cell and might thus serve as an excellent theranostic agent in Photothermal therapy applications.

Combining PD-L1 Inhibitors with Immunogenic Cell Death Triggered by Chemo-Photothermal therapy via a Thermosensitive Liposome System to Stimulate Tumor-specific Immunological Response

Nanoscale ◽  
2021 ◽  
Author(s):  
Jie Yu ◽  
Xidong He ◽  
Zigui Wang ◽  
Yu Peng Wang ◽  
Sha Liu ◽  
...  
Keyword(s):  
Cell Death ◽  
Immune Responses ◽  
Photothermal Therapy ◽  
Immunological Response ◽  
Immune Checkpoint Blockade ◽  
Immunogenic Cell Death ◽  
Adaptive Immune Responses ◽  
Adaptive Immune ◽  
Thermosensitive Liposome ◽  
Liposome System

Immune checkpoint blockade (ICB) therapy in combination with immunogenic death (ICD) triggered by photothermal therapy (PTT) and oxaliplatin (OXA) treatment was expected to elicit both innate and adaptive immune responses...

A facile green synthesis of type II water soluble CdTe/CdS core shell nanoparticles

2014 ◽  
Vol 133 ◽  
pp. 9-13 ◽  
Author(s):  
Oluwatobi.S. Oluwafemi ◽  
Olamide A. Daramola ◽  
Vuyelwa Ncapayi
Keyword(s):  
Green Synthesis ◽  
Water Soluble ◽  
Core Shell ◽  
Type Ii ◽  
Shell Nanoparticles ◽  
Core Shell Nanoparticles

scholarly journals A Novel Fast Photothermal Therapy Using Hot Spots of Gold Nanorods for Malignant Melanoma Cells

Nanomaterials ◽  
2018 ◽  
Vol 8 (11) ◽  
pp. 880 ◽  
Author(s):  
Yanhua Yao ◽  
Nannan Zhang ◽  
Xiao Liu ◽  
Qiaofeng Dai ◽  
Haiying Liu ◽  
...  
Keyword(s):  
Cell Death ◽  
Malignant Melanoma ◽  
Gold Nanorods ◽  
Plasmon Resonance ◽  
Photothermal Therapy ◽  
Treatment Time ◽  
High Energy ◽  
Melanoma Cells ◽  
Photothermal Effect ◽  
A375 Cells

In this paper, the plasmon resonance effects of gold nanorods was used to achieve rapid photothermal therapy for malignant melanoma cells (A375 cells). After incubation with A375 cells for 24 h, gold nanorods were taken up by the cells and gold nanorod clusters were formed naturally in the organelles of A375 cells. After analyzing the angle and space between the nanorods in clusters, a series of numerical simulations were performed and the results show that the plasmon resonance coupling between the gold nanorods can lead to a field enhancement of up to 60 times. Such high energy localization causes the temperature around the nanorods to rise rapidly and induce cell death. In this treatment, a laser as low as 9.3 mW was used to irradiate a single cell for 20 s and the cell died two h later. The cell death time can also be controlled by changing the power of laser which is focused on the cells. The advantage of this therapy is low laser treatment power, short treatment time, and small treatment range. As a result, the damage of the normal tissue by the photothermal effect can be greatly avoided.

scholarly journals TB-4 Antitumor effects of a novel curcumin derivative curcumin monoglucuronide on glioblastoma cells in vitro and in vivo

2021 ◽  
Vol 3 (Supplement_6) ◽  
pp. vi6-vi6
Author(s):  
Takashi Fujii ◽  
Shun Yamamuro ◽  
Masamichi Takahashi ◽  
Akihide Kondo ◽  
Yoshitaka Narita ◽  
...  
Keyword(s):  
Cell Death ◽  
Water Soluble ◽  
Dependent Manner ◽  
Antitumor Effects ◽  
Multiple Cell ◽  
Human Gbm ◽  
Dose Dependent ◽  
Novel Therapeutic

Abstract The therapeutic outcome of glioblastomas (GBMs) is still very poor. Therefore, invention of novel therapeutic methods against GBM cases is considered urgent. The antitumor effects of naturally-derived compounds are attracting attention recently, and therapeutic efficacy of curcumin, a plant-derived compound previously used for multiple purpose, has been indicated in many cancer systems; however, clinical application of curcumin is considered difficult because of its poor bioavailability (under 1 %). Curcumin monoglucuronide (CMG), a water-soluble prodrug of curcumin recently developed for overcoming this weakness, has been demonstrated excellent antitumor effects for several malignancies in vitro and in vivo; therefore, we investigated the effects of CMG against GBM cells. CMG induced cell death of human GBM cells lines (T98G, U251MG, and U87MG) by dose dependent manner by triggering multiple forms of cell death such as apoptosis and perthanatos. Immunoblotting of CMG-treated GBM cell lysates demonstrated activation of multiple cell death signaling. Furthermore, immunodeficiency mice harboring intracerebral U87MG cell xenografts systemically treated by CMG showed significantly prolonged survival compared with control mice. These results suggest CMG would be a novel therapeutic agent against GBM cases.

Water-Soluble Dinitrosyl Iron Complex (DNIC): a Nitric Oxide Vehicle Triggering Cancer Cell Death via Apoptosis

2016 ◽  
Vol 55 (18) ◽  
pp. 9383-9392 ◽  
Author(s):  
Shou-Cheng Wu ◽  
Chung-Yen Lu ◽  
Yi-Lin Chen ◽  
Feng-Chun Lo ◽  
Ting-Yin Wang ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Cell Death ◽  
Cancer Cell ◽  
Iron Complex ◽  
Water Soluble ◽  
Dinitrosyl Iron Complex ◽  
Cancer Cell Death ◽  
Dinitrosyl Iron

Selective cell death by water-soluble Fe-porphyrins with superoxide dismutase (SOD) activity

2002 ◽  
Vol 91 (2) ◽  
pp. 349-355 ◽  
Author(s):  
Nobuyoshi Kasugai ◽  
Toru Murase ◽  
Toshiyuki Ohse ◽  
Shoji Nagaoka ◽  
Hiroyoshi Kawakami ◽  
...  
Keyword(s):  
Cell Death ◽  
Superoxide Dismutase ◽  
Water Soluble ◽  
Sod Activity

Induction of cell death by photodynamic therapy with water-soluble lipid-membrane-incorporated [60]fullerene

2007 ◽  
Vol 5 (8) ◽  
pp. 1158 ◽  
Author(s):  
Atsushi Ikeda ◽  
Yuki Doi ◽  
Koji Nishiguchi ◽  
Keiko Kitamura ◽  
Mineo Hashizume ◽  
...  
Keyword(s):  
Cell Death ◽  
Photodynamic Therapy ◽  
Lipid Membrane ◽  
Water Soluble
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