APOE moderates compensatory recruitment of neuronal resources during working memory processing in healthy older adults

2017 ◽  
Vol 56 ◽  
pp. 127-137 ◽  
Author(s):  
Elisa Scheller ◽  
Jessica Peter ◽  
Lena V. Schumacher ◽  
Jacob Lahr ◽  
Irina Mader ◽  
...  
Keyword(s):  
Older Adults ◽  
Working Memory ◽  
Healthy Older Adults ◽  
Memory Processing

scholarly journals Reviewing working memory training gains in healthy older adults: A meta-analytic review of transfer for cognitive outcomes

2019 ◽  
Vol 103 ◽  
pp. 163-177 ◽  
Author(s):  
Ana C. Teixeira-Santos ◽  
Célia S. Moreira ◽  
Rosana Magalhães ◽  
Carina Magalhães ◽  
Diana R. Pereira ◽  
...  
Keyword(s):  
Older Adults ◽  
Working Memory ◽  
Cognitive Outcomes ◽  
Working Memory Training ◽  
Memory Training ◽  
Healthy Older Adults ◽  
Analytic Review

scholarly journals The Long-Term Efficacy of Working Memory Training in Healthy Older Adults: A Systematic Review and Meta-Analysis of 22 Randomized Controlled Trials

2020 ◽  
Vol 75 (8) ◽  
pp. e174-e188
Author(s):  
Jianhua Hou ◽  
Taiyi Jiang ◽  
Jiangning Fu ◽  
Bin Su ◽  
Hao Wu ◽  
...  
Keyword(s):  
Older Adults ◽  
Working Memory ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Memory Training ◽  
Long Term Effects ◽  
Healthy Older Adults ◽  
Randomized Controlled ◽  
Randomized Controlled Studies

Abstract Objectives The long-lasting efficacy of working memory (WM) training has been a controversial and still ardently debated issue. In this meta-analysis, the authors explored the long-term effects of WM training in healthy older adults on WM subdomains and abilities outside the WM domain assessed in randomized controlled studies. Method A systematic literature search of PubMed, Web of Science, PsycINFO, Cochrane Library, ProQuest, clinicaltrials.gov, and Google Scholar was conducted. Random-effects models were used to quantitatively synthesize the existing data. Results Twenty-two eligible studies were included in the meta-analysis. The mean participant age ranged from 63.77 to 80.1 years. The meta-synthesized long-term effects on updating were 0.45 (95% confidence interval = 0.253–0.648, <6 months: 0.395, 0.171–0.619, ≥6 months: 0.641, 0.223–1.058), on shifting, 0.447 (0.246–0.648, <6 months: 0.448, 0.146–0.75, ≥6 months: 0.446, 0.176–0.716); on inhibition, 0.387 (0.228–0.547, <6 months: 0.248, 0.013–0.484, ≥6 months: 0.504, 0.288–0.712); on maintenance, 0.486 (0.352–0.62, <6 months: 0.52, 0.279–0.761, ≥6 months: 0.471, 0.31–0.63). Discussion The results showed that WM training exerted robust long-term effects on enhancing the WM system and improving processing speed and reasoning in late adulthood. Future studies are needed to use different tasks of the same WM construct to evaluate the WM training benefits, to adopt more ecological tasks or tasks related to daily life, to improve the external validity of WM training, and to identify the optimal implementation strategy for WM training.

Gains in language comprehension relating to working memory training in healthy older adults

2012 ◽  
Vol 28 (5) ◽  
pp. 539-546 ◽  
Author(s):  
Barbara Carretti ◽  
Erika Borella ◽  
Michela Zavagnin ◽  
Rossana de Beni
Keyword(s):  
Older Adults ◽  
Working Memory ◽  
Language Comprehension ◽  
Working Memory Training ◽  
Memory Training ◽  
Healthy Older Adults

scholarly journals Neural markers of category-based selective working memory in aging

2018 ◽  
Author(s):  
Robert M Mok ◽  
M. Clare O'Donoghue ◽  
Nicholas E Myers ◽  
Erin H.S. Drazich ◽  
Anna Christina Nobre
Keyword(s):  
Older Adults ◽  
Working Memory ◽  
Selective Attention ◽  
Memory Task ◽  
Relevant Information ◽  
Anterior Cingulate ◽  
Memory Processing ◽  
Normal Cognitive Function ◽  
Psychophysiological Interaction ◽  
Relevant Category

Working memory (WM) is essential for normal cognitive function, but shows marked decline in aging. Studies have shown that the ability to attend selectively to relevant information amongst competing distractors is related to WM capacity. The extent to which WM deficits in aging are related to impairments in selective attention is unclear. To investigate the neural mechanisms supporting selective attention in WM in aging, we tested a large group of older adults using functional magnetic resonance imaging whilst they performed a category-based (faces/houses) selective-WM task. Older adults were able to use attention to encode targets and suppress distractors to reach high levels of task performance. A subsequent, surprise recognition-memory task showed strong consequences of selective attention. Attended items in the relevant category were recognised significantly better than items in the ignored category. Neural measures also showed reliable markers of selective attention during WM. Purported control regions including the dorsolateral and inferior prefrontal and anterior cingulate cortex were reliably recruited for attention to both categories. Activation levels in category-sensitive visual cortex showed reliable modulation according to attentional demands, and positively correlated with subsequent memory measures of attention and WM span. Psychophysiological interaction analyses showed that activity in category-sensitive areas were coupled with non-sensory cortex known to be involved in cognitive control and memory processing, including regions in the PFC and hippocampus. In summary, we found that brain mechanisms of attention for selective WM are relatively preserved in aging, and individual differences in these abilities corresponded to the degree of attention-related modulation in the brain.

scholarly journals Cardiorespiratory fitness, physical activity and pulse pressure as predictors of learning in a multicomponent intervention in healthy older adults

2021 ◽  
Author(s):  
Jonna Nilsson ◽  
Maria Ekblom ◽  
Olga Tarassova ◽  
Martin Lövdén
Keyword(s):  
Physical Activity ◽  
Older Adults ◽  
Working Memory ◽  
Cardiorespiratory Fitness ◽  
Pulse Pressure ◽  
Intervention Period ◽  
Healthy Older Adults ◽  
Multicomponent Intervention ◽  
Predictive Role

This project concerns new analyses based on pre-existing data from a randomized controlled multicomponent intervention study combining physical exercise and cognitive training in healthy older adults. The project tests the predictive role of cardiorespiratory fitness, physical activity and pulse pressure for learning in a working memory training context, in combination with physical exercise and in isolation. Specifically, two learning outcomes are considered: change in trained working memory tasks from before to after the intervention period (pre-post change) and day-by-day change in n-back performance during the intervention period (up to 32 timepoints). The results did not support a predictive role of cardiorespiratory fitness, physical activity or pulse pressure for learning in this particular study context. Please note that this document is intended solely as a report of the results pertaining to the registered hypotheses on Open Science Framework (https://osf.io/h5npm), simply to ensure transparency also of the null findings. As such, this document is not intended for formal peer-review or publication. If you are interested in the results, please do not hesitate to contact the author of this document ([email protected]).

scholarly journals Effects of Parkinson’s disease and dopamine on digit span measures of working memory

2018 ◽  
Author(s):  
John Patrick Grogan ◽  
Lisa Emily Knight ◽  
Laura Smith ◽  
Nerea Irigoras Izagirre ◽  
Alexandra Howat ◽  
...  
Keyword(s):  
Older Adults ◽  
Parkinson’S Disease ◽  
Working Memory ◽  
Parkinson's Disease ◽  
Digit Span ◽  
The Other ◽  
Healthy Older Adults ◽  
Memory Processes ◽  
Dopaminergic Medication ◽  
Conflicting Evidence

ABSTRACTRationaleParkinson’s disease (PD) impairs working memory (WM) - the ability to maintain items in memory for short periods of time and manipulate them. There is conflicting evidence on the nature of the deficits caused by the disease, and the potential beneficial and detrimental effects of dopaminergic medication on different WM processes.ObjectivesWe hypothesised that PD impairs both maintenance and manipulation of items in WM and dopaminergic medications improve this in PD patients but impair it in healthy older adults.MethodsWe tested 68 PD patients ON and OFF their dopaminergic medication, 83 healthy age-matched controls, and 30 healthy older adults after placebo and levodopa administration. We used the digit span, a WM test with three components (forwards, backwards and sequence recall) that differ in the amount of manipulation required. We analysed the maximum spans and the percentage of lists correctly recalled, which probe capacity of WM and the accuracy of the memory processes within this capacity, respectively.ResultsPD patients had lower WM capacity across all three digit span components, but only showed reduced percentage accuracy on the components requiring manipulation (backwards and sequence spans). Dopaminergic medication did not affect performance in PD patients. In healthy older adults, levodopa did not affect capacity, but did impair accuracy on one of the manipulation components (sequence), without affecting the other (backwards).ConclusionsThis suggests a non-dopaminergic deficit of maintenance capacity and manipulation accuracy in PD patients, and a potential “overdosing” of intact manipulation mechanisms in healthy older adults by levodopa.

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