Magnetization Transfer Weighted EPI Facilitates Cortical Depth Determination in Native fMRI Space

Purpose: to investigate the diagnostic opportunities of contrast magnetic resonance imaging with the effect of magnetization transfer effect in the diagnosis of focal metastatic lesions in the brain.Materials and methods.Images of contrast MRI of the brain of 16 patients (mean age 49 ± 18.5 years) were analysed. Diagnosis of the direction is focal brain lesion. All MRI studies were carried out using the Toshiba Titan Octave with magnetic field of 1.5 T. The contrast agent is “Magnevist” at concentration of 0.2 ml/kg was used. After contrasting process two T1-weighted studies were performed: without T1-SE magnetization transfer with parameters of pulse: TR = 540 ms, TE = 12 ms, DFOV = 24 sm, MX = 320 × 224 and with magnetization transfer – T1-SE-MTC with parameters of pulse: ΔF = −210 Hz, FA(МТС) = 600°, TR = 700 ms, TE = 10 ms, DFOV = 23.9 sm, MX = 320 x 224. For each detected metastatic lesion, a contrast-to-brain ratio (CBR) was calculated. Comparative analysis of CBR values was carried out using a non-parametric Wilcoxon test at a significance level p < 0.05. To evaluate the sensitivity and specificity of the techniques in the detection of metastatic foci (T1-SE and T1-SE-MTC), ROC analysis was used. The sample is divided into groups: 1 group is foci ≤5 mm in size, 2 group is foci from 6 to 10 mm, and 3 group is foci >10 mm. Results.Comparative analysis of CBR using non-parametric Wilcoxon test showed that the values of the CBR on T1-weighted images with magnetization transfer are significantly higher (p <0.001) that on T1-weighted images without magnetization transfer. According to the results of the ROC analysis, sensitivity in detecting metastases (n = 90) in the brain on T1-SE-MTC and T1-SE was 91.7% and 81.6%, specificity was 100% and 97.6%, respectively. The accuracy of the T1-SE-MTC is 10% higher in comparison with the technique without magnetization transfer. Significant differences (p < 0.01) between the size of the foci detected in post-contrast T1- weighted images with magnetization transfer and in post-contrast T1-weighted images without magnetization transfer, in particular for foci ≤5 mm in size, were found. Conclusions1. Comparative analysis of CBR showed significant (p < 0.001) increase of contrast between metastatic lesion and white matter on T1-SE-MTC in comparison with T1-SE.2. The sensitivity, specificity and accuracy of the magnetization transfer program (T1-SE-MTC) in detecting foci of metastatic lesions in the brain is significantly higher (p < 0.01), relative to T1-SE.3. The T1-SE-MTC program allows detecting more foci in comparison with T1-SE, in particular foci of ≤5 mm (96% and 86%, respectively, with p < 0.05).

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Faculty Opinions recommendation of In-depth determination and analysis of the human paired heavy- and light-chain antibody repertoire.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.725276248.793520416 ◽

2016 ◽

Author(s):

Sebastian Fugmann

Keyword(s):

Light Chain ◽

Antibody Repertoire ◽

Depth Determination ◽

Light Chain Antibody

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Faculty Opinions recommendation of Separating Dipolar and Chemical Exchange Magnetization Transfer Processes in 1 H-CEST.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.727154021.793528801 ◽

2017 ◽

Author(s):

Thomas Szyperski

Keyword(s):

Chemical Exchange ◽

Magnetization Transfer ◽

Transfer Processes

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Spin-lattice relaxation and magnetization transfer in intracranial tumors in vivo: Effects of Gd-DTPA on relaxation parameters

Magnetic Resonance Imaging ◽

10.1016/0730-725x(94)00126-n ◽

1995 ◽

Vol 13 (3) ◽

pp. 379-385 ◽

Cited By ~ 16

Author(s):

Timo Kurki ◽

Markku Komu

Keyword(s):

Magnetization Transfer ◽

Lattice Relaxation ◽

Spin Lattice Relaxation ◽

Intracranial Tumors ◽

Spin Lattice ◽

Relaxation Parameters ◽

In Vivo Effects

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Magnetization Transfer Ratio of Peripheral Nerve and Skeletal Muscle

Clinical Neuroradiology ◽

10.1007/s00062-021-01067-5 ◽

2021 ◽

Author(s):

Olivia Fösleitner ◽

Véronique Schwehr ◽

Tim Godel ◽

Fabian Preisner ◽

Philipp Bäumer ◽

...

Keyword(s):

Skeletal Muscle ◽

Body Weight ◽

Sciatic Nerve ◽

Linear Regression ◽

Peripheral Nerve ◽

Regression Model ◽

Multiple Linear Regression ◽

Linear Regression Model ◽

Magnetization Transfer ◽

Multiple Linear Regression Model

Abstract Purpose To assess the correlation of peripheral nerve and skeletal muscle magnetization transfer ratio (MTR) with demographic variables. Methods In this study 59 healthy adults evenly distributed across 6 decades (mean age 50.5 years ±17.1, 29 women) underwent magnetization transfer imaging and high-resolution T2-weighted imaging of the sciatic nerve at 3 T. Mean sciatic nerve MTR as well as MTR of biceps femoris and vastus lateralis muscles were calculated based on manual segmentation on six representative slices. Correlations of MTR with age, body height, body weight, and body mass index (BMI) were expressed by Pearson coefficients. Best predictors for nerve and muscle MTR were determined using a multiple linear regression model with forward variable selection and fivefold cross-validation. Results Sciatic nerve MTR showed significant negative correlations with age (r = −0.47, p < 0.001), BMI (r = −0.44, p < 0.001), and body weight (r = −0.36, p = 0.006) but not with body height (p = 0.55). The multiple linear regression model determined age and BMI as best predictors for nerve MTR (R2 = 0.40). The MTR values were different between nerve and muscle tissue (p < 0.0001), but similar between muscles. Muscle MTR was associated with BMI (r = −0.46, p < 0.001 and r = −0.40, p = 0.002) and body weight (r = −0.36, p = 0.005 and r = −0.28, p = 0.035). The BMI was selected as best predictor for mean muscle MTR in the multiple linear regression model (R2 = 0.26). Conclusion Peripheral nerve MTR decreases with higher age and BMI. Studies that assess peripheral nerve MTR should consider age and BMI effects. Skeletal muscle MTR is primarily associated with BMI but overall less dependent on demographic variables.

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Evaluation of the Swallow-Tail Sign and Correlations of Neuromelanin Signal with Susceptibility and Relaxations

Tomography ◽

10.3390/tomography7020010 ◽

2021 ◽

Vol 7 (2) ◽

pp. 107-119

Author(s):

Tzu-Wei Lee ◽

Cheng-Yu Chen ◽

Kuan Chen ◽

Chao-Wei Tso ◽

Hui-Hsien Lin ◽

...

Keyword(s):

Magnetization Transfer ◽

Systematic Evaluation ◽

Joint Analysis ◽

Quantitative Susceptibility Mapping ◽

Widespread Application ◽

Hyperintense Signal ◽

Significant Difference ◽

Relaxation Measurements ◽

Iron Deposits ◽

Older Subjects

The presence of a swallow-tail sign in the nigrosome-1 with hyperintense signal shown on the susceptibility-weighted imaging (SWI) has been shown to be sensitive in detecting the abnormal iron deposits in this area. A systematic evaluation in healthy subjects is required before this tool can be recommended in a widespread application. We evaluated a simple and practical SWI approach using a multiecho gradient-echo sequence with an improved contrast-to-noise ratio (CNR). We also evaluated the association of the neuromelanin imaging contrast behavior with the susceptibility and relaxation measurements. Twenty-five older and 23 young healthy adults were evaluated. The CNRs of the nigrosome-1 were compared along with method and group. Correlations of the nigrosome-1 neuromelanin signal in the neuromelanin-sensitive imaging with CNRs in the susceptibility, T1 and T2 mappings were examined. Two different coils were used to confirm the reproducibility. Compared with the single-echo, multiecho SWI can improve the CNR of the swallow-tail sign. We found significant correlations between neuromelanin signal and CNRs in the susceptibility and T2 mappings, and T1 value. The older subjects exhibited increased CNRs compared with the young adults. No significant difference was observed in the measurements between 20 and 64 channels. The multiecho technique allows the high-quality nigrosome-1 images in SWI and allows for a joint analysis of T2* and quantitative-susceptibility mapping at high spatial resolution. The correlations of neuromelanin-sensitive imaging with susceptibility and T2 imply that the iron content in the nigrosome-1 may have significant influences on the hyperintensity of neuromelanin in the magnetization transfer-related contrast.

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