Working memory functioning in schizophrenia patients and their first-degree relatives: cognitive functioning shedding light on etiology

2005 ◽  
Vol 43 (6) ◽  
pp. 930-942 ◽  
Author(s):  
Heather M. Conklin ◽  
Clayton E. Curtis ◽  
Monica E. Calkins ◽  
William G. Iacono
Keyword(s):  
Working Memory ◽  
Cognitive Functioning ◽  
First Degree Relatives ◽  
Memory Functioning

scholarly journals Relationship between Apgar scores and long-term cognitive outcomes in individuals with Down syndrome

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Laura del Hoyo Soriano ◽  
Tracie C. Rosser ◽  
Debra R. Hamilton ◽  
Danielle J. Harvey ◽  
Leonard Abbeduto ◽  
...  
Keyword(s):  
Working Memory ◽  
Down Syndrome ◽  
Cognitive Functioning ◽  
Apgar Score ◽  
Visual Memory ◽  
Receptive Vocabulary ◽  
Cognitive Outcomes ◽  
Cognitive Testing ◽  
Cognitive Measures ◽  
Verbal Comprehension

AbstractThis study examined the contribution of the Apgar score at 1 and 5 min after birth to later cognitive functioning in 168 individuals with Down syndrome who were between 6 and 25 years of age at time of cognitive testing. Our results showed that a lower Apgar score at 1 min was related to a worse performance in later cognitive measures of receptive vocabulary, verbal comprehension and production, visual memory and working memory. Results also showed that a lower Apgar score at 5 min was only related to worse later outcomes of verbal comprehension and production and auditory working memory. Our findings suggest a need for future studies investigating how specific perinatal events reflected in the Apgar score are linked to later cognitive functioning in individuals with Down syndrome.

scholarly journals The Relationship Between Daily Rapid-Eye Movement Sleep and Cognitive Functioning in Older Adults

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 159-159
Author(s):  
Tiana Broen ◽  
Tomiko Yoneda ◽  
Jonathan Rush ◽  
Jamie Knight ◽  
Nathan Lewis ◽  
...  
Keyword(s):  
Older Adults ◽  
Working Memory ◽  
Cognitive Functioning ◽  
Eye Movement ◽  
Rem Sleep ◽  
Cognitive Tests ◽  
Rapid Eye Movement ◽  
Targeted Interventions ◽  
The Impact ◽  
The Relationship

Abstract Previous cross-sectional research suggests that age-related decreases in Rapid-Eye Movement (REM) sleep may contribute to poorer cognitive functioning (CF); however, few studies have examined the relationship at the intraindividual level by measuring habitual sleep over multiple days. Applying a 14-day daily diary design, the current study examines the dynamic relationship between REM sleep and CF in 69 healthy older adults (M age=70.8 years, SD=3.37; 73.9% female; 66.6% completed at least an undergraduate degree). A Fitbit device provided actigraphy indices of REM sleep (minutes and percentage of total sleep time), while CF was measured four times daily on a smartphone via ambulatory cognitive tests that captured processing speed and working memory. This research addressed the following questions: At the within-person level, are fluctuations in quantity of REM sleep associated with fluctuations in next day cognitive measures across days? Do individuals who spend more time in REM sleep on average, perform better on cognitive tests than adults who spend less time in REM sleep? A series of multilevel models were fit to examine the extent to which each index of sleep accounted for daily fluctuations in performance on next day cognitive tests. Results indicated that during nights when individuals had more REM sleep minutes than was typical, they performed better on the working memory task the next morning (estimate = -.003, SE = .002, p = .02). These results highlight the impact of REM sleep on CF, and further research may allow for targeted interventions for earlier treatment of sleep-related cognitive impairment.

scholarly journals Child maltreatment, cognitive functions and the mediating role of mental health problems among maltreated children and adolescents in Uganda

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Herbert E. Ainamani ◽  
Godfrey Z. Rukundo ◽  
Timothy Nduhukire ◽  
Eunice Ndyareba ◽  
Tobias Hecker
Keyword(s):  
Mental Health ◽  
Working Memory ◽  
Child Maltreatment ◽  
Executive Functions ◽  
Cognitive Functioning ◽  
Children And Adolescents ◽  
Mental Health Problems ◽  
Depression Scale ◽  
Well Being ◽  
Health Problems

Abstract Background Child maltreatment poses high risks to the mental health and cognitive functioning of children not only in childhood but also in later life. However, it remains unclear whether child maltreatment is directly associated with impaired cognitive functioning or whether this link is mediated by mental health problems. Our study aimed at examining this research question among children and adolescents in Uganda. Methods A sample of 232 school-going children and adolescents with a mean age of 14.03 (SD = 3.25) was assessed on multiple forms of maltreatment using the Maltreatment and Abuse Chronology Exposure—Pediatric Version (pediMACE). Executive functions were assessed by the Tower of London task and working memory by the Corsi Block Tapping task, while mental health problems were assessed using the Child PTSD Symptom Scale for PTSD and the Center for Epidemiological Studies Depression Scale for Children (CES-DC). Results In total, 232 (100%) of the participant reported to have experienced at least one type of maltreatment in their lifetime including emotional, physical, and sexual violence as well as neglect. We found a negative association between child maltreatment and executive functions (β = − 0.487, p < 0.001) and working memory (β = − 0.242, p = 0.001). Mental health problems did not mediate this relationship. Conclusions Child maltreatment seems to be related to lower working memory and executive functioning of affected children and adolescents even after controlling for potential cofounders. Our study indicates that child maltreatment the affects children’s cognitive functionality beyond health and well-being.

The role of goals and affect in working memory functioning

1999 ◽  
Vol 11 (2) ◽  
pp. 213-230 ◽  
Author(s):  
Elizabeth A Linnenbrink ◽  
Allison M Ryan ◽  
Paul R Pintrich
Keyword(s):  
Working Memory ◽  
Memory Functioning

scholarly journals Broad cognitive complaints but subtle objective working memory impairment in fibromyalgia patients

PeerJ ◽  
2018 ◽  
Vol 6 ◽  
pp. e5907 ◽  
Author(s):  
Marina Pidal-Miranda ◽  
Alberto Jacobo González-Villar ◽  
María Teresa Carrillo-de-la-Peña ◽  
Elena Andrade ◽  
Dolores Rodríguez-Salgado
Keyword(s):  
Working Memory ◽  
Clinical Symptoms ◽  
Poor Performance ◽  
Cognitive Status ◽  
Future Research ◽  
Neuropsychological Performance ◽  
Healthy Controls ◽  
Cognitive Complaints ◽  
Cognitive Difficulties ◽  
Memory Functioning

BackgroundCognitive dysfunction in fibromyalgia (FM) encompasses objective cognitive difficulties, as measured in neuropsychological tests, and self-reported cognitive complaints. Although it has been suggested that FM patients display problems in working memory, the data are inconsistent, and the overall working memory status of the patients is unclear. It is also not clear whether the working memory problems are related to cognitive complaints or how the dyscognition is affected by the characteristic clinical symptoms of FM.MethodsTo clarify these aspects, we explored the neuropsychological performance for different components of working memory and the subjective self-perception of cognitive status in a sample of 38 women with FM. They were compared with a matched group of 32 healthy women.ResultsOur findings suggested that the FM patients do not differ from healthy controls in their overall working memory functioning. Only a poor performance was found in a single task of visuospatial working memory, mediated by the presence of depressive symptoms, fatigue and pain. The FM patients also displayed a higher level of perception of cognitive difficulties than healthy controls, and this difference was mediated by depression and fatigue. Furthermore, cognitive complaints in FM patients were only associated with a lower verbal WM capacity.DiscussionFM patients have a subtle specific impairment in their working memory functioning, as well as elevated concern about their cognitive status. These findings suggest a disconnection between neuropsychological performance and subjective complaints. In FM patients, clinical variables such as pain, fatigue, and depression play an important role in dyscognition, as assessed by both objective and subjective measures, and should be taken into account in future research.

scholarly journals Child maltreatment, cognitive functions and the mediating role of mental health problems among maltreated children and adolescents in Uganda

2020 ◽  
Author(s):  
Herbert E Ainamani ◽  
Godfrey Z Rukundo ◽  
Timothy Nduhukire ◽  
Eunice Ndyareba ◽  
Tobias Hecker
Keyword(s):  
Mental Health ◽  
Working Memory ◽  
Child Maltreatment ◽  
Executive Functions ◽  
Cognitive Functioning ◽  
Children And Adolescents ◽  
Mental Health Problems ◽  
Depression Scale ◽  
Well Being ◽  
Health Problems

Abstract Background: Child maltreatment poses high risks to the mental health and cognitive functioning of children not only in childhood but also in later life. However, it remains unclear whether child maltreatment is directly associated with impaired cognitive functioning or whether this link is mediated by mental health problems. Our study aimed at examining this research question among children and adolescents in Uganda. Methods: A sample of 232 school-going children and adolescents with a mean age of 14.03 (SD = 3.25) was assessed on multiple forms of maltreatment using the Maltreatment and Abuse Chronology Exposure – Pediatric Version (pediMACE). Executive functions were assessed by the Tower of London task and working memory by the Corsi Block Tapping task, while mental health problems were assessed using the Child PTSD Symptom Scale for PTSD and the Center for Epidemiological Studies Depression Scale for Children (CES-DC).Results: In total, 232(100%) of the participant reported to have experienced at least one type of maltreatment in their lifetime ranging from having been intentionally pushed by an authority figure (89.7%, n = 208) to entering an object in the participant’s body (2.6%, n =6). We found a negative association between child maltreatment and executive functions (β = -0.487, p < .001) and working memory (β = -0.242, p = .001). Mental health problems did not mediate this relationship.Conclusions: Child maltreatment seems to be related to lower working memory and executive functioning of affected children and adolescents even after controlling for potential cofounders. Our study indicates that child maltreatment affects children’s cognitive functionality beyond health and well-being.

scholarly journals COGNITIVE FUNCTIONING AMONG BREAST CANCER SURVIVORS AND NON-CANCER PARTICIPANTS: EVIDENCE FOR SIMILARITIES

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S649-S650
Author(s):  
Giancarlo Pasquini ◽  
Brent J Small ◽  
Jacqueline Mogle ◽  
Martin Sliwinski ◽  
Stacey B Scott
Keyword(s):  
Breast Cancer ◽  
Working Memory ◽  
Executive Functioning ◽  
Cancer Survivors ◽  
Cognitive Functioning ◽  
Processing Speed ◽  
Breast Cancer Survivors ◽  
Cancer History ◽  
History Of ◽  
History Of Cancer

Abstract Breast cancer survivors may experience accelerated decline in cognitive functioning compared to same-aged peers with no cancer history (Small et al., 2015). Survivors may show important differences in mean-level performance or variability in cognitive functioning compared to those without a history of cancer (Yao et al., 2016). This study compared ambulatory cognitive functioning in a sample of breast cancer survivors and an age-matched community sample without a history of cancer (n_cancer=47, n_non-cancer=105, age range: 40-64 years, M=52.13 years). Participants completed three cognitive tasks measuring working memory, executive functioning, and processing speed up to five times per day for 14 days. Results indicated no mean-level differences in cognitive performance on the three tasks between cancer survivors and those without cancer history (p’s&gt;.05). Unexpectedly, women without cancer history showed more variability than survivors on working memory but not on the other two tasks. Across both groups, those without a college education performed worse on executive functioning (B=-0.05, SE=0.03, p&lt;.05) and working memory (B=0.94, SE=0.36, p&lt;.05) compared to those that completed college. Additionally, older age was associated with slower processing speed (B=31.67, SE=7.44, p&lt;.001). In sum, this study did not find mean-level group differences in cognitive functioning between cancer survivors and age-matched women without a history of cancer. Contrary to hypotheses, those without a history of cancer were more variable on working memory. Results suggested similarities in cognitive functioning in the two samples and that education and age are important predictors of cognitive functioning independent of cancer history.

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