The rationale is that Saint Tyagaya’s devotional Sangeetham creates brain activity to contemplate on God and therefore God becomes neurologically real. This form of spiritual development and contemplative singing exercise could strengthen neurological circuits and manipulate a devotee’s emotion to produce love, empathy, compassion, benevolence and tolerance. The research is a validation of the psychometric assessment extending from Swami Tyagaya, devotional Sangeetham, God, neuro-psychology and spirituality. The methodology shows the development of a questionnaire survey with a grand total of Eighty two questions to measure five different types of subjects. The Questionnaire addresses the society’s knowledge, belief, devotion, attitudes and educational progress over the five subjects. The compilation of questionnaire was distributed to the Indian community in Malaysia. Four hundred and ten volunteers responded to tell their experiential views of Sangeetham, Swami Tyagaya, brain, devotion, God and spirituality. The Questionnaire data were analyzed using Pearson product-moment correlation coefficient. The result showed that there are strong positive correlation between Sangeetham, devotional reliance, God, brain Swami Tyagaya and spiritualism. These results conclusively indicate that Swami Tyagaya’s devotional Sangeetham strongly influences the spiritual experience of the Indian devotees in Malaysia.