Effects of moderate-intensity exercise training on plasma biomarkers of inflammation and endothelial dysfunction in older patients with type 2 diabetes

2006 ◽  
Vol 16 (8) ◽  
pp. 543-549 ◽  
Author(s):  
Giacomo Zoppini ◽  
Giovanni Targher ◽  
Cristina Zamboni ◽  
Cristina Venturi ◽  
Vittorio Cacciatori ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Endothelial Dysfunction ◽  
Exercise Training ◽  
Older Patients ◽  
Moderate Intensity ◽  
Moderate Intensity Exercise ◽  
Plasma Biomarkers

scholarly journals Effects of a 12-week moderate-intensity exercise training on blood glucose response in patients with type 2 diabetes

Medicine ◽  
2019 ◽  
Vol 98 (36) ◽  
pp. e16860 ◽  
Author(s):  
Shang-Lin Chiang ◽  
Margaret McLean Heitkemper ◽  
Yi-Jen Hung ◽  
Wen-Chii Tzeng ◽  
Meei-Shyuan Lee ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Blood Glucose ◽  
Exercise Training ◽  
Moderate Intensity ◽  
Moderate Intensity Exercise ◽  
Glucose Response ◽  
Blood Glucose Response

Determinants of changes in blood glucose response to short-term exercise training in patients with Type 2 diabetes

2008 ◽  
Vol 115 (9) ◽  
pp. 273-281 ◽  
Author(s):  
Matthew D. Hordern ◽  
Louise M. Cooney ◽  
Elaine M. Beller ◽  
Johannes B. Prins ◽  
Thomas H. Marwick ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Blood Glucose ◽  
Insulin Sensitivity ◽  
Exercise Training ◽  
Cardiorespiratory Fitness ◽  
Training Group ◽  
Moderate Intensity ◽  
Model Assessment ◽  
Short Term

The aim of the present study was to determine the effects of a 4-week exercise training intervention on blood glucose, insulin sensitivity, BMI (body mass index) and cardiorespiratory fitness in patients with Type 2 diabetes, and to identify and establish criteria for patients who are more likely to improve their blood glucose from short-term exercise training. A randomized, controlled trial of exercise training, comprising two supervised and one non-supervised sessions of individualized cardiorespiratory and resistance exercise per week, was performed in 132 healthy patients with Type 2 diabetes (exercise training group, n=68), with the aim of accumulating a minimum of 150 min of moderate-intensity exercise for 4 weeks. BMI, waist circumference, blood pressure, blood lipid profile, blood glucose, insulin, insulin sensitivity [calculated by HOMAIR (homoeostasis model assessment of insulin resistance) and QUICKI (quantitative insulin check index)], β-cell function (calculated by HOMAβ-Cell), HbA1c (glycated haemoglobin) and V̇O2max (maximal oxygen consumption) were measured at baseline and at 4 weeks. The exercise training group had significant improvements in V̇O2max, BMI and triacylglycerols (triglycerides). There were no significant changes in blood glucose, HOMAIR, QUICKI or HOMAβ-Cell. Decreases in blood glucose were significantly predicted by baseline blood glucose and HbA1c, with these variables accounting for 15.9% of the change in blood glucose (P<0.001). ROC (receiver operator characteristic) curve analysis revealed that patients with a blood glucose >8.85 mmol/l (sensitivity=73%, specificity=78%) and HbA1c >7.15% (sensitivity=79%, specificity=60%) were more likely to achieve a clinically significant decrease in blood glucose. In conclusion, in apparently healthy patients with Type 2 diabetes, a 4-week exercise intervention improved cardiorespiratory fitness, BMI and triacylglycerols. Elevated blood glucose and HbA1c predicted improvements in blood glucose.

scholarly journals Impact of type 2 diabetes on cardiorespiratory function and exercise performance

2016 ◽  
Author(s):  
Joanie Caron ◽  
Gregory R. duManoir ◽  
Lawrence Labrecque ◽  
Audrey Chouinard ◽  
Annie Ferland ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Exercise Performance ◽  
Ventilatory Threshold ◽  
Exponential Model ◽  
Cycle Ergometer ◽  
Moderate Intensity ◽  
Moderate Intensity Exercise ◽  
Cardiorespiratory Function ◽  
The Impact

AbstractThe aim of this study was to examine the impact of well-controlled uncomplicated type 2 diabetes (T2D) on exercise performance. Six obese sedentary men with T2D and 7 control participants without diabetes matched for age, sex and body mass index were recruited. Anthropometric characteristics, blood samples, resting cardiac and pulmonary functions and maximal oxygen uptake (VO2max) and ventilatory threshold were measured on a first visit. On the four subsequent visits, participants performed step transitions (6 min) of moderate-intensity exercise on an upright cycle ergometer from unloaded pedaling to 80 % of ventilatory threshold. VO2(τVO2) and HR (τHR) kinetics were characterized with a mono-exponential model. VO2max (27.8±4.0 vs. 27.5±5.3 ml kg-1min-1; p=0.95), τVO2(43±6 vs. 43±10 s; p=0.73) and τHR (42±17 vs. 43±13 s; p=0.94) were similar between diabetics and controls respectively. The remaining variables were also similar between groups. These results suggest that well-controlled T2D is not associated with a reduction in VO2max or slower τVO2and τHR.

Prescribing high-intensity interval exercise by RPE in individuals with type 2 diabetes: metabolic and hemodynamic responses

2019 ◽  
Vol 44 (4) ◽  
pp. 348-356 ◽  
Author(s):  
Ariane Aparecida Viana ◽  
Bianca Fernandes ◽  
Cristian Alvarez ◽  
Guilherme Veiga Guimarães ◽  
Emmanuel Gomes Ciolac
Keyword(s):  
Type 2 Diabetes ◽  
High Intensity ◽  
Perceived Exertion ◽  
Random Order ◽  
Rating Of Perceived Exertion ◽  
Moderate Intensity ◽  
Moderate Intensity Exercise ◽  
Interval Exercise ◽  
High Intensity Interval

We tested the hypothesis that rating of perceived exertion (RPE) is a tool as efficient as the heart rate (HR) response to the cardiopulmonary exercise test (CPX) for prescribing and self-regulating high-intensity interval exercise (HIIE), and that metabolic and hemodynamic response to HIIE is superior than to continuous moderate-intensity exercise (MICE) in individuals with type 2 diabetes mellitus (T2DM). Eleven participants (age = 52.3 ± 3 years) underwent HIIE prescribed and self-regulated by RPE (HIIERPE; 25 min), HIIE prescribed and regulated by an individual’s HR response to CPX (HIIEHR; 25 min), MICE prescribed and self-regulated by RPE (30 min) and control (30 min of seated resting) intervention in random order. HR, blood pressure (BP), capillary glucose, endothelial reactivity, and carotid-femoral pulse wave velocity were assessed before, immediately after, and 45 min after each intervention. Exercise HR, speed, and distance were measured during exercise sessions. Twenty-four-hour ambulatory BP was measured after each intervention. Exercise HR, speed, and distance were similar between HIIERPE and HIIEHR. BP response was not different among HIIERPE, HIIEHR, and MICE. Capillary glycaemia reduction was greater (P < 0.05) after HIIERPE (48.6 ± 9.6 mg/dL) and HIIEHR (47.2 ± 9.5 mg/dL) than MICE (29.5 ± 11.5 mg/dL). Reduction (P < 0.05) in 24-h (6.7 ± 2.2 mm Hg) and tendency toward reduction (P = 0.06) in daytime systolic (7.0 ± 2.5 mm Hg) ambulatory BP were found only after HIIERPE. These results suggest that HIIE is superior to MICE for reducing glycaemia and ambulatory BP, and that the 6–20 RPE scale is a useful tool for prescribing and self-regulating HIIE in individuals with T2DM.

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