Effect of cacao polyphenol-rich chocolate on postprandial glycemia, insulin, and incretin secretion in healthy participants

The aim of present study was to assess the effects and safety of a dry Phaseoli vulgari pericarpium (PVP) extract on postprandial glycemia in healthy participants. A randomized crossover experiment where participants received either PVP extract or placebo. Chemical compounds in dry extract were assessed by established methods. Eighteen healthy participants (9 male and 9 female) aged 29+/-4,8 years, body mass index (BMI) 23+/-3,7 kg/m(2) were recruited among students and staff at the Faculty of Pharmacy, University of Belgrade. All participants were able to follow the study protocol without difficulty. The participants received either PVP extract or placebo 30 minutes before a 50g oral glucose tolerance test (OGTT). The protocol followed the guidelines for the OGTT with blood samples drawn at 0, 15, 30, 60, 90 and 120 min. This study demonstrated that there was no significantly effect of the PVP extract on incremental blood glucose (IBG) and their areas under the curve (AUC) neither male nor female participants. However, IBG together with AUC changes were significantly lower in male compared with female participants in treated and untreated groups. The presence of chrome, soluble fiber, vitamin C, protein, glucose and lectins were also quantified. The applied amount of PVP extract was unable to produce the postprandial hypoglycemia. We assumed that amounts of chrome, soluble fiber, vitamin C which have beneficial effects on diabetes treatment were sufficient to produce hypoglycemia.

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Gastric emptying, mouth-to-cecum transit, and glycemic, insulin, incretin, and energy intake responses to a mixed-nutrient liquid in lean, overweight, and obese males

AJP Endocrinology and Metabolism ◽

10.1152/ajpendo.00533.2012 ◽

2013 ◽

Vol 304 (3) ◽

pp. E294-E300 ◽

Cited By ~ 33

Author(s):

Radhika V. Seimon ◽

Ixchel M. Brennan ◽

Antonietta Russo ◽

Tanya J. Little ◽

Karen L. Jones ◽

...

Keyword(s):

Blood Glucose ◽

Gastric Emptying ◽

Energy Intake ◽

Gut Hormones ◽

Gastrointestinal Hormone ◽

Postprandial Glycemia ◽

Incretin Secretion ◽

Obese Subjects ◽

Insulin Responses ◽

The Impact

Observations relating to the impact of obesity on gastric emptying (GE) and the secretion of gut hormones are inconsistent, probably because of a lack of studies in which GE, gastrointestinal hormone release, and energy intake (EI) have been evaluated concurrently with previous patterns of nutrient intake. GE is known to be a major determinant of postprandial glycemia and incretin secretion in health and type 2 diabetes. The aims of this study were to determine the effects of a mixed-nutrient drink on GE, oro-cecal transit, blood glucose, insulin and incretin concentrations and EI, and the relationship between the glycemic response to the drink with GE in lean, overweight, and obese subjects. Twenty lean, 20 overweight, and 20 obese males had measurements of GE, oro-cecal transit, and blood glucose, insulin, GLP-1, and GIP concentrations for 5 h after ingestion of a mixed-nutrient drink (500 ml, 532 kcal); EI at a subsequent buffet lunch was determined. Habitual EI was also quantified. Glycemic and insulinemic responses to the drink were greater in the obese (both P < 0.05) when compared with both lean and overweight, with no significant differences in GE, intragastric distribution, oro-cecal transit, incretins, or EI (buffet lunch or habitual) between groups. The magnitude of the rise in blood glucose after the drink was greater when GE was relatively more rapid ( r = −0.55, P < 0.05). In conclusion, in the absence of differences in habitual EI, both GE and incretin hormones are unaffected in the obese despite greater glucose and insulin responses, and GE is a determinant of postprandial glycemia.

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Relationship between total plasma homocysteine and the risk of aneurysms – a meta-analysis

VASA ◽

10.1024/0301-1526/a000891 ◽

2020 ◽

pp. 1-6

Author(s):

Hanji Zhang ◽

Dexin Yin ◽

Yue Zhao ◽

Yezhou Li ◽

Dejiang Yao ◽

...

Keyword(s):

Large Scale ◽

Meta Analysis ◽

Single Species ◽

Total Plasma ◽

Control Groups ◽

Randomized Controlled ◽

Randomized Controlled Studies ◽

The Difference ◽

The Relationship ◽

Healthy Participants

Summary: Our meta-analysis focused on the relationship between homocysteine (Hcy) level and the incidence of aneurysms and looked at the relationship between smoking, hypertension and aneurysms. A systematic literature search of Pubmed, Web of Science, and Embase databases (up to March 31, 2020) resulted in the identification of 19 studies, including 2,629 aneurysm patients and 6,497 healthy participants. Combined analysis of the included studies showed that number of smoking, hypertension and hyperhomocysteinemia (HHcy) in aneurysm patients was higher than that in the control groups, and the total plasma Hcy level in aneurysm patients was also higher. These findings suggest that smoking, hypertension and HHcy may be risk factors for the development and progression of aneurysms. Although the heterogeneity of meta-analysis was significant, it was found that the heterogeneity might come from the difference between race and disease species through subgroup analysis. Large-scale randomized controlled studies of single species and single disease species are needed in the future to supplement the accuracy of the results.

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Skin Conductance and Subjective Arousal in Anxiety, Depression, and Comorbidity

Journal of Psychophysiology ◽

10.1027/0269-8803/a000176 ◽

2017 ◽

Vol 31 (4) ◽

pp. 145-157 ◽

Cited By ~ 15

Author(s):

Laina E. Rosebrock ◽

Denada Hoxha ◽

Catherine Norris ◽

John T. Cacioppo ◽

Jackie K. Gollan

Keyword(s):

Skin Conductance ◽

Comparison Group ◽

Group Differences ◽

Autonomic Arousal ◽

Emotional Picture ◽

Self Reports ◽

Picture Viewing ◽

Anxiety Depression ◽

Subjective Arousal ◽

Healthy Participants

Abstract. Skin conductance (SC), an autonomic arousal measure of the sympathetic nervous system, is a sensitive and useful index of physiological arousal. However, SC data does not always align with self-reports of arousal. SC, self-reported arousal, and their association, known as emotion coherence, may be altered with the presence of major psychiatric illness. This study investigated group differences on SC reactivity and self-reported arousal while viewing positive, negative, neutral, and threat images between participants diagnosed with major depression with and without anxiety disorders relative to a healthy comparison group. Additionally, the strength and direction of association between SC reactivity and arousal ratings (emotion coherence) was examined within groups. Unmedicated participants were recruited via online and paper advertisements around Chicago and categorized into one of four groups (Depressed: n = 35, Anxious: n = 44, Comorbid: n = 38, Healthy: n = 29). SC and affect ratings were collected during and after a standardized emotional picture viewing task. SC reactivity was significantly higher during threat images, regardless of group. During threat image presentation, increased SC reactivity occurred during the last few seconds before picture offset; for all other stimulus types, SC reactivity decreased significantly after picture offset. Anxious and comorbid participants rated emotional images as more arousing than healthy participants; there were no observed differences in arousal ratings between depressed and healthy participants. Heightened reactivity in anxiety may manifest in arousal ratings without corresponding increased SC reactivity to emotional images. Results do not suggest underlying altered psychophysiology in this sample of depressed or anxious participants.

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Effects of Experimentally Induced Pain on Mismatch Negativity

Journal of Psychophysiology ◽

10.1027/0269-8803.20.1.21 ◽

2006 ◽

Vol 20 (1) ◽

pp. 21-31 ◽

Cited By ~ 6

Author(s):

Bruce D. Dick ◽

John F. Connolly ◽

Michael E. Houlihan ◽

Patrick J. McGrath ◽

G. Allen Finley ◽

...

Keyword(s):

Cognitive Processing ◽

Mismatch Negativity ◽

Event Related Potentials ◽

Disruptive Effect ◽

Ischemic Pain ◽

Active Attention ◽

Early Processing ◽

Related Potentials ◽

Healthy Participants ◽

Experimentally Induced

Abstract: Previous research has found that pain can exert a disruptive effect on cognitive processing. This experiment was conducted to extend previous research with participants with chronic pain. This report examines pain's effects on early processing of auditory stimulus differences using the Mismatch Negativity (MMN) in healthy participants while they experienced experimentally induced pain. Event-related potentials (ERPs) were recorded using target and standard tones whose pitch differences were easy- or difficult-to-detect in conditions where participants attended to (active attention) or ignored (passive attention) the stimuli. Both attention manipulations were conducted in no pain and pain conditions. Experimentally induced ischemic pain did not disrupt the MMN. However, MMN amplitudes were larger to difficult-to-detect deviant tones during painful stimulation when they were attended than when they were ignored. Also, MMN amplitudes were larger to the difficult- than to the easy-to-detect tones in the active attention condition regardless of pain condition. It appears that rather than exerting a disruptive effect, the presence of experimentally induced pain enhanced early processing of small stimulus differences in these healthy participants.

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Are Emotions Abstract or Concrete?

Experimental Psychology (formerly Zeitschrift für Experimentelle Psychologie) ◽

10.1027/1618-3169/a000374 ◽

2017 ◽

Vol 64 (5) ◽

pp. 315-324 ◽

Cited By ~ 3

Author(s):

Xu Xu ◽

Chunyan Kang ◽

Kaia Sword ◽

Taomei Guo

Keyword(s):

Lexical Decision ◽

Lexical Decision Task ◽

Well Being ◽

Event Related Potential ◽

Decision Task ◽

N400 Amplitude ◽

Abstract Nouns ◽

Concrete Nouns ◽

Emotion Concepts ◽

Healthy Participants

Abstract. The ability to identify and communicate emotions is essential to psychological well-being. Yet research focusing exclusively on emotion concepts has been limited. This study examined nouns that represent emotions (e.g., pleasure, guilt) in comparison to nouns that represent abstract (e.g., wisdom, failure) and concrete entities (e.g., flower, coffin). Twenty-five healthy participants completed a lexical decision task. Event-related potential (ERP) data showed that emotion nouns elicited less pronounced N400 than both abstract and concrete nouns. Further, N400 amplitude differences between emotion and concrete nouns were evident in both hemispheres, whereas the differences between emotion and abstract nouns had a left-lateralized distribution. These findings suggest representational distinctions, possibly in both verbal and imagery systems, between emotion concepts versus other concepts, implications of which for theories of affect representations and for research on affect disorders merit further investigation.

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