Dose-related effect of intranasal corticosteroids on treatment outcome of persistent allergic rhinitis

2008 ◽  
Vol 139 (4) ◽  
pp. 565-569 ◽  
Author(s):  
Virat Kirtsreesakul ◽  
Prichaya Chansaksung ◽  
Suwalee Ruttanaphol
Keyword(s):  
Allergic Rhinitis ◽  
Nasal Symptom ◽  
The Self ◽  
Daily Activities ◽  
Flow Index ◽  
Dosing Regimen ◽  
Intranasal Corticosteroids ◽  
Persistent Allergic Rhinitis ◽  
Daily Dose ◽  
Symptom Scores

Objectives To evaluate the efficacy of the self-adjustable dosing regimen and explore potential dose-response relationships of intranasal corticosteroids in persistent allergic rhinitis. Study Design Prospective cohort study. Subjects and Methods Sixty-nine persistent allergic rhinitis patients were treated with 220 mcg of intranasal triamcinolone acetonide for 28 days. Patients with mild, intermittent symptoms were instructed to use the medication only after symptoms occurred once a day. Patients with symptoms that lasted more than 1 day and/or interrupted daily activities/sleep were instructed to continue the morning daily dose until they were symptom-free for 24 hours before stopping usage. Results All nasal symptom scores and peak expiratory flow index (PEFI) showed statistically significant improvements after treatment. At 28 days after treatment, the number of puffs and weight of steroids used were positively correlated with percentages of improvement in total symptoms score (TSS) and PEFI (ρ = 0.529, r = 0.571 and ρ = 0.350, r = 0.509 respectively). When at least 1400 mcg or 44 puffs were used, 60% TSS and 10% PEFI improvement were achieved. Conclusion A self-adjustable dosing approach proved to be an efficacious approach to controlling allergic rhinitis.

Nasal eosinophilia in nasal smears of patients with persistent and intermittent allergic rhinitis

2018 ◽  
Vol 132 (11) ◽  
pp. 1018-1021 ◽  
Author(s):  
G Berkiten ◽  
İ Aydoğdu ◽  
T L Kumral ◽  
Z Saltürk ◽  
Y Uyar ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Nasal Symptom ◽  
Effector Cells ◽  
Total Nasal Symptom Score ◽  
Persistent Allergic Rhinitis ◽  
Symptom Scores ◽  
Intermittent Allergic Rhinitis ◽  
Nasal Cytology ◽  
The Mean ◽  
Non Allergic Rhinitis

AbstractBackgroundEosinophils are the principal effector cells involved in the pathogenesis of allergic rhinitis. Cell numbers increase in non-allergic rhinitis patients with eosinophilia, aspirin hypersensitivity and nasal polyposis, as well as in allergic rhinitis patients. Exfoliative nasal cytology can be used in the differential diagnosis of allergic rhinitis.ObjectiveTo evaluate nasal eosinophilia in nasal smears of patients with mild, persistent and intermittent allergic rhinitis.MethodsThe study comprised 60 patients with allergic rhinitis and 20 healthy volunteers. The patients were divided into intermittent and persistent allergic rhinitis groups. Nasal smear status, eosinophil numbers and Total Nasal Symptom Scores were compared.ResultsNasal smear results were pathological in 40 of 60 allergic rhinitis patients, which was significantly higher than the rate in controls. The mean nasal eosinophilia score was significantly higher in the intermittent allergic rhinitis than in the persistent allergic rhinitis group (p= 0.029). There was a positive correlation between nasal eosinophilia score and Total Nasal Symptom Score (r = 0.652;p< 0.05) in persistent allergic rhinitis and intermittent allergic rhinitis patients.ConclusionThe nasal smear test is inexpensive, objective and simple to perform, and should be part of the diagnostic investigation.

Correlation of Nasal Fluid Biomarkers and Symptoms in Patients with Persistent Allergic Rhinitis

2020 ◽  
Vol 129 (6) ◽  
pp. 542-547
Author(s):  
Su Il Kim ◽  
Oh Eun Kwon ◽  
Jung Min Park ◽  
Jeon Gang Doo ◽  
Seok Hyun Kim ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Inverse Correlation ◽  
Lavage Fluid ◽  
Nasal Symptom ◽  
Clara Cell ◽  
Cell Protein ◽  
Enzyme Linked Immunosorbent Assay ◽  
Prick Test ◽  
Persistent Allergic Rhinitis ◽  
Nasal Fluid

Objectives: This study investigated whether the biomarkers present in nasal fluid reflect the severity of symptoms in patients with persistent allergic rhinitis (PAR). Methods: We enrolled 29 PAR patients complaining of nasal symptoms and testing positive to skin prick test. Patients’ total nasal symptom score (TNSS) was measured and their nasal lavage fluid (NALF) was collected. The levels of biomarkers including Clara cell protein 16 (CC16), tryptase, and interleukin 5 (IL-5) in NALF were determined via enzyme-linked immunosorbent assay (ELISA). Results: PAR patients were classified into persistent mild and persistent moderate-to-severe groups according to the Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines. The CC16 alone was significantly negatively correlated with TNSS ( P < .05). Further, the CC16 level was significantly lower in persistent moderate-to-severe group than persistent mild group of patients ( P < .05). Conclusions: The levels of CC16 alone among several NALF biomarkers showed an inverse correlation with symptoms of PAR patients.

Sublingual immunotherapy in patients with house dust mite allergic rhinitis: prospective study of clinical outcomes over a two-year period

2016 ◽  
Vol 130 (3) ◽  
pp. 272-277 ◽  
Author(s):  
J Y Soh ◽  
M Thalayasingam ◽  
S Ong ◽  
E X L Loo ◽  
L P Shek ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Allergic Rhinitis ◽  
House Dust ◽  
House Dust Mite ◽  
Sublingual Immunotherapy ◽  
Nasal Symptom ◽  
Medication Usage ◽  
Dust Mite ◽  
Symptom Scores

AbstractBackground:Sublingual immunotherapy in patients with allergic rhinitis sensitised to house dust mites is safe, but its efficacy is controversial and sublingual immunotherapy withBlomia tropicalishas not yet been studied. This study sought to evaluate the efficacy of sublingual immunotherapy with house dust mite extract in children and adults with house dust mite allergic rhinitis over a period of two years.Methods:A prospective observational study was conducted of children and adults diagnosed with house dust mite allergic rhinitis who were treated with sublingual immunotherapy from 2008 to 2012. Total Nasal Symptom Scores, Mini Rhinoconjunctivitis Quality of Life scores and medication usage scores were assessed prospectively.Results:Thirty-nine patients, comprising 24 children and 15 adults, were studied. Total Nasal Symptom Scores and Mini Rhinoconjunctivitis Quality of Life scores dropped significantly at three months into therapy, and continued to improve. Medication usage scores improved at one year into immunotherapy.Conclusion:Sublingual immunotherapy with house dust mite extracts, includingB tropicalis, is efficacious as a treatment for patients with house dust mite allergic rhinitis.

scholarly journals Acupuncture Treatment of a Patient with Persistent Allergic Rhinitis Complicated by Rhinosinusitis and Asthma

2011 ◽  
Vol 2011 ◽  
pp. 1-5 ◽  
Author(s):  
Ae-Ran Kim ◽  
Jun-Yong Choi ◽  
Jong-In Kim ◽  
So-Young Jung ◽  
Sun-Mi Choi
Keyword(s):  
Allergic Rhinitis ◽  
Clinical Studies ◽  
Symptom Relief ◽  
Nasal Symptom ◽  
Forced Expiratory Volume ◽  
Life Questionnaire ◽  
Total Nasal Symptom Score ◽  
Persistent Allergic Rhinitis ◽  
Significant Clinical Improvement ◽  
The Face

A pathophysiologic relationship between allergic rhinitis and rhinosinusitis and asthma has long been suggested. However, few clinical studies of acupuncture have been conducted on these comorbid conditions. A 48-year-old male suffering from persistent allergic rhinitis with comorbid chronic rhinosinusitis and asthma since the age of 18 years was studied. He complained of nasal obstruction, sneezing, cough, rhinorrhea and moderate dyspnea. He occasionally visited local ear-nose-throat clinics for his nasal symptoms, but gained only periodic symptom relief. The patient was treated with acupuncture, infrared radiation to the face and electro-acupuncture. Needles were inserted at bilateral LI20, GV23, LI4 and EX-1 sites with De-qi. Electro-acupuncture was performed simultaneously at both LI20 sites and additional traditional Korean acupuncture treatments were performed. Each session lasted for 10 min and the sessions were carried out twice a week for 5 weeks. The patient’s Mini-Rhinoconjunctivitis Quality-of-Life Questionnaire score decreased from 38, at the beginning of treatment, to 23, 3 weeks after the last treatment. The Total Nasal Symptom Score was reduced from six (baseline) to five, 3 weeks after the last treatment. There was significant clinical improvement in the forced expiratory volume in 1 s—from 3.01 to 3.50 l—with discontinuation of the inhaled corticosteroid, and no asthma-related complaints were reported. Further clinical studies investigating the effectiveness of acupuncture for the patients suffering from allergic rhinitis and/or rhinosinusitis with comorbid asthma are needed.

scholarly journals The Relationship between Serum Vitamin D Levels with Allergic Rhinitis Incidence and Total Nasal Symptom Score in Allergic Rhinitis Patients

2018 ◽  
Vol 6 (8) ◽  
pp. 1405-1409 ◽  
Author(s):  
Lia Restimulia ◽  
Dwi Reno Pawarti ◽  
Haris Mayaguyang Ekorini
Keyword(s):  
Vitamin D ◽  
Allergic Rhinitis ◽  
Pearson Correlation ◽  
Serum Vitamin ◽  
Nasal Symptom ◽  
Strong Negative Correlation ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Symptom Scores ◽  
The Relationship

BACKGROUND: Allergic diseases and vitamin D deficiency were found to have a relationship. However, there was limited number of studies on the relationship between vitamin D with allergic rhinitis (AR) and total nasal symptom scores (TNSS), particularly in determining the cut-off points of serum vitamin D levels which correlated to AR.AIM: As this particular study has never been conducted in Indonesia, the main objective of this study was to investigate this issue.METHODS: The research was conducted at Dr Soetomo Hospital, Surabaya in January 2017. A group of 30 subjects were recruited using consecutive sampling. Levels of serum vitamin D were measured using electrochemiluminescence immunoassay (ECLIA) method while the total nasal symptom scores were obtained by accumulating all the nasal symptoms. Data of serum vitamin D levels and TNSS were analysed statistically with the Pearson correlation test.RESULTS: It was found that the mean of serum 25(OH) vitamin D levels (9.13 ng/mL) of the AR group was significantly lower than the non-AR group (26.22 ng/mL) (P = 0.000). The vitamin D cut-off points which correlated to AR was about 12.83 ng/mL (sensitivity = 80%; specificity = 100%). A Pearson correlation test found a strong, negative correlation between vitamin D levels and TNSS (P = 0.000; r = -0.800).CONCLUSION: There was a strong, negative correlation between serum vitamin D levels with AR and TNSS. The cut-off points of serum vitamin D levels correlated to AR were approximately12.83 ng/mL. Thus, further research needs to be conducted.

scholarly journals Probiotic NVP-1703 Alleviates Allergic Rhinitis by Inducing IL-10 Expression: A Four-week Clinical Trial

Nutrients ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1427
Author(s):  
Min-Gyu Kang ◽  
Seung-Won Han ◽  
Hye-Ryun Kang ◽  
Seok-Jin Hong ◽  
Dong-Hyun Kim ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Bifidobacterium Longum ◽  
Prostaglandin F2α ◽  
Specific Ige ◽  
Nasal Symptom ◽  
Blood Eosinophil ◽  
Dermatophagoides Farinae ◽  
Immunological Parameters ◽  
Blood Eosinophil Count ◽  
Symptom Scores

Although several recent studies reported that probiotics might be beneficial for allergic rhinitis (AR), the effect of probiotics on AR is not consistent and have not been reproduced between studies. We aimed to determine the efficacy and safety of probiotic NVP-1703, a mixture of Bifidobacterium longum and Lactobacillus plantarum, in subjects with perennial AR. Adult subjects with perennial AR received either NVP-1703 (n = 47) or placebo (n = 48) for four weeks. Total nasal symptom scores (TNSS), rhinitis control assessment test (RCAT), blood eosinophil count, allergen-specific IgE, and immunological parameters in serum and urine were compared at baseline and after four weeks. TNSS changes from baseline at weeks 1, 3, and 4 were significant between the NVP-1703 and placebo groups (p = 0.033, 0.031, and 0.029, respectively). RCAT score showed significant differences between the NVP-1703 and placebo groups (p = 0.049) at week 4. Dermatophagoides farinae-specific IgE levels and serum IL-10 levels were significantly different between the NVP-1703 and placebo groups (p = 0.033 and p = 0.047, respectively). IL-10/IL-4 and IL-10/IL-13 ratios were different between the NVP-1703 and placebo groups at week 4 (p = 0.046 and 0.018, respectively). NVP-1703 treatment reduced urinary prostaglandin F2α and leukotriene E4 levels (p > 0.05). Therefore, NVP-1703 can be treatment option for perennial AR.

The changes in different symptom scores during subcutaneous immunotherapy in Chinese house dust mite allergic patients: a two-year, observational study

2019 ◽  
Vol 133 (03) ◽  
pp. 213-219
Author(s):  
Y Tu ◽  
H Zhang ◽  
L Zhao ◽  
P Jin ◽  
X Zi ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
House Dust ◽  
House Dust Mite ◽  
Analogue Scale ◽  
Asthma Symptom ◽  
Nasal Symptom ◽  
Subcutaneous Immunotherapy ◽  
Medication Score ◽  
Dust Mite ◽  
Symptom Scores

AbstractBackgroundSubcutaneous immunotherapy is an effective and safe treatment for allergic rhinitis and allergic asthma. Different symptom scores are used to evaluate the efficacy of subcutaneous immunotherapy in clinical trials.MethodA total of 58 allergic rhinitis patients sensitised to house dust mites, with or without mild asthma, were included. Symptom score, medication score, visual analogue scale score and quality of life were assessed before and after 6, 12 and 24 months of subcutaneous immunotherapy.ResultsAfter two years of subcutaneous immunotherapy, asthma symptom scores nearly reached zero, whereas the scores remained higher for nasal symptoms. The changes in asthma symptom scores were markedly different (p &lt; 0.05) and occurred faster than the changes in nasal symptom scores when compared between monosensitised and polysensitised groups. Significant reductions in visual analogue scale score and medication score were demonstrated after subcutaneous immunotherapy.ConclusionTwo-year subcutaneous immunotherapy with house dust mite vaccine is an effective treatment for both monosensitised and polysensitised allergic patients. The changes in asthma symptom scores were markedly different and occurred quicker than the changes in nasal symptom scores in Chinese house dust mite allergic patients.

scholarly journals Role of Antioxidants on the Clinical Outcome of Patients with Perennial Allergic Rhinitis

2016 ◽  
Vol 7 (2) ◽  
pp. ar.2016.7.0163 ◽  
Author(s):  
Bhushan Chauhan ◽  
Manish Gupta ◽  
Komal Chauhan
Keyword(s):  
Allergic Rhinitis ◽  
Clinical Outcome ◽  
Combined Therapy ◽  
Nasal Symptom ◽  
Therapeutic Effects ◽  
Perennial Allergic Rhinitis ◽  
Open Label ◽  
Double Blind ◽  
Symptom Scores ◽  
The Mean

Background Antioxidants have a preventive or therapeutic role in oxygen free radical-mediated cell and tissue damage. The study aimed to investigate the therapeutic effects of antioxidants and intranasal steroid fluticasone furoate (FF) on the clinical outcome of patients with perennial allergic rhinitis. Methods Subjects with perennial allergic rhinitis (n = 61) were randomly divided into two groups, group A (n = 30) received FF and group B(n = 31) received FF with antioxidants for 6 weeks. Nasal and ocular symptoms were evaluated weekly by using a four-point categoric scale. The efficacy of the study drug was assessed based on the mean change from baseline of the total daytime nasal symptom scores, total nighttime nasal symptom scores, and the composite symptom scores. Results The combined therapy (FF with antioxidants) resulted in marked improvements (p ≤ 0.05) in the mean total daytime nasal symptom scores, total nighttime nasal symptom scores, and composite symptom scores of subjects compared with ones treated with intranasal steroid (FF) alone, which highlighted the therapeutic effect of antioxidants in allergic rhinitis. Conclusion Significant improvement in clinical outcome was observed in subjects who received antioxidants along with FF. However, because this was an open-label study, the results must be interpreted with caution, and further double-blind, placebo-controlled, dose-ranging trials supplemented with different antioxidants together with intranasal steroids are suggested.

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