Age-related hearing loss, vitamin B12, and folate in the elderly

2010 ◽  
Vol 143 (6) ◽  
pp. 826-830 ◽  
Author(s):  
Akeem Olawale Lasisi ◽  
Fatai A. Fehintola ◽  
Oyindamola Bidemi Yusuf
Keyword(s):  
Hearing Loss ◽  
Vitamin B12 ◽  
The Elderly ◽  
Age Related ◽  
Age Related Hearing Loss

Application-Based Hearing Screening in the Elderly Population

2016 ◽  
Vol 126 (1) ◽  
pp. 36-41 ◽  
Author(s):  
Leonid Livshitz ◽  
Reem Ghanayim ◽  
Carmi Kraus ◽  
Raymond Farah ◽  
Ella Even-Tov ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Elderly Population ◽  
The Elderly ◽  
Constant Factor ◽  
Hearing Screening ◽  
Easy Access ◽  
Age Related ◽  
Maximum Benefit ◽  
Hearing Thresholds ◽  
Age Related Hearing Loss

Objectives: The effects of age-related hearing loss are severe. Early detection is essential for maximum benefit. However, most hearing-impaired adults delay obtaining treatment. Diagnostic hearing testing at an appropriate facility is impractical, and new methods for screening audiometry aim to provide easy access for patients and reliable outcomes. The purpose of this study was to examine the accuracy of application-based hearing screening in an elderly population. Methods: The uHear application was downloaded to an iPad. Application-based hearing screening was performed in a non-soundproofed quiet room, and subsequently all participants underwent full diagnostic audiometry in a soundproof booth. Results: Sixty patients were recruited and completed both tests. Significant differences were observed between the hearing results obtained with the application and the standard audiogram at all frequencies and in both ears. Following subtraction of a constant factor of 25 dB from the application-based results in order to compensate for ambient noise, no significant differences in pure tone average were found between the 2 methods. Conclusions: The uHear application is inaccurate in assessing hearing thresholds for screening in the elderly. However, when site-specifically corrected, the uHear application may be used as a screening tool for hearing loss in an elderly population.

scholarly journals Oxidative Stresses and Mitochondrial Dysfunction in Age-Related Hearing Loss

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Chisato Fujimoto ◽  
Tatsuya Yamasoba
Keyword(s):  
Hearing Loss ◽  
Mitochondrial Dysfunction ◽  
Stria Vascularis ◽  
Spiral Ganglion ◽  
Organ Of Corti ◽  
The Elderly ◽  
Laboratory Animals ◽  
Age Related ◽  
Ganglion Neurons ◽  
Age Related Hearing Loss

Age-related hearing loss (ARHL), the progressive loss of hearing associated with aging, is the most common sensory disorder in the elderly population. The pathology of ARHL includes the hair cells of the organ of Corti, stria vascularis, and afferent spiral ganglion neurons as well as the central auditory pathways. Many studies have suggested that the accumulation of mitochondrial DNA damage, the production of reactive oxygen species, and decreased antioxidant function are associated with subsequent cochlear senescence in response to aging stress. Mitochondria play a crucial role in the induction of intrinsic apoptosis in cochlear cells. ARHL can be prevented in laboratory animals by certain interventions, such as caloric restriction and supplementation with antioxidants. In this review, we will focus on previous research concerning the role of the oxidative stress and mitochondrial dysfunction in the pathology of ARHL in both animal models and humans and introduce concepts that have recently emerged regarding the mechanisms of the development of ARHL.

scholarly journals Auditory Processing Performance of the Middle-Aged and Elderly: Auditory or Cognitive Decline?

2018 ◽  
Vol 29 (01) ◽  
pp. 005-014 ◽  
Author(s):  
Cristina F. B. Murphy ◽  
Camila M. Rabelo ◽  
Marcela L. Silagi ◽  
Leticia L. Mansur ◽  
Doris E. Bamiou ◽  
...  
Keyword(s):  
Working Memory ◽  
Hearing Loss ◽  
Cognitive Decline ◽  
Auditory Processing ◽  
The Elderly ◽  
Regression Analyses ◽  
Frequency Pattern ◽  
Speech In Noise ◽  
Age Related ◽  
Age Related Hearing Loss

AbstractDespite the well-established relationship between aging and auditory processing decline, identifying the extent to which age effect is the main factor on auditory processing performance remains a great challenge due to the co-occurrence of age-related hearing loss and age-related cognitive decline as potential confounding factors.To investigate the effects of age-related hearing loss and working memory on the clinical evaluation of auditory processing of middle-aged and elderly.Cross-sectional study.A total of 77 adults between 50 and 70 yr of age were invited to participate in the study.The participants were recruited from a larger study that focused on the assessment and management of sensory and cognitive skills in elderly participants. Only participants with normal hearing or mild-to-moderate age-related hearing loss, with no evidence of cognitive, psychological, or neurological conditions were included. Speech-in-noise, dichotic digit, and frequency pattern tests were conducted as well as a working memory test. The hearing loss effect was investigated using an audibility index, calculated from the audiometric threshold. The performance on the digit span test was used to investigate working memory effects. Both hearing loss and working memory effects were investigated via correlation and regression analyses, partialling out age effects. The significance level was set at p < 0.05.The results demonstrated that, while hearing loss was associated to the speech-in-noise performance, working memory was associated to the frequency pattern and dichotic digit performances. Regression analyses confirmed the relative contribution of hearing loss to the variance in speech-in-noise and working memory test to the variance in frequency pattern and dichotic digit test performance.The performance decline of the elderly in auditory processing tests may be partially attributable to the working memory performance and, consequently, to the cognitive decline exhibited by this population. Mild-to-moderate hearing loss seems to affect performance on specific auditory processing tasks, such as speech in noise, reinforcing the idea that auditory processing disorder in the elderly might also be associated to auditory peripheral deficits.

scholarly journals Age related hearing loss and cognitive impairment - a current perspective

2020 ◽  
Vol 9 (1) ◽  
pp. 317
Author(s):  
Santosh K. Swain
Keyword(s):  
Quality Of Life ◽  
Hearing Loss ◽  
Cognitive Impairment ◽  
Cognitive Decline ◽  
The Elderly ◽  
Elderly Age ◽  
Age Related ◽  
Current Perspective ◽  
Age Related Hearing Loss

Age related hearing loss (ARHL) is one of the commonest health conditions of the elderly people which have an important relation with the cognition. Long standing hearing deprivation leads to decline of the cognitive performance. This has impact on quality of communication and result in social isolation, depression and enhances the dementia. Cognitive decline may be misdiagnosed or over-diagnosed when the sensory abilities of the patients are not properly evaluated. Adequate intervention by use of hearing aid or cochlear implant improves the communication, cognitive function, social, emotion function and positively impact on the quality of life. With rise of the elderly population and concomitant increase of ARHL with associated cognitive impairment, it is imperative to discuss this morbid clinical entity in present scenario. Cognitive decline in elderly age have a profound impact on the affected person, on caregivers and society. The financial costs for cognitive impairment in ARHL are also major source of concern for the society. In this review article, we focus on the epidemiology, pathophysiology, hypotheses of etiological mechanisms between the ARHL and cognitive decline or impairment, impact of cognitive impairment on quality of life and prevention.

scholarly journals Presbycusis and hyperlipidemia: Is there any link?

2020 ◽  
Vol 7 (2) ◽  
pp. 47-57
Author(s):  
Refad A. Azeez
Keyword(s):  
Hearing Loss ◽  
Pure Tone Audiometry ◽  
Thyroid Function Test ◽  
The Elderly ◽  
Cross Sectional Study ◽  
P Value ◽  
Cross Sectional ◽  
Age Related ◽  
Group B ◽  
Age Related Hearing Loss

Age related hearing loss is one of the most common chronic health conditions affecting the elderly people. With aging, risk of Presbycusis and hyperlipidemia increases. Although most studies do reach some sort of agreement, the evidence supporting a relationship between presbycusis and hyperlipidemia remains questionable. The objective of this study is to determine the association between age related hearing loss and hyperlipidemia and assess the severity of hearing loss in hyperlipidemic patients. This cross sectional analytic study was carried out at ENT Out Patient Clinic at Al Sader teaching Hospital from March 2019 to December 2019. A cross‑sectional study on 52 patients with Hyperlipidemia and 42 non Hyperlipidemic patients was carried out during March 2019 to December 2019. All patients were evaluated for hearing loss by subjecting to pure tone audiometry, blood investigations were done in form of lipid profile, blood sugars, thyroid function test, blood urea and serum creatinine levels. Group A consisted of 22 (42.3%) males and 30 (57.7%) female while group B consisted of 23 (54.8%) male and 19 (45.2%) female individuals. Audiological assessment by PTA was show that the prevalence of presbycusis among hyperlipidemic group more than non hyperlipidemic with significant statistical difference (P value <0.05). Prevalence was 76.9%. In conclusion; there is statistically significant association between presbycusis and hyperlipidemia especially those with hyercholestrolemia.

scholarly journals Age-related hearing loss and its association with central obesity: experience at a tertiary centre

2020 ◽  
Vol 8 (8) ◽  
pp. 2798
Author(s):  
Utkarsh Agrawal ◽  
Anjali Singh ◽  
Ashvanee Chaudhary ◽  
Vishwambhar Singh
Keyword(s):  
Hearing Loss ◽  
High Frequency ◽  
The Elderly ◽  
Sensorineural Hearing ◽  
High Frequency Hearing Loss ◽  
Tertiary Centre ◽  
Age Related ◽  
Modifiable Factor ◽  
A Prospective Study ◽  
Age Related Hearing Loss

Background: Presbycusis is a slow, progressive, age-related sensorineural hearing loss, which is insidious, slow, progressive and irreversible disease and usually affects high pitch sound. It can be associated with various factors. Obesity is such a modifiable factor and its independent role with age-related hearing loss needs to be explored.Methods: This is a prospective study carried out over a period of three years in department of otorhinolaryngology at study institute. It included 1000 cases with symmetrical sensorineural hearing loss.Results: Among obese cases, high frequency hearing loss was found in significantly large number of cases. The most common audiogram in both male and female was Abrupt high tone loss type, irrespective of presence or absence of obesity.Conclusions: Obesity is a modifiable factor which has a significant association with high frequency hearing loss among the elderly population.

Audiological and Temporal Bone Findings in Myxedema

1986 ◽  
Vol 95 (3) ◽  
pp. 278-283 ◽  
Author(s):  
A. Parving ◽  
B. Ostri ◽  
J. M. Hansen ◽  
P. Bretlau ◽  
H.-H. Parving
Keyword(s):  
Hearing Loss ◽  
Structural Changes ◽  
Morphological Changes ◽  
The Elderly ◽  
Hearing Sensitivity ◽  
Age Related ◽  
Before And After ◽  
Temporal Bones ◽  
Age Related Hearing Loss ◽  
Observation Period

Fifteen patients with confirmed myxedema at a median age of 48 years (range 32 to 60 years) were referred for audiological evaluation before and after treatment with levothyroxine. The median interval between the pretreatment and posttreatment investigations was 18 months (range 9 to 27 months). In addition, 13 patients at a median age of 78 years (range 64 to 95 years) were audiologically reexamined after long-standing levothyroxine treatment. The observation period upon treatment with levothyroxine was 40 months (range 32 to 46 months). No improvement in hearing sensitivity could be demonstrated either in the younger patients or in the elderly. When compared to an age- and sex-matched unscreened population, the myxedematous patients did not demonstrate any different degree of hearing loss. Histological investigation of the temporal bones from an 83-year-old woman with myxedema, however, showed no morphological changes or deposition of glycosaminoglycans, changes which are compatible with true age-related hearing loss. It is concluded that no association exists between myxedema and hearing impairment and that no morphological or structural changes due to myxedema can be demonstrated in the temporal bones.

scholarly journals Mutations in L-type amino acid transporter-2 support SLC7A8 as a novel gene involved in age-related hearing loss

eLife ◽  
2018 ◽  
Vol 7 ◽  
Author(s):  
Meritxell Espino Guarch ◽  
Mariona Font-Llitjós ◽  
Silvia Murillo-Cuesta ◽  
Ekaitz Errasti- Murugarren ◽  
Adelaida M Celaya ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Amino Acid ◽  
The Elderly ◽  
Causative Role ◽  
Transport Activity ◽  
Functional Studies ◽  
Age Related ◽  
Strong Candidate ◽  
Age Related Hearing Loss

Age-related hearing loss (ARHL) is the most common sensory deficit in the elderly. The disease has a multifactorial etiology with both environmental and genetic factors involved being largely unknown. SLC7A8/SLC3A2 heterodimer is a neutral amino acid exchanger. Here, we demonstrated that SLC7A8 is expressed in the mouse inner ear and that its ablation resulted in ARHL, due to the damage of different cochlear structures. These findings make SLC7A8 transporter a strong candidate for ARHL in humans. Thus, a screening of a cohort of ARHL patients and controls was carried out revealing several variants in SLC7A8, whose role was further investigated by in vitro functional studies. Significant decreases in SLC7A8 transport activity was detected for patient’s variants (p.Val302Ile, p.Arg418His, p.Thr402Met and p.Val460Glu) further supporting a causative role for SLC7A8 in ARHL. Moreover, our preliminary data suggest that a relevant proportion of ARHL cases could be explained by SLC7A8 mutations.

scholarly journals Associations of Dietary Riboflavin, Niacin, and Retinol with Age-related Hearing Loss: An Analysis of Korean National Health and Nutrition Examination Survey Data

Nutrients ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 896 ◽  
Author(s):  
Tae Su Kim ◽  
Jong Woo Chung
Keyword(s):  
Hearing Loss ◽  
National Health ◽  
Smoking Status ◽  
The Elderly ◽  
Nutrition Examination Survey ◽  
Modifying Factors ◽  
Health And Nutrition ◽  
Age Related ◽  
Using Data ◽  
Age Related Hearing Loss

Because age-related hearing loss (ARHL) is irreversible, prevention is very important. Thus, investigating modifying factors that help prevent ARHL is critical for the elderly. Nutritional status or nutritional factors for the elderly are known to be associated with many problems related to aging. Emerging studies suggest that there was the interaction between nutrition and ARHL. We aimed to investigate the possible impact of dietary nutrients on ARHL using data from the fifth Korean National Health and Nutrition Examination Survey (KNHANES) which included 4742 subjects aged ≥ 65 years from 2010 to 2012. All participants underwent an otologic examination, audiologic evaluation, and nutritional survey. The associations between ARHL and nutrient intake were analyzed using simple and multiple regression models with complex sampling adjusted for confounding factors, such as BMI, smoking status, alcohol consumption, and history of hypertension and diabetes. Higher intake groups of riboflavin, niacin and retinol was inversely associated with ARHL prevalence (riboflavin aOR, 0.71; 95% CI, 0.54–0.94; p = 0.016, niacin aOR, 0.72; 95% CI, 0.54–0.96; p = 0.025, retinol aOR 0.66; 95% CI, 0.51–0.86; p = 0.002, respectively). Our findings suggest the recommended intake levels of riboflavin, niacin, and retinol may help reduce ARHL in the elderly.

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