Audiological and Temporal Bone Findings in Myxedema

1986 ◽  
Vol 95 (3) ◽  
pp. 278-283 ◽  
Author(s):  
A. Parving ◽  
B. Ostri ◽  
J. M. Hansen ◽  
P. Bretlau ◽  
H.-H. Parving
Keyword(s):  
Hearing Loss ◽  
Structural Changes ◽  
Morphological Changes ◽  
The Elderly ◽  
Hearing Sensitivity ◽  
Age Related ◽  
Before And After ◽  
Temporal Bones ◽  
Age Related Hearing Loss ◽  
Observation Period

Fifteen patients with confirmed myxedema at a median age of 48 years (range 32 to 60 years) were referred for audiological evaluation before and after treatment with levothyroxine. The median interval between the pretreatment and posttreatment investigations was 18 months (range 9 to 27 months). In addition, 13 patients at a median age of 78 years (range 64 to 95 years) were audiologically reexamined after long-standing levothyroxine treatment. The observation period upon treatment with levothyroxine was 40 months (range 32 to 46 months). No improvement in hearing sensitivity could be demonstrated either in the younger patients or in the elderly. When compared to an age- and sex-matched unscreened population, the myxedematous patients did not demonstrate any different degree of hearing loss. Histological investigation of the temporal bones from an 83-year-old woman with myxedema, however, showed no morphological changes or deposition of glycosaminoglycans, changes which are compatible with true age-related hearing loss. It is concluded that no association exists between myxedema and hearing impairment and that no morphological or structural changes due to myxedema can be demonstrated in the temporal bones.

scholarly journals Interprofessional Education Activity to Improve Communication With Older Adults With Hearing Loss

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 4-4
Author(s):  
Laura Gaeta ◽  
Tara Sharpp
Keyword(s):  
Older Adults ◽  
Hearing Loss ◽  
Nursing Students ◽  
Interprofessional Education ◽  
Complex Case ◽  
Evaluation Data ◽  
Age Related ◽  
Before And After ◽  
Education Activity ◽  
Age Related Hearing Loss

Abstract The purpose of this study was to determine how an interprofessional education (IPE) intervention with Communication Sciences and Disorders (CSAD) and Nursing students can affect their ability to communicate effectively with older adults who have hearing loss. As the older adult demographic increases, healthcare professionals must provide competent care, which includes effectively managing hearing-related communication difficulties in an increasingly diverse population. Faculty received IRB approval to conduct a descriptive mixed-methods study to determine knowledge and satisfaction of students completing an IPE activity. Students were divided into teams of CSAD and Nursing students. Students listened to a brief presentation on IPE before they were introduced to a complex case study of an 84-year-old male with age-related hearing loss. We administered a knowledge assessment questionnaire (KAQ) we created regarding communication with older adults before and after the activity. A total of 92 participants in the two programs (n=36 CSAD, n=56 Nursing) completed the KAQ before and after the activity and an evaluation with a Likert-type scale and open-ended questions. CSAD students scored significantly higher than Nursing students on the KAQ at baseline (F=25.69, p<0.001) and KAQ scores increased significantly (F=57.04, p<0.001) among both groups from pretest to posttest. The evaluation data indicated students were able to learn other perspectives and found the experience valuable. Based on the improvement in scores on the KAQ and evaluation data, this IPE activity increased knowledge related to communication with older adults with hearing loss and awareness of the roles of other professions.

scholarly journals Hearing Disorders and Sensorineural Aging

2014 ◽  
Vol 2014 ◽  
pp. 1-6
Author(s):  
Alessandra Fioretti ◽  
Otello Poli ◽  
Theodoros Varakliotis ◽  
Alberto Eibenstein
Keyword(s):  
Hearing Loss ◽  
Organ Of Corti ◽  
Physiological Age ◽  
Hearing Disorders ◽  
Hearing Sensitivity ◽  
Age Related ◽  
Loss Of Autonomy ◽  
Central Auditory Function ◽  
Central Auditory Pathways ◽  
Age Related Hearing Loss

The physiological age-related hearing loss is defined as presbycusis and it is characterized by reduced hearing sensitivity and problems in understanding spoken language especially in a noisy environment. In elderly the reduced speech recognition is generally caused by a reduction of the cochlear cells in the organ of Corti and degeneration of the central auditory pathways. In order to have a complete management strategy of central and peripheral presbycusis the diagnostic evaluation should include clinical ENT examination, standard audiological tests, and tests of central auditory function. Treatment should include not only the appropriate instruments for peripheral compensation but also auditory rehabilitative training and counseling to prevent social isolation and loss of autonomy. Other common hearing disorders in elderly are tinnitus and hyperacusis which are often undervalued. Tinnitus is characterized by the perception of a “phantom” sound due to abnormal auditory perception. Hyperacusis is defined as a reduced tolerance to ordinary environmental sounds. Furthermore auditory, visual, nociceptive, and proprioceptive systems may be involved together in a possible context of “sensorineural aging.” The aim of this review is to underline the presence of hearing disorders like tinnitus and hyperacusis which in many cases coexist with hearing loss in elderly.

scholarly journals Role of Oxidative Stress in the Senescence Pattern of Auditory Cells in Age-Related Hearing Loss

Antioxidants ◽  
2021 ◽  
Vol 10 (9) ◽  
pp. 1497
Author(s):  
Luz del Mar Rivas-Chacón ◽  
Sofía Martínez-Rodríguez ◽  
Raquel Madrid-García ◽  
Joaquín Yanes-Díaz ◽  
Juan Ignacio Riestra-Ayora ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Hearing Loss ◽  
Molecular Mechanisms ◽  
Morphological Changes ◽  
Cell Damage ◽  
Stria Vascularis ◽  
Organ Of Corti ◽  
Age Related ◽  
Age Related Hearing Loss

Age-related hearing loss (ARHL) is an increasing and gradual sensorineural hearing dysfunction. Oxidative stress is an essential factor in developing ARHL; additionally, premature senescence of auditory cells induced by oxidative stress can produce hearing loss. Hydrogen peroxide (H2O2) represents a method commonly used to generate cellular senescence in vitro. The objective of the present paper is to study H2O2-induced senescence patterns in three auditory cell lines (House Ear Institute-Organ of Corti 1, HEI-OC1; organ of Corti, OC-k3, and stria vascularis, SV-k1 cells) to elucidate the intrinsic mechanisms responsible for ARHL. The auditory cells were exposed to H2O2 at different concentrations and times. The results obtained show different responses of the hearing cells concerning cell growth, β-galactosidase activity, morphological changes, mitochondrial activation, levels of oxidative stress, and other markers of cell damage (Forkhead box O3a, FoxO3a, and 8-oxoguanine, 8-oxoG). Comparison between the responses of these auditory cells to H2O2 is a helpful method to evaluate the molecular mechanisms responsible for these auditory cells’ senescence. Furthermore, this in vitro model could help develop anti-senescent therapeutic strategies for the treatment of AHRL.

Application-Based Hearing Screening in the Elderly Population

2016 ◽  
Vol 126 (1) ◽  
pp. 36-41 ◽  
Author(s):  
Leonid Livshitz ◽  
Reem Ghanayim ◽  
Carmi Kraus ◽  
Raymond Farah ◽  
Ella Even-Tov ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Elderly Population ◽  
The Elderly ◽  
Constant Factor ◽  
Hearing Screening ◽  
Easy Access ◽  
Age Related ◽  
Maximum Benefit ◽  
Hearing Thresholds ◽  
Age Related Hearing Loss

Objectives: The effects of age-related hearing loss are severe. Early detection is essential for maximum benefit. However, most hearing-impaired adults delay obtaining treatment. Diagnostic hearing testing at an appropriate facility is impractical, and new methods for screening audiometry aim to provide easy access for patients and reliable outcomes. The purpose of this study was to examine the accuracy of application-based hearing screening in an elderly population. Methods: The uHear application was downloaded to an iPad. Application-based hearing screening was performed in a non-soundproofed quiet room, and subsequently all participants underwent full diagnostic audiometry in a soundproof booth. Results: Sixty patients were recruited and completed both tests. Significant differences were observed between the hearing results obtained with the application and the standard audiogram at all frequencies and in both ears. Following subtraction of a constant factor of 25 dB from the application-based results in order to compensate for ambient noise, no significant differences in pure tone average were found between the 2 methods. Conclusions: The uHear application is inaccurate in assessing hearing thresholds for screening in the elderly. However, when site-specifically corrected, the uHear application may be used as a screening tool for hearing loss in an elderly population.

scholarly journals Screening Methods for Age-Related Hearing Loss in Older Patients with Cancer: A Review of the Literature

Geriatrics ◽  
2018 ◽  
Vol 3 (3) ◽  
pp. 48 ◽  
Author(s):  
Michelle Lycke ◽  
Tessa Lefebvre ◽  
Lieselot Cool ◽  
Koen Van Eygen ◽  
Tom Boterberg ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Hearing Loss ◽  
Older Patients ◽  
Cumulative Effect ◽  
Screening Methods ◽  
Hearing Sensitivity ◽  
Patients With Cancer ◽  
Age Related ◽  
Age Related Hearing Loss

As people grow older, they may experience loss in hearing sensitivity. Age-related hearing loss may negatively affect the patient’s quality of life as it may lead to social isolation. In older patients with cancer, hearing loss can seriously interfere with the patient’s ability to deal properly with all aspects of their disease, and may have a cumulative effect on their already decreased quality of life. Therefore, the proper screening of those conditions is essential in order to optimise the patient’s comfort during and after treatment. This review article aims at providing a concise image of the nature of age-related hearing loss, and provides an overview of the screening methods that could be used in older patients with cancer.

Expression Profiling of MicroRNAs in the Inner Ear of Elderly People by Real-Time PCR Quantification

2017 ◽  
Vol 22 (3) ◽  
pp. 135-145 ◽  
Author(s):  
Kuwon Sekine ◽  
Tomohiro Matsumura ◽  
Toshihiro Takizawa ◽  
Yurika Kimura ◽  
Shiho Saito ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Inner Ear ◽  
Real Time Pcr ◽  
Expression Profiling ◽  
Molecular Mechanisms ◽  
Elderly Subjects ◽  
Age Related ◽  
Inner Ear Development ◽  
Temporal Bones ◽  
Age Related Hearing Loss

The molecular mechanisms underlying age-related hearing loss are unknown, and currently, there is no treatment for this condition. Recent studies have shown that microRNAs (miRNAs) and age-related diseases are intimately linked, suggesting that some miRNAs may present attractive therapeutic targets. In this study, we obtained 8 human temporal bones from 8 elderly subjects at brain autopsy in order to investigate the expression profile of miRNAs in the inner ear with miRNA arrays. A mean of 478 different miRNAs were expressed in the samples, of which 348 were commonly expressed in all 8 samples. Of these, levels of 16 miRNAs significantly differed between young elderly and old elderly subjects. miRNAs, which play important roles in inner ear development, were detected in all samples, i.e., in both young and old elderly subjects, whether with or without hearing loss. Our results suggest that these miRNAs play important roles not only in development, but also in the maintenance of inner ear homeostasis.

scholarly journals Oxidative Stresses and Mitochondrial Dysfunction in Age-Related Hearing Loss

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Chisato Fujimoto ◽  
Tatsuya Yamasoba
Keyword(s):  
Hearing Loss ◽  
Mitochondrial Dysfunction ◽  
Stria Vascularis ◽  
Spiral Ganglion ◽  
Organ Of Corti ◽  
The Elderly ◽  
Laboratory Animals ◽  
Age Related ◽  
Ganglion Neurons ◽  
Age Related Hearing Loss

Age-related hearing loss (ARHL), the progressive loss of hearing associated with aging, is the most common sensory disorder in the elderly population. The pathology of ARHL includes the hair cells of the organ of Corti, stria vascularis, and afferent spiral ganglion neurons as well as the central auditory pathways. Many studies have suggested that the accumulation of mitochondrial DNA damage, the production of reactive oxygen species, and decreased antioxidant function are associated with subsequent cochlear senescence in response to aging stress. Mitochondria play a crucial role in the induction of intrinsic apoptosis in cochlear cells. ARHL can be prevented in laboratory animals by certain interventions, such as caloric restriction and supplementation with antioxidants. In this review, we will focus on previous research concerning the role of the oxidative stress and mitochondrial dysfunction in the pathology of ARHL in both animal models and humans and introduce concepts that have recently emerged regarding the mechanisms of the development of ARHL.

scholarly journals Auditory Processing Performance of the Middle-Aged and Elderly: Auditory or Cognitive Decline?

2018 ◽  
Vol 29 (01) ◽  
pp. 005-014 ◽  
Author(s):  
Cristina F. B. Murphy ◽  
Camila M. Rabelo ◽  
Marcela L. Silagi ◽  
Leticia L. Mansur ◽  
Doris E. Bamiou ◽  
...  
Keyword(s):  
Working Memory ◽  
Hearing Loss ◽  
Cognitive Decline ◽  
Auditory Processing ◽  
The Elderly ◽  
Regression Analyses ◽  
Frequency Pattern ◽  
Speech In Noise ◽  
Age Related ◽  
Age Related Hearing Loss

AbstractDespite the well-established relationship between aging and auditory processing decline, identifying the extent to which age effect is the main factor on auditory processing performance remains a great challenge due to the co-occurrence of age-related hearing loss and age-related cognitive decline as potential confounding factors.To investigate the effects of age-related hearing loss and working memory on the clinical evaluation of auditory processing of middle-aged and elderly.Cross-sectional study.A total of 77 adults between 50 and 70 yr of age were invited to participate in the study.The participants were recruited from a larger study that focused on the assessment and management of sensory and cognitive skills in elderly participants. Only participants with normal hearing or mild-to-moderate age-related hearing loss, with no evidence of cognitive, psychological, or neurological conditions were included. Speech-in-noise, dichotic digit, and frequency pattern tests were conducted as well as a working memory test. The hearing loss effect was investigated using an audibility index, calculated from the audiometric threshold. The performance on the digit span test was used to investigate working memory effects. Both hearing loss and working memory effects were investigated via correlation and regression analyses, partialling out age effects. The significance level was set at p < 0.05.The results demonstrated that, while hearing loss was associated to the speech-in-noise performance, working memory was associated to the frequency pattern and dichotic digit performances. Regression analyses confirmed the relative contribution of hearing loss to the variance in speech-in-noise and working memory test to the variance in frequency pattern and dichotic digit test performance.The performance decline of the elderly in auditory processing tests may be partially attributable to the working memory performance and, consequently, to the cognitive decline exhibited by this population. Mild-to-moderate hearing loss seems to affect performance on specific auditory processing tasks, such as speech in noise, reinforcing the idea that auditory processing disorder in the elderly might also be associated to auditory peripheral deficits.

scholarly journals Age related hearing loss and cognitive impairment - a current perspective

2020 ◽  
Vol 9 (1) ◽  
pp. 317
Author(s):  
Santosh K. Swain
Keyword(s):  
Quality Of Life ◽  
Hearing Loss ◽  
Cognitive Impairment ◽  
Cognitive Decline ◽  
The Elderly ◽  
Elderly Age ◽  
Age Related ◽  
Current Perspective ◽  
Age Related Hearing Loss

Age related hearing loss (ARHL) is one of the commonest health conditions of the elderly people which have an important relation with the cognition. Long standing hearing deprivation leads to decline of the cognitive performance. This has impact on quality of communication and result in social isolation, depression and enhances the dementia. Cognitive decline may be misdiagnosed or over-diagnosed when the sensory abilities of the patients are not properly evaluated. Adequate intervention by use of hearing aid or cochlear implant improves the communication, cognitive function, social, emotion function and positively impact on the quality of life. With rise of the elderly population and concomitant increase of ARHL with associated cognitive impairment, it is imperative to discuss this morbid clinical entity in present scenario. Cognitive decline in elderly age have a profound impact on the affected person, on caregivers and society. The financial costs for cognitive impairment in ARHL are also major source of concern for the society. In this review article, we focus on the epidemiology, pathophysiology, hypotheses of etiological mechanisms between the ARHL and cognitive decline or impairment, impact of cognitive impairment on quality of life and prevention.

scholarly journals Presbycusis and hyperlipidemia: Is there any link?

2020 ◽  
Vol 7 (2) ◽  
pp. 47-57
Author(s):  
Refad A. Azeez
Keyword(s):  
Hearing Loss ◽  
Pure Tone Audiometry ◽  
Thyroid Function Test ◽  
The Elderly ◽  
Cross Sectional Study ◽  
P Value ◽  
Cross Sectional ◽  
Age Related ◽  
Group B ◽  
Age Related Hearing Loss

Age related hearing loss is one of the most common chronic health conditions affecting the elderly people. With aging, risk of Presbycusis and hyperlipidemia increases. Although most studies do reach some sort of agreement, the evidence supporting a relationship between presbycusis and hyperlipidemia remains questionable. The objective of this study is to determine the association between age related hearing loss and hyperlipidemia and assess the severity of hearing loss in hyperlipidemic patients. This cross sectional analytic study was carried out at ENT Out Patient Clinic at Al Sader teaching Hospital from March 2019 to December 2019. A cross‑sectional study on 52 patients with Hyperlipidemia and 42 non Hyperlipidemic patients was carried out during March 2019 to December 2019. All patients were evaluated for hearing loss by subjecting to pure tone audiometry, blood investigations were done in form of lipid profile, blood sugars, thyroid function test, blood urea and serum creatinine levels. Group A consisted of 22 (42.3%) males and 30 (57.7%) female while group B consisted of 23 (54.8%) male and 19 (45.2%) female individuals. Audiological assessment by PTA was show that the prevalence of presbycusis among hyperlipidemic group more than non hyperlipidemic with significant statistical difference (P value <0.05). Prevalence was 76.9%. In conclusion; there is statistically significant association between presbycusis and hyperlipidemia especially those with hyercholestrolemia.

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