Potent and rapid bactericidal action of alyteserin-1c and its [E4K] analog against multidrug-resistant strains of Acinetobacter baumannii

Peptides ◽  
2010 ◽  
Vol 31 (10) ◽  
pp. 1806-1810 ◽  
Author(s):  
J. Michael Conlon ◽  
Eman Ahmed ◽  
Tibor Pal ◽  
Agnes Sonnevend
Keyword(s):  
Acinetobacter Baumannii ◽  
Multidrug Resistant ◽  
Bactericidal Action ◽  
Resistant Strains

scholarly journals Low concentrations of commercial alcohol hand rubs facilitate growth of and secretion of extracellular proteins by multidrug-resistant strains of Acinetobacter baumannii

2007 ◽  
Vol 56 (12) ◽  
pp. 1595-1599 ◽  
Author(s):  
Justin Edwards ◽  
Geeta Patel ◽  
David W. Wareham
Keyword(s):  
Acinetobacter Baumannii ◽  
Culture Supernatant ◽  
Multidrug Resistant ◽  
Extracellular Proteins ◽  
Nosocomial Pathogen ◽  
Emulsifying Activity ◽  
Health Care Settings ◽  
Low Concentrations ◽  
Resistant Strains ◽  
Minimal Media

Acinetobacter baumannii is increasingly recognized as an important multidrug-resistant nosocomial pathogen. Recent work has highlighted enhanced growth and heightened virulence in the presence of ethyl alcohols. As alcohol-based hand rubs (ABHRs) are extensively used in health care settings, the authors set out to determine whether the hand rubs could also influence the growth of prevalent multidrug-resistant strains circulating in UK hospitals. A significant increase in growth was observed when minimal media were supplemented with concentrations of 1 % and lower of four commercially available hand rubs. In addition, growth in ABHR-supplemented media resulted in secretion of proteins into the culture supernatant. One of these was identified as OmpA, which is recognized as having emulsifying activity, which could potentially confer enhanced pathogenicity to A. baumannii.

Mortality Associated with Acinetobacter baumannii Complex Bacteremia among Patients with War-Related Trauma

2010 ◽  
Vol 31 (1) ◽  
pp. 92-94 ◽  
Author(s):  
Grace Kang ◽  
Joshua D. Hartzell ◽  
Robin Howard ◽  
Robert N. Wood-Morris ◽  
Mark D. Johnson ◽  
...  
Keyword(s):  
Mortality Rate ◽  
Acinetobacter Baumannii ◽  
Young Patients ◽  
Multidrug Resistant ◽  
Low Risk ◽  
Risk Of Death ◽  
High Prevalence ◽  
Acinetobacter Baumannii Complex ◽  
Resistant Strains

We investigated the mortality associated with Adnetobacter baumannii complex bacteremia among a cohort of patients hospitalized for war-related trauma. Despite a high prevalence of multidrug-resistant strains, the 30-day mortality rate was 2%. For relatively young patients with war-related trauma, A. baumannii complex bacteremia appears to be associated with a low risk of death.

scholarly journals Multidrug Resistant Acinetobacter baumannii: Risk Factors for Appearance of Imipenem Resistant Strains on Patients Formerly with Susceptible Strains

PLoS ONE ◽  
2010 ◽  
Vol 5 (4) ◽  
pp. e9947 ◽  
Author(s):  
Jung-Jr Ye ◽  
Ching-Tai Huang ◽  
Shian-Sen Shie ◽  
Po-Yen Huang ◽  
Lin-Hui Su ◽  
...  
Keyword(s):  
Risk Factors ◽  
Acinetobacter Baumannii ◽  
Multidrug Resistant ◽  
Resistant Strains

scholarly journals Association between antibiotic pressure and the risk of colonization/infection by multidrug-resistant Acinetobacter baumannii complex: a time series analysis

2021 ◽  
Author(s):  
María Huertas Vaquero ◽  
◽  
María Ángeles Asencio Egea ◽  
Rafael Carranza González ◽  
Antonio Padilla Serrano ◽  
...  
Keyword(s):  
Time Series ◽  
Acinetobacter Baumannii ◽  
Multidrug Resistant ◽  
Acinetobacter Baumannii Complex ◽  
Amoxicillin Clavulanate ◽  
Resistant Strains ◽  
Individual Use ◽  
The Individual ◽  
The Relationship ◽  
Control Study

Introduction. To analyze the association between antibiotic pressure and the risk of colonization/infection by Acinetobacter baumannii complex (AB), evaluating both the individual and general prescriptions of antibiotics. Methods. This is an analytical, observational, case-control study on patients admitted to an Intensive Care Unit (ICU) during an AB outbreak (14 months). A five-year time series was constructed with the monthly incidence of cases of infection/colonization with strains of AB resistant to each antibiotic administered and with the monthly consumption of these antibiotics in the ICU. Results. We identified 40 patients either infected (23) or colonized (17) by AB and 73 controls. We found an epidemic multidrug-resistant clone of AB in 75% of cases. Risk factors associated with the development of AB infection/colonization were: greater use of medical instruments, the presence of a tracheostomy, cutaneous ulcers, surgical lesions and prior antibiotic therapies. The regression analysis of individual use of antibiotics showed that prior treatment with ceftazidime, ceftriaxone, amoxicillin/clavulanate, imipenem, levofloxacin, linezolid, and vancomycin was a risk factor for acquiring AB. ARIMA models showed that the relationship were greatest and statistically significant when the treatment occurred between 6 months (ceftazidime) and 9 months (imipenem and levofloxacin) prior. Conclusions. The dynamic and aggregate relationship between the incidence of infection/colonization by multidrug-resistant strains of AB and prior antibiotic treatment was statistically significant for intervals of 6 to 9 months.

scholarly journals CsrA Coordinates Compatible Solute Synthesis in Acinetobacter baumannii and Facilitates Growth in Human Urine

2021 ◽  
Author(s):  
Josephine Joy Hubloher ◽  
Kim Schabacker ◽  
Volker Müller ◽  
Beate Averhoff
Keyword(s):  
Acinetobacter Baumannii ◽  
Multidrug Resistant ◽  
Compatible Solute ◽  
Human Pathogen ◽  
Content Type ◽  
Clinical Environments ◽  
Resistant Strains ◽  
Opportunistic Human Pathogen ◽  
Mrna Binding ◽  
Optimal Adaptation

The opportunistic human pathogen Acinetobacter baumannii has become one of the leading causes of nosocomial infections around the world due to the increasing prevalence of multidrug-resistant strains and their optimal adaptation to clinical environments and the human host. Recently, it was found that CsrA, a global mRNA binding posttranscriptional regulator, plays a role in osmotic stress adaptation, virulence, and growth on amino acids of A. baumannii AB09-003 and 17961.

scholarly journals In vitro activity of antibiotic combinations against multidrug-resistant strains of Acinetobacter baumannii and the effects of their antibiotic resistance determinants

2012 ◽  
Vol 328 (1) ◽  
pp. 26-31 ◽  
Author(s):  
Yoko Miyasaki ◽  
Margie A. Morgan ◽  
Raymond C. Chan ◽  
W. Stephen Nichols ◽  
Kristine M. Hujer ◽  
...  
Keyword(s):  
Antibiotic Resistance ◽  
Acinetobacter Baumannii ◽  
Multidrug Resistant ◽  
Vitro Activity ◽  
In Vitro Activity ◽  
Resistance Determinants ◽  
Resistant Strains
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