Protective effects of antioxidin-RL from Odorrana livida against ultraviolet B-irradiated skin photoaging

Peptides ◽  
2018 ◽  
Vol 101 ◽  
pp. 124-134 ◽  
Author(s):  
Di Qin ◽  
Wen-Hui Lee ◽  
Zhiqin Gao ◽  
Weifen Zhang ◽  
Meiyu Peng ◽  
...  
Keyword(s):  
Ultraviolet B ◽  
Protective Effects ◽  
Skin Photoaging

scholarly journals Ameliorative Effects of Peptides from the Oyster (Crassostrea hongkongensis) Protein Hydrolysates against UVB-Induced Skin Photodamage in Mice

Marine Drugs ◽  
2020 ◽  
Vol 18 (6) ◽  
pp. 288
Author(s):  
Zhilan Peng ◽  
Beibei Chen ◽  
Qinsheng Zheng ◽  
Guoping Zhu ◽  
Wenhong Cao ◽  
...  
Keyword(s):  
Topical Application ◽  
Protein Hydrolysates ◽  
Ultraviolet B ◽  
Moisture Loss ◽  
Protective Effects ◽  
Molecular Weight Range ◽  
Uvb Irradiation ◽  
Crassostrea Hongkongensis ◽  
Skin Photoaging

Chronic exposure to ultraviolet B (UVB) irradiation is a major cause for skin photoaging. UVB induces damage to skin mainly by oxidative stress, inflammation, and collagen degradation. This paper investigated the photo-protective effects of peptides from oyster (Crassostrea hongkongensis) protein hydrolysates (OPs) by topical application on the skin of UVB-irradiated mice. Results from mass spectrometry showed that OPs consisted of peptides with a molecular weight range of 302.17–2936.43 Da. In vivo study demonstrated that topical application of OPs on the skin significantly alleviated moisture loss, epidermal hyperplasia, as well as degradation of collagen and elastin fibers caused by chronic UVB irradiation. In this study, OPs treatment promoted antioxidant enzymes (SOD and GPH-Px) activities, while decreased malondialdehyde (MDA) level in the skin. In addition, OPs treatment significantly decreased inflammatory cytokines (IL-1β, IL-6, TNF-α) content, and inhibited inflammation related (iNOS, COX-2) protein expression in the skin. Via inhibiting metalloproteinase 1(MMP1) expression, OPs treatment markedly decreased the degradation of collagen and elastin fibers as well as recovered the altered arrangement of extracellular matrix network in the dermis of skin. Our study demonstrated for the first time that OPs protected against UVB induced skin photodamage by virtue of its antioxidative and anti-inflammatory properties, as well as regulating the abnormal expression of MMP-1. The possible molecular mechanism underlying OPs anti-photoaging is possibly related to downregulating of the MAPK/NF-κB signaling pathway, while promoting TGF-β production in the skin.

scholarly journals Anti-Photoaging Effects of Low Molecular-Weight Fucoidan on Ultraviolet B-Irradiated Mice

Marine Drugs ◽  
2018 ◽  
Vol 16 (8) ◽  
pp. 286 ◽  
Author(s):  
Young-In Kim ◽  
Won-Seok Oh ◽  
Phil Song ◽  
Sungho Yun ◽  
Young-Sam Kwon ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Ultraviolet B ◽  
Low Molecular Weight ◽  
Extracellular Matrix Remodeling ◽  
Matrix Remodeling ◽  
Oxygen Species ◽  
Protective Effects ◽  
Oxidative Stresses ◽  
Skin Photoaging ◽  
Endogenous Antioxidants

Ultraviolet (UV) B exposure induces DNA damage and production of reactive oxygen species (ROS), which causes skin photoaging through signaling pathways of inflammation and modulation of extracellular matrix remodeling proteins, collagens, and matrix metalloproteinase (MMP). As low molecular-weight fucoidan (LMF) has potential antioxidant and anti-inflammatory properties, we examined the protective effects of LMF against UVB-induced photoaging. A UVB-irradiated mouse model was topically treated with myricetin or LMF at 2.0, 1.0 and 0.2 mg/cm2 (LMF2.0, LMF1.0 and LMF0.2, respectively) once a day for 15 weeks. Wrinkle formation, inflammation, oxidative stress, MMP expression, and apoptosis in the treated regions were compared with those in a distilled water-treated photoaging model (UVB control). LMF treatments, particularly LMF2.0 and LMF1.0, significantly inhibited the wrinkle formation, skin edema, and neutrophil recruitment into the photo-damaged lesions, compared with those in the UVB control. While LMF decreased interleukin (IL)-1β release, it increased IL-10. The LMF treatment inhibited the oxidative stresses (malondialdehyde and superoxide anion) and enhanced endogenous antioxidants (glutathione). Additionally, LMF reduced the mRNA expression of MMP-1, 9, and 13. The histopathological analyses revealed the anti-photoaging effects of LMF exerted via its antioxidant, anti-apoptotic, and MMP-9-inhibiting effects. These suggest that LMF can be used as a skin-protective remedy for photoaging.

scholarly journals UVB protective effects of Sargassum horneri through the regulation of Nrf2 mediated antioxidant mechanism

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Eui Jeong Han ◽  
Seo-Young Kim ◽  
Hee-Jin Han ◽  
Hyun-Soo Kim ◽  
Kil-Nam Kim ◽  
...  
Keyword(s):  
Skin Barrier ◽  
Human Keratinocytes ◽  
Underlying Mechanism ◽  
Ultraviolet B ◽  
Sargassum Horneri ◽  
Cellular Damage ◽  
Protective Effects ◽  
Skin Damage ◽  
Antioxidant Mechanism ◽  
Induced Apoptosis

AbstractThe present study aimed to evaluate the protective effect of a methanol extract of Sargassum horneri (SHM), which contains 6-hydroxy-4,4,7a-trimethyl-5,6,7,7a-tetrahydrobenzofuran-2(4H)-one (HTT) and apo-9′-fucoxanthinone, against ultraviolet B (UVB)-induced cellular damage in human keratinocytes and its underlying mechanism. SHM significantly improved cell viability of UVB-exposed human keratinocytes by reducing the generation of intracellular reactive oxygen species (ROS). Moreover, SHM inhibited UVB exposure-induced apoptosis by reducing the formation of apoptotic bodies and the populations of the sub-G1 hypodiploid cells and the early apoptotic cells by modulating the expression of the anti- and pro-apoptotic molecules, Bcl-2 and Bax, respectively. Furthermore, SHM inhibited NF-κB p65 activation by inducing the activation of Nrf2/HO-1 signaling. The cytoprotective and antiapoptotic activities of SHM are abolished by the inhibition of HO-1 signaling. In further study, SHM restored the skin dryness and skin barrier disruption in UVB-exposed human keratinocytes. Based to these results, our study suggests that SHM protects the cells against UVB-induced cellular damages through the Nrf2/HO-1/NF-κB p65 signaling pathway and may be potentially useful for the prevention of UVB-induced skin damage.

Protective effects of phlorotannins against ultraviolet B radiation in zebrafish (Danio rerio)

2011 ◽  
Vol 23 (1) ◽  
pp. 51-e12 ◽  
Author(s):  
Seon-Heui Cha ◽  
Chang-Ik Ko ◽  
Daekyung Kim ◽  
You-Jin Jeon
Keyword(s):  
Danio Rerio ◽  
Ultraviolet B ◽  
Protective Effects ◽  
Ultraviolet B Radiation

scholarly journals UVA Photoprotective Activity of Brown Macroalgae Sargassum cristafolium

Biomedicines ◽  
2019 ◽  
Vol 7 (4) ◽  
pp. 77 ◽  
Author(s):  
Prasedya ◽  
Syafitri ◽  
Geraldine ◽  
Hamdin ◽  
Frediansyah ◽  
...  
Keyword(s):  
Uv Radiation ◽  
Cell Model ◽  
Positive Control ◽  
Uv Spectra ◽  
Protective Effects ◽  
Negative Effects ◽  
Brown Macroalgae ◽  
Uva Irradiation ◽  
Skin Photoaging

Sunscreens today contain several synthetic UV (Ultraviolet) filter molecules to protect the skin epidermis from UV radiation damage. However, these molecules may create several negative effects on human skin. Due to this condition, there is an increase in the development of natural products to replace uses of these synthetic chemicals. Brown macroalgae Sargassum has been recently studied for its photoprotective activities. The purpose of this study is to investigate photoprotective activity of one of most abundant Sargassum species in Lombok coast; Sargassum cristaefolium. Spectrophotometry analysis with UV-VIS revealed the UV spectra absorbing capability of Sargassum cristaefolium (SC) in the UVA spectrum range (314–400 nm). Furthermore, spectrometry analyses with LC-MS revealed the existence of UV absorbing compound MAA-palythene. In correlation, SC ethanol extracts also demonstrate that it could protect DNA from UVA irradiation as analyzed in vitro in HeLa cell model. The effects of SC on UVA exposed-dorsal mice skin have also shown interesting results, as mice pretreated with SC before UVA exposure showed protective activity on the epidermal integrity similar as positive control. Whereas, UV exposed mice without SC or commercial products resulted in increased epidermal thickness, which is the common parameter of skin photoaging. In addition, pretreated mice with SC also show protective effects in the formation of collagen connective tissues. Overall, current results show promising photoprotective activity of SC against UV radiation. More advanced investigations of SC as a potential photoprotective agent would be reasonable for development of macroalgae-based natural skin protection products.

Protective Effects of Micronized Fat against Ultraviolet B–Induced Photoaging

2020 ◽  
Vol 145 (3) ◽  
pp. 712-720
Author(s):  
Anqi He ◽  
Lu Wang ◽  
Qiang Wang ◽  
Wenjie Luan ◽  
Fazhi Qi
Keyword(s):  
Ultraviolet B ◽  
Protective Effects

scholarly journals Oligomeric Procyanidin Nanoliposomes Prevent Melanogenesis and UV Radiation-Induced Skin Epithelial Cell (HFF-1) Damage

Molecules ◽  
2020 ◽  
Vol 25 (6) ◽  
pp. 1458 ◽  
Author(s):  
Yashu Chen ◽  
Fenghong Huang ◽  
David Julian McClements ◽  
Bijun Xie ◽  
Zhida Sun ◽  
...  
Keyword(s):  
Protective Effect ◽  
Fibroblast Cell ◽  
Skin Aging ◽  
Ultraviolet B ◽  
Protective Effects ◽  
Protection Mechanism ◽  
Uva Irradiation ◽  
Culture Model ◽  
Radiation Induced ◽  
Human Foreskin Fibroblast Cell

The potential protective effect of nanoliposomes loaded with lotus seedpod oligomeric procyanidin (LSOPC) against melanogenesis and skin damaging was investigated. Fluorescence spectroscopy showed that, after encapsulation, the LSOPC-nanoliposomes still possessed strong inhibitory effects against melanogenesis, reducing the activity of both monophenolase and diphenolase. Molecular docking indicated that LSOPC could generate intense interactive configuration with tyrosinase through arene–H, arene–arene, and hydrophobic interaction. An ultraviolet radiated cell-culture model (human foreskin fibroblast cell (HFF-1)) was used to determine the protective effects of the LSOPC-nanoliposomes against skin aging and damage. Results showed that LSOPC-nanoliposomes exerted the highest protective effects against both ultraviolet B (UVB) and ultraviolet A (UVA) irradiation groups compared with non-encapsulated LSOPC and a control (vitamin C). Superoxide dismutase (SOD) and malonaldehyde (MDA) assays demonstrated the protection mechanism may be related to the anti-photooxidation activity of the procyanidin. Furthermore, a hydroxyproline assay suggested that the LSOPC-nanoliposomes had a strong protective effect against collagen degradation and/or synthesis after UVA irradiation.

Prevention of the Ultraviolet B-Mediated Skin Photoaging by a Nuclear Factor κB Inhibitor, Parthenolide

2005 ◽  
Vol 315 (2) ◽  
pp. 624-630 ◽  
Author(s):  
Kiyotaka Tanaka ◽  
Junichi Hasegawa ◽  
Kaori Asamitsu ◽  
Takashi Okamoto
Keyword(s):  
Nuclear Factor Κb ◽  
Ultraviolet B ◽  
Nuclear Factor ◽  
Skin Photoaging

scholarly journals Topical Application of Aronia melanocarpa Extract Rich in Chlorogenic Acid and Rutin Reduces UVB-Induced Skin Damage via Attenuating Collagen Disruption in Mice

Molecules ◽  
2020 ◽  
Vol 25 (19) ◽  
pp. 4577
Author(s):  
Young Her ◽  
Tae-Kyeong Lee ◽  
Jong Dai Kim ◽  
Bora Kim ◽  
Hyejin Sim ◽  
...  
Keyword(s):  
Chlorogenic Acid ◽  
High Performance ◽  
Collagen Type ◽  
Collagen Type I ◽  
Ultraviolet B ◽  
Type I ◽  
Protective Effects ◽  
Dorsal Skin ◽  
Skin Damage ◽  
Aronia Melanocarpa

Aronia melanocarpa, a black chokeberry, contains high levels of phenolic acids and polyphenolic flavonoids and displays antioxidative and anti-inflammatory effects. Through high-performance liquid chromatography for extracts from Aronia melanocarpa, we discovered that the extract contained chlorogenic acid and rutin as major ingredients. In this study, we examined the protective effects of the extract against ultraviolet B- (UVB)-induced photodamage in the dorsal skin of institute of cancer research (ICR) mice. Their dorsal skin was exposed to UVB, thereafter; the extract was topically applied once a day for seven days. Photoprotective properties of the extract in the dorsal skin were investigated by clinical skin severity score for skin injury, hematoxylin and eosin staining for histopathology, Masson’s trichrome staining for collagens. In addition, we examined change in collagen type I and III, and matrix metalloproteinase (MMP)-1 and MMP-3 by immunohistochemistry. In the UVB-exposed mice treated with the extract, UVB-induced epidermal damage was significantly ameliorated, showing that epidermal thickness was moderated. In these mice, immunoreactivities of collagen type I and III were significantly increased, whereas immunoreactivities of MMP-1 and 3 were significantly decreased compared with those in the UVB-exposed mice. These results indicate that treatment with Aronia melanocarpa extract attenuates UV-induced photodamage by attenuating UVB-induced collagen disruption: these findings might be a result of the chlorogenic acid and rutin contained in the extract. Based on the current results, we suggest that Aronia melanocarpa can be a useful material for developing photoprotective adjuvant.

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