The association of single nucleotide polymorphisms of the maternal cystathionine-β-synthase gene with early-onset preeclampsia

2016 ◽  
Vol 6 (1) ◽  
pp. 60-65 ◽  
Author(s):  
Kim M. Holwerda ◽  
M. Susanne Weedon-Fekjær ◽  
Anne C. Staff ◽  
Ilja M. Nolte ◽  
Harry van Goor ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Early Onset ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Early Onset Preeclampsia

scholarly journals Maternal cardiovascular-related single nucleotide polymorphisms, genes, and pathways associated with early-onset preeclampsia

PLoS ONE ◽  
2019 ◽  
Vol 14 (9) ◽  
pp. e0222672 ◽  
Author(s):  
Paula Benny ◽  
Kelly Yamasato ◽  
Breck Yunits ◽  
Xun Zhu ◽  
Travers Ching ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Early Onset ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Early Onset Preeclampsia

Su1074 – Association Between Single Nucleotide Polymorphisms in Il-1β, Il-6 and Il-10 and Early-Onset Colorectal Cancer in Puerto Rican Hispanics

2019 ◽  
Vol 156 (6) ◽  
pp. S-501-S-502
Author(s):  
Jorge J. Cruz-Cruz ◽  
Maria Gonzalez-Pons ◽  
Noe E. Crespo ◽  
Lorena Gonzalez-Sepulveda ◽  
Lenis N. Rovira Torres ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Single Nucleotide Polymorphisms ◽  
Puerto Rican ◽  
Early Onset ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Early Onset Colorectal Cancer

scholarly journals Chromosome 9p21.3 is Associated with Early-Onset Coronary Heart Disease in the Irish Population

2008 ◽  
Vol 25 (2) ◽  
pp. 81-85 ◽  
Author(s):  
Weihua Meng ◽  
Anne E. Hughes ◽  
Chris C. Patterson ◽  
Christine Belton ◽  
Frank Kee ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Single Nucleotide Polymorphisms ◽  
Cause Of Death ◽  
Early Onset ◽  
Nucleotide Polymorphisms ◽  
Irish Population ◽  
Single Nucleotide ◽  
The World ◽  
Family Based

Coronary heart disease (CHD) remains a leading cause of death across the world. A region on chromosome 9p21.3 has been recently reported to be associated with CHD. We evaluated 3 SNPs and 3 common haplotypes in the 9p21.3 region in 1494 individuals from 580 Irish families, where at least 1 member had early-onset (males ≤55yr, females ≤60yr) CHD. Genotypes were determined by multiplex SNaPshot technology. Using the combined TDT/S-TDT test, the 3 single nucleotide polymorphisms (SNP), rs10757274, rs2383206 and rs1333049, were strongly associated with early-onset CHD (p= 2.7 × 10-6, 2.7 × 10-6, 3.8 × 10-7, respectively). Analysis of haplotypes by the TRANSMIT program also showed that the GGC haplotype was associated with early-onset CHD (p= 7.9 × 10-7). In conclusion, using a family-based approach in the Irish population, we have confirmed previous reports of association between a region on chromosome 9p21.3 and early-onset CHD.

P2860The effects of single nucleotide polymorphisms in Korean patients with early-onset lone atrial fibrillation after catheter ablation

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
Y M Park ◽  
S Y Roh ◽  
D I Lee ◽  
J Shim ◽  
J.-I Choi ◽  
...  
Keyword(s):  
Catheter Ablation ◽  
Single Nucleotide Polymorphisms ◽  
Early Onset ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Korean Patients ◽  
The Status ◽  
Long Term Follow Up

Abstract Background The status of SNPs among patients with extremely early-onset lone AF and the association with outcome of catheter ablation has not been evaluated before. This study evaluated the status of single nucleotide polymorphisms (SNPs) in Korean patients with early-onset (<40 years old) lone AF and effects on the outcome after catheter ablation. Methods A total of 89 consecutive patients (mean age 35.7±3.7 years, 81 males) with drug-refractory AF (paroxysmal 64.0%) who underwent catheter ablation were included. Sixteen SNPs including rs13376333, rs10465885, rs10033464, rs2200733, rs17042171, rs6843082, rs7193343, rs2106261, rs17570669, rs853445, rs11708996, rs6800541, rs251253, rs3807989, rs11047543 and rs3825214 were genotyped. Serial 48-day Holter electrocardiographic recordings were acquired to detect AF recurrences during long-term follow up. Results Wild type of rs7193343 [CC; 0/7 (0%) vs. CT; 22/40 (55.0%) vs. TT; 18/41 (43.9%), p=0.025] and rs11047543 [GG; 26/69 (37.7%) vs. GA; 13/18 (72.2%) vs. AA; 0/0, p=0.009] and homozygous variant of rs3825214 [AA; 16/31 (51.6%) vs. AG; 22/43 (51.2%) vs. GG; 2/13 (15.4%), p=0.05] were significantly associated with lower rate of late recurrence. When the patients were assigned to four groups according to the number of risk alleles (n=0–3), Kaplan-Meier survival analysis showed incremental prognostic value according to the number of variant alleles (p=0.002) (Figure 1). Figure 1 Conclusions Polymorphisms on rs7193343, rs3825214 and rs11047543 modulate the risk for AF recurrence after catheter ablation during long term follow up in Korean patients with early-onset lone AF. Acknowledgement/Funding Korean Society of Cardiology

Single nucleotide polymorphisms in inflammatory genes and the risk of early onset of lone atrial fibrillation

2010 ◽  
Vol 59 (11) ◽  
pp. 965-969 ◽  
Author(s):  
Kristoffer M. A. Henningsen ◽  
Morten S. Olesen ◽  
Maria Pedersen ◽  
Lone Nielsen ◽  
Stig Haunsø ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Single Nucleotide Polymorphisms ◽  
Early Onset ◽  
Nucleotide Polymorphisms ◽  
Lone Atrial Fibrillation ◽  
Single Nucleotide ◽  
Inflammatory Genes
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