Meta-analysis of polymorphisms in TPH2 gene and suicidal behavior

2014 ◽  
Vol 220 (3) ◽  
pp. 1163-1166 ◽  
Author(s):  
Mee Yun Choong ◽  
Shiau Foon Tee ◽  
Pek Yee Tang
Keyword(s):  
Suicidal Behavior ◽  
Meta Analysis ◽  
Tph2 Gene

Mental disorders as risk factors for suicidal behavior in young people: A meta-analysis and systematic review of longitudinal studies

2019 ◽  
Vol 245 ◽  
pp. 152-162 ◽  
Author(s):  
Margalida Gili ◽  
Pere Castellví ◽  
Margalida Vives ◽  
Alejandro de la Torre-Luque ◽  
José Almenara ◽  
...  
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Young People ◽  
Mental Disorders ◽  
Longitudinal Studies ◽  
Suicidal Behavior ◽  
Meta Analysis

scholarly journals Prevalence of suicidal behavior in young university students: A systematic review with meta-analysis

2021 ◽  
Vol 29 ◽  
Author(s):  
Marília de Oliveira Crispim ◽  
Cândida Maria Rodrigues dos Santos ◽  
Iracema da Silva Frazão ◽  
Cecília Maria Farias de Queiroz Frazão ◽  
Rossana Carla Rameh de Albuquerque ◽  
...  
Keyword(s):  
Systematic Review ◽  
Suicidal Ideation ◽  
University Students ◽  
Suicidal Behavior ◽  
Attempted Suicide ◽  
Data Extraction ◽  
Meta Analysis ◽  
Cross Sectional ◽  
High Prevalence ◽  
Theses And Dissertations

Objective: to identify the prevalence of suicidal behavior in young university students. Method: a systematic review with meta-analysis of cross-sectional studies based on the Joanna Briggs Institute proposal, and carried out in the PubMed, Web of Science, Scopus, PsycINFO and LILACS databases and in the Brazilian Digital Library of Theses and Dissertations, with no language or year restrictions. A total of 2,942 publications were identified. Selection, data extraction and methodological evaluation of the studies were performed by two independent researchers. The meta-analysis was performed considering the random effects model. Results: eleven articles were included in this review. The prevalence variation for suicidal ideation was from 9.7% to 58.3% and, for attempted suicide, it was from 0.7% to 14.7%. The meta-analysis showed a 27.1% prevalence for suicidal ideation in life, 14.1% for ideation in the last year, and 3.1% for attempted suicide in life. Conclusion: the high prevalence of suicidal behavior, even with the considerable heterogeneity of the studies, raises the need to implement interventions aimed at preventing suicide and promoting mental health, especially in the academic environment.

scholarly journals TPH2 Gene Polymorphisms and Major Depression – A Meta-Analysis

PLoS ONE ◽  
2012 ◽  
Vol 7 (5) ◽  
pp. e36721 ◽  
Author(s):  
Jin Gao ◽  
Zhenglun Pan ◽  
Zhian Jiao ◽  
Feng Li ◽  
Guoqing Zhao ◽  
...  
Keyword(s):  
Major Depression ◽  
Gene Polymorphisms ◽  
Meta Analysis ◽  
Tph2 Gene

Effects on suicidal risk: Comparison of clozapine to other newer medicines indicated to treat schizophrenia or bipolar disorder

2021 ◽  
pp. 026988112110297
Author(s):  
Alberto Forte ◽  
Maurizio Pompili ◽  
Benedetta Imbastaro ◽  
Gabriele Pasquale De Luca ◽  
Martina Mastrangelo ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Confidence Intervals ◽  
Suicidal Behavior ◽  
Meta Analysis ◽  
Random Effect ◽  
Paired Comparisons ◽  
Suicidal Risk ◽  
Odds Ratios ◽  
Unique Effect ◽  
Reduce Risk

Background: Clozapine is the only treatment with regulatory-recognition of lowering suicidal risk, at least in schizophrenia patients. It remains uncertain whether such effects extend to other drugs for psychosis. Methods: We searched for reports on rates of suicidal behavior during treatment with clozapine and other modern drugs for psychosis (aripiprazole, olanzapine, risperidone, quetiapine, and ziprasidone) versus comparison or control treatments and analyzed the contrasts by random-effect meta-analysis to obtain pooled odds ratios (ORs) with 95% confidence intervals (CIs). Results: We identified 35 paired comparisons of modern drugs for psychosis versus comparison or control treatments in 18 reports. There was moderate overall superiority of all agents tested over alternatives (OR = 0.522, p = 0.004). With clozapine, this effect was large (OR = 0.229, p < 0.0001) and consistent (7/7 trials), but significant antisuicidal effects were not found with other drugs for psychosis in 28 other trials (OR = 0.941, p = 0.497). Apparent efficacy of specific agents ranked: risperidone ⩾ olanzapine ⩾ aripiprazole ⩾ ziprasidone ⩾ mixed drugs for psychosis ⩾ quetiapine, but none of these differences was significant. Conclusions: An ability of clozapine to reduce risk of suicides and attempts in schizophrenia patients appears to be a unique effect not shared with other modern medicines indicated for schizophrenia or bipolar disorder.

Catechol-o-methyltransferase gene modulation on suicidal behavior and personality traits: review, meta-analysis and association study

2011 ◽  
Vol 45 (3) ◽  
pp. 309-321 ◽  
Author(s):  
Raffaella Calati ◽  
Stefano Porcelli ◽  
Ina Giegling ◽  
Annette M. Hartmann ◽  
Hans-Jürgen Möller ◽  
...  
Keyword(s):  
Personality Traits ◽  
Association Study ◽  
Suicidal Behavior ◽  
Meta Analysis ◽  
Gene Modulation ◽  
Methyltransferase Gene

A meta-analysis of cytokines in suicidal behavior

2015 ◽  
Vol 46 ◽  
pp. 203-211 ◽  
Author(s):  
Déborah Ducasse ◽  
Emilie Olié ◽  
Sébastien Guillaume ◽  
Sylvaine Artéro ◽  
Philippe Courtet
Keyword(s):  
Suicidal Behavior ◽  
Meta Analysis

scholarly journals Gender differences in suicidal behavior in adolescents and young adults: systematic review and meta-analysis of longitudinal studies

2019 ◽  
Vol 64 (2) ◽  
pp. 265-283 ◽  
Author(s):  
Andrea Miranda-Mendizabal ◽  
Pere Castellví ◽  
Oleguer Parés-Badell ◽  
Itxaso Alayo ◽  
José Almenara ◽  
...  
Keyword(s):  
Systematic Review ◽  
Gender Differences ◽  
Young Adults ◽  
Longitudinal Studies ◽  
Suicidal Behavior ◽  
Meta Analysis ◽  
Adolescents And Young Adults

scholarly journals Global Lifetime and 12-Month Prevalence of Suicidal Behavior, Deliberate Self-Harm and Non-Suicidal Self-Injury in Children and Adolescents between 1989 and 2018: A Meta-Analysis

2019 ◽  
Vol 16 (22) ◽  
pp. 4581 ◽  
Author(s):  
Kim-San Lim ◽  
Celine H. Wong ◽  
Roger S. McIntyre ◽  
Jiayun Wang ◽  
Zhisong Zhang ◽  
...  
Keyword(s):  
Suicidal Ideation ◽  
Children And Adolescents ◽  
Suicidal Behavior ◽  
School Attendance ◽  
Meta Analysis ◽  
Full Time ◽  
Deliberate Self Harm ◽  
Self Injury ◽  
Subgroup Analyses ◽  
Self Harm

Objective: This meta-analysis aimed to estimate the global lifetime and 12-month prevalence of suicidal behavior, deliberate self-harm and non-suicidal self-injury in children and adolescents. Methods: A systematic search for relevant articles published between 1989 to 2018 was performed in multiple electronic databases. The aggregate 12-month and lifetime prevalence of suicidal behavior, deliberate self-harm, and non-suicidal self-injury were calculated based on the random-effects model. Subgroup analyses were performed to compare the prevalence according to school attendance and geographical regions. Results: A total of 686,672 children and adolescents were included. The aggregate lifetime and 12-month prevalence of suicide attempts was 6% (95% CI: 4.7–7.7%) and 4.5% (95% CI: 3.4–5.9%) respectively. The aggregate lifetime and 12-month prevalence of suicidal plan was 9.9% (95% CI: 5.5–17%) and 7.5% (95% CI: 4.5–12.1%) respectively. The aggregate lifetime and 12-month prevalence of suicidal ideation was 18% (95% CI: 14.2–22.7%) and 14.2% (95% CI: 11.6–17.3%) respectively. The aggregate lifetime and 12-month prevalence of non-suicidal self-injury was 22.1% (95% CI: 16.9–28.4%) and 19.5% (95% CI: 13.3–27.6%) respectively. The aggregate lifetime and 12-month prevalence of deliberate self-harm was 13.7% (95% CI: 11.0–17.0%) and 14.2% (95% CI: 10.1–19.5%) respectively. Subgroup analyses showed that full-time school attendance, non-Western countries, low and middle-income countries, and geographical locations might contribute to the higher aggregate prevalence of suicidal behaviors, deliberate self-harm, and non-suicidal self-injury. Conclusions: This meta-analysis found that non-suicidal self-injury, suicidal ideation, and deliberate self-harm were the three most common suicidal and self-harm behaviors in children and adolescents.

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