Mental disorders as risk factors for suicidal behavior in young people: A meta-analysis and systematic review of longitudinal studies

IntroductionYoung people who identify as Lesbian, Gay, Bisexual, Transgender, Queer or Questioning (LGBTQ+) are at increased risk for self-harm, suicide ideation and behaviours. However, there has yet to be a comprehensive understanding of what risk factors influence these behaviours within LGBTQ+ young people as a whole. The purpose of this systematic review is to examine risk factors associated with self-harm, suicidal ideation and behaviour in LGBTQ+) young people.Methods and analysisA systematic review will be conducted, conforming to the reporting guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement recommendations. Electronic databases (MEDLINE, Scopus, EMBASE, PsycINFO and Web of Science) will be systematically searched for cross-sectional, prospective, longitudinal, cohort and case–control designs which examine risk factors for self-harm and/or suicidal ideation and behaviour in LGBTQ+ young people (aged 12–25 years). Only studies published in English will be included. No date restrictions will be applied. Study quality assessment will be conducted using the original and modified Newcastle-Ottawa Scales. Meta-analysis or narrative synthesis will be used, dependent on findings.Ethics and disseminationThis is a systematic review of published literature and thereby ethical approval was not sought. The review will be submitted to a peer-reviewed journal, be publicly disseminated at conferences focusing on mental health, self-harm and suicide prevention. The findings will also be shared through public engagement and involvement, particularly those related to young LGBTQ+ individuals.PROSPERO registration numberCRD42019130037.

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Predictors and moderators of outcome of psychotherapeutic interventions for mental disorders in adolescents and young adults: protocol for systematic reviews

Systematic Reviews ◽

10.1186/s13643-021-01788-1 ◽

2021 ◽

Vol 10 (1) ◽

Author(s):

Eleni Vousoura ◽

Vera Gergov ◽

Bogdan Tudor Tulbure ◽

Nigel Camilleri ◽

Andrea Saliba ◽

...

Keyword(s):

Systematic Review ◽

Young Adults ◽

Young People ◽

Mental Disorders ◽

Meta Analysis ◽

Adolescents And Young Adults ◽

Treatment Modalities ◽

Psychotherapeutic Treatment ◽

Psychotherapeutic Interventions ◽

Wide Range

Abstract Background Adolescence and young adulthood is a risk period for the emergence of mental disorders. There is strong evidence that psychotherapeutic interventions are effective for most mental disorders. However, very little is known about which of the different psychotherapeutic treatment modalities are effective for whom. This large systematic review aims to address this critical gap within the literature on non-specific predictors and moderators of the outcomes of psychotherapeutic interventions among adolescents and young adults with mental disorders. Methods The protocol is being reported in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) Statement. PubMed and PsycINFO databases will be searched for randomized controlled and quasi-experimental/naturalistic clinical trials. Risk of bias of all included studies will be assessed by the Mixed Methods Appraisal Tool. The quality of predictor and moderator variables will be also assessed. A narrative synthesis will be conducted for all included studies. Discussion This systematic review will strengthen the evidence base on effective mental health interventions for young people, being the first to explore predictors and moderators of outcome of psychotherapeutic interventions for a wide range of mental disorders in young people. Systematic review registration PROSPERO CRD42020166756.

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Internalizing and externalizing symptoms and suicidal behaviour in young people: a systematic review and meta‐analysis of longitudinal studies

Acta Psychiatrica Scandinavica ◽

10.1111/acps.13036 ◽

2019 ◽

Vol 140 (1) ◽

pp. 5-19 ◽

Cited By ~ 4

Author(s):

V. Soto‐Sanz ◽

P. Castellví ◽

J. A. Piqueras ◽

J. Rodríguez‐Marín ◽

T. Rodríguez‐Jiménez ◽

...

Keyword(s):

Systematic Review ◽

Young People ◽

Longitudinal Studies ◽

Suicidal Behaviour ◽

Meta Analysis ◽

Externalizing Symptoms ◽

Internalizing And Externalizing ◽

Internalizing And Externalizing Symptoms

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Impulsivity in the self-harm and suicidal behavior of young people: A systematic review and meta-analysis

Journal of Psychiatric Research ◽

10.1016/j.jpsychires.2019.05.012 ◽

2019 ◽

Vol 116 ◽

pp. 51-60 ◽

Cited By ~ 6

Author(s):

Catherine M. McHugh ◽

Rico Sze Chun Lee ◽

Daniel F. Hermens ◽

Amy Corderoy ◽

Matthew Large ◽

...

Keyword(s):

Systematic Review ◽

Young People ◽

Suicidal Behavior ◽

Meta Analysis ◽

The Self ◽

Self Harm

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Work-related psychosocial risk factors for stress-related mental disorders: an updated systematic review and meta-analysis

BMJ Open ◽

10.1136/bmjopen-2019-034849 ◽

2020 ◽

Vol 10 (7) ◽

pp. e034849

Author(s):

Henk F van der Molen ◽

Karen Nieuwenhuijsen ◽

Monique H W Frings-Dresen ◽

Gerda de Groene

Keyword(s):

Risk Factors ◽

Systematic Review ◽

Mental Disorders ◽

Meta Analysis ◽

Psychosocial Risk Factors ◽

Psychosocial Risk ◽

Work Related ◽

Organisational Justice ◽

Effort Reward Imbalance ◽

Reward Imbalance

ObjectiveThe objective was to conduct an update of a previously published review and meta-analysis on the association between work-related psychosocial risk factors and stress-related mental disorders (SRD).DesignSystematic review and meta-analysis.Data sourcesMedline, Embase and PsycINFO were searched for articles published between 2008 and 12 August 2019 and references of a systematic review performed for the period before 2008 were included. Primary prospective studies were included when outcome data were described in terms of SRD assessment or a dichotomous outcome, based on a validated questionnaire, and at least two levels of work-related exposure were reported (exposed vs less or non-exposed). We used GRADE to assess the evidence for the associations between risk factors and the onset of SRD.ResultsSeventeen studies met the inclusion criteria. In total, a population of 73 874 workers from Belgium, Denmark, England, Finland, Japan, the Netherlands and Sweden were included in the meta-analysis of 14 prospective cohort studies. This meta-analysis revealed moderate evidence for associations between SRD and effort reward imbalance (OR=1.9, 95% CI 1.70 to 2.15), high job demands (OR=1.6, 95% CI 1.41 to 1.72), organisational justice (ORs=1.6 to 1.7, CIs 1.44 to 1.86), social support (ORs=1.3 to 1.4, CIs 1.16 to 1.69), high emotional demands (OR=1.6, 95% CI 1.35 to 1.84) and decision authority (OR=1.3, CI 1.20 to 1.49). No significant or inconsistent associations were found for job insecurity, decision latitude, skill discretion and bullying.ConclusionModerate evidence was found that work-related psychosocial risk factors are associated with a higher risk of SRD. Effort-reward imbalance, low organisational justice and high job demands exhibited the largest increased risk of SRD, varying from 60% to 90%.

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Interventions to reduce stigma towards mental disorders in young people: protocol for a systematic review and meta-analysis

BMJ Open ◽

10.1136/bmjopen-2020-045726 ◽

2021 ◽

Vol 11 (11) ◽

pp. e045726

Author(s):

Daniel Núñez ◽

Pablo Martínez ◽

Francesca Borghero ◽

Susana Campos ◽

Vania Martínez

Keyword(s):

Mental Health ◽

Systematic Review ◽

Young People ◽

Mental Disorders ◽

Selection Process ◽

Meta Analysis ◽

Critical Evaluation ◽

Third Party ◽

Cochrane Central Register ◽

Study Results

IntroductionThe stigma towards mental disorders can limit the use and effectiveness of available mental health interventions for young people. We aim to systematically review effectiveness of interventions to reduce stigma towards mental disorders in young people, as evidence has not been recently and systematically synthesised on this topic.Methods and analysisWe will conduct a systematic review and meta-analysis of randomised or controlled clinical trials of interventions to reduce stigma towards mental disorders in people aged 10–24 years. Studies involving a comparison group, post intervention and/or follow-up assessments of knowledge, attitudes and/or behaviours towards mental disorders (including help-seeking behaviours), will be included. The Cochrane Central Register of Controlled Trials (CENTRAL), Cumulative Index to Nursing and Allied Health Literature (CINAHL), Embase, PubMed and PsycINFO databases will be searched, without time limits, for eligible studies in English or Spanish, and with results available. Databases will be searched from July 2020 to April 2021. The study selection process, the data extraction and the critical evaluation—with the Cochrane risk-of-bias tool—of included studies will be performed independently and in duplicate by teams of reviewers, with the assistance of a third party, until reaching a high degree of agreement. In the presence of substantial heterogeneity (I2 >75%), a narrative synthesis of the study results will be used. If feasible, we will also conduct a quality effects model for the statistical synthesis of results. If sufficient data are available, subgroup analyses will be performed to assess potential sources of heterogeneity. Doi plots and the Luis Furuya-Kanamori index will be used to assess publication bias. The Grades of Recommendation, Assessment, Development and Evaluation approach will be used to assess the confidence in the evidence reviewed.Ethics and disseminationResults are expected to be published in a peer-reviewed journal in the field of adolescent and/or youth mental health.PROSPERO registration numberCRD42020210901.

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