A polymeric prodrug for non-invasive, real-time reporting drug release based on “turn-on” fluorescent probes

2020 ◽  
Vol 154 ◽  
pp. 104649
Author(s):  
Xiaodan Zhao ◽  
Hengxin Lei ◽  
Yilong Cheng ◽  
Youshen Wu ◽  
Mingming Zhang ◽  
...  
Keyword(s):  
Drug Release ◽  
Real Time ◽  
Fluorescent Probes ◽  
Non Invasive ◽  
Turn On ◽  
Polymeric Prodrug

scholarly journals Non-invasive, real-time reporting drug release in vitro and in vivo

2015 ◽  
Vol 51 (32) ◽  
pp. 6948-6951 ◽  
Author(s):  
Yanfeng Zhang ◽  
Qian Yin ◽  
Jonathan Yen ◽  
Joanne Li ◽  
Hanze Ying ◽  
...  
Keyword(s):  
Drug Release ◽  
Real Time ◽  
Near Infrared ◽  
Reporting System ◽  
Real Time Monitoring ◽  
Near Infrared Fluorescence ◽  
Non Invasive ◽  
Fluorescence Dye

Anin vitroandin vivodrug-reporting system is developed for real-time monitoring of drug release via the analysis of the concurrently released near-infrared fluorescence dye.

scholarly journals Rhodamine scaffolds as real time chemosensors for selective detection of bisulfite in aqueous medium

2019 ◽  
Vol 18 (6) ◽  
pp. 1342-1349 ◽  
Author(s):  
Sumit Roy ◽  
Ashim Maity ◽  
Naren Mudi ◽  
Milan Shyamal ◽  
Ajay Misra
Keyword(s):  
Aqueous Medium ◽  
Real Time ◽  
Fluorescent Probes ◽  
Selective Detection ◽  
Turn On

Rhodamine and its derivatives have been widely used in designing fluorescent ‘turn on’ cation sensors, while very few rhodamine based fluorescent probes have been reported to date for the detection of anions in water.

Polymeric nanotheranostics for real-time non-invasive optical imaging of breast cancer progression and drug release

2014 ◽  
Vol 352 (1) ◽  
pp. 81-89 ◽  
Author(s):  
Shiran Ferber ◽  
Hemda Baabur-Cohen ◽  
Rachel Blau ◽  
Yana Epshtein ◽  
Einat Kisin-Finfer ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Release ◽  
Optical Imaging ◽  
Real Time ◽  
Cancer Progression ◽  
Breast Cancer Progression ◽  
Non Invasive

Peptide‐Driven Targeted Drug‐Delivery System Comprising Turn‐On Near‐Infrared Fluorescent Xanthene–Cyanine Reporter for Real‐Time Monitoring of Drug Release

ChemMedChem ◽  
2019 ◽  
Vol 14 (19) ◽  
pp. 1727-1734 ◽  
Author(s):  
T. M. Ebaston ◽  
Alex Rozovsky ◽  
Alisa Zaporozhets ◽  
Andrii Bazylevich ◽  
Helena Tuchinsky ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Real Time ◽  
Drug Delivery System ◽  
Delivery System ◽  
Targeted Drug Delivery ◽  
Near Infrared ◽  
Turn On ◽  
Targeted Drug ◽  
Targeted Drug Delivery System

Nanoparticles Incorporating a Fluorescence Turn-on Reporter for Real-Time Drug Release Monitoring, a Chemoenhancer and a Stealth Agent: Poseidon’s Trident against Cancer?

2020 ◽  
Vol 18 (1) ◽  
pp. 124-147
Author(s):  
Arjun Attri ◽  
Deepak Thakur ◽  
Taranpreet Kaur ◽  
Sebastian Sensale ◽  
Zhangli Peng ◽  
...  
Keyword(s):  
Drug Release ◽  
Real Time ◽  
Turn On ◽  
Fluorescence Turn On

scholarly journals Time-lapse imaging of cell death in cell culture and whole living organisms using turn-on deep-red fluorescent probes

2018 ◽  
Vol 6 (30) ◽  
pp. 4963-4971 ◽  
Author(s):  
Tia S. Jarvis ◽  
Felicia M. Roland ◽  
Kyle M. Dubiak ◽  
Paul W. Huber ◽  
Bradley D. Smith
Keyword(s):  
Cell Culture ◽  
Cell Death ◽  
Fluorescence Imaging ◽  
Fluorescent Probes ◽  
Time Lapse ◽  
Frog Embryo ◽  
Non Invasive ◽  
Turn On ◽  
Living Organisms ◽  
Time Lapse Imaging

Targeted solvatochromic probe enables non-invasive, time-lapse fluorescence imaging of cell death in cell culture and living frog embryo.

scholarly journals Fluorescent small organic probes for biosensing

2021 ◽  
Author(s):  
Xue Tian ◽  
Lloyd C. Murfin ◽  
Luling Wu ◽  
Simon E. Lewis ◽  
Tony D. James
Keyword(s):  
Real Time ◽  
Small Molecule ◽  
Fluorescent Probes ◽  
High Selectivity ◽  
Signaling Molecules ◽  
Living Systems ◽  
Time Analysis ◽  
Non Invasive ◽  
Real Time Analysis

Small-molecule based fluorescent probes are increasingly important for the detection and imaging of biological signaling molecules due to their simplicity, high selectivity and sensitivity, whilst being non-invasive, and suitable for real-time analysis of living systems.

scholarly journals Comparison of two fluorescent probes in preclinical non-invasive imaging and image-guided debridement surgery of Staphylococcal biofilm implant infections

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Howard Y. Park ◽  
Stephen D. Zoller ◽  
Vishal Hegde ◽  
William Sheppard ◽  
Zachary Burke ◽  
...  
Keyword(s):  
Real Time ◽  
Fluorescent Probes ◽  
Near Infrared ◽  
Fluorescent Imaging ◽  
Image Guided Surgery ◽  
Fluorescence Image ◽  
Guided Surgery ◽  
Non Invasive ◽  
Image Guided ◽  
Infecting Organisms

AbstractImplant-associated infections are challenging to diagnose and treat. Fluorescent probes have been heralded as a technologic advancement that can improve our ability to non-invasively identify infecting organisms, as well as guide the inexact procedure of surgical debridement. This study’s purpose was to compare two fluorescent probes for their ability to localize Staphylococcus aureus biofilm infections on spinal implants utilizing noninvasive optical imaging, then assessing the broader applicability of the more successful probe in other infection animal models. This was followed by real-time, fluorescence image-guided surgery to facilitate debridement of infected tissue. The two probe candidates, a labelled antibiotic that targets peptidoglycan (Vanco-800CW), and the other, a labelled antibody targeting the immunodominant Staphylococcal antigen A (1D9-680), were injected into mice with spine implant infections. Mice were then imaged noninvasively with near infrared fluorescent imaging at wavelengths corresponding to the two probe candidates. Both probes localized to the infection, with the 1D9-680 probe showing greater fidelity over time. The 1D9-680 probe was then tested in mouse models of shoulder implant and allograft infection, demonstrating its broader applicability. Finally, an image-guided surgery system which superimposes fluorescent signals over analog, real-time, tissue images was employed to facilitate debridement of fluorescent-labelled bacteria.

Live Confocal Analysis of Fertilization and Early Development

2001 ◽  
Vol 7 (S2) ◽  
pp. 1012-1013
Author(s):  
Uyen Tram ◽  
William Sullivan
Keyword(s):  
Drosophila Melanogaster ◽  
Embryonic Development ◽  
Real Time ◽  
Early Development ◽  
Fluorescent Probes ◽  
Primary Defect ◽  
Fluorescent Analysis ◽  
Dynamic Event ◽  
Enormous Amount ◽  
Fluorescent Studies

Embryonic development is a dynamic event and is best studied in live animals in real time. Much of our knowledge of the early events of embryogenesis, however, comes from immunofluourescent analysis of fixed embryos. While these studies provide an enormous amount of information about the organization of different structures during development, they can give only a static glimpse of a very dynamic event. More recently real-time fluorescent studies of living embryos have become much more routine and have given new insights to how different structures and organelles (chromosomes, centrosomes, cytoskeleton, etc.) are coordinately regulated. This is in large part due to the development of commercially available fluorescent probes, GFP technology, and newly developed sensitive fluorescent microscopes. For example, live confocal fluorescent analysis proved essential in determining the primary defect in mutations that disrupt early nuclear divisions in Drosophila melanogaster. For organisms in which GPF transgenics is not available, fluorescent probes that label DNA, microtubules, and actin are available for microinjection.

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