scholarly journals Standardized fruit extract of Momordica charantia L protect against vincristine induced neuropathic pain in rats by modulating GABAergic action, antimitotoxic, NOS inhibition, anti-inflammatory and antioxidative activity

2015 ◽  
Vol 97 ◽  
pp. 123-132 ◽  
Author(s):  
Vivek Jain ◽  
Ashutosh Pareek ◽  
Yashumati Ratan ◽  
Nirmal Singh
2012 ◽  
Vol 6 (3) ◽  
pp. 236-244 ◽  
Author(s):  
M. Ullah ◽  
Mir Showkat ◽  
Nazim Uddin Ahme ◽  
Saiful Islam ◽  
Nurul Absar

2012 ◽  
Vol 11 (2) ◽  
pp. 182-190 ◽  
Author(s):  
Monika Sharma ◽  
Shraddha Suman Dash ◽  
Gangadhar Matharasala ◽  
Vanamala Deekshith ◽  
Dharmarajan Sriram ◽  
...  

2021 ◽  
Vol 17 ◽  
pp. 174480692199652
Author(s):  
Feng Zhou ◽  
Xian Wang ◽  
Baoyu Han ◽  
Xiaohui Tang ◽  
Ru Liu ◽  
...  

Microglia activation and subsequent pro-inflammatory responses play a key role in the development of neuropathic pain. The process of microglia polarization towards pro-inflammatory phenotype often occurs during neuroinflammation. Recent studies have demonstrated an active role for the gut microbiota in promoting microglial full maturation and inflammatory capabilities via the production of Short-Chain Fatty Acids (SCFAs). However, it remains unclear whether SCFAs is involved in pro-inflammatory/anti-inflammatory phenotypes microglia polarization in the neuropathic pain. In the present study, chronic constriction injury (CCI) was used to induce neuropathic pain in mice, the mechanical withdrawal threshold, thermal hyperalgesia were accomplished. The levels of microglia markers including ionized calcium-binding adaptor molecule 1 (Iba1), cluster of differentiation 11b (CD11b), pro-inflammatory phenotype markers including CD68, interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), and anti-inflammatory phenotype markers including CD206, IL-4 in the hippocampus and spinal cord were determined on day 21 after CCI. The results showed that CCI produced mechanical allodynia and thermal hyperalgesia, and also increased the expressions of microglia markers (Iba1, CD11b) and pro-inflammatory phenotype markers (CD68, IL-1β, and TNF-α), but not anti-inflammatory phenotype marker (CD206, IL-4) in the hippocampus and spinal cord, accompanied by increased SCFAs in the gut. Notably, antibiotic administration reversed these abnormalities, and its effects was also bloked by SCFAs administration. In conclusion, data from our study suggest that CCI can lead to mechanical and thermal hyperalgesia, while SCFAs play a key role in the pathogenesis of neuropathic pain by regulating microglial activation and subsequent pro-inflammatory phenotype polarization. Antibiotic administration may be a new treatment for neuropathic pain by reducing the production of SCFAs and further inhibiting the process of microglia polarization.


2021 ◽  
Vol 29 ◽  
pp. S237-S238
Author(s):  
C. van der Meulen ◽  
L.A. van de Stadt ◽  
F.P. Kroon ◽  
M.C. Kortekaas ◽  
A. Boonen ◽  
...  

2021 ◽  
Vol 17 (73) ◽  
pp. 163
Author(s):  
Yi Zhu ◽  
Feng Wang ◽  
Jian Huang ◽  
Jun Li ◽  
Kang Chen ◽  
...  

Molecules ◽  
2018 ◽  
Vol 23 (12) ◽  
pp. 3305 ◽  
Author(s):  
Giuseppe Tardiolo ◽  
Placido Bramanti ◽  
Emanuela Mazzon

N-acetylcysteine (NAC), which is an acetylated cysteine compound, has aroused scientific interest for decades due to its important medical applications. It also represents a nutritional supplement in the human diet. NAC is a glutathione precursor and shows antioxidant and anti-inflammatory activities. In addition to the uses quoted in the literature, NAC may be considered helpful in therapies to counteract neurodegenerative and mental health diseases. Furthermore, this compound has been evaluated for its neuroprotective potential in the prevention of cognitive aging dementia. NAC is inexpensive, commercially available and no relevant side effects were observed after its administration. The purpose of this paper is to give an overview on the effects and applications of NAC in Parkinson’s and Alzheimer’s disorders and in neuropathic pain and stroke.


Author(s):  
S C Joshi ◽  
Utkarsh Kaushik ◽  
Aproova Upadhyaya ◽  
Priyanka Sharma

ABSTRACTObjective: The synthesis of nanoparticles from biological processes is evolving a new era of research interests in nanotechnology. Silver nanoparticlesare usually synthesized by chemicals and physical method, which are quite toxic and flammable in nature. This study deals with an environmentfriendly biosynthesis process of antibacterial silver nanoparticles using Momordica charantia fruit.Methods: AgNO3 (5 mM) was allowed to react with fruit extract of M. charantia. Biosynthesis of AgNPs was optimized by changing temperature,pH, and solvent. The silver nanoparticles so formed were characterized using ultraviolet-visible (UV-VIS) spectroscopy, Fourier transform infraredspectroscopy (FTIR), dynamic light scattering (DLS), atomic force microscope (AFM), and scanning electron microscopy (SEM).Results: UV-VIS spectra show absorption peak between 420 and 430 nm. The FTIR analysis showed the alcoholic, lactam, and nitro group presentin the plant extract, which were responsible for the reduction in AgNPs. The SEM images showed the size distribution of the nanoparticles and theaverage size was found to be 50-100 nm. By DLS analysis and AFM analysis, average sizes of the silver nanoparticles were of 150 nm. The results ofthese analyses confirmed the formation of silver nanoparticles. Silver nanoparticles were tested against Bacillus cereus and Staphylococcus epidermidisstrains using disc diffusion method and were found to be effective.Conclusion: Silver nanoparticles so synthesized in this study using fruit extract of M. charantia are simple, easy, and effective technique of nanoparticlesproduction.Keywords: Silver nanoparticles, Momordica charantia, Optimization, Antibacterial, Atomic force microscope, Scanning electron microscopy.


2014 ◽  
Vol 17 (12) ◽  
pp. 1375-1382 ◽  
Author(s):  
Ismail O. Ishola ◽  
Olufunsho Awodele ◽  
Abayomi Micheal Olusayero ◽  
Charles O. Ochieng

2011 ◽  
Vol 7 (4) ◽  
pp. 532-535 ◽  
Author(s):  
O.T. Kolawole ◽  
F.E. Abiona ◽  
S.O. Kolawole ◽  
A.A. Ayankunle ◽  
O.I. Olaniran

Sign in / Sign up

Export Citation Format

Share Document