scholarly journals Overview on the Effects of N-Acetylcysteine in Neurodegenerative Diseases

Molecules ◽  
2018 ◽  
Vol 23 (12) ◽  
pp. 3305 ◽  
Author(s):  
Giuseppe Tardiolo ◽  
Placido Bramanti ◽  
Emanuela Mazzon
Keyword(s):  
Mental Health ◽  
Neuropathic Pain ◽  
Side Effects ◽  
Neurodegenerative Diseases ◽  
Cognitive Aging ◽  
Nutritional Supplement ◽  
Medical Applications ◽  
Scientific Interest ◽  
Human Diet ◽  
Anti Inflammatory

N-acetylcysteine (NAC), which is an acetylated cysteine compound, has aroused scientific interest for decades due to its important medical applications. It also represents a nutritional supplement in the human diet. NAC is a glutathione precursor and shows antioxidant and anti-inflammatory activities. In addition to the uses quoted in the literature, NAC may be considered helpful in therapies to counteract neurodegenerative and mental health diseases. Furthermore, this compound has been evaluated for its neuroprotective potential in the prevention of cognitive aging dementia. NAC is inexpensive, commercially available and no relevant side effects were observed after its administration. The purpose of this paper is to give an overview on the effects and applications of NAC in Parkinson’s and Alzheimer’s disorders and in neuropathic pain and stroke.

scholarly journals Awareness of Medical Applications of Gingko Biloba Among Dental Students

2020 ◽  
Vol 11 (SPL3) ◽  
pp. 937-941
Author(s):  
Nithyanandham Masilamani ◽  
Dhanraj Ganapathy
Keyword(s):  
Side Effects ◽  
Mechanism Of Action ◽  
Ginkgo Biloba ◽  
Herbal Medicines ◽  
Dental Students ◽  
Medical Applications ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Gingko Biloba ◽  
Anti Inflammatory

Herbal medicines reflect a significant portion of new interest in alternative therapies and Ginkgo biloba (GB) features significantly throughout this regard. The GB concentrate and any of its constituents are already thoroughly researched in terms of its impact on behavioral, physiological and psychological consequences linked with neurological and vascular conditions. The purpose of this survey was for assessing the awareness of medical applications of Gingko Biloba amongst dental students. A cross-sectional survey was conducted with a self-administered questionnaire with 10 queries circulated among 100 dental students. The questionnaire assessed the awareness about Ginkgo bilobatherapy in medical applications, their anti-dementia properties, anti alziemer properties, anti-ageing activity, anti-inflammatory activity, and its mechanism of action and side effects. The responses were recorded and analysed.8% of the respondents were aware of the medical applications of Gingko Biloba therapy.6 % were aware of the anti-dementia activity of Gingko Biloba therapy,5% were aware of anti alziemer properties of Gingko Biloba therapy,6% were aware of anti-ageing properties of Gingko Biloba therapy, 5% were aware of anti-inflammatory properties of Gingko Biloba therapy, 5% were aware mechanism of action and side effects of Gingko Biloba therapy. The awareness about the usage of Ginkgo biloba therapy in medicinal applications is low among dental students. Increased awareness programs and sensitization and continuing dental education programs along with greater importance to the curricular modifications, can further enhance knowledge and awareness about Ginkgo biloba therapy.

scholarly journals Awareness of Medicinal Applications of Piper nigrum among Dental Students

2020 ◽  
Vol 11 (SPL3) ◽  
pp. 927-930
Author(s):  
Nithyanandham Masilamani ◽  
Dhanraj Ganapathy
Keyword(s):  
Side Effects ◽  
Mechanism Of Action ◽  
Black Pepper ◽  
Dental Students ◽  
Biologically Active ◽  
Piper Nigrum ◽  
Medical Applications ◽  
Therapeutic Effects ◽  
White Pepper ◽  
Anti Inflammatory

Black pepper includes the many commonly used ingredients upon this planet, remarkable for some of its potent component piperine. White pepper is made with closely related species, while black pepper is prepared by fast processing and wind drying of underripe natural products, white pepper is made from dried, regular and ready-mixed seeds. Piperine has been the conventional biologically active conjugate of Piper nigrum and Piper longum, having been taken into consideration for therapeutic effects. The purpose of this survey was for assessing the awareness of medicinal applications of Piper nigrum amongst dental students. A cross-sectional survey was done with a self-administered questionnaire with 10 questions circulated among 100 dental students. The questionnaire assessed the awareness about Piper nigrumtherapy in medical applications, their immunomodulatory properties, antipyretic properties, antispasmodic activity, anti-inflammatory activity, and its mechanism of action and side effects. The responses were recorded and analysed. 16% of the respondents were aware of the medical applications of Piper nigrum therapy.11 % were aware of the anti immunomodulatory activity of Piper nigrum therapy .9 % were aware of antipyretic properties of Piper nigrum therapy .13 % were aware of antispasmodic properties of Piper nigrum therapy .10 % were aware of anti-inflammatory properties of Piper nigrum therapy . 6 % were an aware mechanism of action and side effects of Piper nigrum therapy. The awareness about the use of Piper nigrum therapy in medicinal applications is low among dental students. Increased awareness programs and sensitization and continuing dental education programs along with greater importance to the curricular modifications, can further enhance knowledge and awareness about Piper nigrum therapy.

scholarly journals Neuroinflammation and Neurodegeneration: The Promising Protective Role of the Citrus Flavanone Hesperetin

Nutrients ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 2336
Author(s):  
Egeria Scoditti
Keyword(s):  
Neurodegenerative Diseases ◽  
Protective Role ◽  
Degenerative Diseases ◽  
Scientific Interest ◽  
Great Abundance ◽  
Human Diet ◽  
Plant Foods ◽  
The Past ◽  
Biological Actions

Over the past 20 years, there has been a remarkable increase in the scientific interest in polyphenols, bioactive compounds naturally present in plant foods and beverages, due to the recognition of their biological actions, their great abundance in the human diet, and their plausible role in the prevention of various chronic degenerative diseases, such as cancer, cardiovascular and neurodegenerative diseases [...]

scholarly journals Awareness of cryotherapy in sports medical applications among dental students

2020 ◽  
Vol 11 (SPL3) ◽  
pp. 1095-1098
Author(s):  
Nithyanandham Masilamani ◽  
Dhanraj Ganapathy
Keyword(s):  
Side Effects ◽  
Mechanism Of Action ◽  
Sports Medicine ◽  
Cross Sectional Study ◽  
Dental Students ◽  
Inflammatory Activity ◽  
Medical Applications ◽  
Cross Sectional ◽  
Medicinal Uses ◽  
Anti Inflammatory

Cryotherapy is the use of cold for either the management of injury or illness, has become common across sports medicine. It remains a well-established procedure for managing serious soft tissue damages. However, there is the disparity between both the theoretical evidence for cryotherapy in clinical trials. This survey was performed for assessing the awareness about cryotherapy in sports medical applications amongst dental students. A cross-sectional study was done with a self-administered questionnaire with 10 questions circulated among 100 dental students. The questionnaire assessed the awareness about cryotherapy in sports medical applications, their medicinal uses, anti-inflammatory activity, mechanism of action and side effects. The responses were recorded and analysed. 87% of the respondents were not aware of medical uses of Cryotherapy.73% were not aware of the anti-inflammatory activity of Cryotherapy.83 % were not aware of the mechanism of action of Cryotherapy. 85% were not aware of the side effects of Cryotherapy. The awareness about the use of cryotherapy in sports medical applications is very less among dental students. Increased awareness programs and sensitization and continuing dental education programs along with greater importance to the curricular modifications in sports dentistry should be incorporated to improve the awareness levels.

scholarly journals Cyclooxygenase-2 Inhibitors as a Therapeutic Target in Inflammatory Diseases

2019 ◽  
Vol 26 (18) ◽  
pp. 3225-3241 ◽  
Author(s):  
Miguel D. Ferrer ◽  
Carla Busquets-Cortés ◽  
Xavier Capó ◽  
Silvia Tejada ◽  
Josep A. Tur ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Side Effects ◽  
Autoimmune Diseases ◽  
Neurodegenerative Diseases ◽  
Selective Inhibitors ◽  
Gastrointestinal Side Effects ◽  
Cardiovascular Pathologies ◽  
Cox 2 ◽  
Anti Inflammatory ◽  
Cox 1

Inflammation plays a crucial role in the development of many complex diseases and disorders including autoimmune diseases, metabolic syndrome, neurodegenerative diseases, and cardiovascular pathologies. Prostaglandins play a regulatory role in inflammation. Cyclooxygenases are the main mediators of inflammation by catalyzing the initial step of arachidonic acid metabolism and prostaglandin synthesis. The differential expression of the constitutive isoform COX-1 and the inducible isoform COX-2, and the finding that COX-1 is the major form expressed in the gastrointestinal tract, lead to the search for COX-2-selective inhibitors as anti-inflammatory agents that might diminish the gastrointestinal side effects of traditional non-steroidal anti-inflammatory drugs (NSAIDs). COX-2 isoform is expressed predominantly in inflammatory cells and decidedly upregulated in chronic and acute inflammations, becoming a critical target for many pharmacological inhibitors. COX-2 selective inhibitors happen to show equivalent efficacy with that of conventional NSAIDs, but they have reduced gastrointestinal side effects. This review would elucidate the most recent findings on selective COX-2 inhibition and their relevance to human pathology, concretely in inflammatory pathologies characterized by a prolonged pro-inflammatory status, including autoimmune diseases, metabolic syndrome, obesity, atherosclerosis, neurodegenerative diseases, chronic obstructive pulmonary disease, arthritis, chronic inflammatory bowel disease and cardiovascular pathologies.

A Brief Review on the Development of Novel Potentially Active Azetidin-2-ones Against Cancer

2020 ◽  
Vol 24 (5) ◽  
pp. 473-486 ◽  
Author(s):  
Ligia S. da Silveira Pinto ◽  
Thatyana R. Alves Vasconcelos ◽  
Claudia Regina B. Gomes ◽  
Marcus Vinícius N. de Souza
Keyword(s):  
Side Effects ◽  
Anticancer Agents ◽  
Heterocyclic Compounds ◽  
Biological Activities ◽  
Present Review ◽  
Pharmacological Properties ◽  
Important Group ◽  
Wide Range ◽  
Anti Inflammatory

Azetidin-2-ones (β-lactams) and its derivatives are an important group of heterocyclic compounds that exhibit a wide range of pharmacological properties such as antibacterial, anticancer, anti-diabetic, anti-inflammatory and anticonvulsant. Efforts have been made over the years to develop novel congeners with superior biological activities and minimal potential for undesirable side effects. The present review aimed to highlight some recent discoveries (2013-2019) on the development of novel azetidin-2-one-based compounds as potential anticancer agents.

Nanotechnological Innovations Enhancing the Topical Therapeutic Efficacy of Quercetin: A Succinct Review

2020 ◽  
Vol 17 (4) ◽  
pp. 270-278
Author(s):  
Maha Nasr ◽  
Rawan Al-Karaki
Keyword(s):  
Side Effects ◽  
Therapeutic Efficacy ◽  
Skin Permeation ◽  
Skin Penetration ◽  
Topical Delivery ◽  
Natural Compounds ◽  
Therapeutic Activity ◽  
Dermatological Diseases ◽  
Anti Inflammatory ◽  
Topical Applications

Nanotechnology is currently a hot topic in dermatology and nutraceutical/cosmeceutical delivery, owing to the advantages it provides in terms of enhancing the skin permeation of drugs, as well as increasing their therapeutic efficacy in the treatment of different dermatological diseases. There is also a great interest in the topical delivery of nutraceuticals; which are natural compounds with both therapeutic and cosmetic benefits, in order to overcome the side effects of topically applied chemical drugs. Quercetin is a key nutraceutical with topical antioxidant and anti-inflammatory properties which was reported to be effective in the treatment of different dermatological diseases, however, its topical therapeutic activity is hindered by its poor skin penetration. This review highlights the topical applications of quercetin, and summarizes the nanocarrier-based solutions to its percutaneous delivery challenges.

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