Extracts of Gomphrena celosioides Mart as potential treatment for urinary tract infections against antibiotic resistant β-lactamase producing uropathogens

2020 ◽  
Vol 132 ◽  
pp. 502-510
Author(s):  
Aitebiremen Gift Omokhua-Uyi ◽  
Johannes Van Staden
Keyword(s):  
Urinary Tract ◽  
Urinary Tract Infections ◽  
Potential Treatment ◽  
Antibiotic Resistant ◽  
Gomphrena Celosioides ◽  
Tract Infections

scholarly journals 1069: Bad bugs: antibiotic-resistant lower urinary tract infections and risk of pyelonephritis in pregnancy

2020 ◽  
Vol 222 (1) ◽  
pp. S660
Author(s):  
Anna DeNoble ◽  
Madison Krischak ◽  
Heather Rosett ◽  
Sarika Sachdeva ◽  
Kristin Weaver ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Urinary Tract Infections ◽  
Lower Urinary Tract ◽  
Antibiotic Resistant ◽  
Tract Infections ◽  
In Pregnancy ◽  
Lower Urinary

scholarly journals Spread of Enterococcal Surface Protein in Antibiotic Resistant Entero-coccus faecium and Enterococcus faecalis isolates from Urinary Tract Infections

2015 ◽  
Vol 9 (1) ◽  
pp. 14-17 ◽  
Author(s):  
Hossein Samadi Kafil ◽  
Ashraf Mohabati Mobarez
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Urinary Tract Infections ◽  
Biofilm Formation ◽  
Urinary Infection ◽  
Surface Protein ◽  
Antibiotic Resistant ◽  
Specific Pcr ◽  
Tract Infections

Enterococci rank among leading cause of nosocomial bacteremia and urinary tract infection in hospital and community acquired infections. Several traits that may contribute to enhanced virulence have been identified in Enterococci. Extracellular surface protein (Esp) is a virulence factor that contributes in biofilm formation and resistance to environmental stresses. In this study we aimed to determine occurrence ofespinE. faeciumandE. faecalisisolates isolated from urinary tract infections and to investigate whether there is any correlation between presence ofespand antibiotic resistance. One hundred and sixty six isolates were collected from patients with UTI and after identification by biochemical and PCR, antibiotic resistances were examined. The presence ofespwas investigated by primer-specific PCR. 43.3% of isolates identified asE. faeciumand 56.7% asE. faecalis. Theespgene was found in 76.1% ofE. faeciumisolates and 77.9% ofE. faecalisisolate. There were significant correlation betweenesppositiveE. faeciumand resistance to Vancomycin (p<0.01), also inE.faecaliswe found correlation betweenesppositive and resistance to Ampicillin, Chloramphenicol and Tetracycline (p<0.01, p<0.01, p<0.01 respectively). Occurrence ofespin our isolates from urinary tract infection was high that indicates importance of this gene in urinary tract infections and shows importance of ability to forming biofilm and hydrophobicity of surface of Enterococci for causing urinary infection by Enterococci. Also, our finding showed significant correlation between resistance to antibiotics and presence ofespin Enterococci.

Urinary Tract Infections with Antibiotic Resistant Organisms in Catheterized Nursing Home Patients

1984 ◽  
Vol 5 (4) ◽  
pp. 173-176 ◽  
Author(s):  
David T. Bjork ◽  
Lawrence L. Pelletier ◽  
Robert R. Tight
Keyword(s):  
Nursing Home ◽  
Urinary Tract ◽  
Urinary Tract Infections ◽  
Resistant Bacteria ◽  
Urinary Catheters ◽  
Antibiotic Resistant ◽  
Inappropriate Use ◽  
Nursing Home Patients ◽  
Tract Infections ◽  
Antibiotic Courses

AbstractLong-term use of indwelling urinary catheters in nursing home (NH) patients is a potential cause of significant morbidity. We retrospectively studied 10 NH patients with chronic indwelling urinary catheters. Sixty-four percent of all 84 antibiotic courses prescribed were for bacteriuria alone without clinical infection. Seventy percent of 63 antibiotic courses were followed by bacteriuria with organisms resistant to the antibiotic administered. Bacteria isolated from NH patients often displayed greater resistance to specific antibiotics than those isolated from hospitalized patients. Four of the 20 urinary tract infections were associated with bacteremia. Three episodes of bacteremia were with highly-resistant organisms and one was fatal. Use of urinary catheters and inappropriate use of antibiotics in NH patients results in urinary tract colonization and infection with resistant bacteria and is an important cause of morbidity and mortality.

scholarly journals Targeting Biofilm of MDR Providencia stuartii by Phages Using a Catheter Model

Antibiotics ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 375
Author(s):  
Chani Rakov ◽  
Shira Ben Porat ◽  
Sivan Alkalay-Oren ◽  
Ortal Yerushalmy ◽  
Mohanad Abdalrhman ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Urinary Tract Infections ◽  
Phage Therapy ◽  
Multiple Drug ◽  
Bacterial Strains ◽  
Antibiotic Resistant ◽  
Isolation And Characterization ◽  
Wide Range ◽  
Providencia Stuartii ◽  
Tract Infections

Providencia spp. are emerging pathogens mainly in nosocomial infections. Providencia stuartii in particular is involved in urinary tract infections and contributes significantly to the high incidence of biofilm-formation in catheterized patients. Furthermore, recent reports suggested a role for multiple drug resistant (MDR) P. stuartii in hospital-associated outbreaks which leads to excessive complications resulting in challenging treatments. Phage therapy is currently one of the most promising solutions to combat antibiotic-resistant infections. However, the number of available phages targeting Providencia spp. is extremely limited, restricting the use of phage therapy in such cases. In the present study, we describe the isolation and characterization of 17 lytic and temperate bacteriophages targeting clinical isolates of Providencia spp. as part of the Israeli Phage Bank (IPB). These phages, isolated from sewage samples, were evaluated for host range activity and effectively eradicated 95% of the tested bacterial strains isolated from different geographic locations and displaying a wide range of antibiotic resistance. Their lytic activity is demonstrated on agar plates, planktonic cultures, and biofilm formed in a catheter model. The results suggest that these bacteriophages can potentially be used for treatment of antibiotic-resistant Providencia spp. infections in general and of urinary tract infections in particular.

scholarly journals Bacteriophages as Potential Treatment for Urinary Tract Infections

2016 ◽  
Vol 7 ◽  
Author(s):  
Wilbert Sybesma ◽  
Reinhard Zbinden ◽  
Nino Chanishvili ◽  
Mzia Kutateladze ◽  
Archil Chkhotua ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Urinary Tract Infections ◽  
Potential Treatment ◽  
Tract Infections

scholarly journals Use of ceragenins as a potential treatment for urinary tract infections

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Urszula Wnorowska ◽  
Ewelina Piktel ◽  
Bonita Durnaś ◽  
Krzysztof Fiedoruk ◽  
Paul B. Savage ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Urinary Tract Infections ◽  
Potential Treatment ◽  
Tract Infections

Diversity and trends in population structure of ESBL-producing Enterobacteriaceae in febrile urinary tract infections in children in France from 2014 to 2017

2019 ◽  
Author(s):  
André Birgy ◽  
Fouad Madhi ◽  
Camille Jung ◽  
Corinne Levy ◽  
Aurélie Cointe ◽  
...  
Keyword(s):  
Population Structure ◽  
Urinary Tract ◽  
Urinary Tract Infections ◽  
Epidemiological Surveillance ◽  
Antibiotic Resistant ◽  
E Coli ◽  
Pathogenic Escherichia Coli ◽  
Febrile Urinary Tract Infections ◽  
Tract Infections ◽  
High Threat

Abstract Background The population structure of extraintestinal pathogenic Escherichia coli evolves over time, notably due to the emergence of antibiotic-resistant clones such as ESBL-producing Enterobacteriaceae (ESBL-E). Objectives To analyse by WGS the genetic diversity of a large number of ESBL-E isolated from urinary tract infections in children from paediatric centres across France between 2014 and 2017 and collected by the National Observatory of febrile urinary tract infection (FUTI) caused by ESBL-E. Methods A total of 40 905 Enterobacteriaceae-positive urine cultures were identified. ESBL-E were found in 1983 samples (4.85%). WGS was performed on 251 ESBL-E causing FUTI. STs, core genome MLST (cgMLST), serotype, fimH allele, ESBL genes and presence of papGII key virulence factor were determined. Results E. coli and Klebsiella pneumoniae were found in 86.9% (218/251) and 11.2% (28/251) of cases, respectively. Several STs predominate among E. coli such as ST131, ST38, ST69, ST73, ST95, ST405, ST12 and ST1193, while no ST emerged in K. pneumoniae. E. coli ST131, ST38 and ST1193 increased during the study period, with a heterogeneity in papGII prevalence (64.5%, 35% and 20% respectively). Most isolates harboured the CTX-M type (97%) with a predominance of blaCTX-M-15. blaCTX-M-27, an emerging variant in E. coli, is found in various STs. cgMLST enabled discrimination of clusters within the main STs. Conclusions The predominance of ST131, and the emergence of other STs such as ST38 and ST1193 combined with ESBL genes deserves close epidemiological surveillance considering their high threat in infectious disease. cgMLST could be a discriminant complementary tool for the analyses.

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