A Novel Established Pyroptosis-participant Genes Signature for Predicting the Prognosis of Idiopathic Pulmonary Fibrosis

Idiopathic pulmonary fibrosis (IPF), caused by a strange reason and characterized by a bad clinical prognosis, is an advanced, long-time, and irreversible interstitial lung disease (ILD). In recent years, it has been confirmed that a pyroptosis is a phlogistic form of programmed cellular demise. At the same time, the expression of the pyroptosis-participant gene (PPG) in IPF and their pertinence behind prognosis remains indistinct. In this research, we identified 17 pyroptosis regulators that were distinguishingly expressed entre IPF and controls. The ground on these distinguishingly expressed genes (DEGs), entire IPF conditions could be uncoupled into two subtypes. The prognostic significance of respective PPG for surviving was assessed to find a polygenes signature doing with a Gene Expression Omnibus (GEO) pack (GSE28042). Via putting into use the least absolute shrinkage and selection operator (LASSO) Cox regression approach, a 6-gene signature was structured and ranged entire IPF sicks in GSE28042 into a shallow-threat or high-threat group. IPF sicks in the shallow-threat group revealed meaningfully upper survival chances than those in the high-threat group (pvalue < 0.001). Exploiting the mid threat-score from GSE28042, IPF sicks from another GEO cohort(GSE70866-GPL17077) were separated into two threat subgroups, and the shallow-threat set had augmented overall survival (OS) time ( P = 0.0018). United the clinical characteristics, the threat-score was a sole element for forecasting the overall survival of IPF sicks. Function enrichment analyses bespoke that modification of morphology or physiology of other organisms, killing of cellular of other organisms, and disruption of cellular of other organisms biological processes were increased in the high-threat group. GSEA(Gene Set Enrichment Analysis) showed that cancer- and autoimmune disease-participant “KEGG” gene sets were highly enriched in the high−threat phenotype. In general, PPGs play a crucial role in IPF and can be done to forecast the prognosis of IPFs, and our consequences suggest that the high-threat group of IPF may be linked with the response of other organisms and autoimmunity as well.

Implications of Sea Toll Programs to National Development Economy: Reinterpretation of Marine Verses In Al-Quran

Indonesia, as an archipelago with a coastline of 81,000 km, is a coastal and marine area that has a variety of vast and diverse resources. With the unique potential and economic value of development, coastal areas are also faced with a high threat, so special handling is needed so that this region can be managed sustainably. Economic development in this framework is realized through the sea toll program. This article will aim to discuss how the sea toll program has an impact on the national development economy and the reinterpretation of marine verses in Al-Quran. This study uses qualitative research methods that are literature research. The sources of data in this study were sourced from books, journals, scientific articles, research reports, laws, and internet websites related to the sea toll program. After all, data have been collected, the data are analyzed by data analysis methods, namely data reduction, data presentation, and conclusion drawing. Findings. The results showed that the use of marine wealth by humans is justified in Al-Quran even it is recommended for the benefit of humans. On the other hand, the development of defense forces requires strong economic capabilities as a form of an effort to realize Indonesia’s ideals as a world maritime nation. Indonesia’s maritime potential can create a dominant economic development power for the Indonesian state to face global or international competition.

Ichthyofauna associated with sandy beaches of the rio Machado, tributary of the rio Madeira, northern Brazil

The rio Machado is an large tributary of the rio Madeira, and investigations of the ichthyofauna are urgent given the current high threat of habitat loss on account of a hydroelectric plant under construction. Our inventory quantified 9,544 specimens, representing four orders and 38 species. Our study provides an unprecedented list of fish species from a poorly studied South American basin. This basin, which is considered one of the world&rsquo;s biodiversity hotspots, presents high endemism, few cases of co-existence of phylogenetically related lineages, low species diversity, and few species occurrences with wide distribution.

Can External Threats Foster a European Union Identity? Evidence from Russia’s Invasion of Ukraine

Can external threats strengthen group identity? A growing body of research in economics emphasises the importance of cultural attributes such as identity for trust and cooperation. However, where these attributes come from is not well understood. This paper examines reactions to the Russian invasion of Ukraine in 2014, looking at European Union member states. Comparing low-threat to high-threat states in a difference-in-differences design, I find a sizeable and persistent positive effect on EU identity. It is associated with higher trust in EU institutions and support for common policies. Lower-level identities remain unaffected, and proximity to Russia and Russian minority size are driving high-threat status.

Experimental Study to Improves Covid-19 Health Protocol Compliance with High Threat and High Efficacy Poster

This study examines the health campaign of Covid-19 using the extended parallel process model (EPPM) theory. The objective and gap that was successfully filled by this research are to examine the effect of the poster with high threat and high efficacy to obedience to implement Covid-19 health protocol in Indonesia context. In contrast, obedience is divided into aspects of attitude and second aspects of behaviour according to Blass's concept of obedience. This study uses a quantitative approach with an experimental method by grouping respondents into two groups. The first is the treatment group that received a poster. The second is a control group that did not receive any posters. The total number of respondents of this research was 95, representing proportionally by categories of sex and categories of age. This research has met the scientific principles required. This study found that poster with high threat and high efficacy has a significant effect of improving the attitude aspects of obedience to implement Covid-19 health protocol because when respondents saw a poster with high threat and high efficacy, respondents felt that the threat posed by covid-19 was so high that could turn into death, another reason is a poster with high threat, and high efficacy evokes the memory of respondents to remember their relatives, close person or family who have been confirmed positive with Covid-19 virus. This study also found that poster with high threat and high efficacy does not affect behavioural aspects. This means that posters with high threat and high efficacy proved to make changes with the attitude aspects to improve people obedience to implement Covid-19 health protocol but, it has not been proven to change the behavioural aspects.Riset ini meneliti kampanye kesehatan Covid-19 menggunakan pisau analisa teori extended parallel process model (EPPM). Tujuan dan celah yang berhasil diisi dari penelitian ini dibandingkan penelitian terdahulu adalah menguji pengaruh pemberian poster ancaman tinggi dan efikasi tinggi terhadap kepatuhan protokol kesehatan Covid-19 dalam konteks Indonesia, adapun kepatuhan dibagi ke dalam dua aspek yakni aspek sikap dan aspek perilaku sesuai konsep kepatuhan Blass. Penelitian ini menggunakan pendekatan kuantitatif yakni metode eksperimen dengan membagi responden ke dalam dua kelompok yang pertama adalah kelompok perlakuan/treatment yang mendapat poster dan kedua adalah kelompok kontrol yang tidak mendapat poster, jumlah responden sebanyak 95 yang mewakili masing-masing kategori jenis kelamin dan kategori usia secara proporsional. Riset ini telah dilaksanakan mengacu pada kaidah-kaidah ilmiah. Hasil penelitian menemukan bahwa pemberian poster ancaman tinggi dan efikasi tinggi berpengaruh signifikan meningkatkan aspek sikap kepatuhan protokol kesehatan Covid-19 karena saat melihat poster ancaman tinggi dan efikasi tinggi responden merasa ancaman yang ditimbulkan oleh Covid-19 amat besar hingga dapat menimbulkan kematian, alasan lain yakni poster ancaman tinggi dan efikasi tinggi membangkitkan memori responden yang teringat orang dekat, kerabat maupun keluarga yang pernah terkonfirmasi positif virus Covid-19. Penelitian ini juga menemukan bahwa poster ancaman tinggi dan efikasi tinggi tidak berpengaruh terhadap aspek perilaku. Artinya pemberian poster ancaman tinggi dan efikasi tinggi terbukti mengubah aspek sikap untuk lebih mematuhi protokol kesehatan Covid-19 tetapi, tidak terbukti mengubah aspek perilaku.

Multi-country cross-sectional study of colonization with multidrug-resistant organisms: protocol and methods for the Antibiotic Resistance in Communities and Hospitals (ARCH) studies

Background Antimicrobial resistance is a global health emergency. Persons colonized with multidrug-resistant organisms (MDROs) are at risk for developing subsequent multidrug-resistant infections, as colonization represents an important precursor to invasive infection. Despite reports documenting the worldwide dissemination of MDROs, fundamental questions remain regarding the burden of resistance, metrics to measure prevalence, and determinants of spread. We describe a multi-site colonization survey protocol that aims to quantify the population-based prevalence and associated risk factors for colonization with high-threat MDROs among community dwelling participants and patients admitted to hospitals within a defined population-catchment area. Methods Researchers in five countries (Bangladesh, Chile, Guatemala, Kenya, and India) will conduct a cross-sectional, population-based prevalence survey consisting of a risk factor questionnaire and collection of specimens to evaluate colonization with three high-threat MDROs: extended-spectrum cephalosporin-resistant Enterobacteriaceae (ESCrE), carbapenem-resistant Enterobacteriaceae (CRE), and methicillin-resistant Staphylococcus aureus (MRSA). Healthy adults residing in a household within the sampling area will be enrolled in addition to eligible hospitalized adults. Colonizing isolates of these MDROs will be compared by multilocus sequence typing (MLST) to routinely collected invasive clinical isolates, where available, to determine potential pathogenicity. A colonizing MDRO isolate will be categorized as potentially pathogenic if the MLST pattern of the colonizing isolate matches the MLST pattern of an invasive clinical isolate. The outcomes of this study will be estimates of the population-based prevalence of colonization with ESCrE, CRE, and MRSA; determination of the proportion of colonizing ESCrE, CRE, and MRSA with pathogenic characteristics based on MLST; identification of factors independently associated with ESCrE, CRE, and MRSA colonization; and creation an archive of ESCrE, CRE, and MRSA isolates for future study. Discussion This is the first study to use a common protocol to evaluate population-based prevalence and risk factors associated with MDRO colonization among community-dwelling and hospitalized adults in multiple countries with diverse epidemiological conditions, including low- and middle-income settings. The results will be used to better describe the global epidemiology of MDROs and guide the development of mitigation strategies in both community and healthcare settings. These standardized baseline surveys can also inform future studies seeking to further characterize MDRO epidemiology globally.

Hypotensive effect of micropulse laser cyclophotocoagulation in hemophthalmos with high intraocular pressure

Purpose. To study the effectiveness of micropulse laser cyclophotocoagulation (CPC) use in the treatment of hemophthalmos with ophthalmic hypertension. Materials and methods. Examination and treatment of 11 patients (11 eyes) with fresh hemophthalmos with secondary uncompensated ophthalmic hypertension were carried out. Antiglaucoma surgery was considered inappropriate due to the high threat of serious hemorrhagic complications. To normalize intraocular pressure (IOP), patients underwent micropulse laser CPС. Results. After microimpulse CPС, all patients on the first day showed a decrease in IOP to an average of 26.6 mm Hg, after 7 days - up to 20.1 mm Hg. After 1 month, 7 patients (7 eyes), against the background of conservative treatment of hemophthalmos with a normalized IOP level (15-20 mm Hg), showed positive dynamics: the hemophthalmos was practically resorbed, an increase in visual acuity was achieved (from 0.3 to 0.8). In 4 patients (4 eyes) there was a decrease in the IOP level to 18-25 mm Hg. All patients underwent a successful vitrectomy with a high functional result, visual acuity ranged from 0.4 to 0.8. Conclusion. The use of micropulse laser CPС is pathogenetically justified and safe in patients with hemophthalmos in combination with high IOP. The use of this approach made it possible to achieve stable normalization of ophthalmotonus, increase the effectiveness of conservative therapy for hemophthalmos, and achieve restoration of visual functions in the examined patients. Key words: hemophthalmos, micropulse laser cyclophotocoagulation, intraocular pressure, ophthalmic hypertension.

How Does Dualistic Passion Fuel Academic Thriving? A Joint Moderated–Mediating Model

Based on the dualistic model of passion, this study developed a joint moderated–mediating model to investigate the mechanism of dualistic passion on academic thriving. We surveyed 960 Chinese university students with a questionnaire. The results showed that harmonious and obsessive passion positively predicted academic thriving, with the effect of harmonious passion being stronger. Academic personal best goal mediated these relationships. Moreover, threat stress appraisal and academic workload jointly moderated the direct effects of harmonious passion on academic personal best goal and obsessive passion on academic personal best goal, and the first stage of the mediating effects of academic personal best goal between harmonious passion and academic thriving as well as obsessive passion and academic thriving. Specifically, for low–threat stress appraisal and academic workload, the direct effect of harmonious passion on academic personal best goal and the mediating effect of academic personal best goal were stronger. Meanwhile, for high–threat stress appraisal and academic workload, the same applied for obsessive passion. These findings provide important implications for educational practice by highlighting an underlying mechanism of how and when dualistic passion, particularly for obsessive passion, can initiate and maintain academic thriving.

Ecology and Conservation of the Laotian langur Trachypithecus laotum in a Protected Area of Laos (Southeast Asia)

Terrestrial species from the Lao People’s Democratic Republic (PDR) are under high threat due to deforestation and overhunting. Previous studies have even defined these forests as subjected to an “empty forest syndrome”, a condition in which forests that are apparently well preserved are instead almost deprived of vertebrate faunas due to extreme exploitation by local communities. Forest specialists, including several primates, are among the most threatened species in the country. The Laotian langur (Trachypithecus laotum) is endemic to Lao PDR, is listed as Endangered by the IUCN Red List, and it is one of the least studied species in the region. A survey on the local distribution, life history and conservation status of the Laotian langur was carried out in Phou Hin Poun National Protected Area, Khammouane Province of Lao PDR. The survey consisted of an initial phase with interviews to select key informants on the Laotian langur and the other primate species of the area. Then, a phase of field surveys along forest transects, totaling 64.1 km of 21 transects, yielded a record of 35 individuals in 9 groups. The highest encounter/detection rate of the Laotian langur was 1 group per km at one sector of the park. In contrast, it was much lower (0.18–0.34 groups/km) in the rest of the protected area. The group sizes were much lower than those observed in the same area between 1994 and 2010, thus suggesting a decline in the population size of langurs. This decline may be linked to habitat loss (timber extraction and mining). Still, also overhunting, as signs of poaching were observed during our field surveys. This was also supported by the reports of our interviewees. Laotian langurs were observed to be sympatric and interact while foraging with the Assamese macaque (Macaca assamensis). In the cases of sympatric occurrence between the two species, we observed that subtle mechanisms of niche partitioning may occur to reduce interspecific competition for food. Further research on the population and ecology of this endangered langur should be conducted to understand the species and aid its conservation.