Reduced parietal alpha power and psychotic symptoms: Test-retest reliability of resting-state magnetoencephalography in schizophrenia and healthy controls

Abstract Objective Time constraints limit the use of measurement-based approaches in research and routine clinical management of psychosis. Computerized adaptive testing (CAT) can reduce administration time, thus increasing measurement efficiency. This study aimed to develop and test the capacity of the CAT-Psychosis battery, both self-administered and rater-administered, to measure the severity of psychotic symptoms and discriminate psychosis from healthy controls. Methods An item bank was developed and calibrated. Two raters administered CAT-Psychosis for inter-rater reliability (IRR). Subjects rated themselves and were retested within 7 days for test-retest reliability. The Brief Psychiatric Rating Scale (BPRS) was administered for convergent validity and chart diagnosis, and the Structured Clinical Interview (SCID) was used to test psychosis discriminant validity. Results Development and calibration study included 649 psychotic patients. Simulations revealed a correlation of r = .92 with the total 73-item bank score, using an average of 12 items. Validation study included 160 additional patients and 40 healthy controls. CAT-Psychosis showed convergent validity (clinician: r = 0.690; 95% confidence interval [95% CI]: 0.610–0.757; self-report: r = .690; 95% CI: 0.609–0.756), IRR (intraclass correlation coefficient [ICC] = 0.733; 95% CI: 0.611–0.828), and test-retest reliability (clinician ICC = 0.862; 95% CI: 0.767–0.922; self-report ICC = 0.815; 95%CI: 0.741–0.871). CAT-Psychosis could discriminate psychosis from healthy controls (clinician: area under the receiver operating characteristic curve [AUC] = 0.965, 95% CI: 0.945–0.984; self-report AUC = 0.850, 95% CI: 0.807–0.894). The median length of the clinician-administered assessment was 5 minutes (interquartile range [IQR]: 3:23–8:29 min) and 1 minute, 20 seconds (IQR: 0:57–2:09 min) for the self-report. Conclusion CAT-Psychosis can quickly and reliably assess the severity of psychosis and discriminate psychotic patients from healthy controls, creating an opportunity for frequent remote assessment and patient/population-level follow-up.

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Test–retest reliability of laser evoked pain perception and fMRI BOLD responses

Scientific Reports ◽

10.1038/s41598-020-79196-z ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Yanzhi Bi ◽

Xin Hou ◽

Jiahui Zhong ◽

Li Hu

Keyword(s):

Resting State ◽

Repeated Measures ◽

Subjective Experience ◽

Pain Perception ◽

Primary Motor Cortex ◽

Intraclass Correlation ◽

Retest Reliability ◽

Repeated Measures Design ◽

Brain Responses ◽

Test Retest Reliability

AbstractPain perception is a subjective experience and highly variable across time. Brain responses evoked by nociceptive stimuli are highly associated with pain perception and also showed considerable variability. To date, the test–retest reliability of laser-evoked pain perception and its associated brain responses across sessions remain unclear. Here, an experiment with a within-subject repeated-measures design was performed in 22 healthy volunteers. Radiant-heat laser stimuli were delivered on subjects’ left-hand dorsum in two sessions separated by 1–5 days. We observed that laser-evoked pain perception was significantly declined across sessions, coupled with decreased brain responses in the bilateral primary somatosensory cortex (S1), right primary motor cortex, supplementary motor area, and middle cingulate cortex. Intraclass correlation coefficients between the two sessions showed “fair” to “moderate” test–retest reliability for pain perception and brain responses. Additionally, we observed lower resting-state brain activity in the right S1 and lower resting-state functional connectivity between right S1 and dorsolateral prefrontal cortex in the second session than the first session. Altogether, being possibly influenced by changes of baseline mental state, laser-evoked pain perception and brain responses showed considerable across-session variability. This phenomenon should be considered when designing experiments for laboratory studies and evaluating pain abnormalities in clinical practice.

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The Effect of General Anesthesia On Test-Retest Reliability of Resting-State FMRI Metrics And Optimization of Scan Length

10.21203/rs.3.rs-992129/v1 ◽

2021 ◽

Author(s):

Faezeh Vedaei ◽

Mahdi Alizadeh ◽

Victor M Romo ◽

Feroze B. Mohamed ◽

Chengyuan Wu

Keyword(s):

Resting State ◽

Intraclass Correlation ◽

Resting State Fmri ◽

Frequency Fluctuation ◽

Retest Reliability ◽

Factors Affecting ◽

Fractional Frequency ◽

Drug Resistant Epilepsy ◽

Test Retest Reliability ◽

Scan Length

Abstract Resting-state functional magnetic resonance imaging (rs-fMRI) has been known as a powerful tool in neuroscience. However, exploring the test-retest reliability of the metrics derived from rs-fMRI BOLD signal is essential particularly in the studies of patients with neurological development. Two factors affecting reliability of rs-fMRI measurements including the effect of anesthesia and scan length have been estimated in this study. A total of 9 patients with drug-resistant epilepsy (DRE) of requiring interstitial thermal therapy (LITT) were scanned in two states of awake and under anesthesia. At each state, two rs-fMRI sessions were obtained that each one lasted 15 minutes, and the effect of scan length was evaluated. Voxel-wise rs-fMRI metrics including amplitude of low fractional frequency fluctuation (ALFF), amplitude of low fractional frequency fluctuation (fALFF), functional connectivity (FC), and regional homogeneity (ReHo) were measured. Intraclass correlation coefficient (ICC) was calculated to estimate the reliability between two sessions of scanning for both states. Overall, our finding revealed that reliability improves under anesthesia as well as by increasing the scanning length of the scanning sessions. Furthermore, we showed that the optimal scan length to achieve reliable rs-fMRI measurements was 3.1 – 7.5 minutes shorter in an anesthetized, compared to wakeful state.

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Quantification of Muscle Strength and Imbalance in Neurogenic Pes Cavus, Compared to Health Controls, Using Hand-Held Dynamometry

Foot & Ankle International ◽

10.1177/107110070502600708 ◽

2005 ◽

Vol 26 (7) ◽

pp. 540-544 ◽

Cited By ~ 53

Author(s):

Joshua Burns ◽

Anthony Redmond ◽

Robert Ouvrier ◽

Jack Crosbie

Keyword(s):

Muscle Strength ◽

Healthy Controls ◽

Foot And Ankle ◽

Foot Deformity ◽

Pes Cavus ◽

Retest Reliability ◽

Ankle Muscle ◽

Cavus Foot ◽

Muscle Groups ◽

Test Retest Reliability

Background: Pes cavus foot deformity in neuromuscular disease is thought to be related to an imbalance of musculature around the foot and ankle. The most common cause of neurogenic pes cavus is Charcot-Marie-Tooth (CMT) disease. The aim of this investigation was to objectively quantify muscle strength and imbalance using hand-held dynamometry in patients diagnosed with CMT and pes cavus, compared to healthy controls. Methods: Muscles responsible for inversion, eversion, plantarflexion, and dorsiflexion of the foot and ankle were measured in 55 subjects (11 CMT patients with a frank pes cavus, and 44 healthy controls with normal feet) using the Nicholas hand-held dynamometer (HHD). Test-retest reliability of the HHD procedure also was determined for each of the four muscle groups in the healthy controls. Results: Test-retest reliability of the HHD procedure was excellent (ICC3,1 = 0.88 to 0.95) and the measurement error was low (SEM = 0.3 to 0.7 kg). Patients with CMT were significantly weaker than normal for all foot and ankle muscle groups tested ( p <0.001). Strength ratios of inversion-to-eversion and plantarflexion-to-dorsiflexion were significantly higher in the patients with CMT and pes cavus compared to individuals with normal foot types ( p > 0.01). Conclusions: Hand-held dynamometry is an objective and reliable instrument to measure muscle strength and imbalance in patients with CMT and a pes cavus foot deformity.

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Test-retest reliability of task-based and resting-state blood oxygen level dependence and cerebral blood flow measures

PLoS ONE ◽

10.1371/journal.pone.0206583 ◽

2018 ◽

Vol 13 (11) ◽

pp. e0206583 ◽

Cited By ~ 10

Author(s):

Štefan Holiga ◽

Fabio Sambataro ◽

Cécile Luzy ◽

Gérard Greig ◽

Neena Sarkar ◽

...

Keyword(s):

Blood Flow ◽

Cerebral Blood Flow ◽

Resting State ◽

Blood Oxygen ◽

Oxygen Level ◽

Blood Oxygen Level ◽

Retest Reliability ◽

Test Retest Reliability ◽

Blood Oxygen Level Dependence

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Test–retest reliability of spatial patterns from resting-state functional MRI using the restricted Boltzmann machine and hierarchically organized spatial patterns from the deep belief network

Journal of Neuroscience Methods ◽

10.1016/j.jneumeth.2019.108451 ◽

2020 ◽

Vol 330 ◽

pp. 108451 ◽

Cited By ~ 2

Author(s):

Hyun-Chul Kim ◽

Hojin Jang ◽

Jong-Hwan Lee

Keyword(s):

Functional Mri ◽

Spatial Patterns ◽

Resting State ◽

Deep Belief Network ◽

Restricted Boltzmann Machine ◽

Boltzmann Machine ◽

Retest Reliability ◽

Belief Network ◽

Test Retest Reliability

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S198. SELF-DISTURBANCES AND THEIR NEURAL SIGNATURES IN SCHIZOPHRENIA

Schizophrenia Bulletin ◽

10.1093/schbul/sbaa031.264 ◽

2020 ◽

Vol 46 (Supplement_1) ◽

pp. S114-S114

Author(s):

Yulia Zaytseva ◽

Eva Kozakova ◽

Pavel Mohr ◽

Filip Spaniel ◽

Aaron Mishara

Keyword(s):

Resting State ◽

Brain Connectivity ◽

Resting State Fmri ◽

Psychotic Symptoms ◽

Healthy Controls ◽

Healthy Individuals ◽

Motor Speech ◽

Cognitive Domains ◽

Aberrant Salience ◽

First Rank Symptoms

Abstract Background The self-disturbances (SDs) concept is considered to be part of the Schneider’s first rank symptoms, i.e., thought-withdrawal, thought-insertion, thought-broadcasting, somatic-passivity experiences, mental/motor automatisms, disrupted unitary self-experience (Mishara et al., 2014). SDs were originally described by W. Mayer-Gross (1920), who observed them in psychotic patients. Methods We classified Mayer-Gross’ findings on SDs into the following categories: experience is new/compelling (aberrant salience), reduced access/importance of autobiographical past, cognitions/emotions occur independently from self’s volition, foreign agents have power over self and developed an SDs scale based on these categories and cognitive domains (perception, motor, speech, thinking etc.). Scale is applied as a measure of the frequency of the experiences. In our current study on phenomenology and neurobiology of psychotic symptoms, we administered the scale to a study group of patients with schizophrenia (N=84) and healthy volunteers (N=170). Further, the resting state fMRI was performed and the group was divided into two subgroups with (N=13) and without self-disturbances (N=10) and in healthy individuals (N=39). Results We found substantial differences in the frequency of self-disturbances in patients with schizophrenia compared to healthy controls (total score differences, Z=-5.83, p< 0.001). On a neural level, patients with self-disturbances experienced a decreased functional brain connectivity of the default mode and salience networks as compared to the patients without self-disturbances and healthy controls. The differences were mainly explained by the factor ‘’foreign agents’’ and the novelty of the experience. Discussion The scale identifies self-disturbances in schizophrenia and confirms self-related processing in patients with schizophrenia to be associated with altered activation in the cortical midline structures. Supported by the grant projects MH CR AZV 17-32957A and MEYS NPU4NUDZ: LO1611.

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