Effect of Allium sativum extract in combination -with orlistat on insulin resistance and disrupted metabolic hormones in high fat diet induced obese rats

Our objective was to investigate and compare the effects of heat-killed (HK) and liveLactobacillus reuteriGMNL-263 (Lr263) on insulin resistance and its related complications in high-fat diet (HFD)-induced rats.

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Exercise ameliorates insulin resistance via regulating TGFβ-activated kinase 1 (TAK1)-mediated insulin signaling in liver of high-fat diet-induced obese rats

Journal of Cellular Physiology ◽

10.1002/jcp.27508 ◽

2018 ◽

Vol 234 (5) ◽

pp. 7467-7474 ◽

Cited By ~ 2

Author(s):

Yong Zhang ◽

Jianyong Wan ◽

Zhen Xu ◽

Tianmiao Hua ◽

Qingyan Sun

Keyword(s):

Insulin Resistance ◽

Insulin Signaling ◽

High Fat Diet ◽

High Fat ◽

Obese Rats

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Ping-tang Recipe (平糖方) improves insulin resistance and attenuates hepatic steatosis in high-fat diet-induced obese rats

Chinese Journal of Integrative Medicine ◽

10.1007/s11655-012-1023-0 ◽

2012 ◽

Vol 18 (4) ◽

pp. 262-268 ◽

Cited By ~ 7

Author(s):

Shu-yu Yang ◽

Neng-jiang Zhao ◽

Xue-jun Li ◽

Hui-jie Zhang ◽

Ke-ji Chen ◽

...

Keyword(s):

Insulin Resistance ◽

Hepatic Steatosis ◽

High Fat Diet ◽

High Fat ◽

Obese Rats

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Obesity induced by high-fat diet promotes insulin resistance in the ovary

Journal of Endocrinology ◽

10.1677/joe-09-0461 ◽

2010 ◽

Vol 206 (1) ◽

pp. 65-74 ◽

Cited By ~ 56

Author(s):

Eliana H Akamine ◽

Anderson C Marçal ◽

João Paulo Camporez ◽

Mara S Hoshida ◽

Luciana C Caperuto ◽

...

Keyword(s):

Insulin Resistance ◽

Signaling Pathway ◽

Insulin Signaling ◽

High Fat Diet ◽

Ovarian Function ◽

Polycystic Ovary ◽

Insulin Signaling Pathway ◽

Female Rats ◽

High Fat ◽

Obese Rats

Besides the effects on peripheral energy homeostasis, insulin also has an important role in ovarian function. Obesity has a negative effect on fertility, and may play a role in the development of the polycystic ovary syndrome in susceptible women. Since insulin resistance in the ovary could contribute to the impairment of reproductive function in obese women, we evaluated insulin signaling in the ovary of high-fat diet-induced obese rats. Female Wistar rats were submitted to a high-fat diet for 120 or 180 days, and the insulin signaling pathway in the ovary was evaluated by immunoprecipitation and immunoblotting. At the end of the diet period, we observed insulin resistance, hyperinsulinemia, an increase in progesterone serum levels, an extended estrus cycle, and altered ovarian morphology in obese female rats. Moreover, in female obese rats treated for 120 days with the high-fat diet, the increase in progesterone levels occurred together with enhancement of LH levels. The ovary from high-fat-fed female rats showed a reduction in the insulin receptor substrate/phosphatidylinositol 3-kinase/AKT intracellular pathway, associated with an increase in FOXO3a, IL1B, and TNFα protein expression. These changes in the insulin signaling pathway may have a role in the infertile state associated with obesity.

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Freeze-dried jaboticaba peel added to high-fat diet increases HDL-cholesterol and improves insulin resistance in obese rats

Food Research International ◽

10.1016/j.foodres.2012.07.052 ◽

2012 ◽

Vol 49 (1) ◽

pp. 153-160 ◽

Cited By ~ 55

Author(s):

Sabrina Alves Lenquiste ◽

Ângela Giovana Batista ◽

Rafaela da Silva Marineli ◽

Nathalia Romanelli Vicente Dragano ◽

Mário Roberto Maróstica

Keyword(s):

Insulin Resistance ◽

High Fat Diet ◽

Hdl Cholesterol ◽

High Fat ◽

Freeze Dried ◽

Obese Rats

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Hibiscus sabdariffa L. calyx extract prevents the adipogenesis of 3T3-L1 adipocytes, and obesity-related insulin resistance in high-fat diet-induced obese rats

Biomedicine & Pharmacotherapy ◽

10.1016/j.biopha.2021.111438 ◽

2021 ◽

Vol 138 ◽

pp. 111438

Author(s):

Benjarat Janson ◽

Janjira Prasomthong ◽

Wachirawadee Malakul ◽

Tantip Boonsong ◽

Sakara Tunsophon

Keyword(s):

Insulin Resistance ◽

High Fat Diet ◽

Hibiscus Sabdariffa ◽

High Fat ◽

Obese Rats

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Moringa oleifera leaf extract ameliorated high-fat diet-induced obesity, oxidative stress and disrupted metabolic hormones

Clinical Phytoscience ◽

10.1186/s40816-019-0140-0 ◽

2019 ◽

Vol 5 (1) ◽

Cited By ~ 2

Author(s):

Azza I. Othman ◽

Maher A. Amer ◽

Asmaa S. Basos ◽

Mohammed A. El-Missiry

Keyword(s):

Oxidative Stress ◽

Insulin Resistance ◽

Body Weight ◽

Liver Function ◽

High Fat Diet ◽

Leaf Extract ◽

Moringa Oleifera ◽

High Fat ◽

Metabolic Hormones ◽

Lipid Fractions

Abstract Background Obesity is a health problem in many countries, and maintaining a perfect weight is challenging. Moringa oleifera leaf extract (ME) is rich in polyphenols with antioxidant and pharmaceutical potential. The present study investigated the potential protective effect of Moringa oleifera leaf extract against obesity induced from a high-fat diet (HFD), oxidative stress and disruption of metabolic hormones compared to simvastatin (SIM) or their combination. Results Rats fed a HFD for 6 weeks exhibited a significant increase in body weight and levels of serum glucose and lipid fractions, verifying an obesity state. There were also higher levels of insulin and leptin and lower gherlin in sera of HFD rats compared to the levels in control rats. Homeostasis model assessment for insulin resistance (HOMA-IR), quantitative insulin sensitivity check index (QUICKI) and the atherogenic index were elevated, indicating the development of insulin resistance and dyslipidaemia in these rats. These changes were accompanied with a significant increase in oxidative stress, as indicated by elevated lipid peroxidation and protein oxidation with low levels of antioxidants in liver. The activities of liver function enzymes, including aspartate amino transferase, alanine amino transferase, alkaline phosphatase and gamma glutamyltransferase, were also significantly increased in serum. Concurrent treatment with 300 mg/kg ME for 6 weeks ameliorated the increase in body weight and improved the levels of glucose, lipid fractions and metabolic hormones, indicating the anti-obesity effect and amelioration of tissue insulin resistance potential of ME. ME treatment also normalized oxidative stress and antioxidants in liver and improved liver function enzymes, indicating the antioxidant potential of ME. The effects of ME were similar to SIM, and the combination of these agents was better than each agent alone. Conclusion We propose that ME extract has anti-obesity and antioxidant potential and may be used as a lipid-lowering drug to control weight, obesity and its pathophysiological consequences.

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Shrimp oil extracted from the shrimp processing waste reduces the development of insulin resistance and metabolic phenotypes in diet-induced obese rats

Applied Physiology Nutrition and Metabolism ◽

10.1139/apnm-2016-0644 ◽

2017 ◽

Vol 42 (8) ◽

pp. 841-849 ◽

Cited By ~ 8

Author(s):

Sandhya Nair ◽

Jacques Gagnon ◽

Claude Pelletier ◽

Nadia Tchoukanova ◽

Junzeng Zhang ◽

...

Keyword(s):

Oxidative Stress ◽

Insulin Resistance ◽

Glucose Tolerance ◽

Chronic Inflammation ◽

High Fat Diet ◽

High Fat ◽

Low Fat ◽

Low Fat Diet ◽

Obese Rats ◽

Shrimp Oil

Diet-induced obesity, insulin resistance, impaired glucose tolerance, chronic inflammation, and oxidative stress represent the main features of type 2 diabetes mellitus. The present study was conducted to examine the efficacy and mechanisms of shrimp oil on glucose homeostasis in obese rats. Male CD rats fed a high-fat diet (52 kcal% fat) and 20% fructose drinking water were divided into 4 groups and treated with the dietary replacement of 0%, 10%, 15%, or 20% of lard with shrimp oil for 10 weeks. Age-matched rats fed a low-fat diet (10 kcal% fat) were used as the normal control. Rats on the high-fat diet showed impaired (p < 0.05) glucose tolerance and insulin resistance compared with rats fed the low-fat diet. Shrimp oil improved (p < 0.05) oral glucose tolerance, insulin response, and homeostatic model assessment-estimated insulin resistance index; decreased serum insulin, leptin, hemoglobin A1c, and free fatty acids; and increased adiponectin. Shrimp oil also increased (p < 0.05) antioxidant capacity and reduced oxidative stress and chronic inflammation. The results demonstrated that shrimp oil dose-dependently improved glycemic control in obese rats through multiple mechanisms.

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Dietary Glycotoxins Impair Hepatic Lipidemic Profile in Diet-Induced Obese Rats Causing Hepatic Oxidative Stress and Insulin Resistance

Oxidative Medicine and Cellular Longevity ◽

10.1155/2019/6362910 ◽

2019 ◽

Vol 2019 ◽

pp. 1-14 ◽

Cited By ~ 3

Author(s):

C. Neves ◽

T. Rodrigues ◽

J. Sereno ◽

C. Simões ◽

J. Castelhano ◽

...

Keyword(s):

Oxidative Stress ◽

Insulin Resistance ◽

Fatty Acid ◽

High Fat Diet ◽

De Novo ◽

Liver Lipid ◽

Lipid Fraction ◽

De Novo Lipogenesis ◽

High Fat ◽

Obese Rats

Nonalcoholic fatty liver disease (NAFLD) is caused by excessive liver lipid accumulation, but insulin resistance is specifically associated with impaired lipid saturation, oxidation, and storage (esterification), besides increased de novo lipogenesis. We hypothesized that dietary glycotoxins could impair hepatic lipid metabolism in obesity contributing to lipotoxicity-driven insulin resistance and thus to the onset of nonalcoholic steatohepatitis (NASH). In diet-induced obese rats with methylglyoxal-induced glycation, magnetic resonance spectroscopy, mass spectrometry, and gas chromatography were used to assess liver composition in fatty acyl chains and phospholipids. High-fat diet-induced obesity increased liver lipid fraction and suppressed de novo lipogenesis but did not change fatty acid esterification and saturation or insulin sensitivity. Despite a similar increase in total lipid fraction when supplementing the high-fat diet with dietary glycotoxins, impairment in the suppression of de novo lipogenesis and decreased fatty acid unsaturation and esterification were observed. Moreover, glycotoxins also decreased polyunsaturated cardiolipins and caused oxidative stress, portal inflammation, and insulin resistance in high-fat diet-induced obese rats. Dietary glycated products do not change total lipid levels in the liver of obese rats but dramatically modify the lipidemic profile, leading to oxidative stress, hepatic lipotoxicity, and insulin resistance in obesity and thus contribute to the onset of NASH.

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