Special Issue: Epigenetic Regulation of Cancer Progression: Promises and Progress

2021 ◽  
Author(s):  
Aamir Ahmad
Keyword(s):  
Cancer Progression ◽  
Epigenetic Regulation ◽  
Special Issue

scholarly journals Epigenetic regulation of cancer progression by EZH2: from biological insights to therapeutic potential

2018 ◽  
Vol 6 (1) ◽  
Author(s):  
Lu Gan ◽  
Yanan Yang ◽  
Qian Li ◽  
Yi Feng ◽  
Tianshu Liu ◽  
...  
Keyword(s):  
Cancer Progression ◽  
Epigenetic Regulation ◽  
Therapeutic Potential

scholarly journals Promoter Hypermethylation and Suppression of Glutathione Peroxidase 3 Are Associated with Inflammatory Breast Carcinogenesis

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Mona M. Mohamed ◽  
Salwa Sabet ◽  
Dun-Fa Peng ◽  
M. Akram Nouh ◽  
Mohamed El-Shinawi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Glutathione Peroxidase ◽  
Cancer Progression ◽  
Epigenetic Regulation ◽  
Ductal Carcinoma ◽  
Methylation Status ◽  
Promoter Hypermethylation ◽  
Normal Breast ◽  
Glutathione Peroxidase 3 ◽  
Breast Tissues

Reactive oxygen species (ROS) play a crucial role in breast cancer initiation, promotion, and progression. Inhibition of antioxidant enzymes that remove ROS was found to accelerate cancer growth. Studies showed that inhibition of glutathione peroxidase-3 (GPX3) was associated with cancer progression. Although the role of GPX3 has been studied in different cancer types, its role in breast cancer and its epigenetic regulation have not yet been investigated. The aim of the present study was to investigate GPX3 expression and epigenetic regulation in carcinoma tissues of breast cancer patients’ in comparison to normal breast tissues. Furthermore, we compared GPX3 level of expression and methylation status in aggressive phenotype inflammatory breast cancer (IBC) versus non-IBC invasive ductal carcinoma (IDC). We found that GPX3 mRNA and protein expression levels were downregulated in the carcinoma tissues of IBC compared to non-IBC. However, we did not detect significant correlation between GPX3 and patients’ clinical-pathological prosperities. Promoter hypermethylation of GPX3 gene was detected in carcinoma tissues not normal breast tissues. In addition, IBC carcinoma tissues showed a significant increase in the promoter hypermethylation of GPX3 gene compared to non-IBC. Our results propose that downregulation of GPX3 in IBC may play a role in the disease progression.

scholarly journals Specific changes in the expression of imprinted genes in prostate cancer—implications for cancer progression and epigenetic regulation

2012 ◽  
Vol 14 (3) ◽  
pp. 436-450 ◽  
Author(s):  
Teodora Ribarska ◽  
Klaus-Marius Bastian ◽  
Annemarie Koch ◽  
Wolfgang A Schulz
Keyword(s):  
Prostate Cancer ◽  
Cancer Progression ◽  
Epigenetic Regulation ◽  
Imprinted Genes

scholarly journals Epigenetic regulation in cancer progression

2014 ◽  
Vol 4 (1) ◽  
pp. 45 ◽  
Author(s):  
Eva Baxter ◽  
Karolina Windloch ◽  
Frank Gannon ◽  
Jason S Lee
Keyword(s):  
Cancer Progression ◽  
Epigenetic Regulation

scholarly journals Tackle Epithelial-Mesenchymal Transition With Epigenetic Drugs in Cancer

2020 ◽  
Vol 11 ◽  
Author(s):  
Bo Dong ◽  
Zhaoping Qiu ◽  
Yadi Wu
Keyword(s):  
Cancer Progression ◽  
Epigenetic Regulation ◽  
Epithelial Mesenchymal Transition ◽  
Differentiation Process ◽  
Epigenetic Drugs ◽  
Mesenchymal Transition ◽  
Pathological Conditions ◽  
Non Coding Rna ◽  
Histone Modifiers ◽  
Cancer Tumor

Epithelial-mesenchymal Transition (EMT) is a de-differentiation process in which epithelial cells lose their epithelial properties to acquire mesenchymal features. EMT is essential for embryogenesis and wound healing but is aberrantly activated in pathological conditions like fibrosis and cancer. Tumor-associated EMT contributes to cancer cell initiation, invasion, metastasis, drug resistance and recurrence. This dynamic and reversible event is governed by EMT-transcription factors (EMT-TFs) with epigenetic complexes. In this review, we discuss recent advances regarding the mechanisms that modulate EMT in the context of epigenetic regulation, with emphasis on epigenetic drugs, such as DNA demethylating reagents, inhibitors of histone modifiers and non-coding RNA medication. Therapeutic contributions that improve epigenetic regulation of EMT will translate the clinical manifestation as treating cancer progression more efficiently.

scholarly journals Special Issue: “Unraveling the Involvement of Adipose Tissue in Breast Cancer Progression”

2021 ◽  
Vol 22 (10) ◽  
pp. 5107
Author(s):  
Tiziana Triulzi
Keyword(s):  
Breast Cancer ◽  
Adipose Tissue ◽  
Cancer Progression ◽  
White Adipose Tissue ◽  
Immune Cells ◽  
Breast Cancer Progression ◽  
Cell Populations ◽  
Special Issue ◽  
Adipocyte Cell ◽  
Heterogeneous Tissue

White adipose tissue (WAT) is a heterogeneous tissue that is composed of adipocytes and several non-adipocyte cell populations, including adipose progenitors, fibroblasts, endothelial and infiltrating immune cells [...]

scholarly journals Epigenetic Regulation in Prostate Cancer Progression

2018 ◽  
Vol 4 (2) ◽  
pp. 101-115 ◽  
Author(s):  
Katia Ruggero ◽  
Sonia Farran-Matas ◽  
Adrian Martinez-Tebar ◽  
Alvaro Aytes
Keyword(s):  
Prostate Cancer ◽  
Cancer Progression ◽  
Epigenetic Regulation ◽  
Prostate Cancer Progression

scholarly journals Epigenetic Regulation of Epithelial to Mesenchymal Transition in the Cancer Metastatic Cascade: Implications for Cancer Therapy

2021 ◽  
Vol 11 ◽  
Author(s):  
Qiu-Luo Liu ◽  
Maochao Luo ◽  
Canhua Huang ◽  
Hai-Ning Chen ◽  
Zong-Guang Zhou
Keyword(s):  
Cancer Cells ◽  
Cancer Progression ◽  
Epigenetic Regulation ◽  
Cancer Metastasis ◽  
Epithelial To Mesenchymal Transition ◽  
Epithelial Mesenchymal Transition ◽  
Mesenchymal Transition ◽  
Metastatic Cascade ◽  
Subsequent Transformation ◽  
Metastatic Cells

Metastasis is the end stage of cancer progression and the direct cause of most cancer-related deaths. The spreading of cancer cells from the primary site to distant organs is a multistep process known as the metastatic cascade, including local invasion, intravasation, survival in the circulation, extravasation, and colonization. Each of these steps is driven by the acquisition of genetic and/or epigenetic alterations within cancer cells, leading to subsequent transformation of metastatic cells. Epithelial–mesenchymal transition (EMT), a cellular process mediating the conversion of cell from epithelial to mesenchymal phenotype, and its reverse transformation, termed mesenchymal–epithelial transition (MET), together endow metastatic cells with traits needed to generate overt metastases in different scenarios. The dynamic shift between these two phenotypes and their transitional state, termed partial EMT, emphasizes the plasticity of EMT. Recent advances attributed this plasticity to epigenetic regulation, which has implications for the therapeutic targeting of cancer metastasis. In this review, we will discuss the association between epigenetic events and the multifaceted nature of EMT, which may provide insights into the steps of the cancer metastatic cascade.

Quantitative Proteomics of Epigenetic Histone Modifications in MCF-7 cells under Estradiol Stimulation

2021 ◽  
Author(s):  
Yechen Hu ◽  
Hao Jiang ◽  
Baofeng Zhao ◽  
Kaiguang Yang ◽  
Zhen Liang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Progression ◽  
Histone Modifications ◽  
Epigenetic Regulation ◽  
Quantitative Proteomics ◽  
Breast Cancer Progression ◽  
Regulation Mechanism ◽  
Estrogen Exposure ◽  
Estradiol Stimulation ◽  
Mcf 7

Estrogen exposure has already been considered to be associated with tumorigenesis and breast cancer progression. To study the epigenetic regulation mechanism in MCF-7 cells under estrogen exposure, which normally results...

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