Cultivating LGBTQ+ Competent Cancer Research: Recommendations from LGBTQ+ Cancer Survivors, Care Partners, and Community Advocates

Abstract Purpose A healthy lifestyle after colorectal cancer (CRC) diagnosis may improve prognosis. Data related to lifestyle change in CRC survivors are inconsistent and potential interrelated changes are unknown. Methods We assessed dietary intake, physical activity, body mass index (BMI), waist circumference, and smoking among 1072 patients diagnosed with stages I–III CRC at diagnosis, 6 months and 2 years post-diagnosis. An overall lifestyle score was constructed based on the 2018 World Cancer Research Fund/American Institute of Cancer Research recommendations (range 0–7). We used linear mixed models to analyze changes in lifestyle over time. Results Participants had a mean (± SD) age of 65 ± 9 years and 43% had stage III disease. In the 2 years following CRC diagnosis, largest changes were noted for sugary drinks (− 45 g/day) and red and processed meat intake (− 62 g/week). BMI (+ 0.4 kg/m2), waist circumference (+ 2 cm), and dietary fiber intake (− 1 g/day) changed slightly. CRC survivors did not statistically significant change their mean intake of fruits and vegetables, alcohol, or ultra-processed foods nor did they change their physical activity or smoking behavior. Half of participants made simultaneous changes that resulted in improved concordance with one component as well as deteriorated concordance with another component of the lifestyle score. Overall lifestyle score changed from a mean 3.4 ± 0.9 at diagnosis to 3.5 ± 0.9 2 years post-diagnosis. Conclusions CRC survivors hardly improve their overall lifestyle after diagnosis. Implications for Cancer Survivors Given the importance of a healthy lifestyle, strategies to effectively support behavior changes in CRC survivors need to be identified.

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Adherence to the World Cancer Research Fund/American Institute for Cancer Research recommendations and head and neck cancers risk

Oral Oncology ◽

10.1016/j.oraloncology.2016.11.012 ◽

2017 ◽

Vol 64 ◽

pp. 59-64 ◽

Cited By ~ 12

Author(s):

Francesca Bravi ◽

Jerry Polesel ◽

Werner Garavello ◽

Diego Serraino ◽

Eva Negri ◽

...

Keyword(s):

Cancer Research ◽

Head And Neck ◽

Head And Neck Cancers ◽

Research Fund ◽

American Institute ◽

The World ◽

Research Recommendations

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Longitudinal changes in sports activity from pre-diagnosis to first five years post-diagnosis: a prospective Chinese breast cancer cohort study

10.21203/rs.3.rs-35306/v2 ◽

2020 ◽

Author(s):

Yuanyuan Lei ◽

Suzanne C. Ho ◽

Carol Kwok ◽

Ashley Cheng ◽

Ka Li Cheung ◽

...

Keyword(s):

Breast Cancer ◽

Physical Activity ◽

Cancer Research ◽

Cancer Survivors ◽

Cancer Diagnosis ◽

Chinese Women ◽

Activity Level ◽

Significant Difference ◽

The Mean ◽

After Cancer

Abstract Background: To compare change in level of physical activity between pre-and post- diagnosis of breast cancer in Chinese women.Methods: Based on an on-going prospective study consisting of 1462 Chinese women with early-stage breast cancer, a validated modified Chinese Baecke questionnaire was used to measure physical activity at baseline (12 months before cancer diagnosis), 18-, 36- and 60-months after diagnosis (over the previous 12 months before each interview).Results: The mean level of physical activity at post-diagnosis was 9.6 metabolic equivalent of task (MET)-hours/week, which was significantly higher than that at pre-diagnosis with mean level of 5.9 MET-hours/week ( P < 0.001). The mean levels of physical activity at 18-, 36- and 60-months follow-up were 9.9, 9.8 and 9.3 MET-hours/week, respectively. There was no significant difference between any two of the three follow-ups at post-diagnosis. The proportions of participant who met World Cancer Research Fund/ American Institute for Cancer Research (WCRF/AICR) recommendation before and after cancer diagnosis were both low, being 20.7% and 35.1%, respectively. Compared to pre-diagnosis, most of the patients improved or had no change on level of physical activity at post-diagnosis, with the respective proportion being 48.2% and 43.8%.Conclusions: Adherence to current lifestyle recommendation for cancer survivors, Chinese women with breast cancer significantly increased level of physical activity level after cancer diagnosis, and such improvement was sustained to five years post-diagnosis. The proportion of patients who met the exercise recommendation for cancer survivors was still low. Encouraging patients on the importance of durable high level of physical activity in breast cancer survivorship is warranted.

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Dietary Supplement Use and Interactions with Tamoxifen and Aromatase Inhibitors in Breast Cancer Survivors Enrolled in Lifestyle Interventions

Nutrients ◽

10.3390/nu13113730 ◽

2021 ◽

Vol 13 (11) ◽

pp. 3730

Author(s):

Maura Harrigan ◽

Courtney McGowan ◽

Annette Hood ◽

Leah M. Ferrucci ◽

ThaiHien Nguyen ◽

...

Keyword(s):

Breast Cancer ◽

Cancer Research ◽

Cancer Survivors ◽

Dietary Supplements ◽

Dietary Supplement ◽

Breast Cancer Survivors ◽

Lifestyle Interventions ◽

Supplement Use ◽

Dietary Supplement Use ◽

Potential Interactions

The use of dietary supplements is common in the general population and even more prevalent among cancer survivors. The World Cancer Research Fund/American Institute for Cancer Research specifies that dietary supplements should not be used for cancer prevention. Several dietary supplements have potential pharmacokinetic and pharmacodynamic interactions that may change their clinical efficacy or potentiate adverse effects of the adjuvant endocrine therapy prescribed for breast cancer treatment. This analysis examined the prevalence of self-reported dietary supplement use and the potential interactions with tamoxifen and aromatase inhibitors (AIs) among breast cancer survivors enrolled in three randomized controlled trials of lifestyle interventions conducted between 2010 and 2017. The potential interactions with tamoxifen and AIs were identified using the Natural Medicine Database. Among 475 breast cancer survivors (2.9 (mean) or 2.5 (standard deviation) years from diagnosis), 393 (83%) reported using dietary supplements. A total of 108 different types of dietary supplements were reported and 36 potential adverse interactions with tamoxifen or AIs were identified. Among the 353 women taking tamoxifen or AIs, 38% were taking dietary supplements with a potential risk of interactions. We observed a high prevalence of dietary supplement use among breast cancer survivors and the potential for adverse interactions between the prescribed endocrine therapy and dietary supplements was common.

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Associations of the dietary World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) recommendations with patient-reported outcomes in colorectal cancer survivors 2–10 years post-diagnosis: a cross-sectional analysis

British Journal Of Nutrition ◽

10.1017/s0007114520003487 ◽

2020 ◽

pp. 1-13

Author(s):

Marlou-Floor Kenkhuis ◽

Bernadette W. A. van der Linden ◽

Jose J. L. Breedveld-Peters ◽

Janna L. Koole ◽

Eline H. van Roekel ◽

...

Keyword(s):

Colorectal Cancer ◽

Cancer Research ◽

Cancer Survivors ◽

Physical Functioning ◽

Patient Reported Outcomes ◽

Fruit And Vegetables ◽

Research Fund ◽

American Institute ◽

Cross Sectional ◽

Patient Reported

Abstract The World Cancer Research Fund and American Institute for Cancer Research (WCRF/AICR) advise cancer survivors to follow their lifestyle recommendations for cancer prevention. Adhering to these recommendations may have beneficial effects on patient-reported outcomes after a cancer diagnosis, but evidence is scarce. We aimed to assess associations of the individual dietary WCRF/AICR recommendations regarding fruit and vegetables, fibre, fast foods, red and processed meat, sugar-sweetened drinks and alcohol consumption with patient-reported outcomes in colorectal cancer (CRC) survivors. Cross-sectional data of 150 stage I–III CRC survivors, 2–10 years post-diagnosis, were used. Dietary intake was measured by 7-d dietary records. Validated questionnaires were used to measure health-related quality of life (HRQoL), fatigue and neuropathy. Confounder-adjusted linear regression models were used to analyse associations of each WCRF/AICR dietary recommendation with patient-reported outcomes. Higher vegetable intake (per 50 g) was associated with better global QoL (β 2·6; 95 % CI 0·6, 4·7), better physical functioning (3·3; 1·2, 5·5) and lower levels of fatigue (−4·5; −7·6, −1·4). Higher fruit and vegetables intake (per 100 g) was associated with better physical functioning (3·2; 0·8, 5·5) and higher intake of energy-dense food (per 100 kJ/100 g) with worse physical functioning (−4·2; −7·1, −1·2). No associations of dietary recommendations with neuropathy were found. These findings suggest that adhering to specific dietary WCRF/AICR recommendations is associated with better HRQoL and less fatigue in CRC survivors. Although the recommendations regarding healthy dietary habits may be beneficial for the well-being of CRC survivors, longitudinal research is warranted to gain insight into the direction of associations.

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Adherence to the World Cancer Research Fund/American Institute for Cancer Research recommendations and colorectal cancer risk

European Journal of Cancer ◽

10.1016/j.ejca.2017.08.015 ◽

2017 ◽

Vol 85 ◽

pp. 86-94 ◽

Cited By ~ 41

Author(s):

Federica Turati ◽

Francesca Bravi ◽

Matteo Di Maso ◽

Cristina Bosetti ◽

Jerry Polesel ◽

...

Keyword(s):

Colorectal Cancer ◽

Cancer Research ◽

Cancer Risk ◽

Colorectal Cancer Risk ◽

Research Fund ◽

American Institute ◽

The World ◽

Research Recommendations

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Exploring Views of Healthcare Professionals, Researchers, and People Living with and beyond Colorectal Cancer on a Healthy-Eating and Active Lifestyle Resource

Nutrients ◽

10.3390/nu11102482 ◽

2019 ◽

Vol 11 (10) ◽

pp. 2482 ◽

Cited By ~ 1

Author(s):

Jana Sremanakova ◽

Debra Jones ◽

Richard Cooke ◽

Sorrel Burden

Keyword(s):

Cancer Research ◽

Cancer Survivors ◽

Healthy Eating ◽

Healthcare Professionals ◽

Bowel Cancer ◽

Evidence Based ◽

Framework Analysis ◽

Active Lifestyle ◽

Research Guidelines ◽

Risk Of Cancer

Background: People after bowel cancer are at high risk of cancer recurrences and co-morbidities, and therefore strategies are needed to reduce these risks. One promising strategy targets modifiable lifestyle factors including diet and physical activity. However, effective, evidence-based resources in adopting new lifestyle habits are currently lacking. Methods: The Healthy-Eating and Active Lifestyle After Bowel Cancer (HEAL ABC) resource was developed incorporating behavior change theory and World Cancer Research Fund and American Institute of Cancer Research guidelines. Focus groups and telephone interviews were conducted with professionals and survivors (age ≥18 years) to obtain feedback on the resource layout, structure, and content. Recorded data were transcribed verbatim and analyzed using framework analysis. Results: Thirty participants evaluated the resource—19 cancer survivors and 11 professionals. Survivors’ mean age was 62 years (SD 11.5), 11 (58%) were females and 8 (42%) were male. Professionals were all females and mean age was 40 years (SD 6.06). Both survivors and professionals evaluated the resource as useful and provided suggestions for improvements. Conclusions: HEAL ABC is an evidence-based resource designed to aid cancer survivors in translating their motivation into action. It was valued positively by both survivors and healthcare professionals and viewed as filling a gap in post-treatment advice.

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1031 Exploring the Impact of Cognitive Behavioral Therapy for Insomnia (CBT-I) on Daytime Productivity in Survivors of Breast Cancer

SLEEP ◽

10.1093/sleep/zsaa056.1027 ◽

2020 ◽

Vol 43 (Supplement_1) ◽

pp. A392-A392

Author(s):

J Kieley ◽

N Walsh ◽

J McCarthy ◽

E Powell ◽

S N Garland

Keyword(s):

Breast Cancer ◽

Cancer Research ◽

Cognitive Behavioral Therapy ◽

Cancer Survivors ◽

Breast Cancer Survivors ◽

Behavioral Therapy ◽

Work Productivity ◽

Cognitive Behavioral ◽

Activity Impairment ◽

The Impact

Abstract Introduction Post-treatment insomnia disorder and fatigue symptoms can impair work and daytime productivity in breast cancer survivors. Cognitive Behavioral Therapy for Insomnia (CBT-I) significantly improves insomnia and daytime fatigue. This feasibility study examined whether improving insomnia and fatigue using CBT-I is associated with improved work and activity productivity in breast cancer survivors. Methods 10 survivors of early stage breast cancer participated in 7 weekly individual CBT-I sessions. The primary outcome was the Work Productivity and Activity Impairment Questionnaire-General Health (WPAIQ-GH) questionnaire. Secondary outcomes were the Insomnia Severity Index (ISI) and the Multidimensional Fatigue Symptom Inventory-Short Form (MFSI-SF). Assessments were conducted at baseline and post-treatment. Paired samples t-tests examined the impact of CBT-I on productivity and fatigue. Linear regression assessed whether change in fatigue was associated with change in productivity. Results Participants had a mean age of 50.8 (range 42-63) and the majority were diagnosed with stage II (60%) cancer. There was a significant reduction in fatigue [t(9)= 2.43, p =.04] and activity impairment due to insomnia [t(9)= 3.105, p <.05] following treatment. Insomnia affected 52% of work productivity at baseline with a non-significant decrease to 15% following treatment [t(3)= 2.25 p= .110]. Reductions in fatigue were significantly associated with reductions in activity impairment [F(1,8)= 7.25, p =.03], accounting for 47.5% of the variability. Conclusion Treating insomnia with CBT-I significantly improved daytime productivity, activity impairment, and fatigue. Controlled research with larger sample sizes is warranted to confirm these preliminary results. Support Nyissa Walsh is a trainee in the Cancer Research Training Program of the Beatrice Hunter Cancer Research Institute (BHCRI). Dr. Sheila Garland is supported by a Scotiabank New Investigator Award from BHCRI.

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