scholarly journals Dietary Supplement Use and Interactions with Tamoxifen and Aromatase Inhibitors in Breast Cancer Survivors Enrolled in Lifestyle Interventions

Nutrients ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 3730
Author(s):  
Maura Harrigan ◽  
Courtney McGowan ◽  
Annette Hood ◽  
Leah M. Ferrucci ◽  
ThaiHien Nguyen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Research ◽  
Cancer Survivors ◽  
Dietary Supplements ◽  
Dietary Supplement ◽  
Breast Cancer Survivors ◽  
Lifestyle Interventions ◽  
Supplement Use ◽  
Dietary Supplement Use ◽  
Potential Interactions

The use of dietary supplements is common in the general population and even more prevalent among cancer survivors. The World Cancer Research Fund/American Institute for Cancer Research specifies that dietary supplements should not be used for cancer prevention. Several dietary supplements have potential pharmacokinetic and pharmacodynamic interactions that may change their clinical efficacy or potentiate adverse effects of the adjuvant endocrine therapy prescribed for breast cancer treatment. This analysis examined the prevalence of self-reported dietary supplement use and the potential interactions with tamoxifen and aromatase inhibitors (AIs) among breast cancer survivors enrolled in three randomized controlled trials of lifestyle interventions conducted between 2010 and 2017. The potential interactions with tamoxifen and AIs were identified using the Natural Medicine Database. Among 475 breast cancer survivors (2.9 (mean) or 2.5 (standard deviation) years from diagnosis), 393 (83%) reported using dietary supplements. A total of 108 different types of dietary supplements were reported and 36 potential adverse interactions with tamoxifen or AIs were identified. Among the 353 women taking tamoxifen or AIs, 38% were taking dietary supplements with a potential risk of interactions. We observed a high prevalence of dietary supplement use among breast cancer survivors and the potential for adverse interactions between the prescribed endocrine therapy and dietary supplements was common.

Vitamin and Mineral Supplement Use Among US Adults After Cancer Diagnosis: A Systematic Review

2008 ◽  
Vol 26 (4) ◽  
pp. 665-673 ◽  
Author(s):  
Christine M. Velicer ◽  
Cornelia M. Ulrich
Keyword(s):  
Cancer Survivors ◽  
Cancer Patients ◽  
Dietary Supplement ◽  
Breast Cancer Survivors ◽  
The United States ◽  
Cancer Site ◽  
Mineral Supplement ◽  
Prostate Cancer Survivors ◽  
Supplement Use ◽  
Dietary Supplement Use

Vitamin and mineral supplement use is thought to be common among the 10 million adults in the United States who have been diagnosed with cancer; however, well-conducted studies of this topic are sparse. Moreover, the biologic effects of supplement use among cancer survivors are not well established and not necessarily beneficial. We present a systematic summary of studies published between 1999 and 2006, 32 in total, addressing vitamin and mineral supplement use among US adult cancer patients and survivors. Supplement use is widespread among cancer patients and longer-term survivors. In studies combining different cancer sites, 64% to 81% of survivors reported using any vitamin or mineral supplements and 26% to 77% reported using any multivitamins. In contrast, approximately 50% of US adults use dietary supplements and 33% use multivitamin/multimineral supplements. Between 14% and 32% of survivors initiate supplement use after diagnosis, and use differs by cancer site. Breast cancer survivors reported the highest use, whereas prostate cancer survivors reported the least. Higher level of education and female sex emerged as factors most consistently associated with supplement use. Up to 68% of physicians are unaware of supplement use among their cancer patients. These results highlight the need for further studies of the association between dietary supplement use and cancer treatment toxicity, recurrence, survival, and quality of life to support evidence-based clinical guidelines for dietary supplement use among cancer patients and longer-term survivors.

scholarly journals Dietary Supplement Use among Adult Cancer Survivors in the United States

2020 ◽  
Vol 150 (6) ◽  
pp. 1499-1508
Author(s):  
Mengxi Du ◽  
Hanqi Luo ◽  
Jeffrey B Blumberg ◽  
Gail Rogers ◽  
Fan Chen ◽  
...  
Keyword(s):  
Cancer Survivors ◽  
Dietary Supplements ◽  
Dietary Supplement ◽  
Nutrient Intake ◽  
The United States ◽  
Vitamin B ◽  
Nutrient Intakes ◽  
Supplement Use ◽  
Adult Cancer Survivors ◽  
Dietary Supplement Use

ABSTRACT Background Many cancer patients initiate dietary supplement use after cancer diagnosis. How dietary supplement use contributes to the total nutrient intake among cancer survivors as compared with individuals without cancer needs to be determined. Objectives We aimed to evaluate nutrient intakes from dietary supplements among cancer survivors in relation to their total nutrient intake and compare those with individuals without cancer. Methods We evaluated the prevalence, dose, and reason for using dietary supplements among 2772 adult cancer survivors and 31,310 individuals without cancer who participated in the NHANES 2003–2016. Results Cancer survivors reported a higher prevalence of any (70.4% vs. 51.2%) and multivitamin/mineral (48.9% vs. 36.6%) supplement use and supplement use of 11 individual vitamins and 8 minerals than individuals without cancer. Overall, cancer survivors had significantly higher amounts of nutrient intake from supplements but lower nutrient intakes from foods for the majority of the nutrients. Compared with individuals without cancer, cancer survivors had a higher percentage of individuals with inadequate intake (total nutrient intake <Estimated Average Requirement or Adequate Intake) for folate, vitamin B-6, niacin, calcium, copper, and phosphorus, due to lower intakes of these nutrients from foods. Cancer survivors also had a higher proportion of individuals with excess intake (total nutrient intake ≥Tolerable Upper Intake Level) for vitamin D, vitamin B-6, niacin, calcium, magnesium, and zinc, contributed by higher intakes of these nutrients from dietary supplements. Nearly half (46.1%) used dietary supplements on their own without consulting health care providers. Conclusions Cancer survivors reported a higher prevalence and dose of dietary supplement use but lower amounts of nutrient intake from foods than individuals without cancer. The inadequate nutrient intake from foods and the short-term and long-term health impact of dietary supplement use, especially at high doses, need to be further evaluated among cancer survivors.

Dietary Supplement Use Among Adult Cancer Survivors in the United States

2019 ◽  
Author(s):  
Mengxi Du ◽  
Jeffrey B. Blumberg ◽  
Zhilei Shan ◽  
Gail Rogers ◽  
Fan Chen ◽  
...  
Keyword(s):  
United States ◽  
Cancer Survivors ◽  
Dietary Supplement ◽  
The United States ◽  
Supplement Use ◽  
Adult Cancer Survivors ◽  
Dietary Supplement Use

scholarly journals Dietary supplement use in elementary school children: a Japanese web-based survey

2021 ◽  
Vol 26 (1) ◽  
Author(s):  
Kazue Ishitsuka ◽  
Satoshi Sasaki ◽  
Hidetoshi Mezawa ◽  
Mizuho Konishi ◽  
Maki Igarashi ◽  
...  
Keyword(s):  
Dietary Supplements ◽  
Dietary Supplement ◽  
Sports Participation ◽  
Web Based ◽  
Mineral Supplements ◽  
Supplement Use ◽  
Health Related Behaviors ◽  
Health Related ◽  
Dietary Supplement Use ◽  
Frequency Of Sports Participation

Abstract Background A variety of dietary supplements are commercially available. However, the efficacy and safety of dietary supplement use in children are not well established. Understanding dietary supplement use is important for developing public health policy regarding dietary supplements. This study aimed to investigate the types of dietary supplements used and characteristics of dietary supplement users among Japanese elementary school children. Method We conducted a cross-sectional web-based questionnaire study. Dietary supplement use, socio-demographics, and health-related behaviors were assessed through mother-reported questionnaire. Types of dietary supplements were identified based on ingredient using product barcodes and brand names. Multivariate logistic regression analysis was conducted to investigate the socio-demographics and health-related behaviors associated with supplement use. Results Among 4933 children, 333 (6.8%) were identified as dietary supplement users. The most common supplement was amino acids or protein (1.4%), followed by n–3 fatty acids or fish oil (1.0%), probiotics (1.0%), multivitamins (0.9%), multivitamin-minerals (0.8%), and botanicals (0.8%). Overall, any dietary supplement use was significantly associated with the highest frequency of sports participation (odds ratio [OR], 2.58; 95% confidence interval [CI], 1.65–4.02), highest household income (OR, 1.87; 95% CI, 1.13–3.10), highest maternal educational level (OR, 1.82; 95% CI, 1.31–2.52), and male sex (OR, 1.38; 95% CI, 1.09–1.75). The highest frequency of sports participation was significantly associated with higher odds of use of amino acids or protein (OR, 6.06; 95% CI, 1.78–20.6) and multivitamins (OR, 3.56; 95% CI, 1.11–11.5), compared to the lowest frequency of sports participation. Conclusion This study showed that Japanese children primarily use non-vitamin, non-mineral supplements. Non-vitamin, non-mineral supplements should thus be included in future studies aimed at monitoring dietary supplement use. We also found that dietary supplement use in children was associated with sports participation. Guidelines for dietary supplement use for children, in particular sport participants, are needed.

scholarly journals Use of dietary supplements in pregnant women in relation to sociodemographic factors – a report from The Environmental Determinants of Diabetes in the Young (TEDDY) study

2013 ◽  
Vol 16 (8) ◽  
pp. 1390-1402 ◽  
Author(s):  
Carin Andrén Aronsson ◽  
Kendra Vehik ◽  
Jimin Yang ◽  
Ulla Uusitalo ◽  
Kristen Hay ◽  
...  
Keyword(s):  
Vitamin D ◽  
Pregnant Women ◽  
Dietary Supplements ◽  
Dietary Supplement ◽  
Maternal Age ◽  
Environmental Determinants ◽  
Supplement Use ◽  
The Usa ◽  
Dietary Supplement Use ◽  
Prospective Longitudinal

AbstractObjectivesThe aim of the present study was to examine the prevalence and associated factors of dietary supplement use, particularly supplements containing vitamin D and fatty acids, in pregnant women enrolled in a multi-national study.DesignThe Environmental Determinants of Diabetes in the Young (TEDDY) study is a prospective longitudinal cohort study. Maternal dietary supplement use was self-reported through questionnaires at month 3 to 4 postpartum.SettingSix clinical research centres; three in the USA (Colorado, Georgia/Florida and Washington) and three in Europe (Sweden, Finland and Germany).SubjectsMothers (n 7326) to infants screened for high-risk HLA-DQ genotypes of type 1 diabetes.ResultsNinety-two per cent of the 7326 women used one or more types of supplement during pregnancy. Vitamin D supplements were taken by 65 % of the women, with the highest proportion of users in the USA (80·5 %). Overall, 16 % of the women reported taking fatty acid supplements and a growing trend was seen in all countries between 2004 and 2010 (P < 0·0001). The use was more common in Germany (32 %) and the USA (24 %) compared with Finland (8·5 %) and Sweden (7·0 %). Being pregnant with the first child was a strong predictor for any supplement use in all countries. Low maternal age (<25 years), higher education, BMI ≥ 25·0 kg/m2 and smoking during pregnancy were factors associated with supplement use in some but not all countries.ConclusionsThe majority of the women used dietary supplements during pregnancy. The use was associated with sociodemographic and behavioural factors, such as parity, maternal age, education, BMI and maternal smoking.

scholarly journals The Prevalence of Dietary Supplement Use Among Elementary, Junior High, and High School Students: A Nationwide Survey in Japan

Nutrients ◽  
2018 ◽  
Vol 10 (9) ◽  
pp. 1176 ◽  
Author(s):  
Etsuko Kobayashi ◽  
Chiharu Nishijima ◽  
Yoko Sato ◽  
Keizo Umegaki ◽  
Tsuyoshi Chiba
Keyword(s):  
High School ◽  
High School Students ◽  
Adverse Events ◽  
Dietary Supplements ◽  
Dietary Supplement ◽  
Parental Education ◽  
Junior High ◽  
The Internet ◽  
Supplement Use ◽  
Dietary Supplement Use

The prevalence of dietary supplement use, such as vitamins, minerals, or fish oil, has increased among children in Japan; however, whether children are using dietary supplements appropriately remains unclear. This study aimed to determine dietary supplement use among children. In August 2017, a nationwide internet preliminary survey of 265,629 mothers aged from 25 to 59 years old was undertaken. Of these, 19,041 mothers of children attending either elementary school, junior high school, or high school were selected. Among them, 16.4% were currently providing their children with dietary supplements and 5.2% had previously given dietary supplements to their children. The prevalence of dietary supplement use was higher in boys than in girls, and the prevalence increased according to their grade. A total of 2439 participants were eligible to undertake a targeted survey on dietary supplement use. Dietary supplements were being taken to maintain health, supplement nutrients, and enhance growth in both boys and girls, and many children (37.5%) were provided with vitamin and mineral supplements. Mothers mainly obtained information concerning dietary supplements via the internet, and supplements were purchased in drug stores or via the internet. The prevalence of dietary supplement use in mothers was 65.4% and may be associated with the prevalence rates in children. Some mothers reported adverse events (3.6%) in their children, such as stomachache, diarrhea, nausea and vomiting, and constipation. The cause-and-effect relationships for adverse events were not clear, but some children were given products for adults. Children are more influenced by dietary supplements compared to adults. To prevent adverse events due to inappropriate use, parental education concerning dietary supplements is essential.

scholarly journals The Use of Dietary Supplements Among African and Caribbean Women Living in the UK: A Cross-Sectional Study

Nutrients ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 847
Author(s):  
Amanda Rodrigues Amorim Adegboye ◽  
Omorogieva Ojo ◽  
Gulshanara Begum
Keyword(s):  
Vitamin D ◽  
Dietary Supplements ◽  
Dietary Supplement ◽  
High Cholesterol ◽  
Black African ◽  
Supplement Use ◽  
Caribbean Women ◽  
Black Caribbean ◽  
Dietary Supplement Use ◽  
The Uk

Previous studies have shown that the use of dietary supplements is associated with the prevention of birth defects, negative pregnancy outcomes and cardiovascular diseases. However, there might be some ethnic disparities in supplement usage suggesting that women who could benefit from it are not frequent users. This study aimed to characterise the use of dietary supplement among Black African and Black Caribbean women living in the United Kingdom (UK). Furthermore, it evaluated possible associations between the use of dietary supplements and health and diet awareness. A total of 262 women self-ascribed as Black African and Black Caribbean living in the UK completed a comprehensive questionnaire on socio-demographic factors, diet, use of supplements and cultural factors. The main outcome variable was the regular use of any type of dietary supplement. Use of vitamin D and/or calcium was also explored. A stepwise logistic regression analysis was applied to identify predictors of regular use of dietary supplements. A total of 33.2% of women reported regular use of any dietary supplements and 16.8% reported use of vitamin D and/or calcium. There were no significant ethnic differences in the use of dietary supplements. Reporting use of the back of food packaging label (odds ratio (OR) 2.21; 95% CI 1.07–4.55); a self-rated healthy diet (OR 2.86; 95% CI 1.19–6.91) and having cardiovascular disease (CVD), hypertension and/or high cholesterol (OR 3.81; 95% CI 1.53–9.49) increased the likelihood of using any dietary supplement. However, having poorer awareness decreased the likelihood (OR 0.94; 95% CI 0.88–0.99) of using any dietary supplement. For the use of vitamin D and/or calcium supplements, the main predictor was having CVD, hypertension and/or high cholesterol (OR 4.43; 95% CI 1.90–10.35). The prevalence of dietary supplement use was low among African and Caribbean women. Thus, awareness of potential benefits of some dietary supplements (e.g., vitamin D) among the Black population should be promoted.

scholarly journals Dietary Supplement Use Among Chinese Primary School Students: A Cross-Sectional Study in Hunan Province

2019 ◽  
Vol 16 (3) ◽  
pp. 374 ◽  
Author(s):  
Hanmei Liu ◽  
Shiya Zhang ◽  
Hanshuang Zou ◽  
Yuanlin Pan ◽  
Qiping Yang ◽  
...  
Keyword(s):  
Primary School ◽  
Dietary Supplements ◽  
Dietary Supplement ◽  
Cross Sectional Study ◽  
Hunan Province ◽  
Primary School Students ◽  
School Students ◽  
Cross Sectional ◽  
Supplement Use ◽  
Dietary Supplement Use

Dietary supplement use is increasing globally, especially among children. However, few studies have been conducted to examine dietary supplement use among Chinese children. The aim of this study was to examine the prevalence of dietary supplement use and the associated factors in primary school students. A cross-sectional study was conducted in four primary schools in Hunan province, China. A total of 706 Chinese parents/caregivers of school children aged 6–12 years old were enrolled. Self-administrated questionnaires were used to collect information about the children’s dietary supplement use, and their socio-demographic characteristics. The prevalence of dietary supplement use in primary school students was 20.4%. Calcium (16.7%), vitamin C (9.2%), and vitamin D (8.5%) were the most commonly used types of dietary supplement. The main reasons for parents/caregivers to purchase dietary supplements for their children were immunity improvement (43.6%), and for growth promotion (36.5%). Some caregivers (26.4%) purchased dietary supplements online, including from dubious or unknown sellers. However, 37.5% of caregivers did not receive formal guidance on supplementation even if they purchased their supplements through formal channels. Parents/caregivers were unclear about the appropriate choices for children’s dietary supplement use. Guidelines and counseling regarding dietary supplements for children may be helpful in public health work.

scholarly journals Determinants of dietary supplement use – healthy individuals use dietary supplements

2015 ◽  
Vol 113 (12) ◽  
pp. 1993-2000 ◽  
Author(s):  
Christina L. F. Kofoed ◽  
Jane Christensen ◽  
Lars O. Dragsted ◽  
Anne Tjønneland ◽  
Nina Roswall
Keyword(s):  
Dietary Supplements ◽  
Dietary Supplement ◽  
Risk Index ◽  
Metabolic Risk ◽  
Health Index ◽  
Danish Population ◽  
Supplement Use ◽  
Urinary Glucose ◽  
Dietary Supplement Use ◽  
Additional Point

The prevalence of dietary supplement use varies largely among populations, and previous studies have indicated that it is high in the Danish population compared with other European countries. The diversity in supplement use across countries indicates that cultural and environmental factors could influence the use of dietary supplements. Only few studies investigating the use of dietary supplements have been conducted in the Danish population. The present cross-sectional study is based on 54 948 Danes, aged 50–64 years, who completed self-administrated questionnaires on diet, dietary supplements and lifestyle between 1993 and 1997. A health index including smoking, physical activity, alcohol and diet, and a metabolic risk index including waist circumference, urinary glucose and measured hypertension were constructed. Logistic regression was used to investigate these determinants in relation to the intake of dietary supplements. We found that 71 % of the participants were dietary supplement users; female sex, older age groups and higher educated participants were more likely to be users of any dietary supplements. One additional point in the health index was associated with 19, 16 and 9 % higher likelihood of being user of any, more common and less common supplements, respectively. In the metabolic risk index, one additional point was associated with 17 and 16 % lower likelihood of being user of any supplement and more common supplements, respectively. No significant association was found for less common supplement use. In conclusion, those with the healthiest lifestyle were more likely to use dietary supplements. Thus, lifestyle and dietary composition should be considered as confounders on supplement use and health outcomes.

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