Functionalization of mesoporous organosilica nanocarrier for pH/glutathione dual-responsive drug delivery and imaging of cancer therapy process

Talanta ◽  
2018 ◽  
Vol 177 ◽  
pp. 203-211 ◽  
Author(s):  
Lin-Lin Hu ◽  
Jie Meng ◽  
Dan-Dan Zhang ◽  
Ming-Li Chen ◽  
Yang Shu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Therapy Process ◽  
Dual Responsive ◽  
Mesoporous Organosilica

scholarly journals Rational design of drug delivery systems for potential programmable drug release and improved therapeutic effect

2019 ◽  
Vol 3 (6) ◽  
pp. 1159-1167 ◽  
Author(s):  
Yuxun Ding ◽  
Jinjian Liu ◽  
Xue Li ◽  
Linlin Xu ◽  
Chang Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Release ◽  
Therapeutic Effect ◽  
Drug Delivery Systems ◽  
Rational Design ◽  
Delivery Systems ◽  
Dual Responsive ◽  
Ph Reduction

pH-Reduction dual responsive nanocarriers (DRNs) achieve programmable release of CA4 and CDDP in cancer therapy.

scholarly journals pH and Redox Dual-Responsive MSN-S-S-CS as a Drug Delivery System in Cancer Therapy

Materials ◽  
2020 ◽  
Vol 13 (6) ◽  
pp. 1279 ◽  
Author(s):  
Yanqin Xu ◽  
Liyue Xiao ◽  
Yating Chang ◽  
Yuan Cao ◽  
Changguo Chen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Release Rate ◽  
Drug Loading ◽  
Impregnation Method ◽  
Amino Groups ◽  
Dual Responsive

In order to achieve a controlled release drug delivery system (DDS) for cancer therapy, a pH and redox dual-responsive mesoporous silica nanoparticles (MSN)-sulfur (S)-S- chitosan (CS) DDS was prepared via an amide reaction of dithiodipropionic acid with amino groups on the surface of MSN and amino groups on the surface of CS. Using salicylic acid (SA) as a model drug, SA@MSN-S-S-CS was prepared by an impregnation method. Subsequently, the stability, swelling properties and drug release properties of the DDS were studied by x-ray diffraction, scanning electron microscopy, Fourier transform infrared microspectroscopy, size and zeta potential as well as Brunauer–Emmett–Teller surface area. Pore size and volume of the composites decreased after drug loading but maintained a stable structure. The calculated drug loading rate and encapsulation efficiency were 8.17% and 55.64%, respectively. The in vitro drug release rate was 21.54% in response to glutathione, and the release rate showed a marked increase as the pH decreased. Overall, double response functions of MSN-S-S-CS had unique advantages in controlled drug delivery, and may be a new clinical application of DDS in cancer therapy.

The facile synthesis of hollow Au nanoflowers for synergistic chemo-photothermal cancer therapy

2015 ◽  
Vol 51 (76) ◽  
pp. 14338-14341 ◽  
Author(s):  
Shengnan Li ◽  
Lingyu Zhang ◽  
Tingting Wang ◽  
Lu Li ◽  
Chungang Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Loading ◽  
Loading Capacity ◽  
Synthetic Route ◽  
Facile Synthesis ◽  
Delivery Performance ◽  
Dual Responsive

A novel, mild and facile synthetic route was first developed to fabricate hollow Au nanoflowers (designated as H-AuNFs) with drug loading capacity, superior photothermal conversion property and pH/NIR dual-responsive drug delivery performance for chemo-photothermal synergistic cancer therapy in vitro and in vivo.

scholarly journals Recent Development to Explore the Use of Biodegradable Periodic Mesoporous Organosilica (BPMO) Nanomaterials for Cancer Therapy

Pharmaceutics ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 890
Author(s):  
Shanmugavel Chinnathambi ◽  
Fuyuhiko Tamanoi
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Delivery Systems ◽  
Biomedical Application ◽  
The Body ◽  
Functional Surface ◽  
Periodic Mesoporous Organosilica ◽  
Mesoporous Organosilica ◽  
Anti Cancer ◽  
Porous Nanomaterials

Porous nanomaterials can be used to load various anti-cancer drugs efficiently and deliver them to a particular location in the body with minimal toxicity. Biodegradable periodic mesoporous organosilica nanoparticles (BPMOs) have recently emerged as promising candidates for disease targeting and drug delivery. They have a large functional surface and well-defined pores with a biodegradable organic group framework. Multiple biodegradation methods have been explored, such as the use of redox, pH, enzymatic activity, and light. Various drug delivery systems using BPMO have been developed. This review describes recent advances in the biomedical application of BPMOs.

Mesoporous organosilica hybrids with a tunable amphoteric framework for controlled drug delivery

2014 ◽  
Vol 2 (38) ◽  
pp. 6487-6499 ◽  
Author(s):  
Madhappan Santha Moorthy ◽  
Ji-Hye Park ◽  
Jae-Ho Bae ◽  
Sun-Hee Kim ◽  
Chang-Sik Ha
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Release ◽  
Controlled Drug Delivery ◽  
Drug Carriers ◽  
Base Hydrolysis ◽  
Mesoporous Organosilica

The integrated nitrile groups in the pore walls of the DU-MSH-CN were converted into reactive –COOH or –NH2groups, by an acid or base hydrolysis technique to achieve large amounts of either –COOH or –NH2groups into the pore walls. Thein vitrodrug release and biocompatibility tests proved the organosilica hybrids suitable for drug carriers in cancer therapy.

Gold nanoshell coated thermo-pH dual responsive liposomes for resveratrol delivery and chemo-photothermal synergistic cancer therapy

2017 ◽  
Vol 5 (11) ◽  
pp. 2161-2171 ◽  
Author(s):  
Meili Wang ◽  
Yanping Liu ◽  
Xuwu Zhang ◽  
Liyao Luo ◽  
Lei Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Stimuli Responsive ◽  
Gold Nanoshell ◽  
Dual Responsive

Stimuli-responsive drug delivery and release have a great significance in cancer therapy.

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