Reproductive toxicity of aluminium—Studies on plasma membrane enzymes in the reproductive organs of mature male albino rats

2018 ◽

pp. 69-86

Author(s):

Asmaa ELnamaky ◽

Amal Halawa ◽

Mamdouh Abouelmaged

Keyword(s):

Reproductive Toxicity ◽

Prostatic Acid Phosphatase ◽

Serum Levels ◽

Reproductive Organs ◽

Male Rats ◽

Albino Rats ◽

Glutathione S Transferase ◽

Significant Drop ◽

Sperm Abnormalities ◽

Pituitary Glands

he present work was designed to investigate the reproductive toxicity induced by oral administration of chlorpyrifos (CPF), cypermethrin (CYP) and their combination in adult male albino rats. Forty mature male albino rats were separated into four groups (10 each), the first group was used as control, while second, third and fourth groups received orally 1/20 LD50 of CPF (10 mg/kg b.wt), 1/20 LD50 of CYP (17.22 mg/kg b.wt) and 1/40 LD50 of CPF plus 1/40 LD50 of CYP (5 mg/kg b.wt CPF plus 8.61 mg/kg b.wt CYP) respectively for 26 days. The results revealed that exposure to CPF and/or CYP induced a significant decrease in the reproductive organs weight. Moreover, a significant decrease in spermatic picture (sperm cell concentration and viability) was observed with high percent of sperm abnormalities. Serum levels of testosterone and pituitary gonadotropins (FSH and LH) have been declined significantly in all treated groups. Significant elevations were observed in malondialdehyde and nitric oxide concentrations, while antioxidant enzymes superoxide dismutase and glutathione-S-transferase activities were decreased significantly as a result of induced oxidative stress. A significant drop in prostatic acid phosphatase activity was observed. Additionally, the results showed some histopathological alterations in the reproductive organs as well as neurological lesions in brain and pituitary glands. In conclusion, CPF and CYP induce deleterious effects on reproductive efficiency of male rats which reflect more obvious impacts when both combined

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Male reproductive toxicity of sodium arsenite in mice

Human & Experimental Toxicology ◽

10.1191/0960327104ht467oa ◽

2004 ◽

Vol 23 (8) ◽

pp. 399-403 ◽

Cited By ~ 88

Author(s):

Niraj Pant ◽

R C Murthy ◽

S P Srivastava

Keyword(s):

Drinking Water ◽

Sodium Arsenite ◽

Sperm Count ◽

Prostate Gland ◽

Reproductive Toxicity ◽

Atomic Absorption Spectrophotometry ◽

Reproductive Organs ◽

Oral Exposure ◽

Human Beings ◽

Testicular Weight

The effect of chronic oral exposure to arsenic on male mouse testicular and accessory sex organ weights, sperm parameters and testicular marker enzymes was studied. In addition, the distribution of arsenic in reproductive organs was measured using atomic absorption spectrophotometry. Sodium arsenite administered to mice (Mus musculus) via drinking water at a dose of 53.39 βmol/L (4 ppm As) for 365 days caused a decrease in the absolute and relative testicular weight. However, epididymal and accessory sex organ weight was similar to control. The activities of marker testicular enzymes such as sorbitol dehydrogenase, acid phosphatase and 17β-hydroxysteroid dehydrogenase (17β-HSD) were significantly decreased, but those of lactate dehydrogenase and γ-glutamyl transpeptidase (γ-GT) were significantly increased. A decrease in sperm count and sperm motility, along with an increase in abnormal sperm, was observed in arsenite-exposed mice. A significant accumulation of arsenic in testes, epididymis, seminal vesicle and prostate gland was observed in treated animals. Thus long term exposure (365 days) at the dose level of 53.39 μmol/L sodium arsenite (4 ppm As), to which human beings are likely to be exposed via drinking water, may cause testicular and spermatotoxic effect.

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Toxicological potential of mycotoxin MT81 and its benzoylated derivative on testicular spermatogenesis and steroidogenesis in mature male Wistar albino rats

Toxicology Mechanisms and Methods ◽

10.3109/15376516.2011.552535 ◽

2011 ◽

Vol 21 (5) ◽

pp. 426-433 ◽

Cited By ~ 4

Author(s):

Sujata Maiti Choudhury ◽

Malaya Gupta ◽

Upal Kanti Majumder

Keyword(s):

Mature Male ◽

Albino Rats ◽

Wistar Albino Rats

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A first observation of spermatogenesis in mature male scalloped hammerheads (Sphyrna lewini) from Zinkwazi, KwaZulu-Natal, South Africa

Fish Physiology and Biochemistry ◽

10.1007/s10695-020-00871-z ◽

2020 ◽

Author(s):

Helené J. Coetzee ◽

Kristina Naidoo ◽

Ina Wagenaar

Keyword(s):

South Africa ◽

Reproductive Organs ◽

Mature Male ◽

Seminiferous Tubules ◽

Stages Of Development ◽

Biometric Data ◽

Sphyrna Lewini ◽

Histological Assessment ◽

Scalloped Hammerhead ◽

Kwazulu Natal

Abstract Sharks are not only threatened, but also have a low fecundity as they are being overfished. The shark family, Sphyrnidae, consists of nine species of which three are found in South African oceans. One of the three Sphyrnidae species, the scalloped hammerhead (Sphyrna lewini) are the most common, but their biology and mode of reproduction are not extensively studied in terms of their reproductive biology. The aim of this study was to describe the germ cell development in the testes of sexually mature male scalloped hammerheads. Three individual male S. lewini were caught at Zinkwazi, KwaZulu-Natal, South Africa. The sharks and their reproductive organs were weighed and measured to collect the biometric data for the condition factor and the gonado-somatic index. Following standard necropsy, the testes were fixed in Bouin’s solution and processed for histological assessment. The histological assessment revealed that the testes of S. lewini consist of seminiferous tubules which form part of a larger lobular structure with germ cells in different stages of development, from spermatogonia to mature spermatozoa. Seven stages of development were identified during the process of spermatogenesis, similar to what has been described for elasmobranchs. In conclusion, this study provides evidence that the testes of S. lewini are diametrical and polyspermatocystic and conforms to the testes structure of elasmobranch males.

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Ameliorative Effects of Honey, Propolis, Pollen, and Royal Jelly Mixture against Chronic Toxicity of Sumithion Insecticide in White Albino Rats

Molecules ◽

10.3390/molecules25112633 ◽

2020 ◽

Vol 25 (11) ◽

pp. 2633 ◽

Cited By ~ 1

Author(s):

Atef M.K. Nassar ◽

Yehia M.M. Salim ◽

Khalid S.A. Eid ◽

Hazem M. Shaheen ◽

Abdullah A. Saati ◽

...

Keyword(s):

Royal Jelly ◽

Corn Oil ◽

Ethylenediaminetetraacetic Acid ◽

Reproductive Organs ◽

Protective Role ◽

Albino Rats ◽

Total Protein Content ◽

Glutathione S Transferase ◽

Significant Toxicity

Sumithion (Fenitrothion) (SUM) is an organophosphorus insecticide used to combat a wide variety of plant pests. Exposure to SUM causes significant toxicity to the brain, liver, kidney, and reproductive organs through, for example, binding to DNA, and it induces DNA damage, which ends with oxidative stress. Therefore, the present study aimed to examine the protective role of bee products: a mixture of honey, propolis, palm pollen, and royal jelly (HPPJ) against SUM-induced toxicity. Twenty-four male albino rats (Rattus norvegicus) were classified into four groups, each containing six rats: control (corn oil), SUM (85 mg/kg; 1/20 LD50), HPPJ, and SUM + HPPJ once daily for 28 consecutive days. Blood samples were gently collected in sterilized ethylenediaminetetraacetic acid (EDTA) tubes for blood picture analyses and tubes without anticoagulant for serum isolation. Serum was used for assays of enzymatic and biochemical characteristics. The results revealed that SUM increased the weights of the liver, kidney, and brain as well as the enzymatic activity of glutathione peroxidase (GP), serum superoxide dismutase (SOD), and glutathione-S-transferase (GST). Additionally, SUM significantly increased the activity of lactate dehydrogenase (LDH), alkaline phosphatase (ALP), and γ-glutamyltransferase (γ-GT) and glucose, uric acid, and creatinine contents, while decreasing the acetylcholine esterase (AChE) activity and total lipids and total protein content. Furthermore, because of the inclusion of phenolic, flavonoids, terpenoids, and sugars, the HPPJ mixture counteracted the hematological, renal, and hepatic toxicity of SUM exposure.

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Reproductive Toxicity of Endosulfan in Male Albino Rats

Bulletin of Environmental Contamination and Toxicology ◽

10.1007/s00128-002-0189-0 ◽

2003 ◽

Vol 70 (2) ◽

pp. 285-289 ◽

Cited By ~ 22

Author(s):

N. Choudhary ◽

S. C. Joshi

Keyword(s):

Reproductive Toxicity ◽

Albino Rats

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Phytomedical Potentials of Chromolaena Odorata Against Arsenic-Induced Testicular Toxicity In Wistar Rats

Nigerian Journal of Basic and Applied Sciences ◽

10.4314/njbas.v27i1.9 ◽

2020 ◽

Vol 27 (1) ◽

pp. 67-75

Author(s):

O.E. Ola-Davies ◽

A.A. Oloye

Keyword(s):

Wistar Rats ◽

Leaf Extract ◽

Sodium Arsenite ◽

Corn Oil ◽

Reproductive Toxicity ◽

Albino Rats ◽

Chromolaena Odorata ◽

Testicular Sperm ◽

Protective Properties ◽

Group B

The testicular, sperm and endocrine protective properties of Chromolaena odorata (CA) in arsenic treated rats were investigated using forty male wistar rats (190-200g) grouped into 4 (A to D) of ten rats each. Oral administrations for 2 weeks of 0.2ml corn oil (A), 2.5mg/kg of sodium arsenite (B), 200mg/kg ethanol leaf extract (ELE) of CA (C), 200mg/kg ELE of CA and 2.5mg/kg sodium arsenite given at 1 hour interval (D) were done. Twenty-four hours after final administrations, semen, blood biochemical and hormonal analyses were carried out after sacrifice of the rats. Results revealed that Group C’s mean scrotal circumference, Left and Right testicular weights were highest across groups and significant compared to group B values (p<0.05). Group C had significantly (P<0.05) highest mean value of sperm motility across the groups just as group A was significantly (p<0.05) higher than those of groups B and D. Significantly low Testosterone and high luteinizing hormone concentrations were observed in group B. It was concluded in this study that ethanol leaf extract of Chromolena odorata had a profound scrotal, testicular, sperm and endocrine protective properties in arsenic-treated wistar strain albino rats. Keywords: Chromolaena odorata, Reproductive toxicity, Arsenic, Testicular, Wistar rats

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