scholarly journals Methamphetamine promotes α-tubulin deacetylation in endothelial cells: The protective role of acetyl-l-carnitine

2015 ◽  
Vol 234 (2) ◽  
pp. 131-138 ◽  
Author(s):  
S. Fernandes ◽  
S. Salta ◽  
T. Summavielle
Keyword(s):  
Endothelial Cells ◽  
Protective Role

scholarly journals Sirt1 Inhibits Oxidative Stress in Vascular Endothelial Cells

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Weijin Zhang ◽  
Qiaobing Huang ◽  
Zhenhua Zeng ◽  
Jie Wu ◽  
Yaoyuan Zhang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Endothelial Cells ◽  
Vascular Endothelial Cells ◽  
Protective Role ◽  
Vascular Endothelial ◽  
Protective Effects ◽  
Beneficial Effects ◽  
Key Factor ◽  
Antioxidative Stress

The vascular endothelium is a layer of cells lining the inner surface of vessels, serving as a barrier that mediates microenvironment homeostasis. Deterioration of either the structure or function of endothelial cells (ECs) results in a variety of cardiovascular diseases. Previous studies have shown that reactive oxygen species (ROS) is a key factor that contributes to the impairment of ECs and the subsequent endothelial dysfunction. The longevity regulator Sirt1 is a NAD+-dependent deacetylase that has a potential antioxidative stress activity in vascular ECs. The mechanisms underlying the protective effects involve Sirt1/FOXOs, Sirt1/NF-κB, Sirt1/NOX, Sirt1/SOD, and Sirt1/eNOs pathways. In this review, we summarize the most recent reports in this field to recapitulate the potent mechanisms involving the protective role of Sirt1 in oxidative stress and to highlight the beneficial effects of Sirt1 on cardiovascular functions.

951 PROTECTIVE ROLE OF APURINIC/APYRIMIDINIC ENDONUCLEASE 1 ON THE OXLDL-INDUCED P66SHC PHOSPHORYLATION IN VASCULAR ENDOTHELIAL CELLS

2012 ◽  
Vol 30 ◽  
pp. e274-e275
Author(s):  
Byeong Hwa Jeon ◽  
Sang Ki Lee ◽  
Myoung Soo Park ◽  
Hee Kyoung Joo ◽  
Eun Jung Cho ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Vascular Endothelial Cells ◽  
Protective Role ◽  
Vascular Endothelial

Evidence for a protective role of placental growth factor in cardiovascular disease

2020 ◽  
Vol 12 (572) ◽  
pp. eabc8587
Author(s):  
Yihong Chen ◽  
Anna Hultgårdh Nilsson ◽  
Isabel Goncalves ◽  
Andreas Edsfeldt ◽  
Gunnar Engström ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Endothelial Cells ◽  
Cardiovascular Risk ◽  
Growth Factor ◽  
Lower Risk ◽  
Protective Role ◽  
Placental Growth Factor ◽  
Trail Receptor ◽  
Population Cohort

Placental growth factor (PlGF) is a mitogen for endothelial cells, but it can also act as a proinflammatory cytokine. Because it promotes early stages of plaque formation in experimental models of atherosclerosis and was implicated in epidemiological associations with risk of cardiovascular disease (CVD), PlGF has been attributed a pro-atherogenic role. Here, we investigated whether PlGF has a protective role in CVD and whether elevated PlGF reflects activation of repair processes in response to vascular stress. In a population cohort of 4742 individuals with 20 years of follow-up, high baseline plasma PlGF was associated with increased risk of cardiovascular death, myocardial infarction, and stroke, but these associations were lost or weakened when adjusting for cardiovascular risk factors known to cause vascular stress. Exposure of cultured endothelial cells to high glucose, oxidized low-density lipoprotein (LDL) or an inducer of apoptosis enhanced the release of PlGF. Smooth muscle cells and endothelial cells treated with PlGF small interference RNA demonstrated that autocrine PlGF stimulation plays an important role in vascular repair responses. High expression of PlGF in human carotid plaques removed at surgery was associated with a more stable plaque phenotype and a lower risk of future cardiovascular events. When adjusting associations of PlGF with cardiovascular risk in the population cohort for plasma soluble tumor necrosis factor–related apoptosis–inducing ligand (TRAIL) receptor-2, a biomarker of cellular stress, a high PlGF/TRAIL receptor-2 ratio was associated with a lower risk. Our findings provide evidence for a protective role of PlGF in CVD.

scholarly journals The Protective Role of T cells against Angiogenic Potential of Pulmonary Endothelial Cells

2009 ◽  
Vol 23 (S1) ◽  
Author(s):  
Laima Taraseviciene‐Stewart ◽  
Liudas Slepikas ◽  
Miguel Fragoso ◽  
Evgenia Gerasimovskaya
Keyword(s):  
T Cells ◽  
Endothelial Cells ◽  
Protective Role ◽  
Angiogenic Potential ◽  
Pulmonary Endothelial Cells
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