scholarly journals Paranoid Hostility but Not Depressive Symptoms Associated with Cytokines During the Premenstrual Phase in Young Women

2021 ◽  
Vol 1 (1) ◽  
Author(s):  
Syros Ioannis
Keyword(s):  
Depressive Symptoms ◽  
Menstrual Cycle ◽  
Young Women ◽  
Proinflammatory Cytokines ◽  
Luteal Phase ◽  
Depression Scale ◽  
Rank Correlation ◽  
Hormonal Changes ◽  
Mean Values ◽  
Tnf Α

It is well known that some women, during their premenstrual phase, express Hostility (Ho) and Depressive symptoms (De). Various studies indicate that Ho and De correlate with circulating concentrations of cytokines. These data support the hypothesis of an inflammation-sensitive mechanism linked to certain psychological states. The aim of this study was to correlate Ho and De with selective proinflammatory cytokines during the menstrual cycle in young women. Twenty-two physically healthy medical students, mean age 22.95+2.83(SD), were studied. All reported regular menses that ranged between 27-33 days. Blood was drawn three times across a single cycle: at follicular phase (FL), at mid luteal phase (ML) and at late luteal phase (LL) corresponding to the premenstrual phase. The following proinflammatory cytokines were determined at each sample: Interleukin 8 (IL-8), Interleukin 6 (IL-6), Interleukin 1α (IL-1α), and Tumor Necrosis Factor-α (TNF-α). Immediately before blood sampling the women completed the Zung self-rating depression scale and the hostility and direction of hostility questionnaire (HDHQ), which comprises five subscales: urge to act out hostility, criticism of others, paranoid hostility, self-criticism and delusional guilt. Spearman’s rank correlation was used to determine the relation between variables at the specific time points; ρ<0.05 was considered significant. Mean values of cytokines did not change significantly throughout the menstrual cycle. Paranoid hostility was positively correlated with IL-8 (Rs=0.476, p=0.046), IL-1α (Rs=0.458, p=0.048) and TNF-α (Rs=0.518, p=0.023) in LLphase. No other significant correlation was found. Cytokines correlate with paranoid hostility and this correlation is probably related with the premenstrual hormonal changes. It is difficult to evaluate the clinical significance of our findings, nevertheless, when exploring the above association, it is necessary to take into consideration the phase of the cycle as well as the special aspects of Ho we seek to study.

scholarly journals The levels of adipokines in relation to hormonal changes during the menstrual cycle in young, normal-weight women

2017 ◽  
Vol 6 (8) ◽  
pp. 892-900 ◽  
Author(s):  
Katarzyna Wyskida ◽  
Grzegorz Franik ◽  
Tomasz Wikarek ◽  
Aleksander Owczarek ◽  
Alham Delroba ◽  
...  
Keyword(s):  
Menstrual Cycle ◽  
Luteal Phase ◽  
Multivariate Regression ◽  
Normal Weight ◽  
Total Testosterone ◽  
Hormonal Changes ◽  
Regression Analyses ◽  
Anthropometric Parameters ◽  
Tnf Α ◽  
Plasma Leptin

Context The aim of this study was to assess the plasma leptin, adiponectin, resistin, visfatin/NAMPT, omentin-1, vaspin, apelin, TNF-α, IL-6 and RBP4 levels in relation to hormonal changes during the menstrual cycle in young, healthy, normal-weight women. Methods The study involved 52 young, healthy, normal-weight women. Anthropometric parameters, body composition and levels of plasma leptin, adiponectin, resistin, visfatin/NAMPT, omentin-1, vaspin, apelin, TNF-α, IL-6 and RBP4 in addition to serum FSH, LH, estradiol, progesterone, 17-OH progesterone, androgens, SHBG and insulin concentrations were measured during a morning in fasting state three times: between days 2–4, days 12–14 and days 24–26 of the menstrual cycle. Results Plasma adiponectin, omentin-1, resistin and visfatin/NAMPT, apelin, TNF-α, IL-6 and RBP4 concentrations were stable during the menstrual cycle, while leptin and vaspin levels were significantly higher in both the midcycle and the luteal phases than those in the follicular phase. Multivariate regression analyses revealed that changes in leptin and vaspin levels between the follicular and the luteal phase are strongly related to changes in total testosterone levels. Conclusions Our results revealed stable levels of adipokines during the phases of the physiological menstrual cycle, except for leptin and vaspin, which showed increased levels in both the midcycle and the luteal phases. This effect was significantly associated with changes in the secretion of testosterone, 17-OH progesterone and insulin in the luteal phase.

EVALUATION OF CHANGES IN CARDIORESPIRATORY FUNCTIONS DURING DIFFERENT PHASES OF THE MENSTRUAL CYCLE IN YOUNG WOMEN

2020 ◽  
Vol 4 (2) ◽  
Author(s):  
Shehnaz Shaikh
Keyword(s):  
Menstrual Cycle ◽  
Sample Size ◽  
Young Women ◽  
Luteal Phase ◽  
Uterine Wall ◽  
Normal Weight ◽  
Follicular Phase ◽  
Menstrual Phase ◽  
Granulose Cells ◽  
Efficiency Test

Introduction: Menstrual cycle or menstruation involved discharge of sanguinous fluid and a sloughing of uterine wall. In women menstruation occurs at regular intervals on an average of 28 days, although most women gave a history of regular intervals of 28 to 30 days. About 10% -15% of women showed cycle at the precise 28 ± 2 days intervals when menstrual calendar was utilized. Normally in young women in different phases of ovarian cycles the plasma levels of estrogen vary. Ovulation occurs in the first 12-13th day of menstrual cycle, which is termed estrogen surge and second occurs in mid-luteal phase. During mid cycle or follicular phase of menstrual cycle the plasma concentration of progesterone is very low about 0.9 ng/mL. its level starts rising owing to secretion from the granulose cells. During luteal phase progesterone level reaches its peak value of 18 ng/mL and its level fall to a minimum value toward the end of the cycle. Estrogen affects local and systemic vasodilation. The menstrual cycle envelops two fundamental stages, the follicular stage (FP) and the luteal stage (LP). The follicular stage can part advance into two substages; the early FP, which is characterised with moo concentrations of both the key hormones estrogen and progesterone; and the mid FP where estrogen is tall autonomously from progesterone. The LP is epitomized by tall concentration of both estrogen and progesterone. These two fundamental stages are isolated by a soak surge in luteinizing hormone activating ovulation. These recurrent changes are said to be frequency unsurprising while long time. Aim: The main aim of this study is to evaluate the Cardiorespiratory functions changes during different Phases of Menstrual Cycle.   Material and methods: In this study, 20 with normal weight, 20 with obese and 20 with overage were included and taken them as a sample size. In this study all the young women those were recruited as a sample size are unmarried, undergraduate female student with the between the age group of 18-22years, having regular 28+6 days menstrual cycle for at least last 6months prior to this study. For the collection of data all the participants were instructed to attend the physiology lab department during each of three different phases. Day-2 during menstrual phase, Day-7, during follicular phase and Day-22 during luteal phase and the following parameters were recorded as Anthropometric measurements, measuring of pulse rate and blood pressure and cardiac efficiency test. Result: In general, work out proficiency changed essentially amid the distinctive stages of the menstrual cycle with the most elevated amid luteal stage and least amid menstrualo stage. There was no critical contrast in impact test amid menstrual stage, follicular stage and luteal stage of menstrual cycle among three bunches of people. Conclusion: We have watched noteworthy increment in cardiac and respiratory proficiency within the luteal stage of the menstrual cycle in ordinary weight people. Lower wellness levels were watched in overweight and stout females. In this manner hone of customary work out and admissions of solid slim down which offer assistance in lessening the weight and in turn the BMI will offer assistance in improving the physical wellness of the people. Keywords: Cardiorespiratory, Menstrual cycle, expiratory blast test

scholarly journals KLK3 as a possible novel early biomarker of environmental exposure in young women living in Polluted area

2021 ◽  
Author(s):  
Salvatore Raimondo ◽  
Mariacira Gentile ◽  
Giusy Esposito ◽  
Tommaso Gentile ◽  
Ida Ferrara ◽  
...  
Keyword(s):  
Menstrual Cycle ◽  
Environmental Impact ◽  
Environmental Exposure ◽  
Luteal Phase ◽  
Prostate Gland ◽  
Environmental Pollutants ◽  
Biological Marker ◽  
Mean Values ◽  
Healthy Women ◽  
Early Biomarker

Abstract Background: Kallikrein Related Peptidase 3 (KLK3) is secreted by Skene's glands and, is considered ancestral homologues of the male prostate gland and has long been used as a biological marker of prostate cancer. Recent studies have shown that the synthesis of KLK3 can be induced by steroid hormones in different tissues of women and in the menstrual cycle it seems to follow the cyclic variation of estradiol and progesterone. In addition, some environmental pollutants such as bisphenols, phthalate / DBP (DiButyl Phthalate) affect AR (Androgen Receptors) mediated signalling that directly regulates KLK3 secretion. This suggests that environmental factors may play a role in KLK3 secretion.Methods: 61 healthy women living in a high environmental impact (HEI) area, 58 healthy women living in a low environmental impact (LEI) area were evaluated on possible presence or changes of KLK3 in serum at different phases of the menstrual cycle: blood samples taken in the follicular phase 5th-6th day, ovulatory phase 12th -13th day and luteal phase 19th -20th day of the menstrual cycle. For this aim, an ultra-sensitive kit for KLK3 with a detection limit of 0.001 ng / mL was used.Results KLK 3 values​​showed two opposite peaks, women from HEI had a positive peak in the ovulatory phase with mean value of 9.90 ± 3.21 pg / mL while women from LEI had a negative peak in the ovulatory phase with mean values ​​of 3.07 ± 1.49 pg / mL. Progesterone, showed a correlation with KLK3. Women from HEI had higher KLK3 values on average and no significant changes were evident between the three withdrawals in the different phases of the cycle. In contrast, women from LEI had a statistically significant decrease between the follicular and ovulatory phase (p <0.0001) and a statistically significant increase (p <0.0001) between the ovulatory and luteal phase.Conclusions: The data obtained seem to go beyond the known role of KLK3. The dosage of KLK3 during the various phases of the menstrual cycle, simple to carry out and with low costs, can represent an effective and early biomarker to assess environmental exposure and useful to recognize the risk early and protect female health, not only reproductive.

scholarly journals Dream Recall and Content versus the Menstrual Cycle: A Cross-Sectional Study in Healthy Women

2019 ◽  
Vol 7 (7) ◽  
pp. 81
Author(s):  
Ioannis Ilias ◽  
Nicholas-Tiberio Economou ◽  
Anastasia Lekkou ◽  
Andrea Romigi ◽  
Eftychia Koukkou
Keyword(s):  
Menstrual Cycle ◽  
Young Women ◽  
Luteal Phase ◽  
Cross Sectional Study ◽  
Dream Content ◽  
Dream Recall ◽  
Sectional Study ◽  
Cross Sectional ◽  
Large Sample ◽  
Hormonal Milieu

The association between sleep and the menstrual cycle has been scarcely studied. This study aimed to investigate the association between dream recall and content and the menstrual cycle among a large sample of young women. To this aim, 944 women were asked about their day of menstrual cycle, whether they remembered the previous night’s dreams and if they did so to describe the dream content as pleasant or unpleasant. A total of 378 women recalled the previous nights’ dreams, with 199 reporting pleasant dream affect/content and 179 reporting unpleasant dream content. In women who recalled their dreams, there was an association of pleasant dream content with the luteal phase (p = 0.038). In conclusion, in women, the hormonal milieu of the luteal phase may influence dream content.

Symptom Frequencies and Intensities in Hospitalized Patients With Advanced Cancer Having Depressive Disorder

2016 ◽  
Vol 34 (5) ◽  
pp. 456-460 ◽  
Author(s):  
Yong Liu ◽  
Fei Liu ◽  
Yang Yu ◽  
Qing Li ◽  
Xin Jin ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Advanced Cancer ◽  
Depressive Disorders ◽  
Depression Scale ◽  
Rank Correlation ◽  
Symptom Assessment ◽  
Hospitalized Patients ◽  
Assessment System ◽  
Wilcoxon Rank Sum Test

Aim: To explore the frequencies and intensities of depressive symptoms associated with hospitalized patients with advanced cancer. Methods: A total of 196 hospitalized patients with advanced cancer were surveyed with the Edmonton Symptom Assessment System and Self-Rating Depression Scale (SDS). The χ2 test and Wilcoxon rank-sum test were used to compare the frequency and intensity of symptoms between patients with and without depressive disorders. Spearman rank correlation was used to test the correlation between depression and symptoms. Results: Of the 196 enrolled patients, 115 (59%) were males. The median age of the patients was 58 (19-80) years. Seventy-six (39%) patients were diagnosed with depression (SDS ≥ 53). Patients with depressive disorders exhibited pain, drowsiness, and nausea along with a higher frequency and intensity of poor self-perception, appetite loss, anxiety, dyspnea, and fatigue. Depressive symptoms were positively correlated with the symptoms. Conclusion: Depressive disorders are very common and severe in hospitalized patients with advanced cancer. Identifying the frequencies and intensities of the symptoms enables early intervention to improve patients’ quality of life.

scholarly journals Quotidian Changes of Genital Tract Cytokines in Human Immunodeficiency Virus-1-Infected Women During the Menstrual Cycle

2014 ◽  
Vol 1 (1) ◽  
Author(s):  
Valerie Cortez ◽  
Katherine Odem-Davis ◽  
Dara A. Lehman ◽  
Jennifer Mabuka ◽  
Julie Overbaugh
Keyword(s):  
Human Immunodeficiency Virus ◽  
Menstrual Cycle ◽  
Genital Tract ◽  
Hormonal Changes ◽  
Colony Stimulating Factor ◽  
Monocyte Chemoattractant Protein 1 ◽  
Tnf Α ◽  
Immunodeficiency Virus ◽  
Interferon Α2 ◽  
Stimulating Factor

Abstract The role of hormonal changes throughout the menstrual cycle on genital tract inflammation during chronic human immunodeficiency virus (HIV) infection is not well defined, but it has implications for HIV prevention. We assessed daily levels of 26 vaginal cytokines and chemokines from 15 women infected with HIV-1. Taking into account coexisting sexually transmitted infections, behavioral factors, and menstruation, this study illustrates cyclic patterns of granulocyte macrophage colony-stimulating factor, interferon-α2, interleukin (IL)-6, IL-10, macrophage inflammatory protein (MIP)-1α, MIP-1β, and tumor necrosis factor (TNF)-α. Progesterone was associated with levels of granulocyte colony-stimulating factor, IL-1α, and monocyte chemoattractant protein-1. Interferon-α2, IL-6, MIP-1α, MIP-1β, and TNF-α levels predicted HIV shedding, but these associations were heavily influenced by the menstrual cycle.

Subgroups with typical courses of depressive symptoms in an elderly population during 13 years of observation: Results from the Heinz Nixdorf Recall Study

2020 ◽  
Vol 66 (8) ◽  
pp. 799-809
Author(s):  
Miriam Engel ◽  
Karl-Heinz Jöckel ◽  
Nico Dragano ◽  
Miriam Engels ◽  
Susanne Moebus
Keyword(s):  
Depressive Symptoms ◽  
Short Form ◽  
Empirical Studies ◽  
Depression Scale ◽  
Population Based ◽  
Epidemiologic Studies ◽  
Depression Score ◽  
Mean Values ◽  
Heinz Nixdorf Recall Study ◽  
Large Fluctuations

Background: Depressive symptoms are volatile over time but empirical studies of intra-individual variations of depressive symptoms over longer periods are sparse. Aims: We aim to examine fluctuation patterns of depressive symptoms and to investigate the possible influence of age, sex and socioeconomic factors on fluctuation in a population-based sample over a period of 13 years. Methods: We used data of 4,251 participants (45–75 years; 51.0% women at baseline) of the Heinz Nixdorf Recall Study with at least two of nine possible measurements obtained in the period between 2000 and 2017. Depressive symptoms were assessed via the Center for Epidemiologic Studies Depression Scale (CES-D) short form. Based on the individual mean values and standard deviation from all measurements, we categorized participants as G1 ‘stable low’, G2 ‘stable high’, G3 ‘stable around cutoff’ and G4 ‘large fluctuations’. Results: Most participants (82.3%) showed stable low depressive symptoms (G1), whereas 2.3% performed stable high values (G2), 6.9% stable around the cutoff (G3) and 8.6% large fluctuations (G4). Conclusion: Our longitudinal results reveal that almost 18% (G2, G3 and G4) of the participants have an increased depression score or strong fluctuations at times. According to our classification, a higher proportion of the participants show anomalies with regard to depression compared to a simple classification into depressed and nondepressed, especially if this is based on a single measurement. Thus, longitudinal measurements of depression can prevent misclassification and provide valuable information about the course of depressive symptoms for a better understanding of the changes of depression.

Hubungan Antara Status Gizi Dan Tingkat Stres Dengan Kejadian Pre-Menstrual Syndrome Pada Remaja Putri Di Pondok Pesantren Lirboyo Kota Kediri Tahun 2016

2017 ◽  
Vol 5 (1) ◽  
Author(s):  
Miftakhul Mualimah ◽  
Ana Wildani
Keyword(s):  
Menstrual Cycle ◽  
Luteal Phase ◽  
Simple Random Sampling ◽  
Physical Symptoms ◽  
Nutrition Status ◽  
P Value ◽  
Hormonal Changes ◽  
Cross Sectional ◽  
Stress Levels ◽  
Current Cycle

ABSTRAK Pre-Menstrual Syndrome adalah kumpulan gejala fisik, psikologis dan emosi yang terkait dengan siklus menstruasi wanita dan secara konsisten terjadi selama fase luteal dari siklus menstruasi akibat perubahan hormonal yang berhubungan dengan siklus saat ovulasi dan menstruasi. Salah satu faktor penyebab pre-menstrual syndrome adalah status gizi dan tingkat stres.Desain penelitian yang digunakan adalah penelitian analitik korelasional dengan menggunakan pendekatan cross sectional. Populasi yang diteliti adalah semua remaja putri usia 12-21 tahun di Pondok Pesantren Lirboyo pada Tahun 2016 sejumlah 127 orang dengan teknik simple random sampling analisa dengan menggunakan spearman rank.Hasil analisis diperoleh nilai p value = 0,000 sehingga  p value  α  maka H0 ditolak dan H1 diterima dengan nilai r =- 0,533. Sedangkan variabel tingkat stres dengan kejadian pre-menstrual syndrome, dengan hasil p value = 0,000 sehingga  p value  α  maka H0 ditolak dan H1 diterima dengan nilai r = 0,650. Berdasarkan hasil penelitian diharapkan angka kejadian pre-menstrual syndrome dapat berkurang dengan cara mengenali dini gejala terjadinya pre-menstrual syndrome dan memberikan penyuluhan kepada santri cara mencegah pre-menstrual syndrome. Kata kunci : status gizi, tingkat stres dan pre-menstrual syndrome.   ABSTRACT Pre-Menstrual Syndrome is collection of physical symptoms, psychological and emotion associated with a woman’s menstrual cycle and consistently occur during the luteal phase of the menstrual cycle due to hormonal changes associated with the current cycle of ovulation and menstruation. One of couses factor pre-menstrual syndromeis nutrition status and stress levels. The research design used an analytic corelation research by using the cross sectional approach. The population of this research were young women aged 12-21 years at Pondok Pesantren Lirboyo in 2016 amount 127 peoples with probability sampling type analyse by spearman rank.The analysis result showed that between nutrition status with pre-menstrual syndrome that p value = 0.000, p value α so H0 was rejected and H1 was accepted by r =-0,533.Futhermore, the result showed that between stress levels with pre-menstrual syndrome, get p value = 0.000 so p value α, H0was rejected and H1 was acceptedby r = 0,650. Based on this result was expected that the incident of pre-menstrual syndromecan be decrease by recognize the symptomps of pre-menstrual syndrome and provide counseling to students how to prevent pre-menstrual syndrome. Keywords : nutrition status, stress levels and pre-menstrual syndrome

scholarly journals Proinflammatory Cytokines Correlate with Depression and Anxiety in Colorectal Cancer Patients

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Diego Oliveira Miranda ◽  
Taís Aparecida Soares de Lima ◽  
Lucas Ribeiro Azevedo ◽  
Omar Feres ◽  
José Joaquim Ribeiro da Rocha ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Proinflammatory Cytokines ◽  
Molecular Mechanisms ◽  
Depression Scale ◽  
Serum Levels ◽  
Anxiety And Depression ◽  
Control Group ◽  
Depression And Anxiety ◽  
Tnf Α ◽  
Cytokine Levels

The objective of this study was to investigate whether serum cytokine levels correlate with depression and anxiety in colorectal cancer (CRC) patients. Twenty patients hospitalized for surgical resection of CRC were included in the study group and twenty healthy volunteers comprised the control group. Depression and anxiety were analyzed using the Hospital Anxiety and Depression Scale (HADS), and serum levels of IL-1β, IL-6, IL-8, IL-10, IL-12, TNF-α, and TGF-βwere measured by Cytometric Bead Array. We found that more than half of CRC patients presented clinically significant levels of anxiety or depression, and 65% of them manifested a combination of severe anxiety and depression. CRC patients had increased serum levels of IL-1β, IL-6, IL-8, and TNF-α but lower IL-10 concentrations. Correlation analysis between HADS score and cytokine levels revealed a positive association of anxiety and/or depression with IL-1β, IL-6, IL-8, and TNF-α and a negative correlation with IL-10. These results indicate that circulating proinflammatory cytokines are involved in the pathophysiology of anxiety and depression in CRC patients. A better understanding of the molecular mechanisms involved in these psychological disorders will allow the design of therapeutic interventions that lead to an improved quality of life and overall survival of CRC patients.

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