Sa1062 Effect of 12 Weeks of Oral Betaine on Homeostasic Model Assessment of Insulin Resistance (Homa-IR) in Non-Diabetic Subjects With Mildly Elevated Fasting Blood Sugar

2014 ◽  
Vol 146 (5) ◽  
pp. S-950 ◽  
Author(s):  
David Nolan ◽  
Timothy R. Morgan ◽  
Elango Kathirvel ◽  
Kengathevy Morgan ◽  
Rachel Gonzalez ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Blood Sugar ◽  
Fasting Blood Sugar ◽  
Model Assessment

scholarly journals Acanthosis nigricans: a clinical marker of insulin resistance

2017 ◽  
Vol 3 (2) ◽  
pp. 161
Author(s):  
Sanjiv V. Choudhary ◽  
Vikrant Saoji ◽  
Adarshlata Singh ◽  
Shivani Mane
Keyword(s):  
Insulin Resistance ◽  
Blood Sugar ◽  
Acanthosis Nigricans ◽  
Serum Insulin ◽  
Univariate Analysis ◽  
Fasting Blood Sugar ◽  
P Value ◽  
Model Assessment ◽  
Fasting Insulin ◽  
Positive Correlation

<p><strong>Background:</strong> Very little information is available regarding the association of acanthosis nigricans with insulin resistance from rural areas of India. Therefore this study was carried out with the aim and objectives to study the association between acanthosis nigricans and insulin resistance and to evaluate correlation of acanthosis nigricans severity, neck severity and neck texture severity with fasting blood sugar &amp; serum insulin especially in this rural part of central India.</p><p><strong>Methods:</strong> In this cross sectional study with comparative group, total 162 age and sex matched subjects were divided into two groups of cases (81) with acanthosis nigricans and comparative subjects (81) without acanthosis nigricans. The severity acanthosis nigricans was assessed using the Burke’s quantitative scale. Fasting blood sugar and fasting insulin levels were estimated to know the Homeostasis model assessment of insulin resistance (HOMA-IR) values. Data was analyzed by using appropriate statistical tests.</p><p><strong>Results:</strong> The age range was 20 to 55 years with the mean of 32.82 ± 10.19 years for cases and 33.67 ± 8.09 for comparative subjects. Univariate analysis which showed significant association of acanthosis nigricans with fasting insulin and HOMA-IR with significant odds ratios and p value (p =0.0001) respectively. Fasting blood sugar showed greater risk of association in cases but it was statistically insignificant with p-value of (p =0.32). Spearman rank coefficient correlation showed weak correlation of HOMA-IR with acanthosis nigricans severity, neck severity and neck texture severity, but showed positive correlation of fasting insulin with acanthosis nigricans severity, neck severity and neck texture severity, with statistically significant P-value (p &lt;0.05).</p><p class="abstract"><strong>Conclusions:</strong> Acanthosis nigricans was strongly associated with insulin resistance with significant odds ratio and statistical significant p value (P &lt; 0.05). Acanthosis nigricans severity, neck severity and neck texture severity showed positive correlation with fasting serum insulin with statistically significant p value (P &lt;0.05). </p>

scholarly journals Association of Osteocalcin with Metabolic Syndrome and its Correlation with Insulin Resistance

2021 ◽  
Author(s):  
Nehali Pattanayak ◽  
Anuva Mishra ◽  
Sucharita Mohanty ◽  
Pramila Kumari Mishra ◽  
Putul Bara
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Blood Sugar ◽  
Serum Insulin ◽  
Fasting Blood Sugar ◽  
Enzyme Linked Immunosorbent Assay ◽  
Model Assessment ◽  
Serum Osteocalcin ◽  
Public Health Burden ◽  
Cardio Vascular

Introduction: Metabolic Syndrome (MetS) is an important public health burden associated with five-fold risk of developing Type 2 Diabetes Mellitus (T2DM) and two fold risk of Cardio Vascular Disease (CVD). Recent studies described that osteoblasts produce osteocalcin which increases insulin secretion and adiponectin production resulting in insulin sensitivity. Aim: To determine the association of serum osteocalcin with MetS and to assess the correlation of insulin resistance Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) with osteocalcin. Materials and Methods: This case-control study was carried out in the Department of Biochemistry at MKCG Medical College, Brahmapur, Odisha, India. By observing the mean and standard deviation from previous studies, with 95% Confidence Interval (CI) and 80% power of study, the sample size was calculated to be 45. Forty eight cases between 20-45 years of age meeting the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) criteria of MetS and 50 age and sex matched healthy individuals were taken as controls. Individuals with any systemic illness or on any kind of medications were excluded from the study. Fasting blood sugar, lipid profile were measured by standard procedures. Serum osteocalcin and serum insulin was estimated by Enzyme-linked Immunosorbent Assay (ELISA) LISA SCAN READER and ROCHE e COBAS 411 electrochemiluminiscence, respectively. Statistical analysis was done in Statistical Package for the Social Sciences (SPSS) 22.0 version software. Results: Serum osteocalcin was found to be lower in cases as compared to controls (7.74±4.62 ng/mL and 23.24±9.74 ng/mL) respectively. Osteocalcin was also found to be significantly negatively correlated with HOMA-IR, Waist Circumference (WC), triglyceride and fasting blood sugar in cases with (r=-0.322, p=0.025), (r=-0.519, p<0.001), (r=-0.401, p=0.005), (r=-0.539, p<0.001), respectively and also in controls with (r=-0.494, p<0.001), (r=-0.176, p=0.245), (r=-0.398, p<0.05), (r=-0.141, p<0.05), respectively. Conclusion: Serum osteocalcin being negatively correlated with insulin resistance may have therapeutic role in prevention of MetS which may be substantiated with further study.

scholarly journals Association between Triglyceride Glucose Index and Insulin Resistance among Thai Obese Adolescents

2020 ◽  
Author(s):  
Thidarat Somdee ◽  
Udomsak Mahaweerawat ◽  
Chatchada Mahaweerawat ◽  
Suneerat Yangyuen
Keyword(s):  
Risk Factors ◽  
Insulin Resistance ◽  
Blood Sugar ◽  
Multiple Logistic Regression Analysis ◽  
Surrogate Marker ◽  
Fasting Blood Sugar ◽  
Model Assessment ◽  
Cross Sectional ◽  
Obese Adolescents ◽  
Tyg Index

Introduction: Global adolescence obesity is considered as the risk factor associated with the development of Insulin Resistance (IR). And, Triglyceride Glucose (TyG) index has been used as an alternative tool to estimate IR. Thailand has also encountered the same trend especially the adolescence obesity risk is increasing because of malconsumption behaviour. Aim: The aim of this study was to assess the association between the TyG index and IR among Thai adolescents. Materials and Methods: This cross-sectional study was carried out on 300 obese adolescents selected from the Obesity Outpatient Clinic of Mahasarakham Provincial Public Health Office during 2009 to 2013. Anthropometric and IR risk factors were measured. The TyG index was calculated as in {fasting Triglycerides (TG) (mg/dL)×fasting blood sugar (mg/dL)}/2, while IR was estimated by Homeostasis Model Assessment for Insulin Resistance (HOMA-IR). Data were analysed by using a multiple logistics regression at 0.05 level of significance running with STATA version 13.0 software. Results: All subjects were divided into tertile groups based on the TyG index to analyse statistically significant differences (p<0.05). ANOVA revealed that there were significant differences in IR risk factors (Basal Metabolic Index, Fasting Blood Sugar level, and Triglyceride level) among the groups. Both TyG index and HOMA-IR level were statistically highly significant among the tertiles (p<0.001). Multiple logistic regression analysis revealed that TyG index can be used as an association factor for IR, in a fully adjusted model after adjusting BMI and Tricep thickness (3.06; 95% CI 1.780, 5.170; p<0.001). Conclusion: The results of the TyG index were significantly associated with IR in thai obese adolescents hence, supporting the use of TyG index as a surrogate marker for IR.

scholarly journals Mitigating effect of metformin on polycystic ovarian syndrome and insulin resistance in rats, and the mechanisms involved

2020 ◽  
Vol 19 (9) ◽  
pp. 1941-1946
Author(s):  
Lanyawen Hu ◽  
Baimiao Wang ◽  
Yingli Tao
Keyword(s):  
Insulin Resistance ◽  
Blood Sugar ◽  
Polycystic Ovarian Syndrome ◽  
Follicle Stimulating Hormone ◽  
Fasting Blood Glucose ◽  
Resistance Index ◽  
New Drugs ◽  
Fasting Blood Sugar ◽  
Ovarian Syndrome ◽  
Stimulating Hormone

Purpose: To study the effect of metformin on polycystic ovarian syndrome (PCOS) and insulin resistance (IR) in rats, and the mechanism involved.Methods: Eighty healthy female SD rats, aged 6 weeks, were selected. Three groups of rats were used: model, metformin + PI3K inhibitor, and metformin groups, with 20/group. Testosterone, leutenizing hormone (LH), and follicle-stimulating hormone (FSH) were assayed by enzyme-linkedassay (ELISA), while HOMA-IR was calculated from fasting blood sugar (FBG); the effect of metformin on the IR of PCOS rats was determined. The expressions of PI3K and AKT in ovaries and liver of rats in each group were assayed by Western blotting.Results: Fasting blood glucose, fasting insulin, and insulin resistance index were markedly higher in model than in control rats, and also significantly higher in inhibitor-treated rats than in metformin rats (p < 0.05). Relative to control, FSH level was higher, while levels of LH, LH/FSH ratio and testosterone in the metformin group were significantly lower (p < 0.05). The expression levels of PI3K and AKT in the ovary and liver were reduced in the inhibitor group, relative to the levels in metformin-treated rats (p < 0.05).Conclusion: Metformin mitigates PCOS-linked ovarian changes and IR in rats via PI3K/AKT route. These findings may be useful in the design of new drugs. Keywords: Metformin, Polycystic ovary syndrome, Leutenizing hormone, Insulin resistance, Fasting blood sugar, Follicle-stimulating hormone

Improvement in fasting blood sugar, anthropometric measurement and hs-CRP after consumption of epigallocatechin-3-gallate (EGCG) in patients with type 2 diabetes mellitus

2019 ◽  
Vol 50 (2) ◽  
pp. 348-359 ◽  
Author(s):  
Said Hadi ◽  
Meysam Alipour ◽  
Vahideh Aghamohammadi ◽  
Sahar Shahemi ◽  
Fatemeh Ghafouri-Taleghani ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Sugar ◽  
Fasting Blood Sugar ◽  
Anthropometric Measurement ◽  
Model Assessment ◽  
Content Type ◽  
Hs Crp

Purpose The epigallocatechin gallate (EGCG) effect in diabetes has been investigated in animal studies, but results of clinical trials are inconsistent. Thus, this study aims to evaluate the effects of EGCG supplementation in patients with type 2 diabetes mellitus (T2DM). Design/methodology/approach A total of 50 patients with T2DM were recruited in a double-blind, randomized, placebo-controlled trial. The eligible participants were randomly allocated to EGCG (n = 25) and placebo (n = 25) groups. The EGCG group received two capsules of EGCG (each capsule contained 150 mg; Shari Made®, Iran) and placebo group was administered two capsules of placebo (starch) for eight weeks. A three-day 24-h dietary recall and anthropometric and laboratory measurements were carried out at the beginning and the end of the study. Findings At the end of the trial, weight and body mass index (BMI) were decreased significantly in both groups, but the reduction was not statistically significant between the two groups. Fasting blood sugar decreased significantly in EGCG group. No significant between-group and within-group differences were found in insulin, homeostatic model assessment of insulin resistance (HOMA-IR) and the quantitative insulin sensitivity check index values. The high-sensitive C-reactive protein (hs-CRP) was significantly reduced in the EGCG group (4.13 ± 0.48-3.93 ± 0.50, p = 0.003) compared to baseline. Originality/value This study showed that consuming 300 mg/day of EGCG for eight weeks in patients with T2DM caused a significant decrease in fasting blood glucose, body weight, BMI and hs-CRP compared to baseline. Therefore, the EGCG supplementation may improve glycemic control, anthropometric and inflammation status in T2DM.

Correlation of Serum Magnesium with Insulin Resistance in North Indian Adult Population

2020 ◽  
Vol 16 (3) ◽  
pp. 254-261
Author(s):  
Geeta Shamnani ◽  
Shekhawat S. Bhartiy ◽  
Rekha Jiwane ◽  
Vani Gupta ◽  
Narsingh Verma ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Sugar ◽  
Serum Magnesium ◽  
Insulin Level ◽  
Fasting Blood Sugar ◽  
Apparently Healthy

Background: Globalization has lead to such lifestyle changes which have produced increase in incidence and prevalence of Type 2 Diabetes Mellitus (T2DM). Magnesium is found to have some role in glucose metabolism. The aim of this study was to investigate the relationship between serum magnesium levels with insulin resistance in apparently healthy adults. Objective: The objective of our study was to evaluate correlation of serum magnesium with fasting blood sugar, insulin level and Homeostasis model assessment-insulin resistance (HOMA-IR) index (indicator of insulin resistance) on the basis of the hypothesis that subjects with hypomagnesaemia are more prone to develop hyperglycemia and insulin resistance. Materials and Methods: The study was a cross-sectional study which was population based. Total 130 apparently healthy adults of age between 25-65 years, were recruited with prior ethical approval and written informed consent. Results: Serum magnesium was found to be negatively correlated with fasting blood sugar (FBS), insulin level and HOMA-IR. Co-relation of magnesium with FBS (r = -0.55, p<0.0001), insulin (r = -0.45, p< 0.0001) and HOMA-IR (r = -0.52, p<0.0001) was significant. Conclusion: As per findings it was concluded that serum magnesium was found to have significant negative correlation with fasting blood sugar (FBS), insulin and HOMA-IR, thus hypomagnesaemia can be suggested to be one of the important predictor of type 2 diabetes mellitus.

scholarly journals Insulin resistance and its associated comorbidities in young individuals: a HOMA study

2017 ◽  
Vol 4 (1) ◽  
pp. 225
Author(s):  
Irfan Ahamed H. B. ◽  
Bilal Bin Abdullah ◽  
Mohammed Ismail ◽  
Syed Aman Jagirdar
Keyword(s):  
Insulin Resistance ◽  
High Risk ◽  
Blood Sugar ◽  
Glycated Hemoglobin ◽  
Pearson Correlation ◽  
Statistical Significance ◽  
Fasting Blood Glucose ◽  
The Body ◽  
Fasting Blood Sugar ◽  
Diabetic Patients

Background: The strongest relationship between insulin resistance and cardiovascular risk factors is observed in middle-aged persons rather than in older individuals. Hence it is important to evaluate the young high risk individuals for insulin resistance and to study its significant co-morbidities. Therefore, the present study was designed to evaluate the high risk individuals for insulin resistance and co-morbidities in young individuals.Methods: The body mass index and the waist-hip ratio of all the participants were measured. A 5 ml of fasting venous blood was collected from each patient and was used for the estimation of fasting blood glucose level, lipid profile, fasting insulin level and glycated hemoglobin using commercially available kit according to the manufacturer’s guidelines. Subjects’ full filling inclusion criteria and preliminary tests for insulin resistance are further evaluated with HOMA. The data obtained was represented as Mean±S.D and was analyzed for statistical significance using chi-square test and correlation of HOMA with study variables were performed using Pearson correlation test using SPSS Version 20. P - value less than 0.05 was considered the level of significance.Results: In the present study we found that, non- diabetic group patients are having strong association with hypertension and insulin resistance. When the study variables in the recruited subjects were correlated with HOMA using Pearson correlation, showed a significant correlation with fasting blood sugar, glycated hemoglobin and hypertension in diabetic patients. In non-diabetic subjects fasting blood sugar and glycated hemoglobin was not correlated significantly. But, hypertension showed a significant correlation.Conclusions: Insulin resistance was strongly associated with co-morbidities like hypertension, obesity,   hyperlipidemia, hyperuricemia. High incidence and prevalence of insulin resistance was also seen in non-diabetic individuals.

scholarly journals The effects of inhaled corticosteroid on insulin sensitivity in asthmatic patients

2018 ◽  
Vol 88 (1) ◽  
Author(s):  
Seyed Hamid Borsi ◽  
Homeira Rashidi ◽  
Maryam Shaabanpour ◽  
Hanieh Raji
Keyword(s):  
Insulin Resistance ◽  
Insulin Sensitivity ◽  
Blood Sugar ◽  
Density Lipoprotein ◽  
Insulin Level ◽  
Airflow Limitation ◽  
Diabetic Patients ◽  
Model Assessment ◽  
Inhaled Corticosteroid ◽  
Asthmatic Patients

Asthma is an inflammatory disease, which causes airflow limitation and increase insulin resistance. The present study was carried out in order to investigate insulin resistance and the effect of inhaled corticosteroid (ICS) on insulin sensitivity in asthmatic patients. A registered (IRCT201605247411N2) interventional, quasi-experimental trial was performed from 2014 to 2015 in Imam Khomeini hospital Ahvaz, Iran. Patients with mild to moderate asthma participated in this study. Spirometry, fasting blood sugar (FBS), blood sugar 2 hour post prandial (BS2HPP), HbA1C, low density lipoprotein (LDL), high density lipoprotein (HDL), Insulin Level, and C reactive protein (CRP) were measured. Then Homeostatic Model Assessment-Insulin Resistance [HOMA-IR] Index calculated. Data were analyzed using paired t-test and McNemar’s test using SPSS 20.0 Software. The study consisted of 35 non-diabetic patients suffering from asthma (20 men and 15 women) with a mean age of 36.6 ±12.3 years. Inhaled corticosteroid had a significant effect on spirometric parameters, but it had no significant effect on other variables. At baseline, mean HbA1C, insulin level and HOMA-IR were 5.5%, 10.9 mIU/L and 2.7 respectively. None of these values changed significantly after treatment with inhaled corticosteroid for two months. The results indicated that there is no relationship between ICS and increased insulin resistance in asthmatic patients.

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