scholarly journals Biosynthetic analysis of the human interferon-γ receptor

1989 ◽  
Vol 264 (20) ◽  
pp. 11981-11988
Author(s):  
G K K Hershey ◽  
R D Schreiber
Keyword(s):  
Interferon Γ ◽  
Human Interferon

scholarly journals Engineered disulfide bonds in recombinant human interferon-γ: the impact of the N-terminal helix A and the AB-loop on protein stability

1996 ◽  
Vol 9 (10) ◽  
pp. 905-912 ◽  
Author(s):  
Gero Waschütza ◽  
Volkhart Li ◽  
Thomas Schäfer ◽  
Dietmar Schomburg ◽  
Carmen Villmann ◽  
...  
Keyword(s):  
Protein Stability ◽  
Disulfide Bonds ◽  
Interferon Γ ◽  
Human Interferon ◽  
The Impact

A point mutation that decreases the thermal stability of human interferon γ

1992 ◽  
Vol 5 (3) ◽  
pp. 249-252 ◽  
Author(s):  
C.A. Lunn ◽  
J. Fossetta ◽  
N. Murgolo ◽  
P. J. Zavodny ◽  
D. Lundell ◽  
...  
Keyword(s):  
Thermal Stability ◽  
Point Mutation ◽  
Interferon Γ ◽  
Human Interferon ◽  
Thermal Stability Of

scholarly journals Mouse Macrophages Carrying Both Subunits of the Human Interferon-γ (IFN-γ) Receptor Respond to Human IFN-γ but Do Not Acquire Full Protection against Viral Cytopathic Effect

1996 ◽  
Vol 271 (51) ◽  
pp. 32659-32666 ◽  
Author(s):  
David Lembo ◽  
Paola Ricciardi-Castagnoli ◽  
Gottfried Alber ◽  
Laurence Ozmen ◽  
Santo Landolfo ◽  
...  
Keyword(s):  
Cytopathic Effect ◽  
Interferon Γ ◽  
Human Interferon ◽  
Mouse Macrophages ◽  
Ifn Γ ◽  
Full Protection ◽  
Viral Cytopathic Effect

scholarly journals Human Interferon γ is encoded by a single class of mRNA

1982 ◽  
Vol 10 (12) ◽  
pp. 3605-3615 ◽  
Author(s):  
Rik Derynck ◽  
David W. Leung ◽  
Patrick W. Gray ◽  
David V. Goeddel
Keyword(s):  
Interferon Γ ◽  
Human Interferon ◽  
Single Class

Effects of annealing lyophilized and spray‐lyophilized formulations of recombinant human interferon‐γ

2003 ◽  
Vol 92 (4) ◽  
pp. 715-729 ◽  
Author(s):  
Serena D. Webb ◽  
Jeffrey L. Cleland ◽  
John F. Carpenter ◽  
Theodore W. Randolph
Keyword(s):  
Interferon Γ ◽  
Human Interferon

The recombinant human interferon-γ receptor is fully functional in a human × murine hybrid containing human chromosome 21

1991 ◽  
Vol 142 (9) ◽  
pp. 765-772 ◽  
Author(s):  
M.R. Bono ◽  
C. Alcaïde-Loridan ◽  
B. Letouzé ◽  
H. Jouin ◽  
S.J.P. Gobin ◽  
...  
Keyword(s):  
Human Chromosome ◽  
Interferon Γ ◽  
Chromosome 21 ◽  
Human Interferon ◽  
Human Chromosome 21

Protein synthesis-dependent potentiation by thyroxine of antiviral activity of interferon-γ

1997 ◽  
Vol 273 (4) ◽  
pp. C1225-C1232 ◽  
Author(s):  
Hung-Yun Lin ◽  
Paul M. Yen ◽  
Faith B. Davis ◽  
Paul J. Davis
Keyword(s):  
Thyroid Hormone ◽  
Antiviral Activity ◽  
Tyrosine Kinase ◽  
Kinase Inhibitor ◽  
Thyroid Hormone Receptor ◽  
Signal Transduction Pathway ◽  
Interferon Γ ◽  
Human Interferon ◽  
Transduction Pathway ◽  
Ifn Γ

We have studied the prenuclear signal transduction pathway by which thyroid hormone potentiates the antiviral activity of human interferon-γ (IFN-γ) in HeLa cells, which are deficient in thyroid hormone receptor (TR). The action of thyroid hormone was compared with that of milrinone, which has structural homologies with thyroid hormone.l-Thyroxine (T4), 3,5,3′-l-triiodothyronine (T3), and milrinone enhanced the antiviral activity of IFN-γ up to 100-fold, a potentiation blocked by cycloheximide. The 5′-deiodinase inhibitor 6- n-propyl-2-thiouracil did not block the T4 effect. 3,3′,5,5′-Tetraiodothyroacetic acid prevented the effect of T4 but not of milrinone. The effects of T4 and milrinone were blocked by inhibitors of protein kinases C (PKC) and A (PKA) and restored by PKC and PKA agonists; only the effect of T4 was blocked by genistein, a tyrosine kinase inhibitor. In separate models, milrinone was shown not to interact with nuclear TR-β. T4 potentiation of the antiviral activity of IFN-γ requires PKC, PKA, and tyrosine kinase activities but not traditional TR.

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