Expression of lymphocyte subpopulations, cytokine serum levels and blood and urine trace elements in nickel sensitised women

Background: Aortic valve sclerosis (AVSc) is defined as the thickening and calcification of aortic valve cusps, in the absence of obstruction of ventricular outflow. AVSc is linked with a clear imbalance in some trace elements. Aims: The objective of this study was to investigate the relationship between AVSc and serum levels of iron (Fe), zinc (Zn), selenium (Se), and copper (Cu). Additionally, this research aimed to explore the clinical significance of human serum zinc, selenium, copper, and iron concentrations as a potential new biomarker for AVSc patients and to clarify the pathophysiological role in individuals at risk of developing AVSc. Patients and methods: The study included 40 subjects with AVSc (25% male and 75% female) who were compared with a healthy control group with the same gender ratio. AVSc was based on comprehensive echocardiographic assessments. Blood samples were taken and Zn and Cu concentrations were determined through the use of atomic absorption spectroscopy. Se was measured using an inductively coupled plasma mass spectrometry device and Fe was measured using a Beckman Coulter instrument. Results: There was a significant difference in the prevalence of diabetes, blood pressure levels, and body mass index between the patients and the healthy subjects ( p < 0.05). The differences between the serum Fe, Se, and Cu levels of the AVSc patients and the healthy subjects ( p > 0.05) were recorded. The serum Zn of AVSc patients when compared was significantly lower compared with that of the control group ( p < 0.01). Conclusion: Patients with AVSc had an imbalance in some of the trace elements in their blood. The patient group’s valves had higher serum Cu levels and lower serum Se, Zn, and Fe concentrations compared with the healthy group’s valves. In the valve patients as compared, AVSc had a high prevalence of obesity, hypertension, and diabetes.

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Serum levels of trace elements in children born after assisted reproductive technology

Clinica Chimica Acta ◽

10.1016/j.cca.2018.09.032 ◽

2019 ◽

Vol 495 ◽

pp. 664-669 ◽

Cited By ~ 3

Author(s):

Xin-ru Xia ◽

Shi-Wen Jiang ◽

Yuan Zhang ◽

You-fang Hu ◽

Hong-gang Yi ◽

...

Keyword(s):

Trace Elements ◽

Assisted Reproductive Technology ◽

Serum Levels ◽

Reproductive Technology

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Serum levels of Cadmium, Calcium, Lead and Iron in Schizophrenic Patients

Dhaka University Journal of Pharmaceutical Sciences ◽

10.3329/dujps.v5i1.221 ◽

1970 ◽

Vol 5 (1) ◽

pp. 9-13 ◽

Cited By ~ 4

Author(s):

Pinky Karim ◽

Md. Iqbal Hossain ◽

AFM Nazmus Sadat ◽

Zabun Nahar ◽

Md. Khalid Hossain ◽

...

Keyword(s):

Trace Elements ◽

Serum Concentration ◽

Prognostic Significance ◽

Serum Levels ◽

Schizophrenic Disorder ◽

Flame Atomic Absorption Spectroscopy ◽

Flame Atomic Absorption ◽

Schizophrenic Patients ◽

Calcium Lead ◽

Exact Correlation

The serum concentration of cadmium (Cd), lead (Pb), calcium (Ca) and iron (Fe) in 30 schizophrenic patients and 30 normal healthy subjects were analyzed by flame atomic absorption spectroscopy. The concentrations of Cd, Pb and Ca in schizophrenic disorder patients was not increased significantly (P > 0.05) compared to that of the cohort controls. But the concentration of Fe in schizophrenic patients was significantly different from that of the cohort control (p < 0.000). The change in serum concentration of different trace elements may have some prognostic significance for the diagnosis of schizophrenic disorder. However further work is suggested to examine the exact correlation between trace elements level and the degree of disorder in schizophrenic patients. Key words: Schizophrenic patients, trace elements, clinical significance Dhaka Univ. J. Pharm. Sci. Vol.5(1-2) 2006 The full text is of this article is available at the Dhaka Univ. J. Pharm. Sci. website

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A correlative study of copper, iron, zinc and haematological parameters in oral cancer patients

MedPulse International Journal of Biochemistry ◽

10.26611/10021923 ◽

2021 ◽

Vol 19 (2) ◽

pp. 22-25

Author(s):

Joel Sabu ◽

Keyword(s):

Trace Elements ◽

Oral Cancer ◽

Serum Level ◽

Cancer Patients ◽

Serum Levels ◽

Haematological Parameters ◽

Oral Carcinogenesis ◽

Group I ◽

Iron And Zinc ◽

Oral Cancer Patients

Background: Alteration in levels of copper, iron and zinc variate the enzymatic actions in our body and thereby play a major role in etiopathogenesis of oral carcinogenesis. Aim of the study: The present study was mainly aimed to estimate, compare and correlate the serum levels of copper, iron and zinc with haematological parameters in oral cancer patients in comparison to normal controls. Methods: The collected serum of cases and controls were analyzed by using standard spectrophotometric methods in spectrophotometer analyzer and the data obtained was analysed and represented as Mean ± SD, mean difference was analyzed by Student’s T-test and Chi- square test for significance and strength of association by Karl Pearson’s correlation using SPSSv23 software. Results: Mean serum level of iron was significantly lower and the levels of zinc and copper in patients with oral cancerous lesions were significantly higher than that of healthy individuals. Pearson’s r data analysis, revealed a significant negative correlation between iron with platelets, and MCHC (Mean Corpuscular Haemoglobin Concentration). A significant positive correlation was seen between iron with haemoglobin and lymphocytes; between copper with leucocytes. Conclusions: The serum levels of zinc and copper in group I were significantly higher when compared to controls. There was a significant lower serum level of iron in Group-I when compared to controls. A significant correlation was seen in between serum trace elements and haematological parameters in oral cancer. This suggests the involvement of trace elements in variations of haematological parameters in the pathogenesis of oral carcinogenesis.

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INFLUENCE OF SOME DISEASED CONDITIONS ON BLOOD SERUM LEVELS OF ANTIOXIDANT VITAMINS AND SOME TRACE ELEMENTS OF EGYPTIAN BALADY SHEEP IN ASSIUT GOVERNORATE

Assiut Veterinary Medical Journal ◽

10.21608/avmj.2000.180463 ◽

2000 ◽

Vol 42.2 (84) ◽

pp. 120-133

Keyword(s):

Trace Elements ◽

Blood Serum ◽

Serum Levels ◽

Antioxidant Vitamins

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Effect of Octopine on Oxidative Stress Indices and Serum Levels of Lipids and Trace Elements in Mice with Breast Cancer

Medical Laboratory Journal ◽

10.29252/mlj.14.5.13 ◽

2020 ◽

Vol 14 (5) ◽

pp. 13-18

Author(s):

Abdolrasoul Hakim Elahi ◽

Rasoul Sharifi ◽

minoo Mahmoodi ◽

Seyed Mehrdad Kassaee ◽

◽

...

Keyword(s):

Breast Cancer ◽

Oxidative Stress ◽

Trace Elements ◽

Serum Levels ◽

Stress Indices

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Serum Levels of Selenium, Zinc, Copper, Manganese, and Iron in Prostate Cancer Patients

Current Urology ◽

10.1159/000499261 ◽

2020 ◽

Vol 14 (1) ◽

pp. 44-49 ◽

Cited By ~ 4

Author(s):

Saleh A.K. Saleh ◽

Heba M. Adly ◽

Altaf A. Abdelkhaliq ◽

Anmar M. Nassir

Keyword(s):

Prostate Cancer ◽

Trace Elements ◽

Cancer Patients ◽

Serum Levels ◽

Cellular Growth ◽

Control Groups ◽

Icp Ms ◽

Copper Manganese ◽

Trace Element Contents ◽

Serum Trace Elements

Backgrounds: Variations of trace element contents may be associated with several diseases including metabolic disorders, cellular growth disturbance, mutation and tumorigenesis. Prostate cancer is the second most common male cancer worldwide and stand fifth most common male cancer in Saudi Arabia. Objective: In the present study, Serum levels of selenium, zinc, copper, manganese, and iron were measured in patients with BPH and prostate cancer aiming to explore the association between these elements and prostate cancer. Patients and Methods: The study included 40 newly diagnosed prostate cancer patients, 22 patients with BPH and 30 healthy male subjects. All participant groups had similar socio-economic levels. Fasting blood samples were collected from all subjects and before any intervention for the patients. Serum PSA concentrations were analyzed by ELIZA and trace elements Se, Zn, Cu, Mn and Fe were measured by ICP-MS. Results: Serum Se, Zn, and Mn levels of prostate cancer patients were significantly decreased compared to control groups. The levels of serum Cu and Fe were significantly higher in prostate cancer patients than in control groups. Conclusion: In the present study, an association was noticed between serum trace elements disturbance and prostate cancer. The decreased levels of Se, Zn, and Mn, and increased Cu and Fe levels may play significant roles in the initiation of prostate cancer. However, future prospective studies on the causes of trace elements alteration in prostate cancer patients are needed as well as to illustrate the relation between different prostate cancer stages and trace elements concentrations.

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