How Predictive Is Breast Arterial Calcification of Cardiovascular Disease and Risk Factors When Found at Screening Mammography?

2007 ◽  
Vol 2007 ◽  
pp. 48-49
Author(s):  
R.L. Birdwell
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Screening Mammography ◽  
Arterial Calcification

How Predictive Is Breast Arterial Calcification of Cardiovascular Disease and Risk Factors When Found at Screening Mammography?

2006 ◽  
Vol 187 (1) ◽  
pp. 73-80 ◽  
Author(s):  
Masako Kataoka ◽  
Ruth Warren ◽  
Robert Luben ◽  
Joanna Camus ◽  
Erika Denton ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Screening Mammography ◽  
Arterial Calcification

scholarly journals Evaluation of mammography detected breast arterial calcifications as a predictor of coronary cardiac risk

2019 ◽  
Vol 50 (1) ◽  
Author(s):  
Engy A. Ali ◽  
Heba Fouad ◽  
Naglaa A. Razek ◽  
Ola M. Saeed ◽  
Sameh M. Helmy
Keyword(s):  
Cardiovascular Disease ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Future Development ◽  
Causes Of Death ◽  
Cardiac Risk ◽  
Screening Mammography ◽  
Arterial Calcification ◽  
Female Patients ◽  
Artery Disease

Abstract Background Cardiovascular disease is one of the leading causes of death so detection of breast arterial calcifications on annually screening mammography can predict the possibility of future cardiovascular problems. Results The 100 female patients were divided into two groups according to age: 1st group with age ranging from 40 to 60 years and 2nd group with age ranging from 61 to 80 years. There is increased percentage of cardiac cases among the BAC-positive patients in the 2nd group with a significant p value = 0.022 and this proved that there was a correlation between presence of BAC and being a cardiac case in the 2nd group, unlike the 1st group which showed no correlation. Conclusion Incidental detection of breast arterial calcification in mammography in females above 60 years warrants further evaluation of their coronary atherosclerotic state and risk of future development of serious coronary artery disease.

Monitoring Cardiovascular Risk Factors in Children on Dialysis

2009 ◽  
Vol 29 (2_suppl) ◽  
pp. 173-175 ◽  
Author(s):  
Rukshana Shroff
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Chronic Kidney Disease ◽  
Cardiovascular Risk ◽  
Kidney Disease ◽  
Arterial Calcification ◽  
Monitoring Methods ◽  
High Mortality Risk ◽  
Common Cause ◽  
Vascular Abnormalities

Cardiovascular disease (CVD) is the most common cause of death in patients with chronic kidney disease (CKD). Structural and functional vascular abnormalities and arterial calcification begin early in the course of renal decline and can be found even in children, contributing to their high mortality risk. Here, I discuss the burden of CVD in children with CKD; currently available methods of monitoring cardiac and vascular damage; the sensitivity of monitoring methods; and whether there is a need for regular monitoring in children with CKD.

Abstract 11288: Breast Arterial Calcifications and Their Association With Cardiovascular Disease in the Prospect Cohort

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Eva J Hendriks ◽  
Joline W Beulens ◽  
Willem P Mali ◽  
Yolanda van der Graaf ◽  
Pim A de Jong ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Cardiovascular Risk ◽  
Cardiovascular Mortality ◽  
Arterial Calcification ◽  
Peripheral Artery ◽  
Artery Disease ◽  
Medial Arterial Calcification

Introduction: Breast arterial calcifications (BAC) are a type of medial arterial calcification observed at mammography. They are more prevalent among diabetes patients and thought to be associated with increased cardiovascular risk, but high quality longitudinal studies are scarce. We aimed to investigate the association of BAC with risk of different types of cardiovascular outcomes. Methods: We performed a series of case-cohort studies nested within the PROSPECT-EPIC cohort, including a random subcohort (n = 1672), and incident cases of coronary heart disease (n=1050), stroke (n=399) peripheral artery disease (n=257), cardiovascular mortality (n=250), and type 2 diabetes (n=526). At baseline BAC was scored as absent, mild, moderate or severe by experienced radiologists. The average follow-up time was 12.0(±1.9) years. We calculated hazard ratios(HRs) using Cox proportional hazards models, adapted to the case-cohort design through Prentice-weighting and adjusting for traditional cardiovascular risk factors. Results: Of the women in the sub cohort with mammograms available (n=1540), 133 women (8.6%) had BAC in at least one breast. Grade was scored as mild in 75 women (4.9%), moderate in 39 women (2.5%) and severe in 19 women (1.2%). BAC presence was borderline significantly (0.05<p<0.10) associated with risk of coronary heart disease, stroke and cardiovascular mortality, with adjusted HR estimates ranging from 1.42 to 1.58. Much larger effect sizes were found for women with the most severe grade of BAC, as they had a HR of 3.43 (95% CI 1.85-6.37) for coronary heart disease, a HR of 3.19 (95% CI 1.52-6.72) for stroke, a HR of 2.92 (95%CI 1.02-8.35) for peripheral artery disease and a HR of 3.55 (95%CI 1.48-8.52) for cardiovascular mortality compared to women without BAC. Conclusions: BAC presence is modestly associated with cardiovascular disease, with an approximately 3-fold increased risk for the severest grade of BAC, independent of traditional risk factors. This indicates a possible contribution of a medial, non-atherosclerotic pathway to cardiovascular disease events. Whether BAC is a marker of medial arterial calcification in different vascular beds needs to be further investigated.

scholarly journals Plasma osteocalcin levels as a predictor of cardiovascular disease in older men and women: a population-based cohort study

2014 ◽  
Vol 171 (2) ◽  
pp. 161-170 ◽  
Author(s):  
Kristin Holvik ◽  
Natasja M van Schoor ◽  
Elisabeth M W Eekhoff ◽  
Martin den Heijer ◽  
Dorly J H Deeg ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Cohort Study ◽  
Population Based ◽  
Metabolic Risk Factors ◽  
Arterial Calcification ◽  
Metabolic Risk ◽  
Increased Risk ◽  
Old Men ◽  
Age And Sex

ObjectiveThe role of osteocalcin (OC) in cardiovascular disease (CVD) is unresolved. We aimed to study the association between plasma OC concentrations and the risk of non-fatal and fatal CVDs. We also aimed to investigate whether such an association, if present, would be mediated by established metabolic risk factors.DesignA population-based longitudinal cohort study.MethodsIn 1995/1996, OC was determined in blood samples drawn from 1319 subjects aged 65–88 years participating in the Longitudinal Aging Study Amsterdam in 1995/1996. The self-reported CVD events were collected every 3 years until 2005/2006, and CVD deaths until 1st January 2007. Cox proportional hazards regression was performed, considering potential confounders (smoking, physical activity, and BMI) and mediators (blood pressure, plasma triglycerides, total and HDL cholesterol, fructosamine, and aortic calcification).ResultsDuring the median 4.1 years follow-up, 709 subjects (53.8%) suffered a CVD event. There was no overall association between OC and CVD: hazard ratio (HR) was 0.97 (95% CI 0.90–1.04) per nmol/l higher plasma OC, adjusted for age and sex. There was a statistical interaction between plasma OC, age, and sex on CVD (P=0.014). In those subjects aged ≥75 years, age-adjusted HRs (95% CI) were 0.86 (0.75–0.99) in men and 1.16 (1.03–1.31) in women per nmol/l higher plasma OC. Adjustment for covariates only slightly attenuated the association in older-old men, but did not affect the association in older-old women.ConclusionA higher plasma OC concentration was associated with a reduced risk of CVD in older-old men and with an increased risk of CVD in older-old women. We found no evidence that this was mediated by arterial calcification or metabolic risk factors.

Serum Retinol and β-carotene Levels and Risk Factors for Cardiovascular Disease in Morbid Obesity

2010 ◽  
Vol 80 (3) ◽  
pp. 159-167 ◽  
Author(s):  
Gabriela Villaça Chaves ◽  
Gisele Gonçalves de Souza ◽  
Andréa Cardoso de Matos ◽  
Dra. Wilza Abrantes Peres ◽  
Silvia Elaine Pereira ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Metabolic Syndrome ◽  
Morbid Obesity ◽  
Serum Levels ◽  
World Health ◽  
Morbidly Obese ◽  
Serum Retinol ◽  
Significant Difference ◽  
Β Carotene

Objective: To evaluate retinol and β-carotene serum levels and their relationship with risk factors for cardiovascular disease in individuals with morbid obesity, resident in Rio de Janeiro. Methodology: Blood serum concentrations of retinol and β-carotene of 189 morbidly obese individuals were assessed. The metabolic syndrome was identified according to the criteria of the National Cholesterol Education Program (NCEP) and World Health Organization (WHO). Lipid profile, insulin resistance, basal insulin, glycemia, blood pressure, and anthropometry and their correlation with retinol and β-carotene serum levels were evaluated. Results: Metabolic syndrome diagnosis was observed in 49.0% of the sample. Within this percentage the levels of β-carotene were significantly lower when body mass index increased. Serum retinol didn't show this behavior. Serum retinol inadequacy in patients with metabolic syndrome (61.3%), according to WHO criterion, was higher (15.8%) than when the whole sample was considered (12.7%). When metabolic syndrome was diagnosed by NCEP criterion, β-carotene inadequacy was higher (42.8%) when compared to the total sample (37.5%). There was a significant difference between average β-carotene values of patients with and without metabolic syndrome (p=0.048) according to the classification of the NCEP. Lower values were found in patients with metabolic syndrome. Conclusion: Considering the vitamin A contribution in antioxidant protection, especially when risk factors for cardiovascular disease are present, it is suggested that great attention be given to morbidly obese. This could aid in prevention and treatment of cardiovascular disease, which affects a significant part of the population.

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