PO-1229: Preliminary data on long term toxicity in young patients with chordoma: C.N.A.O. experience

Abstract Aims Atrioventricular block (AVB) of unknown aetiology is rare in the young, and outcome in these patients is unknown. We aimed to assess long-term morbidity and mortality in young patients with AVB of unknown aetiology. Methods and results We identified all Danish patients younger than 50 years receiving a first pacemaker due to AVB between January 1996 and December 2015. By reviewing medical records, we included patients with AVB of unknown aetiology. A matched control cohort was established. Follow-up was performed using national registries. The primary outcome was a composite endpoint consisting of death, heart failure hospitalization, ventricular tachyarrhythmia, and cardiac arrest with successful resuscitation. We included 517 patients, and 5170 controls. Median age at first pacemaker implantation was 41.3 years [interquartile range (IQR) 32.7–46.2 years]. After a median follow-up of 9.8 years (IQR 5.7–14.5 years), the primary endpoint had occurred in 14.9% of patients and 3.2% of controls [hazard ratio (HR) 3.8; 95% confidence interval (CI) 2.9–5.1; P < 0.001]. Patients with persistent AVB at time of diagnosis had a higher risk of the primary endpoint (HR 10.6; 95% CI 5.7–20.0; P < 0.001), and risk was highest early in the follow-up period (HR 6.8; 95% CI 4.6–10.0; P < 0.001, during 0–5 years of follow-up). Conclusion Atrioventricular block of unknown aetiology presenting before the age of 50 years and treated with pacemaker implantation was associated with a three- to four-fold higher rate of the composite endpoint of death or hospitalization for heart failure, ventricular tachyarrhythmia, or cardiac arrest with successful resuscitation. Patients with persistent AVB were at higher risk. These findings warrant improved follow-up strategies for young patients with AVB of unknown aetiology.

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Corrigendum to: Long-term outcomes in young patients with atrioventricular block of unknown aetiology

European Heart Journal ◽

10.1093/eurheartj/ehab155 ◽

2021 ◽

Keyword(s):

Atrioventricular Block ◽

Young Patients ◽

Unknown Aetiology ◽

Long Term Outcomes

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Long-term mortality in young patients with spontaneous intracerebral haemorrhage: Predictors and causes of death

European Stroke Journal ◽

10.1177/23969873211017723 ◽

2021 ◽

Vol 6 (2) ◽

pp. 185-193

Author(s):

Jamie I Verhoeven ◽

Marco Pasi ◽

Barbara Casolla ◽

Hilde Hénon ◽

Frank-Erik de Leeuw ◽

...

Keyword(s):

Mortality Risk ◽

Intracerebral Haemorrhage ◽

Causes Of Death ◽

Cox Regression ◽

Young Patients ◽

University Hospital ◽

Standardized Mortality Ratio ◽

Excessive Alcohol Consumption ◽

Long Term Mortality

Introduction Intracerebral haemorrhage (ICH) in young adults is rare but has devastating consequences. We investigated long-term mortality rates, causes of death and predictors of long-term mortality in young spontaneous ICH survivors. Patients and methods We included consecutive patients aged 18–55 years from the Prognosis of Intracerebral Haemorrhage cohort (PITCH), a prospective observational cohort of patients admitted to Lille University Hospital (2004–2009), who survived at least 30 days after spontaneous ICH. We studied long-term mortality with Kaplan-Meier analyses, collected causes of death, performed uni-/multivariable Cox-regression analyses for the association of baseline characteristics with long-term mortality. Results Of 560 patients enrolled in the PITCH, 75 patients (75% men) met our inclusion criteria (median age 50 years, interquartile range [IQR] 44–53 years). During a median follow-up of 8.2 years (IQR 5.0–10.1), 26 patients died (35%), with a standardized mortality ratio of 13.0 (95% confidence interval [95% CI] 8.5–18.0) compared to peers from the general population. Causes of death were vascular in 7 (27%) patients, non-vascular in 13 (50%) and unknown in 6 (23%). Global cerebral atrophy (hazard ratio [HR] 3.0, 95% CI 1.1–8.6), modified Rankin Score >2 before ICH (HR 3.4, 95% CI 1.0–11.0), and excessive alcohol consumption (HR 3.3, 95% CI 1.1–10.2) were independently associated with long-term mortality. Discussion We found a 13-fold higher mortality risk for young ICH survivors compared to the general French population. Predictors of long-term mortality were pre-existing conditions, not ICH-characteristics. Conclusion Young ICH survivors remain at increased mortality risk of vascular and non-vascular death for years after ICH.

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LONG-TERM OUTCOMES AFTER OUT-OF-HOSPITAL CARDIAC ARREST IN YOUNG PATIENTS WITH MYOCARDIAL INFARCTION

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(18)30720-4 ◽

2018 ◽

Vol 71 (11) ◽

pp. A179

Author(s):

Ersilia M. Defilippis ◽

Avinainder Singh ◽

Bradley Collins ◽

Ankur Gupta ◽

Arman Qamar ◽

...

Keyword(s):

Myocardial Infarction ◽

Cardiac Arrest ◽

Young Patients ◽

Long Term Outcomes ◽

Hospital Cardiac Arrest

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Awareness and opinion about polycystic ovarian syndrome (PCOS) among young women: a developing country perspective

International Journal of Adolescent Medicine and Health ◽

10.1515/ijamh-2018-0166 ◽

2020 ◽

Vol 0 (0) ◽

Author(s):

Saubhagya Kumar Jena ◽

Lipsa Mishra ◽

Sushree Samiksha Naik ◽

Shahnawaz Khan

Keyword(s):

Young Women ◽

Tertiary Care ◽

Young Patients ◽

Urban Sector ◽

Contraceptive Pills ◽

Validated Questionnaire ◽

Set Up ◽

Ovarian Syndrome

AbstractObjectiveTo explore the perception on PCOS and its prevalence among adolescent and young women.MethodsThe study was conducted over 2 year period in a tertiary care teaching hospital from Eastern India. A pre-formed, validated questionnaire was used to record the details. Descriptive statistics was used to report the findings.ResultsOf 965 young patients with mean (SD) age 20.64 (2.1) years, 27 (2.79 %) were aware of an entity called PCOS. Awareness among adolescents with PCOS was 25.9 % (7/27). All aware patients belonged to the urban sector with professionals constituting around 48%, of which 11% were students. The major source of information among aware patients was from doctors (40.7%), and friends and Internet (25.9%); rest being from books, newspapers, and teachers. Majority (70%) were aware that diet restriction and exercise were the primary modalities of treatment, whereas, only 3.7% knew about the role of contraceptive pills in PCOS.ConclusionsAwareness regarding PCOS among the young women is very low mainly in the rural set up. Doctors and health staffs should play a major role in spreading awareness of the entity to prevent long term complications.

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Long-Term Outcome and Prognostic Factors of Sporadic Colorectal Cancer in Young Patients

Medicine ◽

10.1097/md.0000000000003641 ◽

2016 ◽

Vol 95 (19) ◽

pp. e3641 ◽

Cited By ~ 11

Author(s):

Tae Jun Kim ◽

Eun Ran Kim ◽

Sung Noh Hong ◽

Dong Kyung Chang ◽

Young-Ho Kim

Keyword(s):

Colorectal Cancer ◽

Prognostic Factors ◽

Young Patients ◽

Sporadic Colorectal Cancer ◽

Term Outcome ◽

Long Term Outcome

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Abnormal renal haemodynamics during exercise in young patients with mild essential hypertension without treatment and during long-term propranolol therapy

Scandinavian Journal of Clinical and Laboratory Investigation ◽

10.1080/00365517809108821 ◽

1978 ◽

Vol 38 (6) ◽

pp. 567-571 ◽

Cited By ~ 9

Author(s):

E. B. Pedersen

Keyword(s):

Essential Hypertension ◽

Young Patients ◽

Renal Haemodynamics ◽

Propranolol Therapy

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CLINICAL PROFILE OF PATIENTS OF YOUNG STROKE.

10.36106/ijar/3218440 ◽

2021 ◽

pp. 68-70

Author(s):

Nitin Hiraman Suryawanshi ◽

Amit Aggarwal ◽

Abhijit Kadam

Keyword(s):

Diabetes Mellitus ◽

Risk Factors ◽

Young Patients ◽

Behavioural Pattern ◽

Long Term Outcomes ◽

Short Term ◽

Traditional Risk Factors ◽

The Individual ◽

Stroke In Young

A study of stroke in young patients has recently become a subject of interest. This is due to a lot of impact on the individual and society. Study of stroke in young patients can lead to therapeutical results affecting both short term and long-term outcomes. Our study is hospital based retrospective study for duration of 1 year. Thi Methods: Results: s study revealed stroke in young in 25.16% of all stroke cases, with cerebral infarction in 56% and followed by intracerebral haemorrhage in 25.64%, and cerebral venous thrombosis in 18%. The most common presenting symptom was hemiparesis. The most prevalent risk factor for stroke in young was hypertension followed by diabetes mellitus, alcohol consumption and smoking. Stroke in young requires a differe Conclusion: nt approach to investigate and treat. This is due to different underlying etilogy as compared to elderly. Although traditional risk factors are associated with stroke, behavioural pattern such as smoking and alcohol may cause and promote development of stroke in young.

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