P2353 Supplementary treatment with abacorS, a soy protein based dietary supplement, reduces plasma concentrations of total and LDL cholesterols in statin-treated hypercholesterolemic patients

2003 ◽  
Vol 24 (5) ◽  
pp. 458 ◽  
Author(s):  
P CLAUSEN
Keyword(s):  
Dietary Supplement ◽  
Soy Protein ◽  
Plasma Concentrations ◽  
Supplementary Treatment

Safety and immunostimulatory activity of the dietary supplement Houttuynia cordata Thunb. fermentation product in healthy volunteers

2021 ◽  
Author(s):  
Khanutsanan Woranam ◽  
Jeerati Prompipak ◽  
Piroon Mootsikapun ◽  
Gulsiri Senawong ◽  
Limthong Promdee ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Dietary Supplement ◽  
Plasma Concentrations ◽  
Antiretroviral Drugs ◽  
Sprague Dawley ◽  
Houttuynia Cordata ◽  
Fermentation Product ◽  
Sprague Dawley Rats ◽  
Significant Difference ◽  
Houttuynia Cordata Thunb

Abstract Houttuynia cordata Thunb. fermentation product (HCFP) is widely used in Thailand as a dietary supplement for immune support with no experimental verification. The aim of this study was to investigate the safety and immunomodulation of HCFP in healthy adult volunteers. The effect of HCFP on antiretroviral drugs (TDF and EFV) was also evaluated in Sprague Dawley rats. The basic characteristics and blood chemistry of ten healthy volunteers did not show any significant differences between before and after 4 weeks of intervention with a daily intake of HCFP, and no major adverse event was observed. However, the LDL-c level was significantly decreased after 4 weeks of intervention. Immunomodulation assay revealed that the percentage of neutrophil was significantly increased after 8 weeks of intervention in 30 healthy volunteers. Meanwhile, the mean of CD4+ and CD8+ T-cell ratio was not significantly increased after 8 weeks of intervention. In addition, the plasma concentrations of EFV and TDF in Sprague Dawley rats showed no significant difference between single drug group and combination with HCFP group, suggesting that HCFP has no effect on the plasma level of antiretroviral drugs.

scholarly journals Interaction of Carbamazepine with Herbs, Dietary Supplements, and Food: A Systematic Review

2013 ◽  
Vol 2013 ◽  
pp. 1-15 ◽  
Author(s):  
Sophia Yui Kau Fong ◽  
Qiong Gao ◽  
Zhong Zuo
Keyword(s):  
Systematic Review ◽  
Drug Interactions ◽  
Dietary Supplements ◽  
Dietary Supplement ◽  
Plasma Concentrations ◽  
Inclusion Criteria ◽  
First Line ◽  
Pharmacodynamic Interaction ◽  
Herbal Products ◽  
Therapeutic Outcomes

Background. Carbamazepine (CBZ) is a first-line antiepileptic drug which may be prone to drug interactions. Systematic review of herb- and food-drug interactions on CBZ is warranted to provide guidance for medical professionals when prescribing CBZ.Method. A systematic review was conducted on six English databases and four Chinese databases.Results. 196 out of 3179 articles fulfilled inclusion criteria, of which 74 articles were reviewed and 33 herbal products/dietary supplement/food interacting with CBZ were identified. No fatal or severe interactions were documented. The majority of the interactions were pharmacokinetic-based (80%). Traditional Chinese medicine accounted for most of the interactions (n=17), followed by food (n=10), dietary supplements (n=3), and other herbs/botanicals (n=3). Coadministration of 11 and 12 of the studied herbal products/dietary supplement/food significantly decreased or increased the plasma concentrations of CBZ. Regarding pharmacodynamic interaction, Xiao-yao-san, melatonin, and alcohol increased the side effects of CBZ while caffeine lowered the antiepileptic efficacy of CBZ.Conclusion. This review provides a comprehensive summary of the documented interactions between CBZ and herbal products/food/dietary supplements which assists healthcare professionals to identify potential herb-drug and food-drug interactions, thereby preventing potential adverse events and improving patients’ therapeutic outcomes when prescribing CBZ.

Soy Protein May Prevent, Treat Hypertension

2005 ◽  
Vol 38 (18) ◽  
pp. 6
Author(s):  
BRUCE JANCIN
Keyword(s):  
Soy Protein

Variations Across the Menstrual Cycle in EEG Activity During Thinking and Mental Relaxation

1999 ◽  
Vol 13 (3) ◽  
pp. 163-172 ◽  
Author(s):  
R. Krug ◽  
M. Mölle ◽  
H.L. Fehm ◽  
J. Born
Keyword(s):  
Menstrual Cycle ◽  
Divergent Thinking ◽  
Spectral Power ◽  
Plasma Concentrations ◽  
Task Demands ◽  
Menstrual Phase ◽  
Convergent Thinking ◽  
Eeg Activity ◽  
Dimensional Complexity ◽  
Mental Relaxation

Abstract Previous studies have indicated: (1) peak performance on tests of divergent creative thinking during the ovulatory phase of the menstrual cycle; (2) compared to convergent analytical thinking, divergent thinking was found to be associated with a distinctly increased dimensional complexity of ongoing EEG activity. Based on these findings, we hypothesized that cortical information processing during the ovulatory phase is characterized by an increased EEG dimensionality. Each of 16 women was tested on 3 occasions: during the ovulatory phase, the luteal phase, and menses. Presence of the phases was confirmed by determination of plasma concentrations of estradiol, progesterone, and luteinizing hormone. The EEG was recorded while the women performed: (1) tasks of divergent thinking; (2) tasks of convergent thinking; and (3) during mental relaxation. In addition to EEG dimensional complexity, conventional spectral power analysis was performed. Behavioral data confirmed enhanced creative performance during the ovulatory phase while convergent thinking did not vary across cycle phases. EEG complexity was higher during divergent than convergent thought, but this difference remained unaffected by the menstrual phase. Influences of the menstrual phase on EEG activity were most obvious during mental relaxation. In this condition, women during the ovulatory phase displayed highest EEG dimensionality as compared with the other cycle phases, with this effect being most prominent over the central and parietal cortex. Concurrently, power within the alpha frequency band as well as theta power at frontal and parietal leads were lower during the luteal than ovulatory phase. EEG results indicate that task demands of thinking overrode effects of menstrual cycle. However, with a less demanding situation, an ovulatory increase in EEG dimensionality became prominent suggesting a loosening of associative habits during this phase.

Constituents from the botanical dietary supplement wild yam

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
SH Dong ◽  
D Nikolic ◽  
C Simmler ◽  
F Qiu ◽  
RB van Breemen ◽  
...  
Keyword(s):  
Dietary Supplement ◽  
Wild Yam

Very Low Activated Factor VII and Reduced Factor VII Antigen in Familial Abetalipoproteinaemia

1998 ◽  
Vol 80 (08) ◽  
pp. 233-238 ◽  
Author(s):  
K. A. Mitropoulos ◽  
M. N. Nanjee ◽  
D. J. Howarth ◽  
J. C. Martin ◽  
M. P. Esnouf ◽  
...  
Keyword(s):  
Plasma Concentrations ◽  
Positive Association ◽  
Factor Ix ◽  
Factor Vii ◽  
Unesterified Fatty Acid ◽  
Factor Xii ◽  
Factor X ◽  
Factor Xi ◽  
Activated Factor Vii ◽  
Normal Mean

SummaryAbetalipoproteinaemia is a rare disorder of apolipoprotein B metabolism associated with extremely low plasma concentrations of triglyce-ride. To discover whether the general positive association between factor VII and triglyceride levels extends to this condition, 5 patients were compared with 18 controls. All patients had a triglyceride below 100 μmol/l. Plasma unesterified fatty acid concentration was normal. Although factor IX activity was only slightly reduced (mean 88% standard) and factor IX antigen was normal, mean activated factor VII in patients was strikingly reduced to 34% of that in controls, a level similar to that found in haemophilia B. The patients’ mean factor VII activity and factor VII antigen were also significantly reduced to 54% and 63% of those in controls, respectively. Mean factor XI activity and tissue factor pathway inhibitor activity were reduced in patients to 70% and 75% of control values respectively, while factor XII, factor XI antigen, factor X, prothrombin and protein C were normal.

Parallel Reduction of Plasma Levels of High and Low Molecular Weight Kininogen in Patients with Cirrhosis

1999 ◽  
Vol 82 (11) ◽  
pp. 1428-1432 ◽  
Author(s):  
Cheryl Scott ◽  
Francesco Salerno ◽  
Elettra Lorenzano ◽  
Werner Müller-Esterl ◽  
Angelo Agostoni ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Liver Disease ◽  
Liver Function ◽  
Plasma Levels ◽  
Plasma Concentrations ◽  
Normal Subjects ◽  
Low Molecular Weight ◽  
Major Band ◽  
Sds Page ◽  
Normal Controls

SummaryLittle is known about the regulation of high-molecular-weight-kininogen (HK) and low-molecular-weight-kininogen (LK) or the relationship of each to the degree of liver function impairment in patients with cirrhosis. In this study, we evaluated HK and LK quantitatively by a recently described particle concentration fluorescence immunoassay (PCFIA) and qualitatively by SDS PAGE and immunoblotting analyses in plasma from 33 patients with cirrhosis presenting various degrees of impairment of liver function. Thirty-three healthy subjects served as normal controls. Patients with cirrhosis had significantly lower plasma levels of HK (median 49 μg/ml [range 22-99 μg/ml]) and LK (58 μg/ml [15-100 μg/ml]) than normal subjects (HK 83 μg/ml [65-115 μg/ml]; LK 80 μg/ml [45-120 μg/ml]) (p < 0.0001). The plasma concentrations of HK and LK were directly related to plasma levels of cholinesterase (P < 0.0001) and albumin (P < 0.0001 and P < 0.001) and inversely to the Child-Pugh score (P < 0.0001) and to prothrombin time ratio (P < 0.0001) (reflecting the clinical and laboratory abnormalities in liver disease). Similar to normal individuals, in patients with cirrhosis, plasma HK and LK levels paralleled one another, suggesting that a coordinate regulation of those proteins persists in liver disease. SDS PAGE and immunoblotting analyses of kininogens in cirrhotic plasma showed a pattern similar to that observed in normal controls for LK (a single band at 66 kDa) with some lower molecular weight forms noted in cirrhotic plasma. A slight increase of cleavage of HK (a major band at 130 kDa and a faint but increased band at 107 kDa) was evident. The increased cleavage of HK was confirmed by the lower cleaved kininogen index (CKI), as compared to normal controls. These data suggest a defect in hepatic synthesis as well as increased destructive cleavage of both kininogens in plasma from patients with cirrhosis. The decrease of important regulatory proteins like kininogens may contribute to the imbalance in coagulation and fibrinolytic systems, which frequently occurs in cirrhotic patients.

Sign in / Sign up

Export Citation Format

Share Document