FP1.3 Longitudinal study of the molecular epidemiology of extended spectrum β-lactamase-producing Escherichia coli

Extra-intestinal pathogenic Escherichia coli (ExPEC) is commonly associated with causing urinary tract and bloodstream infections. Over the past two decades, the antimicrobial resistance of ExPEC has increasingly been reported [1]. Given that Saudi Arabia annually hosts mass religious events, such as Hajj, this review investigated several aspects of antimicrobial resistance of ExPEC in this country including the current prevalence of resistance and molecular epidemiology of ExPEC isolates. Generally, the overall prevalence of antibiotic resistance of ExPEC in Saudi Arabia is on increase. The current emergence of colistin resistance in ExPEC represents a major challenge to public health. Local molecular epidemiological studies have shown the dominance of E. coli sequence type 131 (E. coli ST131) over other major ExPEC STs. This is an important observation given that this clone has been associated with high multidrug resistance and extended-spectrum β-lactamases carriage. To reduce the burden of this resistance in the future, it would be crucial to avoid uncontrolled use of antibiotics in either clinical settings or animal food industry. Keywords: Extra-intestinal pathogenic Escherichia coli, Antimicrobial resistance, ST131, Saudi Arabia, Colistin resistance, Extended-spectrum β-lactamases

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MOLECULAR EPIDEMIOLOGY OF QUINOLONE RESISTANT STRAINS OF EXTENDED SPECTRUM BETA-LACTAMASE PRODUCING ESCHERICHIA COLI

Pakistan Journal of Medical Sciences ◽

10.12669/pjms.315.8186 ◽

2015 ◽

Vol 31 (5) ◽

Cited By ~ 2

Author(s):

Süleyman Durmaz ◽

Duygu Percin ◽

Barıs Derya Ercal

Keyword(s):

Escherichia Coli ◽

Molecular Epidemiology ◽

Beta Lactamase ◽

Extended Spectrum Beta Lactamase ◽

Extended Spectrum ◽

Resistant Strains

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Molecular epidemiology of extended spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae in a tertiary care hospital

Indian Journal of Medical Microbiology ◽

10.4103/0255-0857.129856 ◽

2014 ◽

Vol 32 (2) ◽

pp. 205

Author(s):

N Kammili ◽

N Cherukuri ◽

S Palvai ◽

GP Pazhni ◽

T Ramamurthy ◽

...

Keyword(s):

Escherichia Coli ◽

Klebsiella Pneumoniae ◽

Molecular Epidemiology ◽

Tertiary Care Hospital ◽

Tertiary Care ◽

Care Hospital ◽

Extended Spectrum

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Nationwide Study of the Prevalence, Characteristics, and Molecular Epidemiology of Extended-Spectrum-β-Lactamase-Producing Enterobacteriaceae in France

Antimicrobial Agents and Chemotherapy ◽

10.1128/aac.00906-07 ◽

2007 ◽

Vol 52 (2) ◽

pp. 786-789 ◽

Cited By ~ 33

Author(s):

Muriel Galas ◽

Jean-Winoc Decousser ◽

Nelly Breton ◽

Thierry Godard ◽

Pierre Yves Allouch ◽

...

Keyword(s):

Escherichia Coli ◽

Klebsiella Pneumoniae ◽

Molecular Epidemiology ◽

Molecular Analysis ◽

Enterobacter Aerogenes ◽

Nationwide Study ◽

E Coli ◽

Extended Spectrum ◽

Prevalent Species

ABSTRACT Among 10,872 isolates of Enterobacteriaceae from a nationwide study of 88 French hospitals in 2005, 169 (1.7%) expressed an extended-spectrum β-lactamase. The most prevalent species were Escherichia coli (48.5%), Enterobacter aerogenes (23.7%), and Klebsiella pneumoniae (14.8%). Molecular analysis underlined the polyclonal spread of CTX-M-expressing E. coli, primarily isolates of the CTX-M-1 subgroup.

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