In vivo and in vitro antimicrobial activity of silver sulfadiazine and cerium nitrate

1981 ◽  
Vol 10 (9) ◽  
pp. 501
Author(s):  
Mark Shaffer
Keyword(s):  
Antimicrobial Activity ◽  
Silver Sulfadiazine ◽  
Cerium Nitrate ◽  
In Vitro Antimicrobial Activity

CHLORHEXIDINE/SILVER SULFADIAZINE COATED CATHETERS: EFFECT OF DURATION OF CATHETERIZATION ON IN VITRO ANTIMICROBIAL ACTIVITY.

1995 ◽  
Vol 23 (Supplement) ◽  
pp. A172
Author(s):  
Manisha Wagle ◽  
Angela Brueggemann ◽  
Gary Doern ◽  
Lena Napolitano ◽  
Robert Sherertz ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Silver Sulfadiazine ◽  
In Vitro Antimicrobial Activity

scholarly journals Wild Italian Prunus spinosa L. Fruit Exerts In Vitro Antimicrobial Activity and Protects Against In Vitro and In Vivo Oxidative Stress

Foods ◽  
2019 ◽  
Vol 9 (1) ◽  
pp. 5
Author(s):  
Luisa Pozzo ◽  
Rossella Russo ◽  
Stefania Frassinetti ◽  
Francesco Vizzarri ◽  
Július Árvay ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Antimicrobial Activity ◽  
Total Phenolic ◽  
Antioxidant Power ◽  
In Vitro Antimicrobial Activity ◽  
Food Industries ◽  
Gram Positive Bacteria ◽  
Prunus Spinosa

Polyphenol-rich foods could have a pivotal function in the prevention of oxidative stress-based pathologies and antibacterial action. The purpose of this study was to investigate the in vitro antimicrobial activity, as well as the in vitro and In Vivo antioxidant capacities of wild Prunus spinosa L. fruit (PSF) from the southeast regions of Italy. The total phenolic content (TPC) was quantified, and the single polyphenols were analyzed by HPLC-DAD, showing high rutin and 4-hydroxybenzoic acid levels, followed by gallic and trans-sinapic acids. PSF extract demonstrated antimicrobial activity against some potentially pathogenic Gram-negative and Gram-positive bacteria. Besides, we investigated the cellular antioxidant activity (CAA) and the hemolysis inhibition of PSF extract on human erythrocytes, evidencing both a good antioxidant power and a marked hemolysis inhibition. Furthermore, an In Vivo experiment with oxidative stress-induced rats treated with a high-fat diet (HFD) and a low dose of streptozotocin (STZ) demonstrated that PSF has a dose-dependent antioxidant capacity both in liver and in brain. In conclusion, the wild Italian Prunus spinosa L. fruit could be considered a potentially useful material for both nutraceutical and food industries because of its antioxidant and antimicrobial effects.

scholarly journals Prolonged Antimicrobial Activity of a Catheter Containing Chlorhexidine-Silver Sulfadiazine Extends Protection against Catheter Infections In Vivo

2001 ◽  
Vol 45 (5) ◽  
pp. 1535-1538 ◽  
Author(s):  
Stefano Bassetti ◽  
Jean Hu ◽  
Ralph B. D'Agostino ◽  
Robert J. Sherertz
Keyword(s):  
Antimicrobial Activity ◽  
First Generation ◽  
Rabbit Model ◽  
Silver Sulfadiazine ◽  
Catheter Infection ◽  
Zones Of Inhibition ◽  
Catheter Implantation ◽  
Catheter Infections

ABSTRACT The present study evaluated in vitro and in vivo a new chlorhexidine (C)-silver sulfadiazine (S) vascular catheter (the CS2 catheter) characterized by a higher C content and by the extended release of the surface-bound antimicrobials. The CS2 catheter was compared with a first-generation, commercially available CS catheter (the CS1 catheter). The CS2 catheter produced slightly smaller zones of inhibition (mean difference, 0.9 mm [P < 0.001]) at 24 h against Staphylococcus aureus and five other microorganisms by several different methodologies. However, in a rabbit model, both CS catheters were similarly efficacious in preventing a catheter infection when the rabbits were inoculated with 104 to 107 CFU of S. aureus at the time of catheter insertion. The CS2 catheter retained its antimicrobial activity significantly longer in vitro and in vivo (half-lifes exceeded 34 and 7 days, respectively) and was also significantly more efficacious in preventing a catheter infection when 106 CFU of S. aureus was inoculated 2 days after catheter implantation (P < 0.001). These results suggest that prolonged anti-infective activity on the external catheter surface provides improved efficacy in the prevention of infection.

scholarly journals In Vitro Antimicrobial Activity of GSQ1530, a New Heteroaromatic Polycyclic Compound

2002 ◽  
Vol 46 (10) ◽  
pp. 3168-3174 ◽  
Author(s):  
Yigong Ge ◽  
Stacey Difuntorum ◽  
Sofia Touami ◽  
Ian Critchley ◽  
Roland Bürli ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Therapeutic Potential ◽  
Clinical Isolates ◽  
In Vivo Studies ◽  
Cross Resistance ◽  
Minimal Bactericidal Concentration ◽  
Gram Positive ◽  
In Vitro Antimicrobial Activity

ABSTRACT GSQ1530 is a compound derived from a newly identified class of antibiotics referred to as heteroaromatic polycyclic (HARP) antibiotics. The aim of this study was to assess the in vitro antimicrobial activity of GSQ1530. By using an NCCLS broth microdilution assay, the activities of GSQ1530 and other antibiotics were coevaluated against 215 clinical isolates. The MICs at which 90% of isolates are inhibited (MIC90s) of GSQ1530 for methicillin-susceptible Staphylococcus aureus and methicillin-resistant S. aureus (MRSA) were 2 and 4 μg/ml, respectively. The MIC90s of GSQ1530 for the streptococci tested were 2 μg/ml or less, regardless of their susceptibilities to other antibiotics. The MIC90 of GSQ1530 for the enterococci tested (including vancomycin-resistant enterococci) was 4 μg/ml. No cross-resistance was found between GSQ1530 and other known antibiotics. In a separate assay, GSQ1530 demonstrated excellent activity against vancomycin-intermediate-susceptible staphylococci (MIC90, 1 μg/ml). The minimal bactericidal concentration test was conducted with 73 clinical isolates; GSQ1530 was cidal against streptococci and staphylococci but static against enterococci. An in vitro killing kinetic study revealed a time-dependent profile, with at least a 3-log reduction of bacterial growth within 6 h after exposure to four times the MICs of GSQ1530 for both S. aureus and Streptococcus pneumoniae. The checkerboard study showed that GSQ1530 had a synergistic interaction with rifampin against MRSA. The test medium was found to have little effect on in vitro antimicrobial potency. The MICs of GSQ1530 for gram-positive cocci were 4- to 32-fold higher in the presence of serum proteins. GSQ1530 has high levels of plasma protein binding (91 and 89% for rat and human plasma, respectively). These preliminary results demonstrate that GSQ1530, a representative compound of our novel HARP antibiotics, has broad-spectrum activity against gram-positive bacteria. This novel class of antibacterial compounds is profiled in vivo to assess the therapeutic potential in humans. Ongoing in vivo studies will assess whether this class of molecules has promising in vivo efficacy and safety profiles.

scholarly journals In Vitro Antimicrobial Activity and Probiotic Potential of Bifidobacterium and Lactobacillus against Species of Clostridium

Nutrients ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 448 ◽  
Author(s):  
Cinara Monteiro ◽  
Monique do Carmo ◽  
Bruna Melo ◽  
Matheus Alves ◽  
Camilla dos Santos ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Gas Production ◽  
Host Cells ◽  
Clostridium Species ◽  
Adhesive Properties ◽  
In Vitro Antimicrobial Activity ◽  
Probiotic Potential ◽  
Susceptibility Profiles

Many Clostridium species are found as commensal members of the intestinal microbiota. However, imbalances of the microbiota may lead to certain infections caused by these microorganisms, mainly Clostridium butyricum, Clostridium difficile, and Clostridium perfringens. In many cases, infection recurrence can occur after antibiotics, indicating the need for novel therapeutic options that act on the pathogens and also restore the microbiota. Herein, the in vitro antimicrobial activity and probiotic potential of clinical and reference strains of Bifidobacterium and Lactobacillus were investigated against Clostridium species. Antimicrobial activity was evaluated by the agar spot test and inhibition of gas production. Then, the probiotic potential of selected strains was assessed by analyzing their coaggregation ability, adhesive properties to host cells and mucin, tolerance to acidic pH and bile salts, and antimicrobial susceptibility profiles. Lactobacillus plantarum ATCC 8014 was the most promising strain based on its inhibitory activity against Clostridium spp. Also, this strain met criteria to be considered a probiotic based on its coaggregation ability, adhesive properties, and tolerance to harsh pH and bile acid salt conditions. The results indicate that among the studied strains, L. plantarum ATCC 8014 presents probiotic potential for controlling infections induced by the studied Clostridium species and should be further evaluated in in vivo animal models.

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