HLA-DRB1∗0405 is the Predominant Allele in Brazilian Patients With Vogt-Koyanagi-Harada Disease

1998 ◽  
Vol 59 (3) ◽  
pp. 183-188 ◽  
Author(s):  
A.C Goldberg ◽  
J.H Yamamoto ◽  
J.M Chiarella ◽  
M.L.C Marin ◽  
M Sibinelli ◽  
...  
Keyword(s):  
Predominant Allele

scholarly journals Variance analysis of immunoglobulin alleles in natural populations of rabbit (Oryctolagus cuniculus): the extensive interallelic divergence at the b locus could be the outcome of overdominance-type selection.

Genetics ◽  
1993 ◽  
Vol 135 (1) ◽  
pp. 171-187 ◽  
Author(s):  
W van der Loo
Keyword(s):  
Heavy Chain ◽  
Light Chain ◽  
Gene Diversity ◽  
Natural Populations ◽  
Constant Region ◽  
Immunoglobulin Light Chain ◽  
Evolutionary Patterns ◽  
B Locus ◽  
Type Selection ◽  
Predominant Allele

Abstract Population genetic data are presented which should contribute to evaluation of the hypothesis that the extraordinary evolutionary patterns observed at the b locus of the rabbit immunoglobulin light chain constant region can be the outcome of overdominance-type selection. The analysis of allele correlations in natural populations revealed an excess of heterozygotes of about 10% at the b locus while heterozygote excess was not observed at loci determining the immunoglobulin heavy chain. Data from the published literature, where homozygote advantage was suggested, were reevaluated and found in agreement with data here presented. Gene diversity was evenly distributed among populations and showed similarities with patterns reported for histocompatibility loci. Analysis of genotypic disequilibria revealed strong digenic associations between the leading alleles of heavy and light chain constant region loci in conjunction with trigenic disequilibria corresponding to a preferential association of b locus heterozygosity with the predominant allele of the heavy chain e locus. It is argued that this may indicate compensatory or nonadditive aspects of a putative heterozygosity enhancing mechanism, implying that effects at the light chain might be more pronounced in populations fixed for the heavy chain polymorphism.

HLA-DQB genetic susceptibility and rheumatic heart disease: a case-control study

2020 ◽  
Vol 28 (3) ◽  
pp. 147-151
Author(s):  
Neha Sharma ◽  
Devinder Toor ◽  
Lokajeet Baro ◽  
Mriganka S Chaliha ◽  
Giriraj Kusre ◽  
...  
Keyword(s):  
Socioeconomic Status ◽  
Heart Disease ◽  
Genetic Susceptibility ◽  
Rheumatic Heart Disease ◽  
Case Control Study ◽  
Case Control ◽  
Clinical Profile ◽  
Predominant Allele ◽  
Control Study ◽  
Rheumatic Heart

Background Rheumatic heart disease is a major global health concern, especially in low- and middle-income countries. The pathogenesis is attributable to an aberrant immune response, host genetic factors, and socioeconomic status. The objective of this study was to screen HLA-DQB1 alleles as genetic susceptibility markers in rheumatic heart disease patients in Assam, North East India, and to correlate the predominant allele with socioeconomic status and clinical profile. Methods A case-control study of 100 echocardiography-confirmed rheumatic heart disease patients and age- and sex-matched healthy controls from Assam Medical College and Hospital was conducted. Human leukocyte antigen typing was performed using HLA-DQ typing kit. A questionnaire was designed to study the socioeconomic status and clinical profile of rheumatic heart disease patients. Results Among the 9 alleles studied, HLA-DRBQ1*03:01 was found to be the statistically significant predominant allele in this population, especially in the Ahom ethnic group. In the HLA-DRBQ1*03:01-positive population, rural dwelling was found to be a significantly increased risk factor for rheumatic heart disease. Among severe cases, 90% of mitral stenosis, 40% of mitral regurgitation, and 33.3% of aortic regurgitation cases were HLA-DRBQ1*03:01-positive. Also, 50% of aortic valve thickening and 36.8% of mitral valve thickening cases were found in this population. Conclusion Our data suggest that HLA-DRBQ1*03:01 is a significant susceptibility marker in this population, and predominant in the rural population. Furthermore, it may play an important role in determining the pattern of valve damage in rheumatic heart disease patients.

scholarly journals HLA B-27 Subtypes in Turkish Patients with Spondyloarthropathy and Healthy Controls

2004 ◽  
Vol 20 (6) ◽  
pp. 309-312 ◽  
Author(s):  
Fatma Savran Oguz ◽  
Lale Ocal ◽  
Ali Sarper Diler ◽  
Hilmi Ozkul ◽  
Faruk Asicioglu ◽  
...  
Keyword(s):  
Turkish Population ◽  
Study Group ◽  
Healthy Controls ◽  
Hla B27 ◽  
Caucasian Patients ◽  
Male Patients ◽  
Different Populations ◽  
The Difference ◽  
Turkish Patients ◽  
Predominant Allele

The frequency and the distribution of HLA-B27 subtypes in spondylarthropathy (SpA) patients and controls were investigated in a sample Turkish population. B27 subtyping was performed by PCR-SSP method in two groups: 49 unrelated HLA-B27 positive Turkish patients with the diagnosis of SpA according to the European Spondyloarthropathy Study Group Criteria, and 55 HLA-B27 positive healthy controls. The frequency of HLA-B∗27 was 2.6% in the Turkish population, and B∗2705 was the predominant allele among patients with SpA. The difference was mainly between male patients and male controls The proportion of B∗2705 among B27-positive patients and controls was significantly different (P = 0.02). Our study supports other reports from different populations which showed that B∗2705 and B∗2702 were more frequent in Caucasian patients with SpA.

scholarly journals Developmental Stage-Specific Imprinting ofIPLin Domestic Pigs (Sus scrofa)

2010 ◽  
Vol 2010 ◽  
pp. 1-6
Author(s):  
Shengping Hou ◽  
Yuming Chen ◽  
Jie Liang ◽  
Li Li ◽  
Tongshan Wu ◽  
...  
Keyword(s):  
Developmental Stage ◽  
Developmental Stages ◽  
Pcr Analysis ◽  
Maternal Allele ◽  
Domestic Pig ◽  
Specific Sequence ◽  
Domestic Pigs ◽  
Old Adult ◽  
Exon 1 ◽  
Predominant Allele

Imprinted in placenta and liver (IPL) gene has been identified as an imprinted gene in the mouse and human. Its sequence and imprinting status, however, have not been determined in the domestic pigs. In the present study, a 259 base pair-specific sequence forIPLgene of the domestic pig was obtained and a novel SNP, a T/C transition, was identified inIPLexon 1. The C allele of this polymorphism was found to be the predominant allele in Landrace,Yorkshire, and Duroc. The frequency of CC genotype and C allele are different in Duroc as compared with Yorkshire (P=.038andP=.005, resp.). Variable imprinting status of this gene was observed in different developmental stages. For example, it is imprinted in 1-dayold newborns (expressed from the maternal allele), but imprinting was lost in 180-day-old adult (expressed from both parental alleles). Real-time PCR analysis showed the porcineIPLgene is expressed in all tested eight organ/tissues. The expression level was significantly higher in spleen, duodenum, lung, and bladder of 180-day-old Lantang adult compared to that in 1-day-old newborns Lantang pigs (P<.05). In conclusion, the imprinting of the porcineIPLgene is developmental stage and tissue specific.

The human RIT2 core promoter short tandem repeat predominant allele is species-specific in length: a selective advantage for human evolution?

2017 ◽  
Vol 292 (3) ◽  
pp. 611-617 ◽  
Author(s):  
Babak Emamalizadeh ◽  
Abofazl Movafagh ◽  
Hossein Darvish ◽  
Somayeh Kazeminasab ◽  
Monavvar Andarva ◽  
...  
Keyword(s):  
Human Evolution ◽  
Tandem Repeat ◽  
Short Tandem Repeat ◽  
Core Promoter ◽  
Selective Advantage ◽  
Species Specific ◽  
Predominant Allele ◽  
Short Tandem

scholarly journals Herders of Indian and European Cattle Share Their Predominant Allele for Lactase Persistence

2011 ◽  
Vol 29 (1) ◽  
pp. 249-260 ◽  
Author(s):  
Irene Gallego Romero ◽  
Chandana Basu Mallick ◽  
Anke Liebert ◽  
Federica Crivellaro ◽  
Gyaneshwer Chaubey ◽  
...  
Keyword(s):  
Lactase Persistence ◽  
European Cattle ◽  
Predominant Allele

scholarly journals Extensive genetic diversity in the HLA class II region of Africans, with a focally predominant allele, DRB1*1304.

1992 ◽  
Vol 89 (6) ◽  
pp. 2277-2281 ◽  
Author(s):  
A. V. Hill ◽  
C. E. Allsopp ◽  
D. Kwiatkowski ◽  
T. E. Taylor ◽  
S. N. Yates ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Class Ii ◽  
Hla Class Ii ◽  
Predominant Allele ◽  
Allele Drb1

scholarly journals GENE IDENTITY AND GENETIC DIFFERENTIATION OF POPULATIONS IN THE FINITE ISLAND MODEL

Genetics ◽  
1983 ◽  
Vol 104 (3) ◽  
pp. 497-512
Author(s):  
Naoyuki Takahata
Keyword(s):  
Gene Flow ◽  
Population Subdivision ◽  
Gene Frequencies ◽  
Panmictic Population ◽  
Predominant Type ◽  
Subdivided Population ◽  
Genetic Differentiation Of Populations ◽  
Analytical Formulas ◽  
Neutral Mutations ◽  
Predominant Allele

ABSTRACT A formula for the variance of gene identity (homozygosity) was derived for the case of neutral mutations using diffusion approximations for the changes of gene frequencies in a subdivided population. It is shown that when gene flow is extremely small, the variance of gene identity for the entire population at equilibrium is smaller than that of the panmictic population with the same mean gene identity. On the other hand, although a large amount of gene flow makes a subdivided population equivalent to a panmictic population, there is an intermediate range of gene flow in which population subdivision can increase the variance. This increase results from the increased variance between colonies. In such a case, each colony has a predominant allele, but the predominant type may differ from colony to colony. The formula for obtaining the variance allows us to study such statistics as the coefficient of gene differentiation and the correlation of heterozygosity. Computer simulations were conducted to study the distribution of gene identity as well as to check the validity of the analytical formulas. Effects of selection were also studied by simulations.

scholarly journals A Novel 65-bp Indel in the GOLGB1 Gene Is Associated with Chicken Growth and Carcass Traits

Animals ◽  
2020 ◽  
Vol 10 (3) ◽  
pp. 475 ◽  
Author(s):  
Rong Fu ◽  
Tuanhui Ren ◽  
Wangyu Li ◽  
Jiaying Liang ◽  
Guodong Mo ◽  
...  
Keyword(s):  
Developmental Disorders ◽  
Genetic Parameters ◽  
Biological Function ◽  
Carcass Traits ◽  
Abdominal Fat ◽  
Fat Percentage ◽  
Inhibiting Factor ◽  
Chicken Population ◽  
Yellow Index ◽  
Predominant Allele

Golgin subfamily B member 1 (GOLGB1) gene encodes the coat protein 1 vesicle inhibiting factor, giantin. Previous study showed that mutations of the GOLGB1 gene are associated with dozens of human developmental disorders and diseases. However, the biological function of GOLGB1 gene in chicken is still unclear. In this study, we detected a novel 65-bp insertion/deletion (indel) polymorphism in the chicken GOLGB1 intron 5. Association of this indel with chicken growth and carcass traits was analyzed in a yellow chicken population. Results showed that this 65-bp indel was significantly associated with chicken body weight (p < 0.05), highly significantly associated with neck weight, abdominal fat weight, abdominal fat percentage and the yellow index b of breast (p < 0.01). Analysis of genetic parameters indicated that “I” was the predominant allele. Except for the yellow index b of breast, II genotype individuals had the best growth characteristics, by comparison with the ID genotype and DD genotype individuals. Moreover, the mRNA expression of GOLGB1 was detected in the liver tissue of chicken with different GOLGB1 genotypes, where the DD genotype displayed high expression levels. These findings hinted that the 65-bp indel in GOLGB1 could be assigned to a molecular marker in chicken breeding and enhance production in the chicken industry.

Sign in / Sign up

Export Citation Format

Share Document