A14 Remote development of premature infants with extremely low body weight at birth

2012 ◽  
Vol 88 ◽  
pp. S106
Author(s):  
N. Kharitonova ◽  
I. Belyaeva ◽  
G. Yatsyk ◽  
E. Bombardirova
2013 ◽  
Vol 3 (1) ◽  
pp. 65-69 ◽  
Author(s):  
Gordana Grgić ◽  
Elvira Brkičević ◽  
Dženita Ljuca ◽  
Edin Ostrvica ◽  
Azur Tulumović

Introduction: Preterm delivery is the delivery before 37 weeks of gestation are completed. The incidence of preterm birth ranges from 5 to 15%. Aims of the study were to determine the average body weight, Apgar score after one and five minutes, and the frequency of the most common complications in preterminfants.Methods: The study involved a total of 631 newborns, of whom 331 were born prematurely Aims of this study were to (24th-37th gestational weeks-experimental group), while 300 infants were born in time (37-42 weeks of gestation-control group).Results: Average body weight of prematurely born infants was 2382 grams, while the average Apgar score in this group after the fi rst minute was 7.32 and 7.79 after the fifth minute. The incidence of respiratory distress syndrome was 50%, intracranial hemorrhage, 28.1% and 4.8% of sepsis. Respiratory distresssyndrome was more common in infants born before 32 weeks of gestation. Mortality of premature infants is present in 9.1% and is higher than that of infants born at term.Conclusions: Birth body weight and Apgar scores was lower in preterm infants. Respiratory distress syndrome is the most common fetal complication of prematurity. Intracranial hemorrhage is the second most common complication of prematurity. Mortality of premature infants is higher than the mortality of infants born at term birth.


2020 ◽  
pp. 97-99
Author(s):  
T. Erler

Background. Medical care for premature babies in Germany is divided into two levels. Perinatal centers of the first level provide care for infants with body weight at birth <1500 g. Perinatal centers of the second level provide care for children whose body weight exceeds 1500 g. In order to be included in the list of first level institutions, the hospital must, among other, be able to pick up children from other institutions in the surrounding region. Mobile incubators are used for this purpose. Such an incubator is a kind of a mobile intensive care unit. In some cases, the incubator is delivered to the desired location by helicopter, but in most cases, specialized road transport is used. Objective. To describe neonatological medical care in Germany. Materials and methods. Analysis of own experience and available literature data on this issue. Results and discussion. In recent years, Germany experiences a decrease in the number of births, which causes the problem of professional training of doctors. Hospitals with the fewest births are closed due to lack of efficiency. Although there are some fluctuations from year to year, in general, the number of premature babies with extremely low birth weight remains approximately constant. Prematurity remains one of the most important problems of modern medicine, as it is accompanied by high mortality rates. The earlier the premature birth is and the lower the body weight is, the higher these rates are. Prematurity is caused by numerous risk factors. Multiple pregnancies are accompanied by the highest risk of premature birth. The presence of twins or triples increases this risk by 7.7 times. Other risk factors include vaginal bleeding in late pregnancy, preeclampsia, and a history of preterm birth. Over the past 20 years, the survival of children born before 32 weeks of pregnancy or weighing <1500 g has increased by almost 20 %. The smallest premature baby born in our clinic is a baby born at 24 weeks of gestation with a body weight of 350 g. Nowadays in Germany, the survival rate of infants born after 24 weeks of gestation is almost 80 %, and after 29 weeks – almost 100 %. It should be noted that maintaining the life of a premature baby from birth to discharge costs 250-300 thousand euros. Bronchopulmonary dysplasia is an important problem of premature infants, especially in case of mechanical lung ventilation (MLV) or joining infections. Up to 40 % of children who die from complications of bronchopulmonary dysplasia can be saved. If possible, MLV and infections should be avoided, premature births should be prevented, so-called neuroprotective ventilation and nasal or mask devices that do not require intubation should be used. Surfactants have made great progress in the management of premature infants. The modern LISA (less invasive surfactant administration) method allows to inject a surfactant into a child’s lungs without intubation. In the early 20th century, 100 % oxygen was used in the resuscitation of newborns, but now we use air (21 % oxygen) or a mixture containing up to 30 % oxygen. To prevent necrotizing enterocolitis, premature infants are prescribed probiotics based on lyophilized lactic acid bacteria and bifidobacteria. Breast milk is an another way to prevent this complication of prematurity. There is a breast milk bank in Potsdam. Conclusions. 1. Prematurity remains one of the most important problems of modern medicine, as it is accompanied by high mortality rates. 2. Multiple pregnancies are accompanied by the highest risk of premature birth. 3. Nowadays in Germany, the survival rate of children born after 24 weeks of gestation is almost 80 %, and after 29 weeks – almost 100 %. 4. Surfactants and the LISA method have made great progress in the management of premature infants. 5. Probiotics and breast milk are prescribed to premature babies to prevent necrotizing enterocolitis.


PEDIATRICS ◽  
1956 ◽  
Vol 18 (1) ◽  
pp. 50-58
Author(s):  
Elaine G. Fichter ◽  
John A. Curtis

All newborn infants, both full-term and premature, who received, on the first day of life, a single subcutaneous injection of sulfadiazine, 100 mg./kg. body weight, maintained a satisfactory concentration of sulfonamide in the blood for 48 hours thereafter. This therapeutic concentration was subsequently maintained by single 24-hour doses of 50 mg./kg. body weight given subcutaneously, or by single 12-hour doses of 50 mg./kg. body weight given orally. A therapeutic concentration in the blood is generally considered to be a minimum of 5 mg./100 ml. Based on these data the authors recommend the following sulfonamide dosage schedules: A. Infants under 24 hours of age, full-term and premature: 1) subcutaneous sodium sulfadiazine, initial dose 100 mg./ kg. body weight, followed in 48 hours by 50 mg./kg. body weight as a single dose, and repeated each 24-hour period thereafter, or 2) subcutaneous sodium sulfadiazine, initial dose 100 mg./kg. body weight, followed in 48 hours by an oral preparation in the amount of 50 mg./kg. as a single oral dose, each 12-hour period thereafter. (This was evaluated only in full-term infants.) B. Premature infants over 48 hours of age. (This dosage schedule is comparable to that generally accepted for older infants and children): 1) subcutaneous sodium sulfadiazine, initial dose 100 mg./kg. body weight, followed in 12 hours by 50 mg./kg. body weight as a single dose, each 12-hour period thereafter, or 2) oral sulfonamide preparation, initial dose 100 mg./kg. body weight, followed in 12 hours by 50 mg./kg. body weight as a single dose, each 12-hour period thereafter.


PEDIATRICS ◽  
1962 ◽  
Vol 29 (1) ◽  
pp. 18-25
Author(s):  
O. Robert Levine ◽  
Sidney Blumenthal

An attempt has been made to determine a maximum safe digitalizing dose of digoxin for healthy premature infants. The experimental design has utilized a three-by-three Latin square, in which premature infants in three predetermined weight and age categories have been assigned at ran dom to each of three digitalizing dosages: 30, 50 and 75 µ/kg body weight of digoxin. The total scheduled dosage was administered intramuscularly in three equally divided doses at 8-hour intervals. Control electrocardiograms were taken, and tracings were obtained after two-thirds of the dosage had been given, 4 hours after digitalization was completed, and at 24-hour intervals thereafter. Digitalis intoxication was defined in terms of electrocardiographic criteria. Twenty-seven infants were tested with 30 µg/kg body weight of digoxin, 26 with 50 µg/kg and 27 with 75 µg/kg. The incidence of digitalis intoxication was 2.5% at the 30 µg/kg dosage level, 9.4% at 50 µg/ kg, and 33.3% at 75 µg/kg. The null hypothesis is rejected with a high degree of probability. Insufficient data were available for statistical analysis of age differences in incidence of intoxication. The data indicates, however, that premature infants tested during the first 72 hours of life may have a diminished tolerance to the glycoside. Side-effects of glycoside administration were noted in only a few of the infants, were rarely severe and were short-lived. The electrocardiographic manifestations of digitalis intoxication were widely varied. Sinus node depression with ectopic supra-ventricular beats and rhythms, and atrio-ventricular conduction disturbances were the most common arrhythmias observed. An irritable ventricular focus was observed in only 1 of the 12 intoxicated infants. In most cases a regular sinus rhythm had returned with 48 hours of full digitalization. However one infant still had evidence of arrhythmia 9 days later. On the basis of the data presented, the following conclusions are reached: 1. The administration of 75 µg/kg body weight of digoxin, for the digitalization of healthy premature infants, in the manner described, incurs an excessive risk of digitalis intoxication. 2. Although 50 µg/kg represents a more reasonable risk among these infants, and 30 µg/kg a minimal risk, one must be alert to the occasional infant who may have an unusual intolerance to the drug. It is recommended that digitalization be carried out under close electrocardiographic control, as no clinical criteria correlated well with the development of digitalis intoxication in these infants. Tracing of adequate length, in which the P waves are well defined, should be obtained during digitalization and at daily intervals until the infant is being given a stable maintenance dosage.


PEDIATRICS ◽  
1950 ◽  
Vol 6 (1) ◽  
pp. 55-71
Author(s):  
BRUCE D. GRAHAM ◽  
HELEN S. REARDON ◽  
JAMES L. WILSON ◽  
MAKEPEACE U. TSAO ◽  
MARY L. BAUMANN

Arterial blood studies were performed on 44 premature infants while in atmosphere and greater concentrations of oxygen. Analyses were made for oxygen content, oxygen capacity and hematocrit. Concomitant plethysmographic studies were made on 29 occasions. Results were as follows: 1. Only 25% (7) of the premature infants studied breathed regularly in atmosphere; the remaining individuals breathed with some degree of periodicity (44%) or completely irregularly (30%). 2. As the concentration of oxygen being breathed was raised, then more of the group shifted to a regular type of respiration until when in 75-85% oxygen, 88% of the group then breathed with a regular type of respiration. 3. a. The percentage arterial oxygen saturation of the group averaged 93% in atmosphere, 96% in 30-55% oxygen, 100% saturation in 70-79% oxygen being breathed and 102% in 80-89% oxygen. b. In atmosphere, when compared on age basis, the younger group (1-14 days) had essentially the same arterial oxygen saturation as the older group (14-65 days). In an atmosphere of 70-90% oxygen, the saturation of the younger group increased to 102% while the older group rose to 100%. c. When compared on body weight basis, the 0.9-1.3 kg. group increased the arterial oxygen saturation of 85% in atmosphere to 102% when 70-85% oxygen was administered; the 1.3-1.8 kg. group, 93% to 101%; the 1.8-2.3 kg. group, 9% to 100%. (It is noted that either on age or body weight basis the group with higher hematocrit attained higher arterial oxygen saturation when 70-85% oxygen was administered than the group with lower hematocrit.) 4. a. A statistical analysis of the respiratory records revealed an average rise of 30% in minute volume when 30-40% oxygen was administered, this rise being significantly maintained as higher concentrations (to 90%) of oxygen were administered. b. An average significant rise in respiratory rate of 30% was noted when 30-40% oxygen was administered which slowly fell to the original rate level as oxygen administered was increased to 80-90% concentration. c. Consequently, the tidal volume (volume per respiration) gradually increased to 30% above the level in atmosphere as oxygen administered was increased to 80-90% concentration.


1992 ◽  
Vol 54 (6) ◽  
pp. 1223-1225 ◽  
Author(s):  
Mikio Ohmi ◽  
Motohisa Tofukuji ◽  
Kaori Sato ◽  
Takahiko Nakame ◽  
Naoshi Sato ◽  
...  

2008 ◽  
Vol 17 (9) ◽  
pp. 1174-1181 ◽  
Author(s):  
Li-Li Chen ◽  
Yi-Chang Su ◽  
Chia-Hsien Su ◽  
Hung-Chih Lin ◽  
Hsien-Wen Kuo

1968 ◽  
Vol 42 (4) ◽  
pp. 585-590 ◽  
Author(s):  
A. P. MOWAT

SUMMARY Total urinary d-glucaric acid excretion increased with age and weight gain in males and was found to be low in terms of unit body weight in the newborn. In premature infants, there was a direct relationship between the serum bilirubin level and urinary d-glucaric acid excretion. In women excretion was not found to vary with the menstrual cycle, but was increased during prolonged therapy with contraceptive agents.


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