Background: Pregnancy and childbirth are important events in the life of a woman. Life with the new born can be very rewarding but it can be very tough for some women. This phase of life brings about many hormonals, physical and emotional changes in the women during childbirth. Aims and objectives were to find out the prevalence and risk factors of post-partum depression (PPD) in urban area of Indore district and to assess the socio demographic profile of study populationMethods: The study was a cross sectional community-based study, conducted on women who had delivered within a period of 6 weeks to 3 months. 100 women from urban area were selected from Indore district through simple random sampling. Informed consent in written was taken from the mothers. The study tool was pre designed semi structured questionnaire and Edinburgh post-natal depression scale (EPDS) scale, data were entered in excel sheet and analyzed using SPSS software, appropriate statistical test were applied wherever necessary.Results: In our study it was found that prevalence of PPD in urban Indore was 23%. We found that age at the time of marriage below 18 years, mode of delivery (LSCS), initiation of breast feeding (after 1 hour) and birth weight of baby less than 2.5 kg had a strong association with PPD. In our study 58% had normal vaginal delivery and 42% had LSCS in urban area. In urban areas 36% gave a history of birth weight of babies <2.5 kg.Conclusions: Symptoms of PPD were significantly high in urban Indore mothers and they were strongly associated with risk factors.