PMS42 THE EFFECT OF LIFESTYLE CHOICES ON THE RISK OF IMPAIRMENT IN RHEUMATOID ARTHRITIS PATIENTS: AN ANALYSIS OF AEROBIC EXERCISE AND CIGARETTE SMOKING

Introduction Rheumatoid arthritis (RA) disease is a systemic progressive inflammatory autoimmune disorder. Elderly-onset RA can be assumed as a benign form of RA. Until recently, face-to-face therapeutic sessions between health professionals and patients are usually the method of its treatment. However, during pandemics, including coronavirus disease 2019 (COVID-19), teletherapeutic sessions can extensively increase the patient safety especially in elderly patients who are more vulnerable to these infections. Thus, the aim of this study was to evaluate a novel teletherapy approach for management of elderly patients suffering from RA by utilizing laser acupuncture. Methods A teletherapy system was used for management of elderly patients suffering from RA. Sixty participants were allocated randomly into two groups and the ratio was 1:1. Patients in the first group were treated with laser acupuncture and telerehabilitation sessions, which consisted of aerobic exercise and virtual reality training. Patients in the second group received telerehabilitation sessions, which consisted of aerobic exercise and virtual reality training. Evaluation of patients was done by using the Health Assessment questionnaire (HAQ), the Rheumatoid Arthritis Quality of Life (RAQoL) questionnaire, and the analysis of interleukin-6 (IL-6), serum C-reactive protein (CRP), plasma adenosine triphosphate (ATP) concentration and plasma malondialdehyde (MDA). Results A statistically significant difference was found in CRP, RAQoL, IL-6 and MDA between the pre- and post-treatments in the first group ( p < 0.05) favouring the post-treatment group, while the HAQ showed a statistically significant difference between pre- and post-treatments ( p < 0.05) in both groups. Statistically significant post-treatment differences were also observed between the two groups ( p < 0.05) in RAQoL, CRP, ATP and MDA, favouring the first group. Discussion Laser acupuncture teletherapy could be suggested as a reliable treatment method for elderly patients suffering from RA, as it can provide a safe and effective therapeutic approach. Teletherapy provided safer access to health professionals and patients while giving a high patient satisfaction value with a relatively lower cost (ClinicalTrials.gov Identifier: NCT04684693).

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Smoking Functions as a Negative Regulator of IGF1 and Impairs Adipokine Network in Patients with Rheumatoid Arthritis

Mediators of Inflammation ◽

10.1155/2016/3082820 ◽

2016 ◽

Vol 2016 ◽

pp. 1-8 ◽

Cited By ~ 11

Author(s):

Malin C. Erlandsson ◽

Roberto Doria Medina ◽

Sofia Töyrä Silfverswärd ◽

Maria I. Bokarewa

Keyword(s):

Rheumatoid Arthritis ◽

Cigarette Smoking ◽

Serum Levels ◽

Negative Regulator ◽

Lower Serum ◽

Bivariate Correlation ◽

Novel Association ◽

Long Term Prognosis ◽

Never Smokers

Objectives.Smoking is pathogenic for rheumatoid arthritis (RA) being tightly connected to the genetic and serological risk factors for this disease. This study aims to understand connections between cigarette smoking and serum levels of IGF1 and adipokines in RA.Methods.Serum levels of IGF1 and adipokines leptin, adiponectin, resistin, and visfatin were measured in two independent cohorts of RA patients from Gothenburg (n=350) and Leiden (n=193). An association of these parameters with smoking was tested in a direct comparison and proved by bivariate correlation analysis. The obtained associations were further tested in multivariate regression models where the confounders (age, gender, disease duration, and BMI) were controlled.Results.The smokers had significantly lower serum levels of IGF1, adiponectin, and leptin compared to never smokers. In regression analysis, smoking and low leptin, but not adiponectin, were associated and predicted low IGF1. Additionally, high disease activity and high BMI increased the probability of low leptin.Conclusions.The study indicates cigarette smoking as an important cause of a relative IGF1 and leptin deficiency in RA patients. This novel association between smoking and hypoleptinemia may be of importance for long-term prognosis of RA and for prediction of comorbidities.

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Association between cigarette smoking and release of tumour necrosis factor and its soluble receptors by peripheral blood mononuclear cells in patients with rheumatoid arthritis

Rheumatology ◽

10.1093/rheumatology/kel094 ◽

2006 ◽

Vol 45 (10) ◽

pp. 1223-1229 ◽

Cited By ~ 45

Author(s):

J. R. Glossop ◽

P. T. Dawes ◽

D. L. Mattey

Keyword(s):

Rheumatoid Arthritis ◽

Cigarette Smoking ◽

Peripheral Blood Mononuclear Cells ◽

Peripheral Blood ◽

Tumour Necrosis ◽

Mononuclear Cells ◽

Soluble Receptors ◽

Peripheral Blood Mononuclear ◽

Blood Mononuclear Cells ◽

Necrosis Factor

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EFFECT OF AEROBIC EXERCISE ON FATIGUE AND DEPRESSION IN INDIVIDUALS WITH RHEUMATOID ARTHRITIS

International Journal of Physiotherapy and Research ◽

10.16965/ijpr.2020.173 ◽

2020 ◽

Vol 8 (6) ◽

pp. 3674-3679

Author(s):

Sanjeev Kumar Singh ◽

◽

Afsha Mulla ◽

Farheen Farooque Khan ◽

Ronika Agrawal ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Aerobic Exercise ◽

Outcome Measures ◽

Exercise Intervention ◽

Depression Scale ◽

Joint Disease ◽

Exercise Session ◽

P Value ◽

Target Heart Rate ◽

Convenience Sample

Background: Rheumatoid arthritis (RA) is an autoimmune, systemic, inflammatory condition causing pain, disability, and psychological distress. It is the most common chronic inflammatory joint disease, affecting 0.1-1% of the population. Women are affected 3 times more than men. Because of its chronic, painful, and disabling character, RA tends to have a profound impact on health-related quality of life (HRQOL). Materials and methods: In the present study a convenience sample of 30 individuals between 30 to 60 years of age group according to the inclusion and exclusion criteria. The exercise intervention was participation in aerobic exercise session 3 times weekly for 6 weeks. The session consisted of 3 phases –1)Warm-up phase 2).Aerobic period 3) Cool down phase.Subjects were given their target heart rate for 40% and 60% of their HRmax. They were instructed to start exercising at 40% and progress to 60% as tolerated given their subjective exertion using the Talk Test (being able to talk while exercising without being short of breath). Global Fatigue Index Of The Multidimensional Assessment Of Fatigue Questionnaire (GFI) and The Center for Epidemiologic Studies- Depression Scale (CES-D)were used as outcome measures for evaluating fatigue and severity of depression respectively in the subjects and the data was statistically analysed. Results: Paired t-test was done for pre and post mean values for MAF-GFI scale. The results showed statistically significant values for both the outcome measures (p value < 0.05). Conclusion: The present study concludes that 6 weeks of aerobic exercise showed significant effect in decreasing fatigue and depression in individuals with rheumatoid arthritis. KEY WORDS: Rheumatoid Arthritis, Fatigue, Depression, Aerobic Exercise.

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AB0371 The effect of cumulative exposure to cigarette smoking on vascular damage in patients with rheumatoid arthritis

10.1136/annrheumdis-2018-eular.6707 ◽

2018 ◽

Author(s):

M. Aguilar-Zamora ◽

M. Robustillo-Villarino ◽

L. Montolio Chiva ◽

A.V. Orenes Vera ◽

À. Martinez-Ferrer ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Cigarette Smoking ◽

Vascular Damage ◽

Cumulative Exposure

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Does Aerobic Exercise Mitigate the Effects of Cigarette Smoking on Arterial Stiffness?

Journal of Clinical Hypertension ◽

10.1111/jch.12385 ◽

2014 ◽

Vol 16 (9) ◽

pp. 640-644 ◽

Cited By ~ 13

Author(s):

Wonil Park ◽

Motohiko Miyachi ◽

Hirofumi Tanaka

Keyword(s):

Arterial Stiffness ◽

Cigarette Smoking ◽

Aerobic Exercise

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Protective Effect of Aerobic Exercise on the Nasal Mucosa of Rats Against the Histopathologic Changes in Cigarette Smoke Exposure

Ear Nose & Throat Journal ◽

10.1177/0145561319900758 ◽

2020 ◽

Vol 99 (7) ◽

pp. 453-459

Author(s):

Özlem Akkoca ◽

Ceren Ersoz Unlu ◽

Ilkan Tatar ◽

Mustafa Fevzi Sargon ◽

Dilara Zeybek ◽

...

Keyword(s):

Cigarette Smoking ◽

Protective Effect ◽

Aerobic Exercise ◽

Cigarette Smoke ◽

Nasal Mucosa ◽

Significant Difference ◽

Group 3 ◽

Group 2 ◽

Harmful Effects ◽

Group 1

Introduction: Smoking is a public health problem that has been proven to have adverse effects on human health. Aerobic exercise has positive effects on the human body, especially on the respiratory system. Objective: The aim of this experimental animal model study was to determine whether regular aerobic exercise has a protective effect against the harmful effects of cigarette smoke on the nasal mucosa of rats. Methods: A total of 24 male Wistar albino rats were randomly separated into 3 groups of 8: group 1 (cigarette smoking), group 2 (cigarette smoking and exercise), and group 3 (control group). At the end of the experiment period, histopathological (light and electron microscopy) and immunohistochemical (GSTA 1, CYP1A1, and CYP2E1) evaluations were made of the nasal mucosa of the animals. Results: Goblet cell loss and basal membrane thickening were significantly lower in group 2 and group 3 compared to group 1. In the electron microscope evaluation, the inflammatory expressions of the goblet cells were observed in a very small area in group 2. In group 1, these were distributed over large areas between the mucosal cells. There was seen to be significant swelling of the mitochondria in group 1 compared to the other groups. No statistically significant difference was determined between the groups with respect to GSTA1, CYP2E1, and CYP1A1 scores ( P > .05). Conclusion: The results of this study showed that regular aerobic exercise has a protective effect against the harmful effects of smoking on the nasal mucosa of rats.

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