scholarly journals EFFECT OF AEROBIC EXERCISE ON FATIGUE AND DEPRESSION IN INDIVIDUALS WITH RHEUMATOID ARTHRITIS

2020 ◽  
Vol 8 (6) ◽  
pp. 3674-3679
Author(s):  
Sanjeev Kumar Singh ◽  
◽  
Afsha Mulla ◽  
Farheen Farooque Khan ◽  
Ronika Agrawal ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Aerobic Exercise ◽  
Outcome Measures ◽  
Exercise Intervention ◽  
Depression Scale ◽  
Joint Disease ◽  
Exercise Session ◽  
P Value ◽  
Target Heart Rate ◽  
Convenience Sample

Background: Rheumatoid arthritis (RA) is an autoimmune, systemic, inflammatory condition causing pain, disability, and psychological distress. It is the most common chronic inflammatory joint disease, affecting 0.1-1% of the population. Women are affected 3 times more than men. Because of its chronic, painful, and disabling character, RA tends to have a profound impact on health-related quality of life (HRQOL). Materials and methods: In the present study a convenience sample of 30 individuals between 30 to 60 years of age group according to the inclusion and exclusion criteria. The exercise intervention was participation in aerobic exercise session 3 times weekly for 6 weeks. The session consisted of 3 phases –1)Warm-up phase 2).Aerobic period 3) Cool down phase.Subjects were given their target heart rate for 40% and 60% of their HRmax. They were instructed to start exercising at 40% and progress to 60% as tolerated given their subjective exertion using the Talk Test (being able to talk while exercising without being short of breath). Global Fatigue Index Of The Multidimensional Assessment Of Fatigue Questionnaire (GFI) and The Center for Epidemiologic Studies- Depression Scale (CES-D)were used as outcome measures for evaluating fatigue and severity of depression respectively in the subjects and the data was statistically analysed. Results: Paired t-test was done for pre and post mean values for MAF-GFI scale. The results showed statistically significant values for both the outcome measures (p value < 0.05). Conclusion: The present study concludes that 6 weeks of aerobic exercise showed significant effect in decreasing fatigue and depression in individuals with rheumatoid arthritis. KEY WORDS: Rheumatoid Arthritis, Fatigue, Depression, Aerobic Exercise.

scholarly journals The relation between cardiovascular affection and erosive articular changes in patients with rheumatoid arthritis

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
M M H Hassabelnabi ◽  
N Y Assaf ◽  
H F Zidan ◽  
G M M Abushanab
Keyword(s):  
Rheumatoid Arthritis ◽  
Risk Factors ◽  
Cardiovascular Risk ◽  
Power Doppler ◽  
Premenopausal Women ◽  
Joint Disease ◽  
P Value ◽  
Physical Medicine ◽  
Bone Erosions ◽  
The Mean

Abstract Background rheumatoid arthritis is currently regarded as independent cardiovascular risk factor. Accelerated atherosclerosis considered as an extra-articular manifestation of RA that occurs as a result of interaction between traditional CV risk factors and inflammatory activity of joint disease. Both atherosclerosis and RA have in common inflammatory mediators. Objectives the presented study aimed to find the relation between cardiovascular affection and erosive articular changes in RA. Subjects and Methods The presented study included 40 patients’ men and premenopausal women that were diagnosed with rheumatoid arthritis fulfilling the 2010 ACR/EULAR classification criteria for rheumatoid arthritis recruited from the physical Medicine, Rheumatology, and Rehabilitation outpatient clinics of Ain Shams University, patients underwent laboratory investigation, carotid duplex, musculoskeletal ultrasound and echocardiography. Results Among 40 RA patients, 16 (40%) had erosions in both hands and 24 (60%) without erosion with no statistically significance difference between both sides of hand and feet, only 3 patients (7.5%) had active erosion exhibited by power Doppler. The presence of erosion positively correlated with the mean CIMT (p-value &lt; 0.001) with mean 0.827±0.149, The presence of carotid plaques as a marker of advanced atherosclerosis showed statistically significant value with erosions (p = 0.001). There was positive relation between erosions with disease duration (p-value &lt; 0.001), and negatively with DAS-28 (p = 0.083). Out of 33 patients with positive RF, 16 patients had erosions with statistically significant value (p = 0.017). Conclusion Since the presence of bone erosions was highly associated with higher mean CIMT, consequently, we recommend that when finding bone erosions in rheumatoid arthritis patient, good monitoring should be given to cardiovascular risk factors with early and proper treatment to limit the progression of erosions and protect against atherosclerosis and its complications.

scholarly journals Anxiety, Depression, and Common Chronic Diseases, and Their Association With Social Determinants in Saudi Primary Care

2021 ◽  
Vol 12 ◽  
pp. 215013272110549
Author(s):  
Leena R. Baghdadi ◽  
Mohammed Khalid Alhassan ◽  
Fawaz Hindi Alotaibi ◽  
Khalid Badr AlSelaim ◽  
Abdulrahman Abdulkhaliq Alzahrani ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Type 2 Diabetes ◽  
Primary Care ◽  
Chronic Diseases ◽  
Social Determinants ◽  
Depression Scale ◽  
Anxiety And Depression ◽  
P Value ◽  
Psychological Conditions

Introduction: Patients with chronic diseases can experience psychological conditions, including anxiety and depression. However, the association between chronic diseases and these psychological conditions remains unclear. This study aimed to identify the relationship between anxiety, depression, and common chronic diseases (hypertension, type 2 diabetes, dyslipidemia, and rheumatoid arthritis), and their association with social determinants at an outpatient primary care setting. Methods: The validated hospital anxiety and depression scale was administered electronically to eligible participants. For each condition (anxiety and depression), participants were categorized as normal, borderline abnormal, and abnormal, according to their score out of 21 (≤7 = normal, 8-10 = borderline abnormal, ≥11 = abnormal). The scores and numbers of participants in each category were analyzed and compared with their demographic characteristics and chronic diseases for associations and relationships. Results: We recruited 271 participants (mean age of 51.65 + 11.71 years) attending primary care clinics. Of these patients, 17.7% and 8.9% had borderline abnormal and abnormal depression, respectively, and 10.3% and 8.9% of patients had borderline abnormal anxiety and abnormal anxiety. Common social determinants and lifestyle factors were examined. Age, gender, and sugary drinks’ consumption significantly increased the odds of hypertension and type 2 diabetes; vigorous physical activity 3 times a week, decreased the odds of developing these chronic diseases. Adjusted regression models showed a statistically significant association between the hospital anxiety and depression scale score for borderline and abnormal anxiety and the presence of type 2 diabetes (OR 3.04 [95% CI 1.13, 8.19], P-value = .03 and OR 4.65 [95% CI 1.63,13.22], P-value <.03, respectively) and dyslipidemia (OR 5.93 [95% CI 1.54, 22.86], P-value = .01, and OR 4.70 [95% CI 0.78, 28.35], P-value = .09, respectively). The odds of developing depression were 4 times higher ( P-value .04) in patients with rheumatoid arthritis. Conclusion: Among patients attending primary care outpatient clinics, anxiety, and depression were significantly associated with type 2 diabetes and rheumatoid arthritis, respectively. Social determinants and lifestyle factors play a major role in the development of common chronic diseases in Saudi Arabia. Primary care physicians should consider the patients’ psychological status, sociodemographic status, and lifestyle risks during the management of chronic diseases.

Effect of Aerobic Exercise on Menstrual difficulties among Adolescent Girls

2021 ◽  
pp. 305-308
Author(s):  
Sheena Luvina E ◽  
Jayasankari S. ◽  
Leena L. Raju ◽  
Ravichandran Ravichandran
Keyword(s):  
Aerobic Exercise ◽  
Adolescent Girls ◽  
Sampling Technique ◽  
Exercise Session ◽  
P Value ◽  
Significant Difference ◽  
Before And After ◽  
Post Test ◽  
Menstrual Distress ◽  
Pharmacological Method

Adolescence is a phase of changeover from childhood to adulthood. For a girl, adolescence is a blend of physical and psychological preparation to enrol into a safe motherhood1. Menstruation is a basic female physiological process, capable of affecting the several other metabolisms within the body2. This study was conducted to Assess the Effect of Aerobic Exercises on Menstrual Difficulties among Adolescent Girls in a Selected School at Puducherry. Pre experimental one group pretest post-test design was used in this study. 60 adolescent girls who fulfilled the inclusion criteria were selected by Purposive sampling technique. On day one clinical variables and level of menstrual distress was assessed using Modified Moos Menstrual Distress Questionnaire with previous month experience. Aerobic Exercise session was started from 5th day of the cycle up to 22nd day weekly 3 days for 30minutes in a common room. Post test conducted using Modified Moos Menstrual Distress Questionnaire on the 5th day of the cycle the following month to assess the effectiveness of Aerobic Exercises. The study findings revealed that, the median difference in Menstrual Distress level between pretest and posttest with Aerobic Exercises intervention was observed to be highly statistically significant (p value<.0.001) Findings of the study revealed that there was highly statistically significant difference in the level of Menstrual Distress before and after Aerobic Exercises. Hence the study concluded that Aerobic Exercises being one of non pharmacological method was very effective in decreasing the level of Menstrual Distress among adolescent girls.

scholarly journals Feasibility of a postacute structured aerobic exercise intervention following sport concussion in symptomatic adolescents: a randomised controlled study

2018 ◽  
Vol 4 (1) ◽  
pp. e000404 ◽  
Author(s):  
Rachel Micay ◽  
Doug Richards ◽  
Michael G Hutchison
Keyword(s):  
Aerobic Exercise ◽  
Usual Care ◽  
Exercise Intervention ◽  
Cycle Ergometer ◽  
Phase Iii ◽  
Exercise Session ◽  
Controlled Study ◽  
Care Group ◽  
Activity Levels ◽  
Symptom Status

ObjectiveThe utility of structured exercise for rehabilitation purposes early in the postacute phase (ie, beyond the initial 24–48 hours of advised rest) following sport-related concussion (SRC) remains largely unexplored. This study examined the feasibility of implementing a standardised aerobic exercise (AE) intervention in the postacute stage of SRC recovery in a sample of adolescent students with SRC compared with usual care.MethodsSymptomatic adolescents with SRC were randomised to one of two groups: Aerobic Exercise (n=8) or Usual Care (n=7). The AE intervention, beginning on day 6 postinjury, comprised eight sessions with progressive increases in intensity and duration on a cycle ergometer. Usual care consisted of rest followed by physician-advised progressions in activity levels in an unsupervised setting. All participants were evaluated by physician at weeks 1, 2, 3 and 4 postconcussion. Outcome measures included: (1) Intervention feasibility: symptom status pre-post exercise sessions and completion of intervention and (2) Clinical recovery: symptom status at weeks 1, 2, 3 and 4 postinjury and medical clearance date.ResultsAll participants completed the exercise sessions as part of the AE intervention and symptom exacerbation was not associated with any exercise session. The AE group experienced greater symptom resolution compared with the Usual Care Group across the recovery timeline.ConclusionA structured AE protocol appears to be safe and feasible to administer in the postacute stage of SRC recovery in adolescents and should be explored as part of a full Phase III Clinical Trial.

scholarly journals “THE EFFECTIVENESS OF AEROBIC EXERCISE ON OBESE AND OVERWEIGHT CHILDREN: A QUASI EXPERIMENTAL STUDY”

2020 ◽  
pp. 4-6
Author(s):  
Richa R Jadhav ◽  
Shivagouda Patil
Keyword(s):  
Experimental Study ◽  
Aerobic Exercise ◽  
Exercise Intervention ◽  
Rank Test ◽  
Control Group ◽  
P Value ◽  
Overweight Children ◽  
Anthropometric Parameters ◽  
Quasi Experimental ◽  
Signed Rank Test

Background: Childhood obesity has become an epidemic in the recent years. Reports suggest that children suffering from obesity are predisposed to obesity in adulthood as well the many related comorbidities like hypertension, diabetes, etc. Therefore, it is necessary to develop programs to curb obesity early on. Aim: To study the effectiveness of aerobic exercise on obese and overweight children Methodology: A quasi-experimental study carried out at two schools in Kolhapur, Maharashtra (n=30, control and experimental each). A pilot study was first carried out in two schools (n=8), followed by the main study. Post discussions with the experts in the field, a questionnaire tool was developed and validated. Overweight and obese adolescents were included in the study. Anthropometric parameters like height, weight, body mass Index were recorded. and aerobic exercise intervention was provided for a month by a trained instructor. After one-month anthropometric measurements were taken again. Difference between the parameters were calculated by Wilcoxon signed rank test. P-value of <0.05 was considered as significant. Results: There was a significant reduction in the weight (P=9.14e-07) , BMI (P= 1.805e-06) and waist to hip ratio (P=0.0005) in the experimental group as opposed to control group where no difference was observed. Conclusion: Aerobic exercise has a significant effect on the reduction of weight in obese and overweight adolescents and should be considered in schools and at community levels

Increased Active Hamstring Stiffness After Exercise in Women With a History of Low Back Pain

2013 ◽  
Vol 22 (1) ◽  
pp. 47-52 ◽  
Author(s):  
Rebecca J. Bedard ◽  
Kyung-Min Kim ◽  
Terry L. Grindstaff ◽  
Joseph M. Hart
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Aerobic Exercise ◽  
Outcome Measures ◽  
Perceived Exertion ◽  
Exercise Session ◽  
Electromyographic Activity ◽  
Low Back ◽  
Exercise Protocol ◽  
History Of

Objective:To compare active hamstring stiffness in female subjects with and without a history of low back pain (LBP) after a standardized 20-min aerobic-exercise session.Design:Case control.Setting:Laboratory.Participants:12 women with a history of recurrent episodes of LBP (age = 22.4 ± 2.1 y, mass = 67.1 ± 11.8 kg, height = 167.9 ± 8 cm) and 12 matched healthy women (age = 21.7 ± 1.7 y, mass = 61.4 ± 8.8 kg, height = 165.6 ± 7.3 cm). LBP subjects reported an average 6.5 ± 4.7 on the Oswestry Disability Index.Interventions:Participants walked at a self-selected speed (minimum 3.0 miles/h) for 20 min. The treadmill incline was raised 1% grade per minute for the first 15 min. During the last 5 min, participants adjusted the incline of the treadmill so they would maintain a moderate level of perceived exertion through the end of the exercise protocol.Main Outcome Measures:During session 1, active hamstring stiffness, hamstring and quadriceps isometric strength, and concurrently collected electromyographic activity were recorded before and immediately after the exercise protocol. For session 2, subjects returned 48–72 h after exercise for repeat measure of active hamstring stiffness.Results:Hamstring active stiffness (Nm/rad) taken immediately postexercise was not significantly different between groups. However, individuals with a history of recurrent LBP episodes presented significantly increased hamstring stiffness 48–72 h postexercise compared with controls. For other outcomes, there was no group difference.Conclusions:Women with a history of recurrent LBP episodes presented greater active hamstring stiffness 48–72 h after aerobic exercise.

Influence of Aerobic Exercise Volume on Postconcussion Symptoms

2021 ◽  
pp. 036354652110057
Author(s):  
David R. Howell ◽  
Danielle L. Hunt ◽  
Stacey E. Aaron ◽  
William P. Meehan ◽  
Can Ozan Tan
Keyword(s):  
Aerobic Exercise ◽  
Exercise Test ◽  
Symptom Severity ◽  
Exercise Intervention ◽  
Standard Of Care ◽  
Secondary Outcome ◽  
Initial Visit ◽  
Target Heart Rate ◽  
Level Of Evidence ◽  
Symptom Resolution

Background: Aerobic exercise has emerged as a useful treatment to improve outcomes among individuals who experience a concussion. However, compliance with exercise recommendations and the effect of exercise volume on symptom recovery require further investigation. Purpose: To examine (1) if an 8-week aerobic exercise prescription, provided within 2 weeks of concussion, affects symptom severity or exercise volume; (2) whether prescription adherence, rather than randomized group assignment, reflects the actual effect of aerobic exercise in postconcussion recovery; and (3) the optimal volume of exercise associated with symptom resolution after 1 month of study. Study Design: Cohort study; Level of evidence, 2. Methods: Individuals randomized to an exercise intervention (n = 17; mean age, 17.2 ± 2.0 years; 41% female; initially tested a mean of 11.3 ± 2.8 days after injury) or standard of care (n = 20; mean age, 16.8 ± 2.2 years; 50% female; initially tested a mean of 10.7 ± 3.2 days after injury) completed an aerobic exercise test within 14 days of injury. They returned for assessments 1 month and 2 months after the initial visit. The aerobic exercise group was instructed to exercise 5 d/wk, 20 min/d (100 min/wk), at a target heart rate based on an exercise test at the initial visit. Participants reported their exercise volume each week over the 8-week study period and reported symptoms at each study visit (initial, 1 month, 2 months). Because of low compliance in both groups, there was no difference in the volume of exercise between the 2 groups. Results: There were no significant symptom severity differences between the intervention and standard-of-care groups at the initial (median Post-Concussion Symptom Inventory, 15 [interquartile range = 10, 42] vs 20 [11, 35.5]; P = .26), 1-month (4 [0, 28] vs 5.5 [0.5, 21.5]; P = .96), or 2-month (6.5 [0, 27.5] vs 0 [0, 4]; P = .11) study visits. Exercise volume was similar between groups (median, 115 [54, 225] vs 88 [28, 230] min/wk for exercise intervention vs standard of care; P = .52). Regardless of group, those who exercised <100 min/wk reported significantly higher symptom severity at the 1-month evaluation compared with those who exercised ≥100 min/wk (median, 1.5 [0, 7.5] vs 12 [4, 28]; P = .03). Exercising ≥160 min/wk successfully discriminated between those with and those without symptoms 1 month after study commencement (classification accuracy, 81%; sensitivity, 90%; specificity, 78%). Conclusion: Greater exercise volume was associated with lower symptom burden after 1 month of study, and an exercise volume >160 min/wk in the first month of the study was the threshold associated with symptom resolution after the first month of the study. Because our observation on the association between exercise volume and symptom level is a retrospective and secondary outcome, it is possible that participants who were feeling better were more likely to exercise more, rather than the exercise itself driving the reduction in symptom severity.

Immuno-biological Assessments of Temporomandibular Joint Disease in Patients with Immune-mediated Rheumatic Conditions. A cross sectional study of 273 cases

2018 ◽  
Vol 68 (12) ◽  
pp. 2987-2991
Author(s):  
Cristina Iordache ◽  
Bogdan Vascu ◽  
Eugen Ancuta ◽  
Rodica Chirieac ◽  
Cristina Pomirleanu ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Psoriatic Arthritis ◽  
Temporomandibular Joint ◽  
Final Analysis ◽  
Cross Sectional Study ◽  
Joint Disease ◽  
Sectional Study ◽  
Cross Sectional ◽  
Immune Parameters ◽  
Immune Mediated

Temporomandibular joint (TMJ) is commonly involved in various immune-mediated rheumatic disorders accounting for significant disability and impaired quality of life. The aim of our study was to assess inflammatory and immune parameters in patients with TMJ arthritis related to rheumatoid arthritis (RA), juvenile idiopathic arthritis (JIA), ankylosing spondylitis (AS) and psoriatic arthritis (PsA) and to identify potential relation with severity and dysfunction of TMJ pathology. We performed a cross-sectional study in a cohort of 433 consecutive RA, 32 JIA, 258 AS, and 103 PsA. Only patients presenting with clinically significant TMJ involvement (273) related to their rheumatic condition were included in the final analysis. TMJ involvement is traditionally described in chronic inflammatory rheumatic disorders, particularly in patients with higher levels of inflammation as detected in rheumatoid arthritis and psoriatic arthritis. Disease activity and severity, as well as biological and positive serological assessments (rheumatoid factor, anti-cyclic citrullinated peptide, IL-1) remain significant determinants of the severity of TMJ arthritis.

Treatment with Melittin Induces Apoptosis and Autophagy of Fibroblast-like Synoviocytes in Patients with Rheumatoid Arthritis

2020 ◽  
Vol 21 (8) ◽  
pp. 734-740 ◽  
Author(s):  
Shou-di He ◽  
Ning Tan ◽  
Chen-xia Sun ◽  
Kang-han Liao ◽  
Hui-jun Zhu ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Caspase 3 ◽  
Joint Destruction ◽  
Joint Disease ◽  
Enzyme Linked Immunosorbent Assay ◽  
Caspase 9 ◽  
Inflammatory Processes ◽  
Related Proteins ◽  
Local Stimulation ◽  
Fibroblast Like Synoviocytes

Background: Melittin, the major medicinal component of honeybee venom, exerts antiinflammatory, analgesic, and anti-arthritic effects in patients with Rheumatoid Arthritis (RA). RA is an inflammatory autoimmune joint disease that leads to irreversible joint destruction and functional loss. Fibroblast-Like Synoviocytes (FLS) are dominant, special mesenchymal cells characterized by the structure of the synovial intima, playing a crucial role in both the initiation and progression of RA. Objective: In this study, we evaluated the effects of melittin on the viability and apoptosis of FLS isolated from patients with RA. Methods: Cell viability was determined using CCK-8 assays; apoptosis was evaluated by flow cytometry, and the expression levels of apoptosis-related proteins (caspase-3, caspase-9, BAX, and Bcl-2) were also determined. To explore whether melittin alters inflammatory processes in RA-FLS, IL-1β levels were determined using an enzyme-linked immunosorbent assay (ELISA). Furthermore, we performed GFP-LC3 punctate fluorescence dot assays and western blotting (for LC3, ATG5, p62, and Beclin 1) to assess autophagy in RA-FLS. Results: Our results show that melittin can significantly impair viability, promote apoptosis and autophagy, and inhibit IL-1β secretion in RA-FLS. Conclusion: Melittin may be useful in preventing damage to the joints during accidental local stimulation.

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