EFFECTS OF MOXONIDINE ON BLOOD PRESSURE, HEART RATE, LIPIDS AND FASTING BLOOD SUGAR IN YOUNG PATIENTS WITH THE METABOLIC SYNDROME

2008 ◽  
Vol 9 (1) ◽  
pp. 250
Author(s):  
D. Koumoutsea ◽  
I. Karydis ◽  
M. Dilanas ◽  
D. Doulgerakis ◽  
S. Papaoikonomou ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Heart Rate ◽  
Blood Sugar ◽  
Young Patients ◽  
Fasting Blood Sugar ◽  
The Metabolic Syndrome

scholarly journals Contribution of Metabolic Syndrome in Controlling Diabetes Mellitus According to Gender in Indonesia (RISKESDAS 2018)

2020 ◽  
Vol 13 (1) ◽  
pp. 46
Author(s):  
Julianty Pradono ◽  
Delima Delima ◽  
Nunik Kusumawardani ◽  
Frans Dany ◽  
Yudi Kristanto
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Blood Sugar ◽  
Fasting Blood Glucose ◽  
Population Characteristics ◽  
Fasting Blood Sugar ◽  
The Metabolic Syndrome ◽  
Sugar Levels

BACKGROUND: Metabolic syndrome (MetS) is a multiple risk factor for the development of type 2 diabetes mellitus (DM). It is important to understand the contribution of MetS in developing DM in different population characteristics. This study aims to obtain the prevalence of MetS and the magnitude of the contribution of MetS risk factors as a basis for developing targeted DM intervention programs. METHODS: This study used data from the 2018 Riskesdas survey, an Indonesia national health survey, with a total sample of 24,545 individuals aged 15 years and over. This study selected only respondents who had never been diagnosed with diabetes mellitus before the survey was conducted and have complete MetS data according to the National Cholesterol Education Program or Adult Treatment Panel III (NCEP/ATP III) criteria. Data had been analyzed for the Population Attributable Fraction (PAF) statistical test. RESULTS: A total of 29.2 percents of the population with MetS and the prevalence in women (17.2%) was higher than in men (11.9%) Three components of MetS that contribute greatly to DM were fasting blood glucose levels, hypertension and high triglyceride levels. If the men population can maintain two risk factors (fasting blood sugar levels and blood pressure) under normal conditions, the prevalence of DM can be reduced by as much as 15 percent. In women, if three factors (fasting blood sugar levels, blood pressure, and triglyceride levels) can be maintained under normal conditions, the prevalence of DM can be reduced by 29.9 percent. CONCLUSION: Prevention strategy of DM need to include monitoring and controlling of the metabolic syndrome and behavioral risk factors, that can be applied in primary health center as well as in community-based setting of health program.

scholarly journals DIAGNOSA PENYAKIT JANTUNG PADA PONSEL MENGGUNAKAN POHON KEPUTUSAN

2015 ◽  
Vol 1 (1) ◽  
Author(s):  
Febri Maspiyanti
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Chest Pain ◽  
Blood Sugar ◽  
Fasting Blood Sugar ◽  
Average Heart Rate ◽  
Resting Blood Pressure

Berkembangnya teknologi kini dapat mempermudah seorang praktisi medis untuk mendiagnosa dengan cepat dan tepat apakah seorang pasien menderita penyakit jantung atau tidak layaknya seorang dokter spesialis jantung yang sudah berpengalaman. Hal tersebut dibutuhkan sebagai usaha dalam deteksi dini penyakit jantung. Penelitian ini bertujuan untuk mencari pola dari penyakit jantung dan membangun sebuah aplikasi mobile untuk mendeteksi penyakit jantung berdasarkan Pohon Keputusan (Pohon Keputusan). Dalam penelitian ini digunakan dataset sejumlah 294 data pasien yang terdiri dari 13 atribut dan 1 atribut sebagai kelas. Kami menggunakan age, sex, chest pain type, resting blood pressure, cholesterol, fasting blood sugar, resting ECG, average heart rate, examine induced angina, T or ST oldpeak, ST slope, number of major vessels, general heart rate sebagai input, dan sehat atau sakit sebagai output. Penelitian ini berhasil menghasilkan akurasi sebesar 81,29% dan mengimplementasikan aturan-aturan yang dihasilkan oleh Pohon Keputusan kedalam aplikasi ponsel. Kata kunci : Penyakit Jantung, Pohon Keputusan, Ponsel.

scholarly journals Effects Of Music Therapy On Clinical And Biochemical Parameters Of Metabolic Syndrome

1970 ◽  
Vol 6 (2) ◽  
pp. 108-115 ◽  
Author(s):  
Madhuri Sharma ◽  
Dr Rajnee ◽  
Kamlesh Chandra Mathur
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Music Therapy ◽  
Blood Sugar ◽  
Biochemical Parameters ◽  
Conventional Treatment ◽  
Fasting Blood Sugar ◽  
Control Group ◽  
Study Group ◽  
Waist Hip Ratio

Background: Music therapy is a new approach being used for the management of metabolic abnormalities and stress related illness. Objective: To study the effect of Music therapy on various clinical and biochemical parameters of Metabolic Syndrome. Methods: This cross sectional study was carried out on 100 patients of metabolic syndrome selected randomly. These patients were divided into two equal groups after age, sex adjustment. In control group (group I) 50 patients underwent the conventional treatment. 50 patients in study group were treated with supervised music protocol along with conventional treatment. The Body Mass Index, ;Waist-Hip ratio, Blood pressure, Fasting blood sugar were monitored weekly while HbA1c and lipid profile were determined at the baseline and after three months of exposure to music therapy. Statistical analysis was performed by employing student t- test. Results: In the study group there was a significant decrease in BMI (27.18±5.02 to 25.44±3.49 kg/m2, p<0.05), waist hip ratio (0.95±0.05 to 0.93±0.05 cm, p<0.05), Fasting blood sugar (196.00±47.80mg/ dl to152.00±16.19mg/dl , p<0.001), HbA1c (8.41±1.31% to 7.08±0.78 % p<0.001), Systolic Blood Pressure (151.00±12.10 to 136±9.04 mmHg p<0.001), Diastolic Blood Pressure (94±4.80 to 86.44±3.16 mmHg, p<0.01), Mean serum cholesterol (257.80±18.92 to 229.12±17.82mg/dl, p<0.001) and triglycerides (180.86±14.04 to 136.50±8.92mg/dl, p<0.001), LDL (167.97±14.40 to 140.20±15.41mg/dl, p<0.001), and VLDL (33.60±2.88 to 28.04±3.08mg/dl, p<0.001) and increase in HDL (33.32±3.38 to 39.71±3.41mg/dl, p<0.001), when compared with those of control group not receiving the music therapy along with the conventional treatment. Conclusion: The promising outcomes of Music therapy showed that it may be considered as a useful adjunct to conventional treatment in management of the metabolic syndrome. This study advocates music therapy to establish it from a general well being concepts to a neuroscience guided model. DOI: http://dx.doi.org/10.3329/jbsp.v6i2.9760 JBSP 2011 6(2): 108-115

scholarly journals GCKR Common functional polymorphisms are associated with metabolic syndrome and its components: a 10-year retrospective cohort study in Iranian adults

2021 ◽  
Author(s):  
Asiyeh Sadat Zahedi ◽  
Mahdi Akbarzadeh ◽  
Bahareh Sedaghati-khayat ◽  
Atefeh Seyedhamzehzadeh ◽  
Maryam S Daneshpour
Keyword(s):  
Metabolic Syndrome ◽  
Cohort Study ◽  
Blood Sugar ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Fasting Blood Sugar ◽  
The Metabolic Syndrome ◽  
Functional Variants ◽  
Sugar Levels ◽  
Metabolic Syndrome Components

Abstract Background: Previous studies reported that common functional variants (rs780093, rs780094, and rs1260326) in the glucokinase regulator gene (GCKR) were associated with metabolic syndrome despite the simultaneous association with the favorable and unfavorable metabolic syndrome components. We decided to evaluate these findings in a cohort study with a large sample size of Iranian adult subjects, to our knowledge for the first time. We investigated the association of the GCKR variants with incident MetS in mean follow-up times for nearly ten years.Methods: Analysis of this retrospective cohort study was performed among 5666 participants of the Tehran Cardiometabolic Genetics Study (TCGS) at 19-88 years at baseline. Linear and logistic regression analyses were used to investigate the metabolic syndrome (JIS criteria) association and its components with rs780093, rs780094, and rs1260326 in an additive genetic model. Cox regression was carried out to peruse variants' association with the incidence of metabolic syndrome in the TCGS cohort study.Results: In the current study, we have consistently replicated the association of the GCKR SNPs with higher triglyceride and lower fasting blood sugar levels (p<0.05) in Iranian adults. The CT genotype of the variants was associated with lower HDL-C levels. The proportional Cox adjusted model regression resulted that TT carriers of rs780094, rs780093, and rs1260326 were associated with 20%, 23%, and 21% excess risk metabolic syndrome incidence, respectively (p<0.05).Conclusions: Elevated triglyceride levels had the strongest association with GCKR selected variants among the metabolic syndrome components. Despite the association of these variants with decreased fasting blood sugar levels, T alleles of the variants were associated with metabolic syndrome incidence; so whether individuals are T allele carriers of the common functional variants, they have a risk factor for the future incidence of metabolic syndrome.

scholarly journals GCKR common functional polymorphisms are associated with metabolic syndrome and its components: a 10-year retrospective cohort study in Iranian adults

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Asiyeh Sadat Zahedi ◽  
Mahdi Akbarzadeh ◽  
Bahareh Sedaghati-Khayat ◽  
Atefeh Seyedhamzehzadeh ◽  
Maryam S. Daneshpour
Keyword(s):  
Metabolic Syndrome ◽  
Cohort Study ◽  
Blood Sugar ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Fasting Blood Sugar ◽  
The Metabolic Syndrome ◽  
Functional Variants ◽  
Sugar Levels ◽  
Metabolic Syndrome Components

Abstract Background Previous studies reported that common functional variants (rs780093, rs780094, and rs1260326) in the glucokinase regulator gene (GCKR) were associated with metabolic syndrome despite the simultaneous association with the favorable and unfavorable metabolic syndrome components. We decided to evaluate these findings in a cohort study with a large sample size of Iranian adult subjects, to our knowledge for the first time. We investigated the association of the GCKR variants with incident MetS in mean follow-up times for nearly 10 years. Methods Analysis of this retrospective cohort study was performed among 5666 participants of the Tehran Cardiometabolic Genetics Study (TCGS) at 19–88 years at baseline. Linear and logistic regression analyses were used to investigate the metabolic syndrome (JIS criteria) association and its components with rs780093, rs780094, and rs1260326 in an additive genetic model. Cox regression was carried out to peruse variants’ association with the incidence of metabolic syndrome in the TCGS cohort study. Results In the current study, we have consistently replicated the association of the GCKR SNPs with higher triglyceride and lower fasting blood sugar levels (p < 0.05) in Iranian adults. The CT genotype of the variants was associated with lower HDL-C levels. The proportional Cox adjusted model regression resulted that TT carriers of rs780094, rs780093, and rs1260326 were associated with 20%, 23%, and 21% excess risk metabolic syndrome incidence, respectively (p < 0.05). Conclusions Elevated triglyceride levels had the strongest association with GCKR selected variants among the metabolic syndrome components. Despite the association of these variants with decreased fasting blood sugar levels, T alleles of the variants were associated with metabolic syndrome incidence; so whether individuals are T allele carriers of the common functional variants, they have a risk factor for the future incidence of metabolic syndrome.

scholarly journals GCKR Common Functional Polymorphisms are Associated with Metabolic Syndrome and its Components: A 10-Year Retrospective Cohort Study in Iranian Adults

2020 ◽  
Author(s):  
Asiyeh Sadat Zahedi ◽  
Mahdi Akbarzadeh ◽  
Bahareh Sedaghati-khayat ◽  
Atefeh Seyedhamzehzadeh ◽  
Maryam S Daneshpour
Keyword(s):  
Metabolic Syndrome ◽  
Cohort Study ◽  
Blood Sugar ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Fasting Blood Sugar ◽  
The Metabolic Syndrome ◽  
Functional Variants ◽  
Sugar Levels ◽  
Metabolic Syndrome Components

Abstract Background: Some previous studies reported that common functional variants (rs780093, rs780094, and rs1260326) in the glucokinase regulator gene (GCKR) were associated with metabolic syndrome despite the simultaneous association with the favorable and unfavorable metabolic syndrome components. We decided to examine these findings, to our knowledge for the first time, in Iranian adults. We investigated the association of the GCKR variants with incident MetS in mean follow-up times for nearly ten years.Methods: Analysis of this retrospective cohort study was performed among 5666 participants of the Tehran Cardiometabolic Genetics Study (TCGS) at 19-88 years at baseline. Linear and logistic regression analyses were used to investigate the metabolic syndrome (JIS criteria) association and its components with rs780093, rs780094, and rs1260326 in an additive genetic model. Cox regression was carried out to peruse variants' association with the incidence of metabolic syndrome in the TCGS cohort study.Results: In the current study, we have consistently replicated the association between the T-allele of GCKR SNPs and higher triglyceride levels and lower fasting blood sugar levels (p<0.05) in the Iranian population. The CT genotype of all three variants was associated with lower HDL-C levels. The proportional Cox adjusted model regression resulted that TT carriers of rs780094, rs780093, and rs1260326 were associated with 20%, 23%, and 21% excess risk metabolic syndrome incidence, respectively (p<0.05).Conclusions: Elevated triglyceride levels had the strongest association with GCKR selected variants among the metabolic syndrome components. Despite the association of these variants with decreased fasting blood sugar levels, T alleles of the variants were associated with metabolic syndrome incidence; so whether individuals are T allele carriers of the common functional variants, they have a risk factor for the future incidence of metabolic syndrome.

scholarly journals A case-control study to find out the prevalence of metabolic syndrome in patients with psoriasis as compared to age and sex matched controls

2021 ◽  
Author(s):  
Shilpa Patwekar ◽  
Nitin Chaudhari ◽  
Chandrakant B. Poulkar ◽  
Swapna S. Khatu ◽  
Abhishek S. Patokar ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Blood Sugar ◽  
Case Control Study ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Severity Index ◽  
Case Control ◽  
Fasting Blood Sugar ◽  
Control Study

<p><strong>Background: </strong>Psoriasis is an immune mediated chronic inflammatory dermatosis and it is associated with high risk of cardiovascular events. Aim of the study was to estimate the prevalence of metabolic syndrome and its association with disease severity in patients with psoriasis.</p><p><strong>Methods:</strong> This was a case control study which included 150 cases of chronic plaque psoriasis and 150 healthy controls. All subjects underwent detailed history and clinical examination including measurement of blood pressure and waist circumference and psoriasis area and severity index (PASI) score. Fasting blood sugar, triglyceride, cholesterol, and high-density lipoprotein cholesterol levels were tested following overnight fasting. Various parameters of metabolic syndrome were compared in two groups using chi square test and fisher’s exact test. Statistical analysis of the data was done using epi-info <sup>TM</sup> software.</p><p><strong>Results:</strong> Prevalence of metabolic syndrome was more common in patients of psoriasis than in control (56.67% vs. 17.33%; p&lt;0.0001). Psoriatic patients had higher prevalence of abdominal obesity (57.33% vs. 27.33%; p=0.0037), elevated blood pressure (32% vs. 12%; p=0.0001), elevated fasting blood sugar level (62% vs. 22%; p&lt;0.0001), hypertriglyceridemia (44.66% vs. 32%; p=0.0326), low level of HDL cholesterol (64% vs. 21.33%; p&lt;0.0001 and alcohol abuse (22.22% vs. 14.66%; p=0.0154).</p><p><strong>Conclusions:</strong> The findings in our study demonstrated a robust association between psoriasis and metabolic syndrome and its components, irrespective of psoriasis severity.</p>

scholarly journals GCKR Common functional polymorphisms are associated with metabolic syndrome and its components: a 10-year retrospective cohort study in Iranian adults

2021 ◽  
Author(s):  
Asiyeh Sadat Zahedi ◽  
Mahdi Akbarzadeh ◽  
Bahareh Sedaghati-khayat ◽  
Atefeh Seyedhamzehzadeh ◽  
Maryam S Daneshpour
Keyword(s):  
Metabolic Syndrome ◽  
Cohort Study ◽  
Blood Sugar ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Fasting Blood Sugar ◽  
The Metabolic Syndrome ◽  
Functional Variants ◽  
Sugar Levels ◽  
Metabolic Syndrome Components

Abstract Background Previous studies reported that common functional variants (rs780093, rs780094, and rs1260326) in the glucokinase regulator gene (GCKR) were associated with metabolic syndrome despite the simultaneous association with the favorable and unfavorable metabolic syndrome components. We decided to evaluate these findings in a cohort study with a large sample size of Iranian adult subjects, to our knowledge for the first time. We investigated the association of the GCKR variants with incident MetS in mean follow-up times for nearly ten years. Methods Analysis of this retrospective cohort study was performed among 5666 participants of the Tehran Cardiometabolic Genetics Study (TCGS) at 19–88 years at baseline. Linear and logistic regression analyses were used to investigate the metabolic syndrome (JIS criteria) association and its components with rs780093, rs780094, and rs1260326 in an additive genetic model. Cox regression was carried out to peruse variants' association with the incidence of metabolic syndrome in the TCGS cohort study. Results In the current study, we have consistently replicated the association of the GCKR SNPs with higher triglyceride and lower fasting blood sugar levels (p < 0.05) in Iranian adults. The CT genotype of the variants was associated with lower HDL-C levels. The proportional Cox adjusted model regression resulted that TT carriers of rs780094, rs780093, and rs1260326 were associated with 20%, 23%, and 21% excess risk metabolic syndrome incidence, respectively (p < 0.05). Conclusions Elevated triglyceride levels had the strongest association with GCKR selected variants among the metabolic syndrome components. Despite the association of these variants with decreased fasting blood sugar levels, T alleles of the variants were associated with metabolic syndrome incidence; so whether individuals are T allele carriers of the common functional variants, they have a risk factor for the future incidence of metabolic syndrome.

Role of genetic factors in the development of hypertension in young patients with metabolic syndrome

2020 ◽  
pp. 23-32
Author(s):  
Elena Korneeva ◽  
Mikhail Voevoda ◽  
Sergey Semaev ◽  
Vladimir Maksimov
Keyword(s):  
Metabolic Syndrome ◽  
High Risk ◽  
Arterial Hypertension ◽  
Genetic Factors ◽  
Young Patients ◽  
Integrin Αiibβ3 ◽  
Ace Gene ◽  
The Metabolic Syndrome

Results of the study related to polymorphism of ACE gene (rs1799752)‎, integrin αIIbβ3, and CSK gene (rs1378942) influencing development of arterial hypertension in young patients with metabolic syndrome are presented. Hypertension as a component of the metabolic syndrome was detected in 15.0% of young patients. Prevalence of mutant alleles of the studied genes among the examined patients was quite high, so homozygous DD genotype was found in 21.6%, and mutant D allele of the ACE gene in 47.4%. A high risk of hypertension in patients with MS was detected in carriers of the T allele of the CSK (rs1378942) gene – 54.8%, which was most often observed in a combination of polymorphic ACE and CSK gene loci (p = 0.0053).

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