scholarly journals A case-control study to find out the prevalence of metabolic syndrome in patients with psoriasis as compared to age and sex matched controls

2021 ◽  
Author(s):  
Shilpa Patwekar ◽  
Nitin Chaudhari ◽  
Chandrakant B. Poulkar ◽  
Swapna S. Khatu ◽  
Abhishek S. Patokar ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Blood Sugar ◽  
Case Control Study ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Severity Index ◽  
Case Control ◽  
Fasting Blood Sugar ◽  
Control Study

<p><strong>Background: </strong>Psoriasis is an immune mediated chronic inflammatory dermatosis and it is associated with high risk of cardiovascular events. Aim of the study was to estimate the prevalence of metabolic syndrome and its association with disease severity in patients with psoriasis.</p><p><strong>Methods:</strong> This was a case control study which included 150 cases of chronic plaque psoriasis and 150 healthy controls. All subjects underwent detailed history and clinical examination including measurement of blood pressure and waist circumference and psoriasis area and severity index (PASI) score. Fasting blood sugar, triglyceride, cholesterol, and high-density lipoprotein cholesterol levels were tested following overnight fasting. Various parameters of metabolic syndrome were compared in two groups using chi square test and fisher’s exact test. Statistical analysis of the data was done using epi-info <sup>TM</sup> software.</p><p><strong>Results:</strong> Prevalence of metabolic syndrome was more common in patients of psoriasis than in control (56.67% vs. 17.33%; p&lt;0.0001). Psoriatic patients had higher prevalence of abdominal obesity (57.33% vs. 27.33%; p=0.0037), elevated blood pressure (32% vs. 12%; p=0.0001), elevated fasting blood sugar level (62% vs. 22%; p&lt;0.0001), hypertriglyceridemia (44.66% vs. 32%; p=0.0326), low level of HDL cholesterol (64% vs. 21.33%; p&lt;0.0001 and alcohol abuse (22.22% vs. 14.66%; p=0.0154).</p><p><strong>Conclusions:</strong> The findings in our study demonstrated a robust association between psoriasis and metabolic syndrome and its components, irrespective of psoriasis severity.</p>

scholarly journals Analysis of metabolic syndrome factors to determine contributions to pathogenesis of mammary gland disease in Japanese women– Case-control study based on health screening results

2020 ◽  
Author(s):  
Tadayuki Iida ◽  
Sakika Sumida ◽  
Yoshikawa Masao ◽  
Nagaoka Kaoru
Keyword(s):  
Breast Cancer ◽  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Mammary Gland ◽  
Waist Circumference ◽  
Odds Ratio ◽  
Case Control Study ◽  
Hdl Cholesterol ◽  
Case Control ◽  
Control Study

Abstract Background: Recently, the relationship between obesity and breast cancer has been clarified, and findings obtained in a study that used body mass index (BMI) suggested that its presence might increase the risk for development of that disease. However, the association between metabolic syndrome caused by obesity and development of mammary gland disease has not been elucidated in a longitudinal manner. In the present case-control study, that association was examined.Methods: Two hundred sixty-five women who underwent breast cancer screening with mammography and measurements of metabolic syndrome factors, including waist circumference, blood glucose, and triglycerides, HDL-cholesterol levels, and systolic and diastolic blood pressure, twice within a 2-year period at the Disease Prevention Promotion and Research Center of the Dai-ikai Medical Corporation were enrolled. To determine the presence of mammary gland disease, 2 expert physicians interpreted radiogram findings, with category 3 or higher shown by mammography considered to indicate an abnormality.Results and Discussion: Waist circumference at the initial measurement was shown to be significantly associated (odds ratio=1.036, p=0.045) as a risk factor for onset of mammary gland disease. During the 2-year examination period, changes in systolic blood pressure (odds ratio=1.020, p=0.085) and diastolic pressure (odds ratio=1.040, p=0.065) showed a marginally significant association. As for protective factors, HDL-cholesterol level (odds ratio=0.982, p=0.064) at the initial examination was confirmed to have a marginally significant relationship. We concluded that waist circumference and 2-year changes in systolic and diastolic blood pressure are risk factors for mammary gland disease, while HDL-cholesterol level is a protective factor.

scholarly journals Determinants of Cardiovascular Disease among Urban Women with Psoriasis: A Case–Control Study

2020 ◽  
Vol 5 (02) ◽  
pp. 102-108 ◽  
Author(s):  
Sudha Bala ◽  
Archana Mavoori ◽  
Harshal Pandve ◽  
Chinmayee Biswal ◽  
Vijay Prasanna ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Blood Glucose ◽  
Waist Circumference ◽  
Case Control Study ◽  
Low Density Lipoprotein ◽  
Fasting Blood Glucose ◽  
Density Lipoprotein ◽  
Case Control ◽  
Low Density ◽  
Control Study

Abstract Background and Aim Psoriasis have a direct impact on development of cardiovascular risk factors leading to atherosclerosis and metabolic abnormalities. In order to prevent the complications, early and prompt identification of factors through various parameters help in primary and secondary prevention of cardiovascular diseases (CVDs) among these psoriatic patients. Therefore the aim of this study is to determine the prevalence of various determinants for cardiovascular diseases among cases and controls. Methods A hospital based case control study at a tertiary care hospital included women from the out patient department, aged above 18 years who were known cases of psoriasis. 114 patients were recruited with 1:1 ratio between cases and controls. All patients were evaluated using semi structured interview schedule with socio demographic variables, duration of disease, family history, and usage of drugs. Severity of disease was assessed through the psoriasis area severity index (PASI). Body surface area (BSA), body mass index (BMI), waist circumference and blood pressure measurement were done using standard methods. Lipid profile, high sensitivity C-Reactive protein (HsCRP) and blood sugar through calibrated analyzers having quality control. Carotid intima media thickness (CIMT) was assessed by using carotid Doppler technique to measure atherosclerosis. Results One hundred fourteen patients, means 57 pairs of cases and controls were analyzed in this study. Significant determinants among cases were raised such as waist circumference (p = 0.025), diastolic blood pressure (p = 0.0001), low density lipoprotein (p = 0.002) and fasting blood glucose (p = 0.004) when compared to controls. HsCRP and CIMT were also raised among cases but only CIMT was statistically significant when compared to controls (p = 0.0001). We also found raised determinants among psoriatic arthritis patients compared to psoriasis. Conclusion Psoriasis patients had high waist circumference, diastolic blood pressure, low density lipoprotein, fasting blood glucose, and CIMT when compared to controls. Early identification of these determinants make them amenable for prevention.

scholarly journals The association of depression with metabolic syndrome parameters and malondialdehyde (MDA) in obese women: A case-control study

2021 ◽  
Vol 11 (4) ◽  
pp. 492-497
Author(s):  
Elnaz Vaghef-Mehrabani ◽  
Azimeh Izadi ◽  
Mehrangiz Ebrahimi-Mameghani
Keyword(s):  
Oxidative Stress ◽  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Depressive Symptoms ◽  
Lipid Profile ◽  
Case Control Study ◽  
Case Control ◽  
Obese Women ◽  
Anthropometric Parameters ◽  
Control Study

Background: There is evidence for a bidirectional association between obesity and depression, and obesity is the main risk factor for metabolic syndrome (MetS). This study aimed to compare oxidative stress and MetS features between depressed and non-depressed obese women and study the association of depressive symptoms, oxidative stress, and components of MetS. Methods: In this case-control study conducted in Tabriz (East Azarbaijan, Iran), obese women (body mass index [BMI]: 30-40 kg/m2 ) with a primary diagnosis of major depressive disorder (MDD; based on diagnostic interview with a psychiatrist; n=75) and their age-matched non-depressed controls (n=150) were enrolled. Beck Depression Inventory-version II (BDI-II) was used to assess depressive symptoms in both groups. Anthropometric parameters, blood pressure, fasting blood sugar (FBS), lipid profile and malondialdehyde (MDA) were measured. Results: No significant differences in anthropometric parameters and blood pressure were observed between the two groups. However, FBS of the MDD group was significantly higher than the control (P<0.05). FBS was significantly correlated with BDI-II scores (r=0.158, P=0.017). No significant difference in lipid profile was observed between the groups. Serum MDA level was significantly lower in the MDD group and was inversely associated with BDI-II scores (r=-0.328, P<0.001). Overall, MDD was not significantly associated with MetS in our study (OR=0.848, 95% CI: 0.484, 1.487; P=0.566). Conclusion: Although we found a correlation between higher depressive symptoms and some adverse metabolic outcomes, our findings do not support a significant association between MDD and MetS.

scholarly journals Metabolic syndrome in south Indian population with skin tags: a hospital-based case control study

2020 ◽  
Vol 8 (10) ◽  
pp. 3682
Author(s):  
Bobbili Tarun Kesava Naidu ◽  
Kavya Baddireddy
Keyword(s):  
Metabolic Syndrome ◽  
High Density Lipoprotein ◽  
Case Control Study ◽  
Density Lipoprotein ◽  
Case Control ◽  
High Density ◽  
South Indian Population ◽  
Significant Difference ◽  
Skin Tags ◽  
Control Study

Background: Metabolic syndrome is a constellation of several clinical and laboratory cardiovascular risk factors that have been linked with numerous medical and dermatologic conditions. Recent evidence suggests a strong association between skin tags and insulin resistance and obesity, yet there is a paucity of data on relation of skin tags with metabolic syndrome as a whole. Aim of the study was to evaluate the strength of association between skin tags and metabolic syndrome.Methods: 70 patients with skin tags and an equal number of age and gender matched controls were enrolled in a hospital-based case control study. Anthropometric measures, blood pressure, fasting glucose, high density lipoprotein cholesterol and triglycerides were measured. Metabolic syndrome was diagnosed by the presence of 3 or more of the south Asian modified national cholesterol education program’s adult panel III criteria. Statistical analysis was performed using chi square test, and odds ratio was calculated. P≤0.05 were considered significant.Results: Metabolic syndrome was significantly more common in patients with skin tags than in controls (70% vs. 26%, p<0.001). Triglycerides and waist circumference values were significantly increased in cases as compared to controls (p<0.05).  There was no statistically significant difference in the high-density lipoprotein levels, fasting blood glucose levels and presence of hypertension among cases and controls.Conclusion: Skin tags when present in multiple could be an early warning sign for Metabolic syndrome. They serve a cutaneous marker to initiate early detection and intervention of at-risk patients for cardiovascular disorders.

scholarly journals An inverse association of weight and the occurrence of asymptomatic gallbladder stone disease in Hypercholesterolemia patients in northwest China: a case-control study.

2020 ◽  
Author(s):  
Binwu Sheng ◽  
Qingbin Zhao ◽  
Mao Ma ◽  
Jianqin Zhang
Keyword(s):  
Blood Pressure ◽  
Serum Lipids ◽  
Case Control Study ◽  
Density Lipoprotein ◽  
Case Control ◽  
Stone Disease ◽  
Inverse Association ◽  
Gallbladder Stone ◽  
Control Study ◽  
New Onset

Abstract Background: Despite the fact that the majority of gallstones formed in the gallbladder are mainly composed of cholesterol, as they are formed from cholesterol-supersaturated bile, and hypercholesterolemia is a common metabolic disorder, which is closely related to cardiac, hepatic, renal and other oxidative damage inflammation and necrosis , there is still no consensus regarding the contribution of blood serum lipids in the pathogenesis of gallbladder stone disease (GSD). Here, we aimed to investigate the relationship between hypercholesterolemia and the risk of new-onset asymptomatic GSD, and to determine the prevalence of factors associated with new-onset asymptomatic GSD in patients with hypercholesterolemia. Methods: In this case-control study, we enrolled 927 Chinese patients with new-onset asymptomatic gallstone disease and 845 healthy controls starting in August 2012. Patients were matched for age, gender, race, occupation, systolic blood pressure, diastolic blood pressure, and fasting blood glucose levels (FBG). Body mass index (BMI), nonalcoholic fatty liver disease (NAFLD) and serum lipids indexes were compared and the relationships between BMI, blood lipid and gallbladder stone hazards were examined by using logistic multivariate regression models. Results: The result showed a significant higher morbidity with GSD in hypercholesterolemia than non-hypercholesterolemia patients (Χ 2 =17.211, P <0.001). Of hypercholesterolemia patients, low density lipoprotein (OR=1.493, P=0.029) and NAFLD (OR=2.723, P =0.022) were significant risk factors for GSD, while male sex (OR=0.244, P=0.033), weight (OR=0.961, P =0.022), high density lipoprotein (OR=0.305, P<0.001), and FBG (OR=0.687, P =0.034) significantly negatively correlated with GSD in univariate analysis. Multivariate logistic regression indicated weakly positive correlations with NAFLD (OR=3.284, P =0.054), and significant negative correlations with weight (OR=0.930, P =0.018), HDL-c (OR=0.144, P <0.001), and GSD. Conclusion: Hypercholesterolemia acts as an independent risk factor for new-onset asymptomatic GSD, while obesity and NAFLD are synergistic factors. Interestingly, we are the first to report that elevated weight was inversely associated with GSD in patients with hypercholesterolemia. The results of this study suggest that it is crucial to control hyperlipidemia effectively first instead of weight loss which might make the situation worse，and this might be of great significance for prevention of GSD in obese patients with hyperlipidemia.

scholarly journals Relationship between serum lipid levels and ischemic stroke in patients with atrial fibrillation: a nested case–control study based on the China Atrial Fibrillation Registry

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Fei Li ◽  
Xin Du ◽  
Liu He ◽  
Chao Jiang ◽  
Shijun Xia ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Blood Pressure ◽  
Ischemic Stroke ◽  
Case Control Study ◽  
Density Lipoprotein ◽  
Case Control ◽  
Control Group ◽  
Stroke Group ◽  
Nested Case Control ◽  
Control Study

Abstract Background Atrial fibrillation (AF) is an important risk factor for acute ischemic stroke. Methods A nested case–control study was conducted among patients diagnosed with AF, whose information was acquired from the prospective China Atrial Fibrillation Registry (China-AF), from August 2011 to December 2018. Results This study compared patients with stroke group (n = 145) with a matched control group (n = 577). Demographic data were similar except for body mass index (BMI), diastolic blood pressure (DBP) which were higher, and new oral anticoagulant (NOAC) treatment rate which was lower in the stroke group (all P < 0.05). Baseline median [IQR] levels of including triglyceride (TG) were higher in the stroke group (21.96 [16.74, 21.52], mg/dL) than the control group (19.62 [14.76, 27.36], mg/dL) (P = 0.012), while the total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) were similar between the two groups. Elevated TG and HDL-C were positively associated with ischemic stroke (OR 1.01, 95% CI 1.00–1.02, P = 0.032; OR 1.03, 95% CI 1.00–1.05, P = 0.025), after adjustment for BMI, systolic blood pressure, DBP, CHA2DS2-VASc score, HAS-BLED score, NOAC, LDL-C and HDL-C. However, NOAC (OR 0.20, 95% CI 0.05–0.84, P = 0.029) could decrease the likelihood of ischemic stroke in patients with AF. In subgroup analysis, higher TG level remained significantly associated with ischemic stroke for AF patients without a history of smoking (OR 1.26, 95% CI 1.02–1.55, P = 0.028). Conclusion Higher level of TG and HDL-C were positively associated with ischemic stroke in patients with AF.

scholarly journals Decreased Level of Nitric Oxide in Preeclamptic Pregnancy: A Relationship with PON1 Arylesterase Activity

2019 ◽  
pp. 1-10
Author(s):  
Swati Digambar Sawant ◽  
Mukund R. Mogarekar
Keyword(s):  
Nitric Oxide ◽  
Case Control Study ◽  
Multivariate Logistic Regression Analysis ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Case Control ◽  
Lipoprotein Cholesterol ◽  
Paraoxonase 1 ◽  
P Value ◽  
Control Study

Aims: The aim of the study was to evaluate the status and diagnostic utility of PON1. (Paraoxonase-1) Arylesterase and nitric oxide as indicator of antioxidant status in preeclampsia. Study Design:  Analytical case control study. Place and Duration of Study: Sample: Department of obstretics and gynecology Department, G. M. C. Ambajogai, between July 2010 and July 2012. Methodology: We conducted a case-control study of 57 women with preeclampsia and 57 women with uncomplicated deliveries. We measured PON1 Arylesterase activity, Nitric oxide and lipid profile. Results: Serum levels of LDLc (low density lipoprotein cholesterol) are higher in cases than in controls and are statistically significant (p=0.023). However serum HDLc (high density lipoprotein cholesterol) levels are decreased significantly (p = 0.017). Serum PON1 Arylesterase showed significant decrease in cases152.68 KU/L versus controls 180.89 KU/L, p value=0.002.  Serum nitric oxide also showed significant decrease in cases 22.77 ± 4.792 umol/L versus controls 25.127 umol/L, p=0.010. PON1 Arylesterase activity is found to be positively correlated with serum HDL cholesterol (r = 0.449, p value< 0.001). Multivariate logistic regression analysis was done. Conclusion: Our observed results show decrease in the antioxidant PON1 Arylesterase activity point towards their role in the pathogenesis of Preeclampsia.

scholarly journals Association of serum uric acid and serum lipid profile in pre- eclampsia- A hospital based case-control study

2020 ◽  
Vol 4 (3) ◽  
pp. 831-834
Author(s):  
Shikha Rizal ◽  
Bishal Raj Joshi ◽  
Amita Dhakal ◽  
Reshu Agrawal Sagtani
Keyword(s):  
Blood Pressure ◽  
Uric Acid ◽  
Pregnant Women ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Serum Uric Acid ◽  
Case Control Study ◽  
Density Lipoprotein ◽  
Case Control ◽  
Control Study

Introduction: Pre-eclampsia, one of the most common medical complication in pregnancy results in considerable maternal and fetal morbidity and mortality. Endothelial dysfunction is a central feature of pre-eclampsia. Elevated serum uric acid level may serve as a marker for early diagnosis of the disease as well as a surrogate for clinical severity of the condition. High serum values of triglycerides, total cholesterol, low- density lipoprotein and and low levels of high density lipoprotein are all significantly related to risk developing preeclampsia.  Objective: To find out the association between serum uric acid levels and lipid profile in pre-eclamptic women and compare it with the normal pregnant women.  Methodology: A case control study was conducted among 180 pregnant women (90 cases of pre-eclamptic women and 90 cases of age matched normal pregnant women) between 21-35 years who were admitted in the Gynaecology and Obstetrics ward of Nobel Medical College and Teaching Hospital, Biratnagar. Blood pressure was measured. Serum from all the patients were analyzed for the following biochemical parameters: serum uric acid, triglyceride, total cholesterol, LDL-C and HDL- C. The data were collected and entered in MS-Excel and analyzed using Statistical Package for Social Sciences (SPSS) ver. 16 software. Results: Mean serum uric acid of pre-eclamptic women was higher than those of normal pregnant women  which was found to be statistically significant with p value <0.001. Among the lipid parameters, serum triglyceride and total cholesterol was significantly higher in pre-eclamptic women whereas high density lipoprotein was significantly lower in pre-eclamptic. Also there was a positive co-relation between triglyceride and blood pressure and a negative co-relation between HDL-C in preeclamptic women. Conclusion: Development of simple and inexpensive methods to predict and prevent pre-eclampsia in early stage is very important. Thus, our study concludes the utility of measurement of serum uric acid and lipid profile for screening patients at risk of developing pre-eclampsia.

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