scholarly journals Gastroprotective effect of the aqueous leaf extract of Guiera senegalensis in Albino rats

2013 ◽  
Vol 6 (10) ◽  
pp. 771-775 ◽  
Author(s):  
GC Akuodor ◽  
AD Essien ◽  
E David-Oku ◽  
KC Chilaka ◽  
JL Akpan ◽  
...  
Keyword(s):  
Leaf Extract ◽  
Albino Rats ◽  
Gastroprotective Effect ◽  
Aqueous Leaf Extract ◽  
Guiera Senegalensis

scholarly journals In vitro Antioxidant and In vivo Hepatocurative and Nephrocurative Activities of Aqueous Leaf Extract of Newbouldia laevis in Albino Rats

2021 ◽  
pp. 114-125
Author(s):  
Mohammed A. Sulaiman ◽  
Mahmoud S. Jada ◽  
Augustine Elizabeth ◽  
Abubakar Umar Modibbo
Keyword(s):  
Oral Administration ◽  
Leaf Extract ◽  
Kidney Diseases ◽  
Albino Rats ◽  
Protein Levels ◽  
Ameliorative Effect ◽  
Liver And Kidney ◽  
Aqueous Leaf Extract

The in vitro antioxidant activity and in vivo hepatocurative and nephrocurative potential of Newbouldia laevis aqueous leaf extract (NLALE) was evaluated. The study used 30 male, albino rats (Rattus norvegicus) weighing 180 ± 20 g, of which 25 were intoxicated by oral administration of a single dose of diclofenac (100 mg/kg b. wt.). Animals were treated by oral administration of silymarin (200 mg/kg b. wt.), furosemide (1.5 mg/kg b. wt.) and NLALE (200 mg/kg and 400 mg/kg b. wt.) for seven consecutive days before animals were sacrificed on the 8th day and serum/plasma was analyzed for biochemical markers of hepatotoxicity and nephrotoxicity. Phytochemical screening of NLALE revealed the presence of alkaloids, flavonoids, glycosides, phenols, saponins, steroids and tannins. The extract scavenged DPPH radical, reduced Fe3+ and inhibited TBARs in comparable manner to ascorbic acid in vitro. NLALE also attenuated diclofenac-induced liver and kidney intoxication as indicated by the significantly (p<0.05) reduced levels of serum biomarkers of hepatotoxicity: ALT, AST, bilirubin, but increased total protein levels and nephrotoxicity: urea, creatinine, Na+ and K+. The observed effects are dose dependent as the 400 mg/kg b. wt. appeared to be more potent than the 200 mg/kg b. wt. dose. It may be concluded from this study that Newbouldia laevis leaf has ameliorative effect against diclofenac-induced hepatotoxicity and nephrotoxicity probably through antioxidative mechanism and the curative claim and the folkloric use of the plant in the treatment of liver and kidney diseases have been scientifically validated

scholarly journals HEPATOPROTECTIVE AND ANTI-HEPATOTOXIC ACTIVITIES OF AQUEOUS LEAF EXTRACT OF TACAZZEA BARTERI AGAINST CARBON TETRACHLORIDE INDUCED HEPATOTOXICITY IN ALBINO RATS

2013 ◽  
Vol 2 (9) ◽  
pp. 60-65 ◽  
Author(s):  
Obioha Mary Quinette Uru ◽  
Ilodigwe Emmanuel Emeka ◽  
Ajaghaku Daniel Lotanna ◽  
Umeokoli Blessing Ogechukwu
Keyword(s):  
Carbon Tetrachloride ◽  
Leaf Extract ◽  
Albino Rats ◽  
Aqueous Leaf Extract

scholarly journals Protective Effect of Costus afer Aqueous Leaf Extract (CALE) on Low-Dose Heavy Metal Mixture-Induced Alterations in Serum Lipid Profile and Hematological Parameters of Male Wistar Albino Rats

2020 ◽  
Vol 2020 ◽  
pp. 1-12
Author(s):  
Brilliance O. Anyanwu ◽  
Chinna N. Orish ◽  
Anthonet N. Ezejiofor ◽  
Ify L. Nwaogazie ◽  
Orish E. Orisakwe ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Leaf Extract ◽  
Low Dose ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Treated Group ◽  
Albino Rats ◽  
Metal Mixture ◽  
Aqueous Leaf Extract ◽  
Costus Afer

The present work investigated the protective effects of Costus afer Ker Gawl. aqueous leaf extract (CALE) on lipid profile and hematological changes induced by exposure to low-dose heavy metal mixture in male albino rats. The experimental animals were divided into six weight matched groups. The normal (group 1) and toxic (group 2) controls received deionized water and metal mixture (20 mg/kg PbCl2, 1.61 mg/kg CdCl2, and 0.40 mg/kg HgCl2), respectively. Test rats in groups 3, 4, and 5 were treated with metal mixture and CALE (750, 1500, and 2250 mg/kg, respectively), and group 6 received metal mixture and ZnCl2. All treatments were administered through oral gavage for 12 weeks. LDHMM caused a marked increase ( p < 0.05 ) in cholesterol, triglyceride, low-density lipoprotein (LDL), and very low-density lipoprotein (VLDL) levels and a decrease in high-density lipoprotein (HDL), percentage body weight gain, and feed and fluid intake. Also, a significant decrease in RBC, Hb, and PCV, a significant increase in WBC, and no significant increase in platelet PLT were observed in the metal mixture-treated group. But in CALE treated groups, their levels were found to attain almost normal values as found in normal control which is also similar to the zinc-treated group. Costus afer may hold a promise in improving lipid profile and hemodynamic picture in cardiovascular diseases.

scholarly journals Wound-healing Activity of the Aqueous Leaf Extract and Fractions of Ficus exasperata (Moraceae) and its Safety Evaluation on Albino Rats

2014 ◽  
Vol 4 (4) ◽  
pp. 246-252 ◽  
Author(s):  
Victoria Nonyelum Umeh ◽  
Emmanuel Emeka Ilodigwe ◽  
Daniel Lotanna Ajaghaku ◽  
Earnest Oghenesuvwe Erhirhie ◽  
Goodies Emuesiri Moke ◽  
...  
Keyword(s):  
Wound Healing ◽  
Leaf Extract ◽  
Safety Evaluation ◽  
Albino Rats ◽  
Aqueous Leaf Extract ◽  
Wound Healing Activity

scholarly journals Pre-treatment effects against the diclofenac-induced toxicity by the aqueous leaf extract of Madhuca longifolia on female Wistar albino rats for 10 and 15 days

2020 ◽  
pp. 132-143
Author(s):  
Jerine Peter Simon ◽  
Sibi Karthik Saravanan ◽  
Jayashree Sathiyaranayanan ◽  
Radhakrishnan Vidya ◽  
Usha Kumari ◽  
...  
Keyword(s):  
Leaf Extract ◽  
Control Group ◽  
Albino Rats ◽  
Histopathological Analysis ◽  
Group I ◽  
Madhuca Longifolia ◽  
Aqueous Leaf Extract ◽  
Pre Treatment ◽  
Wistar Albino Rats ◽  
Enzyme Markers

Diclofenac is used to treat rheumatism disorders, which are associated with the damages of renal, gastric and hepatic organs. Diclofenac is a pharmaceutical drug that is known to induce toxicity on its overdosage and long-term usage. Madhuca longifolia is known to have antioxidant, anti-inflammatory and anti-ulcer activity. It is an evergreen tree that is reported to have many ethnomedicinal uses. The other properties of Madhuca longifolia include anti-diabetic, analgesic and anti-microbial activities. Our study aims to evaluate the pre-treatment activity against the diclofenac-induced toxicity by the Madhuca longifolia aqueous leaf extract in Wistar albino rats for 10 and 15 days. Rats were divided as Group-I: Normal control, Group-II: Diclofenac on the last two days, Group-III and group-IIIa: Diclofenac + Aqueous Leaf Extract of Madhuca longifolia, Group-IV and group-IVb: Diclofenac + Silymarin, Group -V and group-Va: Aqueous Madhuca longifolia leaf extract. After the sacrifice, the rats were studied for antioxidant assay, renal enzyme markers, liver enzyme markers, and histopathological analysis of the kidney, stomach, intestine, and liver. As a result, we could identify that Madhuca longifolia has reduced the toxic changes in rats caused by diclofenac.

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