Whitish elevated lesion in the oesophagus: verrucous carcinoma

Background: Adenocarcinoma with enteroblastic differentiation is a subtype of alpha-fetoprotein (AFP) producing adenocarcinoma. This type of tumor is associated with a poor prognosis and is prone to metastasize. Esophageal adenocarcinoma with enteroblastic differentiation is extremely rare.Case presentation: The patient was a 65-year-old woman who was referred to our hospital with dysphagia. Endoscopic examination revealed an elevated lesion 20mm in diameter at 17cm from the upper incisors. Endoscopic submucosa dissection (ESD) was performed and histopathological examination revealed tubular adenocarcinoma composed of cuboidal cells with clear cell cytoplasm. Immunohistochemical stain was diffusely positive for Sall-like protein 4 (SALL4) and weakly positive for AFP and glypican 3. From this result, we diagnosed esophageal adenocarcinoma with enteroblastic differentiation. The patient is still alive without recurrence of cancer 40 months after ESD.Conclusion: To our knowledge, this is the first report to undergo ESD for esophageal adenocarcinoma with enteroblastic differentiation arising from ectopic gastric mucosa in the esophagus.Abbreviations: AFP: alfa-fetoprotein; CA19-9: carbohydrate antigen 19-9; CEA: carcinoembryonic antigen; ESD: endoscopic submucosal dissection; EUS: endoscopic ultrasound; FDG-PET: [18F] fluorodeoxyglucose positron emission tomography; ME: magnifying endoscopy; NBI: narrow band imaging; SALL 4: Sall-like protein 4; SCC: squamous cell carcinoma antigen.

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Multidisciplinary Approach of a Very Rare Infected Verrucous Carcinoma of the Scrotum

Revista de Chimie ◽

10.37358/rc.19.4.7153 ◽

2019 ◽

Vol 70 (4) ◽

pp. 1476-1478

Author(s):

Laura Raducu ◽

Adelaida Avino ◽

Cristina-Nicoleta Cozma ◽

Sorin Nedelea ◽

Andra-Elena Balcangiu-Stroescu ◽

...

Keyword(s):

Adjuvant Therapy ◽

Rare Disease ◽

Chronic Inflammation ◽

Male Patient ◽

Multidisciplinary Approach ◽

Verrucous Carcinoma ◽

Surgical Excision ◽

Diagnosis And Treatment ◽

Wide Surgical Excision ◽

The Right

Verrucous carcinoma of the scrotum is an extremely rare disease and most cases are thought to result from poor hygiene and chronic inflammation. Currently, it has not been well characterized, the etiology, diagnosis and treatment remaining poorly understood. We present the case of a 50-year-old male patient diagnosed with verrucous carcinoma of the right hemiscrotum. Wide surgical excision was performed. Favorable outcomes can be achieved by surgery, even without any adjuvant therapy, but patients should be carefully followed up.

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Breast Angiosarcoma with a Preoperative Diagnosis of Late Recurrence of Breast Cancer: A Case Report

Case Reports in Oncology ◽

10.1159/000513906 ◽

2021 ◽

pp. 604-609

Author(s):

Rika Kouhashi ◽

Shinichiro Kashiwagi ◽

Yuka Asano ◽

Tamami Morisaki ◽

Sae Ishihara ◽

...

Keyword(s):

Breast Cancer ◽

Preoperative Diagnosis ◽

Vascular Endothelial Cells ◽

Interstitial Fibrosis ◽

Late Recurrence ◽

Breast Conserving Surgery ◽

Surrounding Tissue ◽

Axillary Lymph ◽

Elevated Lesion ◽

The Right

Angiosarcoma is a malignant mesenchymal tumor characterized by the presence of vascular endothelial cells. Although rare, angiosarcoma developing in the mammary glands has a poor prognosis. We report a case of breast angiosarcoma with a preoperative diagnosis of late recurrence of breast cancer. A 78-year-old woman noticed a tumor in her right breast and visited our hospital. The patient had undergone breast-conserving surgery and axillary lymph node dissection from the right breast 12 years before the visit. The tumor was diagnosed as T4bN0M0, stage IIIB. Anastrozole was administered as postoperative adjuvant therapy for 5 years; the patient also received 50-Gy whole-breast radiation therapy after surgery. Physical examination during her visit revealed an elevated lesion with blue purpura around the nipple in the right breast. We performed breast ultrasound and detected a well-defined 19.6 × 16.4 × 10.7 mm hypoechoic tumor in the left subareolar area. The patient underwent core needle biopsy (CNB). Based on the CNB specimen findings, she was suspected to experience late local recurrence after surgery. Therefore, she underwent total mastectomy after breast-conserving surgery. A dark-red tumor sized 18 × 12 mm was found in a specimen from the nipple. The pathological diagnosis of the specimen revealed short spindle-shaped tumor cells with strong nuclear pleomorphism and a significant interstitial fibrosis. Immunohistochemistry using D2-40 and CD31 antibodies showed irregular luminal proliferation at the anastomosis, infiltration into the surrounding tissue, and massive necrosis, thereby leading to the diagnosis of breast angiosarcoma. We have reported a case of breast angiosarcoma with a preoperative diagnosis of late recurrence of breast cancer.

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An extremely rare case of a gastric accessory spleen: case report and review of the literature

BMC Gastroenterology ◽

10.1186/s12876-021-01852-z ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Guiqin Chen ◽

Lei Nie ◽

Tijiang Zhang

Keyword(s):

Rare Case ◽

Accessory Spleen ◽

Gastric Fundus ◽

Pathological Examination ◽

Review Of The Literature ◽

Gastric Bleeding ◽

Computed Tomographic ◽

Normal Spleen ◽

Elevated Lesion ◽

Lesser Curvature

Abstract Background The accessory spleen has no anatomical or vascular relationship with the normal spleen, The tissue structure and physiological function of the accessory spleen are the same as those of the normal spleen, which usually locate in the splenic hilum and the tail of the pancreas. The aims of this manuscript are to present a rare case of the gastric accessory spleen and a review of the literature. Case presentation A 19-year-old male patient was sent to the emergency department with stomach bleeding after drinking alcohol. The computed tomographic scan showed a 1.2 cm × 1.7 cm mass at the lesser curvature of the gastric fundus. Gastrointestinal endoscopy displayed a submucosal elevated lesion on the gastric fundus, and gastrectomy was performed. Postoperative pathological examination proved an accessory spleen in the stomach. The postoperative course was uneventful, and the patient was discharged on the 6th day after the surgery. Conclusions The accessory spleen at the fundus of stomach is extremely rare, especially in this case, which is accompanied by acute gastric bleeding, and it is difficult to diagnosis before operation. Many literatures reported that it was misdiagnosis as tumor, so it is necessary to diagnose accessory spleen correctly.

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Oral Cancer: Raising Awareness of the Importance of Suspicion in Early Detection

Primary Dental Journal ◽

10.1177/2050168420980959 ◽

2021 ◽

Vol 10 (1) ◽

pp. 10-12

Author(s):

Farooq Ahmed ◽

Honieh Bolooki ◽

Senathrajah Ariyaratnam ◽

Michael N. Pemberton

Keyword(s):

Squamous Cell Carcinoma ◽

Oral Cancer ◽

Early Detection ◽

Cell Carcinoma ◽

Squamous Cell ◽

Verrucous Carcinoma ◽

Mucosal Lesion ◽

Morbidity And Mortality ◽

Raising Awareness ◽

Suspicious Lesions

Oral cancer is a significant cause of morbidity and mortality worldwide. In this article we present two cases of potentially innocuous looking lesions, initially thought to be traumatic in origin, but later diagnosed as cancer. The first patient presented with a persistent laceration thought to be caused by an accidental shaving injury, which was subsequently diagnosed as squamous cell carcinoma. The second patient presented with a hyperplastic mucosal lesion, suspected as forming due to denture-clasp irritation, which was subsequently diagnosed as proliferative verrucous carcinoma. The importance of early detection and palpation of suspicious lesions is emphasised in this article.

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Pseudoepitheliomatous keratotic and micaceous balanitis: low-risk human papilloma virus detection in two further cases

International Journal of STD & AIDS ◽

10.1177/0956462420961947 ◽

2020 ◽

pp. 095646242096194

Author(s):

Marialuisa Corbeddu ◽

Luca Pilloni ◽

Roberta Satta ◽

Laura Atzori ◽

Franco Rongioletti

Keyword(s):

Human Papillomavirus ◽

Verrucous Carcinoma ◽

Virus Detection ◽

Low Risk ◽

Hpv Testing ◽

Papilloma Virus ◽

Hpv Dna ◽

Proliferative Markers ◽

Male Patients ◽

Papillomavirus Dna

We report two cases of histologically documented pseudoepitheliomatous keratotic and micaceous balanitis in middle-aged male patients, which showed positivity for low-risk serotype human papillomavirus DNA. To our knowledge, only one other case has been documented. Further immunohistochemical proliferative markers were performed and compared to literature findings in penile epithelial proliferations. Evolution to invasive verrucous carcinoma has been associated with absence of HPV DNA. Thus, if confirmed by further studies, HPV testing should be included in pseudoepitheliomatous keratotic and micaceous balanitis assessment to address prognosis, and management.

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Appendiceal cancer leading to intussusception detected incidentally during follow-up for Peutz–Jeghers syndrome

Clinical Journal of Gastroenterology ◽

10.1007/s12328-020-01200-w ◽

2020 ◽

Vol 13 (6) ◽

pp. 1136-1143

Author(s):

Kazuhiro Kurihara ◽

Takanori Suganuma

Keyword(s):

Malignant Tumors ◽

Endoscopic Examination ◽

Autosomal Dominant Disorder ◽

Tomography Image ◽

Elevated Lesion ◽

Poorly Differentiated ◽

Lower Endoscopy ◽

Peutz Jeghers Syndrome ◽

Computed Tomography Image

AbstractPeutz–Jeghers syndrome is an autosomal dominant disorder characterized by hamartomatous polyposis, pigmentation, and malignant tumors. We report a case of ileocecal carcinoma that was incidentally detected during follow-up for Peutz–Jeghers syndrome. A 39-year-old man with solitary Peutz–Jeghers syndrome had undergone three abdominal surgeries. He had been followed up via upper and lower gastrointestinal endoscopy and small intestinal endoscopy. In the endoscopic examination of the lower gastrointestinal tract, a 35 mm large, bumpy, elevated lesion was observed in the cecum. This lesion was not observed 9 months earlier during lower endoscopy. Biopsy of the specimen confirmed tubulovillous adenoma and carcinoma. This lesion was judged to be an indication for operation, and we performed ileocecectomy + D3 lymph node dissection. From the excised specimen, poorly differentiated carcinoma and adenoma components in contact with Peutz–Jeghers-type polyps in the appendix were recognized. A review of the computed tomography image obtained 2 years ago confirmed appendiceal swelling. We suspect that the ileocecal carcinoma in the appendix may have rapidly developed within the 9 months, and was incidentally detected on lower endoscopic examination during follow-up. For the prevention of appendicular tumorigenesis, prophylactic appendectomy may be considered in certain cases during follow-up for Peutz–Jeghers syndrome.

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Research on miRNA-195 and target gene CDK6 in oral verrucous carcinoma

Cancer Gene Therapy ◽

10.1038/cgt.2017.18 ◽

2017 ◽

Vol 24 (7) ◽

pp. 282-288 ◽

Cited By ~ 7

Author(s):

Z Deng ◽

Y Wang ◽

X Fang ◽

F Yan ◽

H Pan ◽

...

Keyword(s):

Target Gene ◽

Verrucous Carcinoma

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Intra-Abdominal Localisation of a Buschke-Lowenstein Tumour: Case Presentation and Review of the Literature

Case Reports in Transplantation ◽

10.1155/2013/187682 ◽

2013 ◽

Vol 2013 ◽

pp. 1-6 ◽

Cited By ~ 2

Author(s):

N. E. Wester ◽

E. M. Hutten ◽

C. Krikke ◽

Robert A. Pol

Keyword(s):

Interferon Therapy ◽

Verrucous Carcinoma ◽

Treatment Options ◽

Condyloma Acuminata ◽

Review Of The Literature ◽

Case Presentation ◽

Advantages And Disadvantages ◽

Literature Overview ◽

Mucosal Surfaces ◽

Tumour Reduction

Giant condyloma acuminatum or Buschke-Lowenstein tumour is a very rare disease which usually is located in the genital, anorectal, and perianal regions. It is regarded as a type of verrucous carcinoma occurring on anogenital mucosal surfaces where it is locally invasive but displays a benign cytology. We describe a case of a 24-year-old woman with persisting condyloma acuminata progressing to a large intra-abdominal Buschke-Lowenstein tumour. To our knowledge such an advanced stage has only been reported once before. The severity and extent of the tumour both determine the treatment and patient outcome. Treatment was impeded by cachexia, an immunosuppressive state after kidney transplantation and difficulties in establishing a reliable diagnose. Interferon treatment was started which initially led to tumour reduction but was complicated by an interferon-induced pancreatitis, pneumonia, and fasciitis necroticans resulting in death. We present a literature overview on the treatment options for a Buschke-Lowenstein tumour, with emphasis on interferon therapy, with all the advantages and disadvantages.

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